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β-Amyloid (25-35) Beta Amyloid chemical

Name: β-Amyloid (25-35)
Brand: Selleck Chemicals
SKU: E2948
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E2948

β-Amyloid (25-35) (Amyloid beta-peptide (25-35), Aβ25-35, β-Amyloid peptide (25-35)) is a highly toxic synthetic derivative of Amyloid beta-peptide (Aβ-peptides) which forms fibrillary aggregates. This compound, with the sequence GSNKGAIIGLM, is involved in the pathogenesis of Alzheimer's disease.

Chemical Structure

Molecular Weight: 1060.27

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Quality Control

Batch: E294801 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.08%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS/MSDS
Datasheet

99.08

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE)
Other Beta Amyloid Inhibitors	FPS-ZM1 EUK 134 Ginsenoside Rg1 (-)-epigallocatechin Tabersonine hydrochloride Ginsenoside Re Hoechst 34580 Simufilam Tenuifolin Brazilin

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (94.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	1060.27	Formula	C₄₅H₈₁N₁₃O₁₄S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	131602-53-4	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/15293994/ [2] https://pubmed.ncbi.nlm.nih.gov/25471398/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-07)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05806697	RECRUITING	Alzheimer Disease; Memory Complaint; Memory Disorders	Institut National de la Santé Et de la Recherche Médicale, France	2023-04-14
NCT06470061	NOT_YET_RECRUITING	Alzheimer Disease; Mild Cognitive Impairment; Cognitive Decline	Zaparackas and Knepper LTD	2024-07	PHASE2
NCT05361382	ACTIVE_NOT_RECRUITING	Alzheimer Disease	Tharick Pascoal	2022-03-02	PHASE1
NCT07343999	NOT_YET_RECRUITING	Transthyretin Cardiac Amyloidosis	Universidad de Burgos	2026-06
NCT05642429	ACTIVE_NOT_RECRUITING	Alzheimer Disease	Institute for Molecular Medicine	2023-02-27	PHASE1
NCT06604390	COMPLETED	Elderly Individuals Aged 60 Years or Older; Mild Cognitive Impairment (MCI)	Rahmi Novita Yusuf	2024-02-01

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