Isopsoralen

Catalog No.S3892 Synonyms: angelicin

Isopsoralen Chemical Structure

Molecular Weight(MW): 186.16

Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.

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Biological Activity

Description Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
In vitro

Isopsoralen treatment stimulates the accumulation of cartilage nodules in a dose-dependent manner. Isopsoralen enhances the expressions of chondrogenic marker genes such as collagen II, collagen X, OCN, Smad4 and Sox9 in a time-dependent manner. Furthermore, isopsoralen induces the activation of extracellular signal-regulated kinase (ERK) and p38 MAP kinase, but not that of c-jun N-terminal kinase (JNK). Isopsoralen significantly enhances the protein expression of BMP-2 in a time-dependent manner and mediates a chondromodulating effect by BMP-2 or MAPK signaling pathways[2].

In vivo Isopsoralen has significant osteoprotective effect in female and male mice with sex hormone deprivation. After administration of isopsoralen for 8 weeks, Bone strength increases and trabecular bone microstructure improves[1]. After intravenous administration to wistar rats, the elimination half-lives of isopsoralen is 5.35 h. The area under the curves of the tissues for isopsoralen decrease in the following order: kidney > lung > liver > heart > spleen > brain. After oral administration to Wistar rats, the elimination half-lives of isopsoralen is 5.56 h, and its bioavailability is 70.35%[3].

Protocol

Cell Research:

[2]

+ Expand
  • Cell lines: ATDC5 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 24 h
  • Method:

    ATDC5 cells are seeded in 96-well plate at a density of 5×103 cells/well and incubated overnight in media supplemented with 10% FBS followed by treatment with various concentrations of isopsoralen. After 24h of incubation, cells are washed with phosphate-buffered saline (PBS) and then treated with media containing 100 μg/ml MTT for 2 h at 37℃. The cells are then washed with PBS, and dissolved in 200 μl of DMSO. The resulting solubilized purple formazan is quantified by measuring the absorbance at a wavelength of 540 nm using a spectrophotometer.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: ICR mice
  • Formulation: water
  • Dosages: 10 mg/kg and 20 mg/kg
  • Administration: intragastrically
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 14 mg/mL (75.2 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 186.16
Formula

C11H6O3

CAS No. 523-50-2
Storage powder
in solvent
Synonyms angelicin

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID