For research use only.

Licensed by Pfizer Catalog No.S1835 Synonyms: CP-62993, XZ-450

12 publications

Azithromycin Chemical Structure

CAS No. 83905-01-5

Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

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10mM (1mL in DMSO) USD 163 In stock
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Selleck's Azithromycin has been cited by 12 publications

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Biological Activity

Description Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
protein synthesis [1]
In vitro

Azithromycin reduces about 40% of IL-8 mRNA and protein expression in cystic fibrosis (CF) cells reaching the levels of non-CF cells. Azithromycin results in 50% and 70% reduction of NF-kappaB and AP-1 DNA binding, respectively, leading to levels of non-CF cells. [1] Azithromycin significantly enhances the intensity of a co-stimulatory molecule, CD80, on DCs but not CD86 and CD40 in dendritic cells (DCs). Azithromycin significantly increases the production of IL-10 and Clarithromycin (CAM) significantly inhibits the production of IL-6 by DCs. Azithromycin increases IL-10 and CAM decreases IL-2 productions significantly, when naive T cells derived from spleen are co-cultured with DCs treated in advance with LPS and these macrolides. [2] Azithromycin selectively inhibits fluid-phase endocytosis of horseradish peroxidase and lucifer yellow in J774 mouse macrophages. Azithromycin delays sequestration of receptor-bound transferrin and peroxidase-anti-peroxidase immune complexes into cell-surface endocytic pits and vesicles. Azithromycin down-regulates cell surface transferrin receptors, but not Fc gamma receptors, by causing a major delay in the accessibility of internalized transferrin receptors to the recycling route, without slowing down subsequent efflux, resulting in redistribution of the surface pool to an intracellular pool. [3] Azithromycin inserts into the DOPC lipid bilayer, so as to decrease its cohesion and to facilitate the merging of DPPC into the DOPC fluid matrix. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa 299 NI[2UWdCdnSrY3jsZY16\GmjbDDhd5NigQ>? NInj[ow1PCC2bzC0PEBpenN? M2jxS2FvfGmlaHzhcZllcWGuIHHjeIl3cXS7IHHnZYlve3RiQ3jsZY16\GmjIITyZYNpd22jdHnzJJNmem:4YYKgUFIhcW6oZXP0[YQhcW5iaIXtZY4hUGWOYTCyPVkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIH71cYJmeiCxZjDpcoNtfXOrb36gZo9lcWW|IH3lZZN2emWmIHHmeIVzKDR2IITvJFQ5KGi{czDifUBFSVCLIIP0ZYlvcW6pLXLhd4VlKEiFUzDhd5NigSxiSVO1NF0xNjd{N988UU4> Mn3wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{M{K1PFQoRjJ7MkOyOVg1RC:jPh?=
THP1 NVviRpB[TnWwY4Tpc44h[XO|YYm= M{jYUlMxKG2rboO= M3TSRmRzfWdidYD0ZYtmKGmwIHj1cYFvKFSKUEGgZ4VtdHNiYYSgdGghPiC2bzC3JIFnfGW{IEOwJI1qdnN? MkLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3NkSzOlUoRjF7NU[0N|Y2RC:jPh?=
THP1 MnTKSpVv[3Srb36gZZN{[Xl? MlXKNlQhcHK| NUfqWIJqTHK3ZzD1dJRic2ViaX6gbJVu[W5iVFjQNUBk\WyuczDh[pRmeiB{NDDodpMhcW5icILld4Vv[2Vib3[geoVz[XCjbXns M3rWc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NU[0N|Y2Lz5zOUW2OFM3PTxxYU6=
THP1 NGG2VGlHfW6ldHnvckBie3OjeR?= NGLQfW8zPCCqcoO= MnfqSJJ2\yC3cIThb4UhcW5iaIXtZY4hXEiSMTDj[YxteyCjZoTldkAzPCCqcoOgbY4heHKnc3XuZ4Uhd2ZiZ3Xt[oljem:8aXy= M1HyUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NU[0N|Y2Lz5zOUW2OFM3PTxxYU6=
Hep2 MUfBcpRq[2iuYX35[IlidCCjc4PhfS=> MWS0JJVoN22u MYS4JIhzew>? MmDXRY51cS2FaHzhcZllcWGuIHHjeIl3cXS7IHHnZYlve3RiQ3jsZY16\GmjIITyZYNpd22jdHnzJHNmem:4YYKgUGdXNUx{IHnu[oVkfGWmIHnuJGhmeDJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJNqgmViYX7kJI52dWKncjDv[kBkcGyjbYnkbYFtKGmwY3z1d4lwdiCjdDC0JJVoN22uIITy[YF1\WRiYYSgPEBpenNicH;zeE1qdm[nY4Tpc44h[W6mIEK0JIhzeyCuYYTldkBz\S2rbn\lZ5RqdmdiZoLld4ghUGWyMjDj[YxteyCvb37vcIF6 M1LlWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MkK3PVQ5Lz5|MkKyO|k1QDxxYU6=
Vero E6 NWjr[Gt5SW62aY\pdoFtKGG|c3H5 MYeyJIRigXN? MWjBcpRqfmm{YXyg[YZncWOjY4mgZYdicW6|dDDTRXJUNUOxVj2yJEh{fHKjaX6gRoF3WGG2MTmgbY4hXmW{bzDFOkBk\WyuczDhd5Nme3OnZDDifUBqdmirYnn0bY9vKG:oII\pdoFtKFKQQTDy[ZBtcWOjdHnvckBu\WG|dYLl[EBjgSCUVD3QR3Ih[W[2ZYKgNkBl[Xm|LDDFR|UxRTJwMUNOwG0v M3:4V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzQS9pPlPoSW1DVDxxYU6=
Vero E6 MW\BcpRqfmm{YXygZZN{[Xl? M1vRcVIh\GG7cx?= MnXQRY51cX[rcnHsJIVn\mmlYXP5JIFo[Wmwc4SgV2FTWy2Fb2[tNkApe3S{YXnuJGJiflCjdEGpJIlvKF[ncn:gSVYh[2WubIOgZZN{\XO|ZXSgZpkhcW6qaXLpeIlwdiCxZjD2bZJidCCUTlGgdoVxdGmlYYTpc44hdWWjc4Xy[YQh[nliUmStVGNTKGGodHXyJFIh\GG7czygSWM6OD16Lk[1{txONg>? NGXh[Hg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjlxJ{7DbGVOSkx:L3G+

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 100 mg/mL (133.51 mM)
Ethanol 100 mg/mL (133.51 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 748.98


CAS No. 83905-01-5
Storage powder
in solvent
Synonyms CP-62993, XZ-450
Smiles CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04669288 Not yet recruiting Drug: Azithromycin|Drug: Placebo Asthma|Wheezing University of Arizona|University of Utah|Emory University|Morgan Stanley Children''s Hospital|University of Pittsburgh|Children''s Hospital and Health System Foundation Wisconsin|Children''s Hospital of Philadelphia|Children''s Hospital Medical Center Cincinnati|Boston Children''s Hospital May 2021 Phase 3
NCT04617626 Not yet recruiting Drug: Azithromycin Child Mortality|Azithromycin FHI 360|Côte d''Ivoire National Program for the Fight Against Neglected Tropical Diseases November 15 2020 Not Applicable
NCT04424511 Recruiting Drug: Placebo|Drug: Azithromycin Mortality Tampere University|Center for Vaccine Development CVD-Mali Bamako Mali|University College London UK.|Tro Da Ltd UK|Duke-NUS Graduate Medical School|Bill and Melinda Gates Foundation (Funder)|Pfizer Inc. (Provider of study drugs) October 15 2020 Phase 3
NCT04294069 Recruiting Drug: Azithromycin 500 mg|Drug: Azithromycin Oral Product Preterm Premature Rupture of Membrane Thomas Jefferson University September 14 2020 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID