Catalog No.S3892 Synonyms: angelicin
Molecular Weight(MW): 186.16
Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.
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|Description||Isopsoralen, also known as angelicin, is a constituent of roots and leaves of angelica with anti-inflammatory activity and regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. It also shows antiviral activity against gammaherpesviruses.|
Isopsoralen treatment stimulates the accumulation of cartilage nodules in a dose-dependent manner. Isopsoralen enhances the expressions of chondrogenic marker genes such as collagen II, collagen X, OCN, Smad4 and Sox9 in a time-dependent manner. Furthermore, isopsoralen induces the activation of extracellular signal-regulated kinase (ERK) and p38 MAP kinase, but not that of c-jun N-terminal kinase (JNK). Isopsoralen significantly enhances the protein expression of BMP-2 in a time-dependent manner and mediates a chondromodulating effect by BMP-2 or MAPK signaling pathways.
|In vivo||Isopsoralen has significant osteoprotective effect in female and male mice with sex hormone deprivation. After administration of isopsoralen for 8 weeks, Bone strength increases and trabecular bone microstructure improves. After intravenous administration to wistar rats, the elimination half-lives of isopsoralen is 5.35 h. The area under the curves of the tissues for isopsoralen decrease in the following order: kidney > lung > liver > heart > spleen > brain. After oral administration to Wistar rats, the elimination half-lives of isopsoralen is 5.56 h, and its bioavailability is 70.35%.|
|In vitro||DMSO||14 mg/mL (75.2 mM)|
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