L-Leucine

For research use only.

Catalog No.S3753 Synonyms: (S)-Leucine, Leu

L-Leucine Chemical Structure

CAS No. 61-90-5

Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

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Biological Activity

Description Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
In vitro

Leucine also stimulates protein synthesis in muscle and is closely associated with the release of gluconeogenic precursors, such as alanine, from muscle[1].

In vivo Leucine has a half-life of 45 minutes[1].

Protocol

Solubility (25°C)

In vitro Water 5 mg/mL (38.11 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 131.17
Formula

C6H13NO2

CAS No. 61-90-5
Storage powder
in solvent
Synonyms (S)-Leucine, Leu
Smiles CC(C)CC(C(=O)O)N

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04939051 Not yet recruiting Biological: Obeticholic Acid|Drug: Placebo Administration Barrett Esophagus National Cancer Institute (NCI) December 8 2021 Phase 2
NCT05012982 Not yet recruiting Device: AirBand|Device: uninflated AirBand Anterior Cruciate Ligament Reconstruction Yale University October 2021 Phase 4
NCT04949607 Not yet recruiting Dietary Supplement: Inulin fructooligosaccharide Brain Injury Chronic|Brain Injuries Traumatic Centre for Neuro Skills|University of Texas July 1 2021 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID