Luteolin

Catalog No.S2320 Synonyms: Luteoline, Luteolol, Digitoflavone

For research use only.

Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.

Luteolin Chemical Structure

CAS No. 491-70-3

Selleck's Luteolin has been cited by 17 publications

Purity & Quality Control

Choose Selective ADC Cytotoxin Inhibitors

Biological Activity

Description Luteolin (Luteoline, Luteolol, Digitoflavone) is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2.
Targets
PDE2 [1]
(Cell-free assay)
PDE5 [1]
(Cell-free assay)
PDE4 [1]
(Cell-free assay)
PDE3 [1]
(Cell-free assay)
PDE1 [1]
(Cell-free assay)
6.4 μM(Ki) 9.5 μM(Ki) 11.1 μM(Ki) 13.9 μM(Ki) 15.0 μM(Ki)
In vitro

Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. [1] Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells NE\XTnNHfW6ldHnvckBie3OjeR?= MWSyJIg> M3HzemlvcGmkaYTpc44hd2ZiTl:gdJJw\HWldHnvckBqdiCOUGOtd5RqdXWuYYTl[EBud3W|ZTDSRXczPjRwNzDj[YxteyCycnWtbY5kfWKjdHXkJIZweiB{IHjyd{Bj\W[xcnWgUHBUKHO2aX31cIF1cW:wIH\vdkAzPCCqcoOgZpkhT3KrZYPzJIF{e2G7IH3leIhw\CxiSVO1NF0xNjJzIN88US=> M4rOZVI2OTd4MUi3
HEK293 FS cells NGnhOHBHfW6ldHnvckBie3OjeR?= MlSwTY5pcWKrdHnvckBw\iCQT2i0JIV5eHKnc4Pl[EBqdiCKRVuyPVMhTlNiY3XscJMh[XO|ZYPz[YQh[XNiSELPNkBxem:mdXP0bY9vKGK7IFiyU|IwXHm{L1zQU{Bie3OjeTygTWM2OD1yLki1JO69VQ>? NGiw[owzODd|MUO1Oy=>
CHO cells NIDteGtHfW6ldHnvckBie3OjeR?= MoKwRYdwdmm|dDDhZ5Rqfmm2eTDheEBz[XRiRFHUJIV5eHKnc4Pl[EBqdiCFSF:gZ4VtdHNuIFXDOVA:OS52NTFOwG0> NH[0WY4zODl5MU[1NC=>
human MV4-11 cells NFLFcG5EgXSxdH;4bYNqfHliYYPzZZk> NVvTXFZbPzJiaB?= NXTS[nY2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVVZ2LUGxJINmdGy|IHjhdoJwemmwZzDGUHQ{KG23dHH0bY9vKGGodHXyJFczKGi{czDifUB1\XS{YYrvcIl2dSCkYYPl[EBGgiCFeWTvfEBk\WyuII\pZYJqdGm2eTDhd5NigSxiR1m1NF0yNjd4IN88US=> MWmyN|QyOTB5Mx?=
HEK293 cells MoH1SpVv[3Srb36gZZN{[Xl? NWmz[21vOjRiaB?= NEL2blNC\2:waYP0JIFkfGm4aYT5JIF1KG2xdYPlJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJINwNWW6cILld5Nqdmdid3n0bEBI[Wx2IILldI9zfGW{II\lZ5RweiCjZoTldkAzPCCqcoOgZpkh\HWjbD3seYNq\mW{YYPlJJJmeG:{dHXyJIF{e2G7LDDFR|UxRTJwMzFOwG0> MXmyOFk2PTh6OR?=
human U2OS cells NGL2WXNHfW6ldHnvckBie3OjeR?= NWfkc29IPSCq NX3DRnRxSWexbnnzeEBi[3Srdnn0fUBifCCJUGKzOUBz\WOncITvdkBqdiCqdX3hckBWOk:VIHPlcIx{KGOxZYjwdoV{e2mwZzDHZYw1NV[SMU[tWGVXKGG|c3Xzd4VlKGG|IHLleIEh[XK{ZYP0bY4hfHKjboPsc4NifGmxbjDh[pRmeiB3IHjyd{BjgSCkZYThJIxi[3SjbXHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVMvOiEQvF2= NGPOUIczPDlyMES0Oy=>
RBL-2H3 cells MnXRSpVv[3Srb36gZZN{[Xl? NVLCT4FnUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEmOLUSgdJJw\HWldHnvckBqdiCUQlytNmg{KGOnbHzzJJdieyCmZYTldo1qdmWmLDDJR|UxRTNwNzFOwG0> MW[xNlk2OTB7Mh?=
human mast cells NUHBTWtOTnWwY4Tpc44h[XO|YYm= MkLQTY5pcWKrdHnvckBw\iCVWVugbY4hcHWvYX6gcYF{fCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gcYF{fCClZXzsJIRm\3KjboXsZZRqd25uIFXDOVA:PC53IN88US=> NIXvbWMzOjJ3N{KxNy=>
human LNCAP cells M{LiUGZ2dmO2aX;uJIF{e2G7 M2n2XWRwf26{ZXf1cIF1cW:wIH;mJJBzd3O2YYTlJJNx\WOrZnnjJIFvfGmpZX6gd4VkemW2aX;uJIlvKGi3bXHuJGxPS0GSIHPlcIx{NCCLQ{WwQVUh|ryP MX[yOVAyQTR5OB?=
rat H9c2 cells MVPGeY5kfGmxbjDhd5NigQ>? MV6yOEBp MVPDfZRweHKxdHXjeIl3\SCjY4Tpeol1gSCjZ3HpcpN1KGSxeH;yeYJq[2mwLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIlvKHKjdDDIPYMzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;NT61N{DPxE1? NHH2[I4zODl|Mke2Ni=>
human HT-29 cells M17tTWZ2dmO2aX;uJIF{e2G7 MnHhNVAhdWmwcx?= NVnxfWRNSWexbnnzeEBi[3Srdnn0fUBifCCJUGKzOUBz\WOncITvdkBqdiCqdX3hckBJXC1{OTDj[YxteyCjZoTldkAyOCCvaX7zJIJ6KGS7bnHtbYMhdWG|czDy[YRqe3S{aXL1eIlwdiCjc4PhfUwhTUN3ME23MlI1KM7:TR?= M{G5fFI1QTByNES3
human RS4:11 cells Mo\ZR5l1d3SxeHnjbZR6KGG|c3H5 MXq3NkBp MUHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSV|Q7OTFiY3XscJMhcGG{Yn;ybY5oKHerbHSgeJlx\SCITGSzJIFnfGW{IEeyJIhzeyCkeTD0[ZRz[XqxbHn1cUBj[XOnZDDFfkBEgVSxeDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3ME23MlI2KM7:TR?= NU\L[2NGOjN2MUGwO|M>
NCI-H460 cells M4nJV2Z2dmO2aX;uJIF{e2G7 MoPaNk0zOCCq NXniboRWUW6qaXLpeIlwdiCxZjDBRmNIOiCneIDy[ZN{\WRiaX6gbJVu[W5iTlPJMWg1PjBiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBRcEFiYXPjeY12dGG2aX;uJIFnfGW{IEKgeI8hOjBiaILzJJJmdGG2aY\lJJRwKG[3bXn0doVud3KpaX6gR{whUUN3ME24Mlkh|ryP MWmyNVI4PTN6Nh?=
human H9 cells MnnqSpVv[3Srb36gZZN{[Xl? MkXkN{Bl[Xm| NHjldndCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJUVZzIEPCJIlv\mWldHXkJIlvKGi3bXHuJGg6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IICyOEBidnSrZ3XuJINieHS3cnWgZZN{[XluIFXDOVA:OTBizszN MlnFPFE2QDF4NB?=
MDCK cells NIPyVnREgXSxdH;4bYNqfHliYYPzZZk> M4XEV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KE2GQ1ugZ4VtdHNiYomgUXRVKGG|c3H5MEBESzVyPUGyMlQ1KM7:TR?= MXixPFY1ODB2Mh?=
mouse B16-4A5 cells NWHYUlBvTnWwY4Tpc44h[XO|YYm= NV;UdVhlPzJiaB?= M165TGlvcGmkaYTpc44hd2ZidHjlc5BpgWyuaX7lMZN1cW23bHH0[YQhdWWuYX7v[4Vv\XOrczDpckBud3W|ZTDCNVYuPEF3IHPlcIx{KGGodHXyJFczKGi{czygTWM2OD1zNDFOwG0> M1flXFIxOTh7M{m5
K562 cells MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUe1JIRigXN? MYXHdo94fGhiaX7obYJqfGmxbjDv[kBMPTZ{IHPlcIx{KGK7IGjUWEBie3OjeTDh[pRmeiB3IHThfZMtKEmFNUC9NVQvPjVizszN NW\UPYxOOTd2MUGwPVI>
human H9 cells Mn3zR5l1d3SxeHnjbZR6KGG|c3H5 NHzCSY8{KGSjeYO= NEHlOphEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJQSClZXzsd{Bi\nSncjCzJIRigXNuIFnDOVA:OTZizszN MofZPFE2QDF4NB?=
human HT-29 cells NGnacnRHfW6ldHnvckBie3OjeR?= M2fCbVExKG2rboO= MmP0SIV{\W6|aYTpfoF1cW:wIH;mJGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIFjUMVI6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gfoFxemmwYYP0MYlv\HWlZXSg[Jlv[W2rYzDtZZN{KHKnZHnzeJJq[nW2aX;uJIFnfGW{IEGwJI1qdnNuIFnDOVA:OThwNjFOwG0> M{PKOlI1QTByNES3
human U937 cells M1q3NnBzd2yrZnXyZZRqd25iYYPzZZk> MXW3NkBp NF6yd|NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGW5N|ch[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IGfTWE05KGG|c3H5MEBKSzVyPUKwJO69VQ>? Ml71NVcyPThyNUS=
mouse HT22 cells NVTkZoFZTnWwY4Tpc44h[XO|YYm= M1P4eVMhcA>? MV;O[ZVzd3C{b4TlZ5RqfmViYXP0bZZqfHliaX6gcY92e2ViSGSyNkBk\WyuczDhd5Nme3OnZDDhd{B1NUKRT1itbY5lfWOnZDD0c5hq[2m2eTDheEA1OCC3TTDwdoVqdmO3YnH0[YQh\m:{IEOgbJJ{KG[xbHzve4VlKGK7IIStRm9QUCCrbnT1Z5Rqd25ibXXhd5Vz\WRiYX\0[ZIhQSCqcoOgZpkhVVSWIHHzd4F6 MkT4NlQzPDV7M{m=
human THP1 cells NVTQWnF4TnWwY4Tpc44h[XO|YYm= NG\5VFQzOCEQvF2= NXPCV3ZNOSCq NUnOUXc4TG:5boLl[5Vt[XSrb36gc4YhXFCDLXnu[JVk\WRiTl;YNkBuWk6DIHX4dJJme3Orb36gbY4hcHWvYX6gWGhROSClZXzsd{BifCB{MDD1UUBqdmO3YnH0[YQh\m:{IEGgbJIheHKrb4KgeI8hXFCDIHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliUmStVGNTKGGwYXz5d4l{ MYmyN|c5PjV{MB?=
MDA-MB-231 cells NF;ic5RHfW6ldHnvckBie3OjeR?= MnO0OUDPxE1? MY[xOkBp M3f5ZmlvcGmkaYTpc44hd2ZiUF3BMZN1cW23bHH0[YQhVkZva3HwdIFDKHOrZ37hcIlv\yBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDNSGEuVUJvMkOxJINmdGy|IHH0JFUhfU1iaX7jeYJifGWmIH\vdkAyPiCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 M13wNlI2OTlyNE[2
HL60 cells NHfFW2lRem:uaX\ldoF1cW:wIHHzd4F6 NYK1OnFEOzBizszN MYK0PEBp MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYYSgN|AhfU1iYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigQ>? M{fTUVE5OjV6NESw
Assay
Methods Test Index PMID
Western blot TET1 / TET2 / TET3 ; DNMT1 / DMNT3A / DNMT3B ; p21 / Survivin / Cyclin D1 ; p-VEGFR2 / p-mTOR / pS6K1 / p70S6K1 / pAKT / AKT / MMP-2 / MMP-9 ; ERK / p-ERK / JNK / p-JNK / p38 / p-p38 / Bax / Bcl-2 ; Caspase-3 / Cleaved Caspase-3 / Caspase-8 / Cleaved Caspase-8 ; FADD / PARP / Cleaved PARP 30988303 30930986 23300633 30992674
Immunofluorescence 5-hmC 30988303
Growth inhibition assay Cell viability 30992674
In vivo LD50: Mice >2500mg/kg (i.g.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 286.24
Formula

C15H10O6

CAS No. 491-70-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.

Frequently Asked Questions

Question 1:
Would you please suggest a suitable vehicle to dissolve Luteolin for in vivo i.p. use?

Answer:
Formula: 5% DMSO+40% PEG 300+5% Tween80+ddH2O, working Solution concentration: up to 7.5mg/ml, stable for 30min.

Tags: buy Luteolin | Luteolin supplier | purchase Luteolin | Luteolin cost | Luteolin manufacturer | order Luteolin | Luteolin distributor