Azithromycin (CP-62993)

For research use only.

Licensed by Pfizer Catalog No.S1835 Synonyms: XZ-450

14 publications

Azithromycin (CP-62993) Chemical Structure

CAS No. 83905-01-5

Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

Selleck's Azithromycin (CP-62993) has been cited by 14 publications

Purity & Quality Control

Choose Selective Antibiotics for Mammalian Cell Culture Inhibitors

Biological Activity

Description Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
protein synthesis [1]
In vitro

Azithromycin reduces about 40% of IL-8 mRNA and protein expression in cystic fibrosis (CF) cells reaching the levels of non-CF cells. Azithromycin results in 50% and 70% reduction of NF-kappaB and AP-1 DNA binding, respectively, leading to levels of non-CF cells. [1] Azithromycin significantly enhances the intensity of a co-stimulatory molecule, CD80, on DCs but not CD86 and CD40 in dendritic cells (DCs). Azithromycin significantly increases the production of IL-10 and Clarithromycin (CAM) significantly inhibits the production of IL-6 by DCs. Azithromycin increases IL-10 and CAM decreases IL-2 productions significantly, when naive T cells derived from spleen are co-cultured with DCs treated in advance with LPS and these macrolides. [2] Azithromycin selectively inhibits fluid-phase endocytosis of horseradish peroxidase and lucifer yellow in J774 mouse macrophages. Azithromycin delays sequestration of receptor-bound transferrin and peroxidase-anti-peroxidase immune complexes into cell-surface endocytic pits and vesicles. Azithromycin down-regulates cell surface transferrin receptors, but not Fc gamma receptors, by causing a major delay in the accessibility of internalized transferrin receptors to the recycling route, without slowing down subsequent efflux, resulting in redistribution of the surface pool to an intracellular pool. [3] Azithromycin inserts into the DOPC lipid bilayer, so as to decrease its cohesion and to facilitate the merging of DPPC into the DOPC fluid matrix. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa 299 NWfMRohGSW62aXPocIFugWSrYXygZZN{[Xl? Mom5OFQhfG9iNEigbJJ{ MWXBcpRq[2iuYX35[IlidCCjY4Tpeol1gSCjZ3HpcpN1KEOqbHHtfYRq[SC2cnHjbI9u[XSrczDz[ZJwfmG{IFyyJIlv\mWldHXkJIlvKGi3bXHuJGhmVGFiMkm5JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCwdX3i[ZIhd2ZiaX7jcJV{cW:wIHLv[IlmeyCvZXHzeZJm\CCjZoTldkA1PCC2bzC0PEBpenNiYomgSGFRUSC|dHHpcolv\y2kYYPl[EBJS1NiYYPzZZktKEmFNUC9NE44OjgQvF2u NXTsUJZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyN|I2QDRpPkK5NlMzPTh2PD;hQi=>
THP1 NXrHOlA3TnWwY4Tpc44h[XO|YYm= MYqzNEBucW6| NG[xeWtFenWpIIXweIFs\SCrbjDoeY1idiCWSGCxJINmdGy|IHH0JJBJKDZidH:gO{Bi\nSncjCzNEBucW6| M1L3RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NU[0N|Y2Lz5zOUW2OFM3PTxxYU6=
THP1 M1nRZWZ2dmO2aX;uJIF{e2G7 MUCyOEBpenN? NIXCW5lFenWpIIXweIFs\SCrbjDoeY1idiCWSGCxJINmdGy|IHHmeIVzKDJ2IHjyd{BqdiCycnXz[Y5k\SCxZjD2[ZJieGGvaXy= M2XFWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NU[0N|Y2Lz5zOUW2OFM3PTxxYU6=
THP1 M1X1V2Z2dmO2aX;uJIF{e2G7 Mn65NlQhcHK| NGPrNmxFenWpIIXweIFs\SCrbjDoeY1idiCWSGCxJINmdGy|IHHmeIVzKDJ2IHjyd{BqdiCycnXz[Y5k\SCxZjDn[Y1ncWK{b4rpcC=> NFTxfW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW2OFM3PSd-MUm1OlQ{PjV:L3G+
Hep2 MXHBcpRq[2iuYX35[IlidCCjc4PhfS=> MnrjOEB2\y:vbB?= MV[4JIhzew>? M33PUmFvfGlvQ3jsZY16\GmjbDDhZ5Rqfmm2eTDh[4FqdnO2IFPocIFugWSrYTD0doFkcG:vYYTpd{BU\XKxdnHyJGxIXi2OMjDpcoZm[3SnZDDpckBJ\XB{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckB{cXqnIHHu[EBvfW2kZYKgc4Yh[2iuYX35[IlidCCrbnPseZNqd25iYYSgOEB2\y:vbDD0doVifGWmIHH0JFghcHK|IIDvd5QucW6oZXP0bY9vKGGwZDCyOEBpenNibHH0[ZIhemVvaX7m[YN1cW6pIH\y[ZNpKEincEKgZ4VtdHNibX;uc4xigQ>? NYXERpBzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{KyNlc6PDhpPkOyNlI4QTR6PD;hQi=>
Vero E6 NHvnSGZCdnSrdnnyZYwh[XO|YYm= NXq3TIo1OiCmYYnz NVzKWVlpSW62aY\pdoFtKGWoZnnjZYN6KGGpYXnud5QhW0GUUz3Dc3YuOiBqc4TyZYlvKEKjdmDheFEqKGmwIG\ldo8hTTZiY3XscJMh[XO|ZYPz[YQh[nliaX7obYJqfGmxbjDv[kB3cXKjbDDSUmEhemWybHnjZZRqd25ibXXhd5Vz\WRiYomgVnQuWEOUIHHmeIVzKDJiZHH5d{whTUN3ME2yMlEz|ryPLh?= MkDCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVI6Nyd-Q3jFUWJNRC:jPh?=
Vero E6 NXHkPXNISW62aY\pdoFtKGG|c3H5 NUDkdFJtOiCmYYnz NYK1T|V5SW62aY\pdoFtKGWoZnnjZYN6KGGpYXnud5QhW0GUUz3Dc3YuOiBqc4TyZYlvKEKjdmDheFEqKGmwIG\ldo8hTTZiY3XscJMh[XO|ZYPz[YQh[nliaX7obYJqfGmxbjDv[kB3cXKjbDDSUmEhemWybHnjZZRqd25ibXXhd5Vz\WRiYomgVnQuWEOUIHHmeIVzKDJiZHH5d{whTUN7ME24MlY2|ryPLh?= MkCyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVI6Nyd-Q3jFUWJNRC:jPh?=

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 100 mg/mL (133.51 mM)
Water Insoluble
Ethanol '100 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 748.98


CAS No. 83905-01-5
Storage powder
in solvent
Synonyms XZ-450
Smiles CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04669288 Not yet recruiting Drug: Azithromycin|Drug: Placebo Asthma|Wheezing University of Arizona|University of Utah|Emory University|Morgan Stanley Children''s Hospital|University of Pittsburgh|Children''s Hospital and Health System Foundation Wisconsin|Children''s Hospital of Philadelphia|Children''s Hospital Medical Center Cincinnati|Boston Children''s Hospital May 2021 Phase 3
NCT04617626 Completed Drug: Azithromycin Child Mortality|Azithromycin FHI 360|National Program for the Fight Against Neglected Tropical Diseases Côte d''Ivoire November 20 2020 Not Applicable
NCT04424511 Recruiting Drug: Placebo|Drug: Azithromycin Mortality Tampere University|Center for Vaccine Development CVD-Mali Bamako Mali|University College London Hospitals|Tro Da Ltd UK|Duke-NUS Graduate Medical School|Bill and Melinda Gates Foundation (Funder)|Pfizer Inc. (Provider of study drugs) October 15 2020 Phase 3
NCT04294069 Recruiting Drug: Azithromycin 500 mg|Drug: Azithromycin Oral Product Preterm Premature Rupture of Membrane Thomas Jefferson University September 14 2020 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID