Home Immunology & Inflammation ADC Cytotoxin inhibitor Isopsoralen

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Isopsoralen ADC Cytotoxin inhibitor

Cat.No.S3892

Isopsoralen (Angelicin), also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
Isopsoralen ADC Cytotoxin inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 186.16

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Quality Control

Batch: Purity: 99.91%
99.91

Solubility

In vitro
Batch:

DMSO : 14 mg/mL (75.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 186.16 Formula

C11H6O3

 Storage (From the date of receipt)
CAS No. 523-50-2 Download SDF Storage of Stock Solutions

Synonyms angelicin Smiles C1=CC2=C(C=CO2)C3=C1C=CC(=O)O3

Mechanism of Action

In vitro
Isopsoralen treatment stimulates the accumulation of cartilage nodules in a dose-dependent manner. This compound enhances the expressions of chondrogenic marker genes such as collagen II, collagen X, OCN, Smad4 and Sox9 in a time-dependent manner. Furthermore, it induces the activation of extracellular signal-regulated kinase (ERK) and p38 MAP kinase, but not that of c-jun N-terminal kinase (JNK). It significantly enhances the protein expression of BMP-2 in a time-dependent manner and mediates a chondromodulating effect by BMP-2 or MAPK signaling pathways.
In vivo
Isopsoralen has significant osteoprotective effect in female and male mice with sex hormone deprivation. After administration of this compound for 8 weeks, Bone strength increases and trabecular bone microstructure improves. After intravenous administration to wistar rats, the elimination half-lives of this chemical is 5.35 h. The area under the curves of the tissues for it decrease in the following order: kidney > lung > liver > heart > spleen > brain. After oral administration to Wistar rats, the elimination half-lives of this compound is 5.56 h, and its bioavailability is 70.35%.
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