Azithromycin

For research use only.

Licensed by Pfizer Catalog No.S1835 Synonyms: CP-62993, XZ-450

12 publications

Azithromycin Chemical Structure

CAS No. 83905-01-5

Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 163 In stock
USD 122 In stock
USD 214 In stock
USD 466 In stock
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Selleck's Azithromycin has been cited by 12 publications

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Choose Selective Antibiotics for Mammalian Cell Culture Inhibitors

Biological Activity

Description Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
Targets
protein synthesis [1]
In vitro

Azithromycin reduces about 40% of IL-8 mRNA and protein expression in cystic fibrosis (CF) cells reaching the levels of non-CF cells. Azithromycin results in 50% and 70% reduction of NF-kappaB and AP-1 DNA binding, respectively, leading to levels of non-CF cells. [1] Azithromycin significantly enhances the intensity of a co-stimulatory molecule, CD80, on DCs but not CD86 and CD40 in dendritic cells (DCs). Azithromycin significantly increases the production of IL-10 and Clarithromycin (CAM) significantly inhibits the production of IL-6 by DCs. Azithromycin increases IL-10 and CAM decreases IL-2 productions significantly, when naive T cells derived from spleen are co-cultured with DCs treated in advance with LPS and these macrolides. [2] Azithromycin selectively inhibits fluid-phase endocytosis of horseradish peroxidase and lucifer yellow in J774 mouse macrophages. Azithromycin delays sequestration of receptor-bound transferrin and peroxidase-anti-peroxidase immune complexes into cell-surface endocytic pits and vesicles. Azithromycin down-regulates cell surface transferrin receptors, but not Fc gamma receptors, by causing a major delay in the accessibility of internalized transferrin receptors to the recycling route, without slowing down subsequent efflux, resulting in redistribution of the surface pool to an intracellular pool. [3] Azithromycin inserts into the DOPC lipid bilayer, so as to decrease its cohesion and to facilitate the merging of DPPC into the DOPC fluid matrix. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa 299 NI[2UWdCdnSrY3jsZY16\GmjbDDhd5NigQ>? NInj[ow1PCC2bzC0PEBpenN? M2jxS2FvfGmlaHzhcZllcWGuIHHjeIl3cXS7IHHnZYlve3RiQ3jsZY16\GmjIITyZYNpd22jdHnzJJNmem:4YYKgUFIhcW6oZXP0[YQhcW5iaIXtZY4hUGWOYTCyPVkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIH71cYJmeiCxZjDpcoNtfXOrb36gZo9lcWW|IH3lZZN2emWmIHHmeIVzKDR2IITvJFQ5KGi{czDifUBFSVCLIIP0ZYlvcW6pLXLhd4VlKEiFUzDhd5NigSxiSVO1NF0xNjd{N988UU4> Mn3wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{M{K1PFQoRjJ7MkOyOVg1RC:jPh?=
THP1 NVviRpB[TnWwY4Tpc44h[XO|YYm= M{jYUlMxKG2rboO= M3TSRmRzfWdidYD0ZYtmKGmwIHj1cYFvKFSKUEGgZ4VtdHNiYYSgdGghPiC2bzC3JIFnfGW{IEOwJI1qdnN? MkLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3NkSzOlUoRjF7NU[0N|Y2RC:jPh?=
THP1 MnTKSpVv[3Srb36gZZN{[Xl? MlXKNlQhcHK| NUfqWIJqTHK3ZzD1dJRic2ViaX6gbJVu[W5iVFjQNUBk\WyuczDh[pRmeiB{NDDodpMhcW5icILld4Vv[2Vib3[geoVz[XCjbXns M3rWc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NU[0N|Y2Lz5zOUW2OFM3PTxxYU6=
THP1 NGG2VGlHfW6ldHnvckBie3OjeR?= NGLQfW8zPCCqcoO= MnfqSJJ2\yC3cIThb4UhcW5iaIXtZY4hXEiSMTDj[YxteyCjZoTldkAzPCCqcoOgbY4heHKnc3XuZ4Uhd2ZiZ3Xt[oljem:8aXy= M1HyUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NU[0N|Y2Lz5zOUW2OFM3PTxxYU6=
Hep2 MUfBcpRq[2iuYX35[IlidCCjc4PhfS=> MWS0JJVoN22u MYS4JIhzew>? MmDXRY51cS2FaHzhcZllcWGuIHHjeIl3cXS7IHHnZYlve3RiQ3jsZY16\GmjIITyZYNpd22jdHnzJHNmem:4YYKgUGdXNUx{IHnu[oVkfGWmIHnuJGhmeDJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJJNqgmViYX7kJI52dWKncjDv[kBkcGyjbYnkbYFtKGmwY3z1d4lwdiCjdDC0JJVoN22uIITy[YF1\WRiYYSgPEBpenNicH;zeE1qdm[nY4Tpc44h[W6mIEK0JIhzeyCuYYTldkBz\S2rbn\lZ5RqdmdiZoLld4ghUGWyMjDj[YxteyCvb37vcIF6 M1LlWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzN{MkK3PVQ5Lz5|MkKyO|k1QDxxYU6=
Vero E6 NWjr[Gt5SW62aY\pdoFtKGG|c3H5 MYeyJIRigXN? MWjBcpRqfmm{YXyg[YZncWOjY4mgZYdicW6|dDDTRXJUNUOxVj2yJEh{fHKjaX6gRoF3WGG2MTmgbY4hXmW{bzDFOkBk\WyuczDhd5Nme3OnZDDifUBqdmirYnn0bY9vKG:oII\pdoFtKFKQQTDy[ZBtcWOjdHnvckBu\WG|dYLl[EBjgSCUVD3QR3Ih[W[2ZYKgNkBl[Xm|LDDFR|UxRTJwMUNOwG0v M3:4V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzQS9pPlPoSW1DVDxxYU6=
Vero E6 MW\BcpRqfmm{YXygZZN{[Xl? M1vRcVIh\GG7cx?= MnXQRY51cX[rcnHsJIVn\mmlYXP5JIFo[Wmwc4SgV2FTWy2Fb2[tNkApe3S{YXnuJGJiflCjdEGpJIlvKF[ncn:gSVYh[2WubIOgZZN{\XO|ZXSgZpkhcW6qaXLpeIlwdiCxZjD2bZJidCCUTlGgdoVxdGmlYYTpc44hdWWjc4Xy[YQh[nliUmStVGNTKGGodHXyJFIh\GG7czygSWM6OD16Lk[1{txONg>? NGXh[Hg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjlxJ{7DbGVOSkx:L3G+

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (133.51 mM)
Ethanol 100 mg/mL (133.51 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 748.98
Formula

C38H72N2O12

CAS No. 83905-01-5
Storage powder
in solvent
Synonyms CP-62993, XZ-450
Smiles CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04669288 Not yet recruiting Drug: Azithromycin|Drug: Placebo Asthma|Wheezing University of Arizona|University of Utah|Emory University|Morgan Stanley Children''s Hospital|University of Pittsburgh|Children''s Hospital and Health System Foundation Wisconsin|Children''s Hospital of Philadelphia|Children''s Hospital Medical Center Cincinnati|Boston Children''s Hospital May 2021 Phase 3
NCT04617626 Not yet recruiting Drug: Azithromycin Child Mortality|Azithromycin FHI 360|Côte d''Ivoire National Program for the Fight Against Neglected Tropical Diseases November 15 2020 Not Applicable
NCT04424511 Recruiting Drug: Placebo|Drug: Azithromycin Mortality Tampere University|Center for Vaccine Development CVD-Mali Bamako Mali|University College London UK.|Tro Da Ltd UK|Duke-NUS Graduate Medical School|Bill and Melinda Gates Foundation (Funder)|Pfizer Inc. (Provider of study drugs) October 15 2020 Phase 3
NCT04294069 Recruiting Drug: Azithromycin 500 mg|Drug: Azithromycin Oral Product Preterm Premature Rupture of Membrane Thomas Jefferson University September 14 2020 Phase 4

Tech Support

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID