All Products

Catalog No. Product Name Information
S2958 0375-0604 (KRAS inhibitor-9)

0375-0604 (KRAS inhibitor-9, DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. 0375-0604 (KRAS inhibitor-9, DUN09716) causes G2/M cell cycle arrest and induces apoptosis.

S3306 1,1,1,1-Kestohexaose 1,1,1,1-Kestohexaose is a major DP 6 fructan in crested wheatgrass leaves.
S9109 1-Kestose 1-Kestose (1F-beta-D-Fructosylsucrose), a fructooligosaccharide, could efficiently stimulates Faecalibacterium prausnitzii as well as Bifidobacteria in humans.
E0665 11-Keto-beta-boswellic acid

11-Keto-beta-boswellic acid is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.

S6237 2-Ketoglutaric acid 2-Ketoglutaric acid (AKG, alpha-ketoglutarate, alpha-ketoglutaric acid, 2-oxoglutaric acid), is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase.
A5392 58K Golgi protein Rabbit Recombinant mAb 58K Golgi protein Rabbit Recombinant mAb detects endogenous level of total 58K Golgi protein.
A5204 67kDa Laminin Receptor Rabbit Recombinant mAb 67kDa Laminin Receptor Rabbit Recombinant mAb detects endogenous level of total 67kDa Laminin Receptor.
E0941 K-604 dihydrochloride K-604 dihydrochloride, a potent and selective inhibitor of Acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.
S7331 K-Ras(G12C) inhibitor 12 K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
S7333 K-Ras(G12C) inhibitor 6 K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C).
S7332 K-Ras(G12C) inhibitor 9 K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
S0023 K-Ras-IN-1 K-Ras-IN-1 (MDK-3017) inhibits K-Ras by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
S3519 K-Ras-PDEδ-IN-1 K-Ras-PDEδ-IN-1 is a potent competitive inhibitor of K-Ras-PDEδ that binds to the farnesyl binding pocket of PDEδ with Kd of 8 nM.
S7359 K02288 K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.
S8100 K03861 K03861 (AUZ 454,AUZ454) is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.
E1123 K145 K145 is a selective, substrate-competitive and orally active sphingosine kinase-2 (SphK2) inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM in biochemical assays.
S9934 KA2507 KA2507, a potent, orally active and selective HDAC6 inhibitor with IC50 of 2.5 nM, shows antitumor activities and immune modulatory effects in preclinical models.
E3198 Kadsura longipedunculata Ratan Extract
E2290 Kadsurin Kadsurin, a natural compound from the stems of Kadsura heteroclita (Schizandraceae), results in significant decreases of CCL4- induced lipid-peroxidation products.
E3616 Kaempferia galanga Extract Kaempferia galanga Extract is extracted from the rhizome of Kaempferia galanga L. (Zingiberaceae). Kaempferia galanga is used to get relief from indigestion, swelling, pain, high blood pressure, and dyslipidemia.
S3879 Kaempferide Kaempferide (4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether), a natural compound derived from the roots of kaempferia galanga, has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties.
S9112 Kaempferitrin Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
S2314 Kaempferol (NSC 407289) Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
E2479 Kaempferol-3-O-gentiobioside Kaempferol 3-O-gentiobioside, a flavonoid isolated from C. alata leaves with antidiabetic activity, possesses activity against α-glucosidase and displays carbohydrate enzyme inhibitory effect.
S5468 Kaempferol-3-O-glucorhamnoside Kaempferol 3-neohesperidoside (Kaempferol 3-neohesperidoside), isolated from the herbs of Delphinium grandiflorum L., has insulin-like properties in terms of glucose lowering.
S3278 Kaempferol-3-O-neohesperidoside Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid isolated from the leaf extract of Primula latifolia Lapeyr. and Primula vulgaris Hudson, stimulates glycogen synthesis in rat soleus muscle via PI3K - GSK-3 pathway and MAPK - PP1 pathway.
S3267 Kaempferol-3-O-rutinoside Kaempferol-3-O-rutinoside (Nicotiflorin, Nikotoflorin, Kaempferol 3-O-β-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.
E2294 Kaempferol-7-O-β-D-glucopyranoside Kaempferol-7-O-β-D-glucopyranoside is a flavonoid isolated from Malus pumila Mill. flowers, has antioxidative, anti-inflammatory and procoagulant activities.
E2781 Kahweol

Kahweol is one of the consituents of the coffee from <i>Coffea arabica</i> with anti-inflammatory anti-angiogenic, and anti-cancerous activities.

E2350 Kakkalide Kakkalide is an isoflavone derived from the flowers of Pueraria lobata. Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species (ROS)-associated inflammation.
S0971 Kakuol Kakuol is a natural compound extracted from the rhizomes of Asarum sieboldii with antifungal activity.
E3841 Kale Extract
E2582 kamebakaurin

Kamebakaurin is a natural compound isolated from <i>Isodon japonicus</i>. Kamebakaurin is a potent inhibitor of <b>NF-κB</b> activation by directly targeting DNA-binding activity of p50.

S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
S2315 Kanamycin sulfate Kanamycin sulfate (Kanamycin monosulfate, Ophtalmokalixan) is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections.
E3215 Kansui Radix Extract
E2287 Kansuinine A

Kansuinine A inhibits IL-6-induced Stat3 activation and possesses antiviral and anticancer activities.

E2288 Kansuinine B

Kansuinine B inhibits IL-6-induced Stat3 activation and possesses anti-viral activity, which is be used in the study for COVID-19.

E2291 Kansuiphorin C

Kansuiphorin C ameliorates malignant ascites by modulating gut microbiota and related metabolic functions.

E2608 Karacoline

Karacoline, a diterpene alkaloid found in the plant <i>Aconitum kusnezoffii</i>, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.

S7658 Kartogenin Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
P1132 Kassinin

Kassinin is a peptide derived from the Kassina frog. Kassinin belongs to tachykinin family of neuropeptides. Kassinin is secreted as a defense response, involving in neuropeptide signalling.

S5553 Kasugamycin hydrochloride Kasugamycin is an aminoglycosidic antibiotic isolated from Streptomyces kasugaensis, showing broad-spectrum anti-fungal activity against yeast and various fungus species.
S5968 Kasugamycin hydrochloride hydrate Kasugamycin (Ksg) hydrochloride hydrate, an antibiotic which binds both the 30S and 70S ribosome, specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs.
A5478 KAT9/Elp3 Rabbit Recombinant mAb KAT9/Elp3 Rabbit Recombinant mAb detects endogenous level of total KAT9/Elp3.
E2308 Kauran-16,17-diol (ent-Kauran-16β,17-diol) Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activities, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages.
S9439 Kaurenoic acid Kaurenoic acid (kaurenoate, kaur-16-en-18-oic acid) is a natural diterpenoid found in the herbs of Croton antisyphiliticus. Kaurenoic acid has anti-inflammatory activity, the mechanisms may through inhibition of iNOS and COX-2 expression.
S9409 Kavain Kavain ((+)-Kavain), the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor.
S9901 KB-0742 Dihydrochloride

KB-0742 Dihydrochloride is a potent, selective, and orally bioavailable small molecule inhibitor of the transcription elongation cofactor CDK9 with IC50 of 6 nM for CDK9/cyclin T1 inhibition at 10 μM ATP.

S6532 kb-NB77-78 kb-NB77-78 is an analog of CID797718. However, it shows no inhibitory activty towards PKD1.
S4643 KB-R7943 mesylate KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCX(rev)) with IC50 of 5.7 μM. KB-R7943 mesylate promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux.
S0984 KCC-07 KCC-07 is a potent, selective and brain-penetrant inhibitor of MBD2 (methyl-CpG-binding domain protein 2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling.
A5987 KDM1/LSD1 Rabbit Recombinant mAb KDM1/LSD1 Rabbit Recombinant mAb detects endogenous levels of total KDM1/LSD1.
S1059 KDM4D-IN-1 KDM4D-IN-1 is a potent inhibitor of KDM4D with an IC50 of 0.41 μM.
S6574 KDU691 KDU691 is a Plasmodium PI4K-specific inhibitor with IC50 values of 0.18 μM and 0.061 μM against hypnozoite forms and liver schizontsm, respectively.
E3399 Kelp Extract
S7917 Kenpaullone Kenpaullone (9-Bromopaullone, NSC-664704) is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3β (GSK3β) with IC50 of 0.23 µM.
E2489 Keracyanin chloride

Keracyanin chloride (Cyanidin 3-rutinoside chloride), an anthocyanin, has antioxidant activity.

S2232 Ketanserin Ketanserin (R41468) is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug.
S1353 Ketoconazole (R 41400) Ketoconazole (R 41400) inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. Ketoconazole is an androgen biosynthesis inhibitor.
S3991 Ketoisophorone Ketoisophorone (4-Oxoisophorone), also known as 4-Oxoisophorone, is the major component of saffron spice.
S1645 Ketoprofen Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.
S1646 Ketorolac Ketorolac is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.
S5698 Ketorolac tromethamine salt Ketorolac tromethamine is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2.
S2024 Ketotifen Fumarate Ketotifen Fumarate is a fumaric acid salt of ketotifen which is a H1-antihistamine and mast cell stabilizer.
S5811 Kevetrin hydrochloride Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
E0640 KF-31327 KF-31327 is a selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, used for sexual enhancement study.
S8409 KG-501 (2-naphthol-AS-E-phosphate) KG-501 (2-naphthol-AS-E-phosphate) is a cAMP response element-binding protein (CREB) inhibitor that disrupts CREB-dependent transcription (Ki = 10 μM) and CREB:CBP interaction (Ki = 50 μM). It also disrupts phospho (Ser-133) CREB binding to KIX with a Ki of ≈90 μM, using concentrations of CREB that were within the linear range of the binding assay.
S8938 KGA-2727 KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.
S9012 Khasianine Khasianine is a natural product isolated from the herbs of Solanum nigrum L. and exhibits strong activity against liver damage induced by CCl4.
S5887 Khellin Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Kalangin), a compound isolated from the seeds of Ammi Visnaga Lam (Umbelliferae), is used to treat a variety of maladies.
S5919 KHS101 hydrochloride KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks.
S2906 Ki16198 Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6.
S1315 Ki16425 Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM in RH7777 cell lines, respectively, shows no activity at LPA4, LPA5, LPA6.
S7688 Ki20227 Ki20227 is an orally active and highly selective inhibitor of c-Fms tyrosine kinase(CSF1R) with IC50 of 2 nM, 12 nM, 451 nM and 217 nM for c-Fms, vascular endothelial growth factor receptor-2 (KDR/VEGFR-2), stem cell factor receptor (c-Kit), and platelet-derived growth factor receptor beta (PDGFRβ), respectively.
A5416 KIF3A Rabbit Recombinant mAb KIF3A Rabbit Recombinant mAb detects endogenous level of total KIF3A.
S0289 KIN1148 KIN1148 is an agonist of interferon regulatory factor 3 (IRF3) that induces dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. KIN1148 is an influenza vaccine adjuvant that enhances flu vaccine efficacy.
L1200 Kinase Inhibitor Library A unique collection of 1930 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).
S2316 Kinetin Kinetin (6-Furfuryladenine) is a type of cytokinin, a class of plant hormone that promotes cell division.
S2972 Kinetin riboside Kinetin riboside (N6-Furfuryladenosine) is a cytokinin analog that induces apoptosis in cancer cells. Kinetin riboside inhibits the proliferation of HCT-15 cells with IC50 of 2.5 μM.
E2347 Kinsenoside

kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects. kinsenoside rescues the nucleus pulposus cells (NPCs) viability under oxidative stress and protects against apoptosis, senescence and mitochondrial dysfunction in a Nrf2-dependent way.

E2652 Kira8 Kira8 (Ire-1 inhibitor, AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
E2037 Kisspeptin-10 (human) Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis, acts as a tumor metastasis suppressor via its receptor GPR54, inducing osteoblast differentiation via NFATc4-mediated BMP2 expression.
S3645 Kitasamycin Kitasamycin (Leucomycin) is a macrolide antibiotic. It has antimicrobial activity against a wide spectrum of pathogens.
S0147 KKL-10 KKL-10 is an inhibitor of ribosome rescue that exhibits exceptional broad-spectrum antimicrobial activity against bacteria.
S6562 KKL-35 KKL-35 inhibits the trans-translation tagging reaction with an IC50 of 0.9 µM. It has broad-spectrum antibiotic activity.
E0805 KL-11743 KL-11743 is a potent glucose-competitive inhibitor of the class I glucose transporters with IC50s of 115, 137 and 90 nM for GLUT1, GLUT2, and GLUT3.
S2829 KL-1333 KL-1333 (NQO1 activator 1) is an orally available NAD+ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD + levels via NADH oxidation. KL-1333 (NQO1 activator 1) improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts.
S6304 KL001 KL001 is a stabilizer that specifically interacts with cryptochrome (CRY). KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period.
A5391 KLF4 Rabbit Recombinant mAb KLF4 Rabbit Recombinant mAb detects endogenous level of total KLF4.
S3488 KLH45 KLH45 is a potent and selective inhibitor of DDHD2 with IC50 of 1.3 nM.
S6599 KM11060 KM11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation.
S0856 KM91104 KM 91104 is a cell-permeable inhibitor of V-ATPase that specifically targets the interaction between V-ATPase subunit a3 and subunit B2.
S3456 KML29 KML29 is an extremely selective, orally active and irreversible inhibitor of MAGL with IC50 of 15 nM, 43 nM and 5.9 nM for mouse, rat and human MAGL, respectively.
S6507 KN-92 phosphate KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII).
S6787 KN-93 KN-93 is a cell-permeable, reversible and competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK-II) with Ki of 2.58 μM at rabbit myocardial CaM kinase activity.
S7423 KN-93 Phosphate KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. KN-93 attenuates CaMKII-induced autophagy.
E2527 Knidilin Knidilin (Cnidilin) is isolated from the roots of Angelica dahurica.
S7750 KNK437 KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.
E3289 Knoxia Valerianoides Extract
S8569 KO-947 KO-947 is a potent and selective inhibitor of ERK1/2 kinases. KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling at low nanomolar concentrations.
S7043 Ko143 KO143 is a potent and relatively selective ATP-binding cassette sub-family G member 2 (ABCG2/BCRP) inhibitor. KO143 decreases the ATPase activity of ABCG2 with IC50 of 9.7 nM.
S8303 Kobe0065 Kobe0065 is H-Ras-cRaf1 interaction inhibitor, exhibiting potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
S6527 Kobe2602 Kobe2602 is a selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM).
E3145 Kochiae Fructus Extract
S5174 Kojic acid Kojic acid is a fungal metabolite that inhibits tyrosinase with an IC50 value of 30.6 µM for mushroom tyrosinase. It is a synthetic intermediate used for production of food additives.
E3279 Kombucha Extract
S2949 KPLH1130 KPLH1130 is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) that blocks macrophage polarization and attenuates proinflammatory responses.
A5505 KPNA2 Rabbit Recombinant mAb KPNA2 Rabbit Recombinant mAb detects endogenous level of total KPNA2.
S8444 KPT 9274 ( ATG-019) KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.
S7125 KPT-185 KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.
E2361 KR-33494 KR-33494 is a potent inhibitor of Fas-mediated cell death (FAF1).
S8402 KRIBB11 KRIBB11 abolishes the heat shock-induced luciferase activity with an IC50 of 1.2 μM. It is an inhibitor of the transcription factor Heat Shock Factor 1 (HSF1). KRIBB11 induces growth arrest and apoptosis.
S1557 KRN 633 KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM, weakly inhibits PDGFR-α/β and c-Kit, does not block the phosphorylation of FGFR-1, EGFR or c-Met in cell.
S8499 KRpep-2d KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant. The IC50 value is 1.6 nM.
S0140 KS176 KS176 (compound 9) is a potent and selective inhibitor of the breast cancer resistance protein (BCRP, ABCG2) multidrug transporter with IC50 of 1.39 μM and 0.59 μM in Hoechst 33342 assay and Pheo A assay, respectively.
S8045 KU-0060648 KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.
S1226 KU-0063794 KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks.
S1092 KU-55933 (ATM Kinase Inhibitor) KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.
E2240 Kukoamine A

Kukoamine A is a natural occurring spermine derivative, which acts as a potent inhibitor of trypanothione reductase, with antihypertensive activity.

S0929 Kukoamine B Kukoamine B,a component of Lycii Cortex, exhibits anti-oxidant, anti-acute inflammatory and anti-diabetic properties.
E2541 Kumatakenin

Kumatakenin, a flavonoid isolated from cloves, shows the effect of inducing apoptosis in ovarian cancer cells.

S0727 KUN50259 (DAAO inhibitor-1) KUN50259 (DAAO inhibitor-1, Compound 35) is a potent inhibitor of D-amino acid oxidase (DAAO) with an IC50 of 0.12 μM.
E0920 Kurarinone Kurarinone, a lavandulyl flavanone isolated from a polyphenolic extract of the roots of Sophora flavescens, has anti-inflammatory activity. Kurarinone is a Dopamine D1A Receptor Antagonist and D2L and D4 Receptor Agonist.
E0988 Kushenol A Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, showing IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively. Kushenol A is a flavonoid antioxidant, with inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging.
E2405 Kushenol F

Kushenol F(Sophoraflavanone G) is isolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.  Kushenol F induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.

E2004 Kushenol I Kushenol I is a natural component separated from the roots of Sophora flavescens.
E2427 Kushenol N

Kushenol N is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol N has anti-allergic and vasorelaxation activities.

E2424 Kuwanon G Kuwanon G is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity.
E2349 Kuwanon H Kuwanon H is a flavonoid isolated from Morus bombycis, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a ki value of 290 nM in cells.
E0953 KW-136

KW136 is a new type of HCV NS5A inhibitor, which is being developed to treat HCV infection.

S2158 KW-2449 KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR. Phase 1.
S2685 KW-2478 KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1.
E0608 KX-826 (Pyrilutamide)

KX-826 is an androgen receptor (AR) antagonist and a potential first-in-class topical drug for the treatment of androgenetic alopecia (AGA) and acne vulgaris.

S6500 KX1-004 KX1-004 is a non-ATP competitive inhibitor of Src protein tyrosine kinase (Src-PTK; IC50 = 40 µM).
S2700 KX2-391 (Tirbanibulin) KX2-391, the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Phase 2.
E2376 KY-05009 KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM, which inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells.
S0136 KY-226 KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.
S0458 KY1220 KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.
S6085 KY19382 (A3051) KY19382 (A3051) is a Wnt/β-catenin signalling activator through inhibitory effects on both CXXC5–DVL interaction and GSK3β activity with IC50s of 19 nM and 10 nM, respectively.
S4719 Kynurenic acid Kynurenic acid (Quinurenic acid, Kynurenate), a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.