L-Leucine

Synonyms: (S)-Leucine, Leu

Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

L-Leucine Chemical Structure

L-Leucine Chemical Structure

CAS No. 61-90-5

Purity & Quality Control

L-Leucine Related Products

Signaling Pathway

Biological Activity

Description Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
In vitro
In vitro Leucine also stimulates protein synthesis in muscle and is closely associated with the release of gluconeogenic precursors, such as alanine, from muscle[1].
In Vivo
In vivo Leucine has a half-life of 45 minutes[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05621291 Recruiting
B-All|Acute Lymphoblastic Leukemia
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
May 15 2024 Not Applicable
NCT06340685 Recruiting
Pyruvate Dehydrogenase Complex Deficiency
Jirair Krikor Bedoyan|Ultragenyx Pharmaceutical Inc|University of Pittsburgh
May 2024 Phase 1
NCT06256744 Not yet recruiting
Dietary Supplementation|Exercise
Brock University|University of Toronto
March 2024 Not Applicable
NCT06050668 Not yet recruiting
Femoral Fracture|Fragility Fracture|Muscle Atrophy
Michael C Willey|MEND|University of Iowa
February 2024 Not Applicable

Chemical Information & Solubility

Molecular Weight 131.17 Formula

C6H13NO2

CAS No. 61-90-5 SDF --
Smiles CC(C)CC(C(=O)O)N
Storage (From the date of receipt)

In vitro
Batch:

Water : 13 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy L-Leucine | L-Leucine supplier | purchase L-Leucine | L-Leucine cost | L-Leucine manufacturer | order L-Leucine | L-Leucine distributor