Anti-mouse CD40L (CD154)-InVivo

Catalog No.A2112

The MR-1 monoclonal antibody reacts with mouse CD154 also known as CD40 ligand. The MR-1 monoclonal antibody has been reported to inhibit in vitro activation of B lymphocytes by blocking the binding of CD154 with CD40 on T helper cells as well as inhibit the formation of germinal centers and disrupt antigen-specific T cell responses. Additionally, the MR-1 antibody blocks interactions of T cells and antigen-presenting cells in vitro and blocks the development of experimental autoimmune disease in vivo.

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Protocol

Product Details

Molecular Weight 150 kDa
Clone MR-1
Immunogen Activated mouse Th1 clone D1.6
Formulation PBS buffer, pH 7.0
Isotype Armenian Hamster IgG
Application in vivo/vitro blocking of CD40/CD40L,WB
Storage Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Purification protein A
Sterility 0.2 μM filtered

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID