Home PI3K/Akt/mTOR mTOR activator L-Leucine

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L-Leucine mTOR activator

Cat.No.S3753

Leucine ((S)-Leucine, Leu) is one of nine essential amino acids in humans which is important for protein synthesis and many metabolic functions. It contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
L-Leucine mTOR activator Chemical Structure

Chemical Structure

Molecular Weight: 131.17

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 131.17 Formula

C6H13NO2

 Storage (From the date of receipt)
CAS No. 61-90-5 -- Storage of Stock Solutions

Synonyms (S)-Leucine, Leu Smiles CC(C)CC(C(=O)O)N

Solubility

In vitro
Batch:

Water : 13 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro
Leucine also stimulates protein synthesis in muscle and is closely associated with the release of gluconeogenic precursors, such as alanine, from muscle[1].
In vivo
Leucine has a half-life of 45 minutes[1].
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05621291 Recruiting
B-All|Acute Lymphoblastic Leukemia
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
 May 15 2024 Not Applicable
NCT06340685 Recruiting
Pyruvate Dehydrogenase Complex Deficiency
Jirair Krikor Bedoyan|Ultragenyx Pharmaceutical Inc|University of Pittsburgh
 May 2024 Phase 1
NCT06256744 Not yet recruiting
Dietary Supplementation|Exercise
Brock University|University of Toronto
 March 2024 Not Applicable
NCT06050668 Not yet recruiting
Femoral Fracture|Fragility Fracture|Muscle Atrophy
Michael C Willey|MEND|University of Iowa
 February 2024 Not Applicable

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