AZD7762

Catalog No.S1532

AZD7762 Chemical Structure

Molecular Weight(MW): 362.42

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.

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In DMSO USD 192 In stock
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9 Customer Reviews

  • CAL120 cells were either untreated or pretreated with gemcitabine for 24 hours followed by treatment with AZD7762 and/or MK-1775 for an additional 2 hours (top) or 8 hours (bottom), before lysis. Western blot analysis of Cyclin B1, CDK1 (phospho-Y15 and total) expression, and β-tubulin as loading control.

    Cancer Discov, 2012, 2: 524-539. AZD7762 purchased from Selleck.

    B, time course analysis of the mitotic index after CHK1 or WEE1 inhibition in gemcitabine-arrested CAL120 cells. C, mitotic index of CAL120 and MCF7 cells treated with AZD7762, MK-1775, or the combination for 8 h. Treatment with combination AZD7762 and MK-1775 induces unscheduled mitotic entry in cells with <4N DNA content. D, representative cell-cycle profiles of CAL120 cells treated with AZD7762, MK-1775, or the combination for 8 h assessed by pH3/PI FACS.

    Cancer Discov, 2012, 2: 524-539. AZD7762 purchased from Selleck.

  • E, CAL120 cells were either untreated or pretreated with gemcitabine for 24 hours followed by treatment with AZD7762 and /or MK-1775 for an additional 2 hours (top) or 8 hours (bottom), before lysis. Western blot analysis of Cyclin B1, CDK1 (phospho-Y15 and total) expression, and β-tubulin as loading control. F, induction of the intra–S-phase checkpoint was not affected by WEE1 inhibition. CAL120 cells were pulse-labeled with 10 μmol/L BrdU for 30 minutes, washed (W), and then treated with 1 μmol/L camptothecin (CPT) for 30 minutes. After CPT removal (0 hours), BrdU-labeled S-phase cells (BrdU+ , indicated by boxed area) were monitored at the indicated time points in the absence (iii) or presence of MK-1775 (iv) or AZD7762 as a positive control (v). Control cells (ctr) were not exposed to CPT and cultured in the absence (i) or presence of MK-1775 (ii). Arrowheads indicate delayed S-phase progression.

    Cancer Discov 2012 2, 524-39. AZD7762 purchased from Selleck.

    HNSCC cell lines have in vitro diverse sensitivities to drugs that affect mitotic progression. Fifty-nine HNSCC cell lines were treated with volasertib, AZD1775, or AZD7762 at seven concentrations ranging from 0.018 to 9.613 μM for 72 h, and their viability was estimated using a CellTiter-Glo assay. (A) Representative dose-response curves for cell lines sensitive and resistant to the drugs. (B) Distributions of the IC80 values for the 59 cell lines. The vertical orange line is the Cmax values for each drug.

    Cancer Lett, 2017, 392:71-82. AZD7762 purchased from Selleck.

  • Photomicrographs showing characteristic morphological changes in T24 cells treated with gemcitabine and AZD7762 (24 and 48 h) (c). Scale bar = 100 μm

    J Exp Clin Cancer Res, 2017, 36(1):1. AZD7762 purchased from Selleck.

    (A) GBM6 and GBM12 cells and (B) GBM5 and GBM14 cells were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 + AZD0530 for 48h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion based cell staining (±SE M, n= 3) *p < 0.05 greater than CHK1 inhibitor value. (C) GBM5 and GBM14 cells were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 +AZD0530 for 24 h and cell lysates were immunoblotted against cleaved caspase 3, PARP 1 and P-ERK1/2. (D) Medulloblastoma cell lines DAOY, VC312 and D283 were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 + AZD0530 for 48 h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion (±SE M, n = 3) *p < 0.05 greater than CHK1 inhibitor value. The cell lysates were immunoblotted against cleaved caspases-3, cleaved caspases-7 and P-ER K1/2.

    Cancer Biol Ther 2012 13. AZD7762 purchased from Selleck.

  • GBM5, 6, 12 and 14 cells were treated with AZD7762 (300nM), AZD6244 (500nM) or AZD7762 + AZD6244 for 48h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion(±SE M, n = 3) *p < 0.05 greater than CHK1 inhibitor value.

    Cancer Biol Ther 2012 13. AZD7762 purchased from Selleck.

    MCF7 cells were plated in triplicate and treated with vehicle (VEH, DMSO) , AZD0530 (125 nM), AZD7762 (50 nM) or AZD7762 and AZD0530. Cells were isolated 48 h after exposure and subjected to the indicated various cell viability assays. Data for each assay is the mean of all data points from two studies(* p < 0.05 greater than CHK1 inhibitor value).

    Cancer Biol Ther 2011 12, 215-28. AZD7762 purchased from Selleck.

  • SRC family kinases play a key role in the regulation of the ERK1/2 pathway by CHK1 inhibitors. (A) Transformed mouse embryonic fibroblasts, MEF (wild type, WT; deleted for SRC/FYN/Y es , SYF) were treated with vehicle (VE, DMSO) , UCN-01 (100 nM) or AZD7762 (50 nM). Cells were isolated at the indicated time points and subjected to SDS PAGE followed by immunoblotting to determine the phosphorylation of ERK1/2 (p-ERK1/2), the phosphorylation of SRCY461 (p -Y 416 Src ) or the expression of GAPDH . Data are from a representative of three separate studies. (B) MCF7 cells were treated with vehicle (V eh, DMSO) , UCN-01 (100 nM), pp2 (10 μM), AZD7762 (50 nM) or UCN-01+ pp2 or AZD7762+ pp2. Cells were isolated 2 h after drug exposure and subjected to SDS PAGE f ollowed by immunoblotting to determine the phosphorylation of ERK1/2 ( p-ERK1/2) or the expression of e RK2 protein. Data are from a representative of two separate studies.

    Cancer Biol Ther 2011 12, 215-28. AZD7762 purchased from Selleck.

Purity & Quality Control

Choose Selective Chk Inhibitors

Biological Activity

Description AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
Targets
Chk1 [1]
(Cell-free assay)
Chk2 [1]
(Cell-free assay)
5 nM <10 nM
In vitro

AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KASUMI-1 M{jsTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP2bGdKSzVyPUCuNFAxOjN2IN88US=> MlnHV2FPT0WU
NKM-1 NIL6emdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPvR3BKSzVyPUCuNFAxPDF3IN88US=> M3zVNnNCVkeHUh?=
MV-4-11 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fiSmlEPTB;MD6wNFA1OjVizszN MUfTRW5ITVJ?
NCI-H1703 Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qyXWlEPTB;MD6wNFY1OyEQvF2= MUHTRW5ITVJ?
A204 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M376[mlEPTB;MD6wNFg2PiEQvF2= NHzGWYFUSU6JRWK=
CGTH-W-1 NYftWFR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTsWWZbUUN3ME2wMlAyPDJizszN NG\KbZFUSU6JRWK=
MLMA NGLjXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\2T5N6UUN3ME2wMlAzQDR7IN88US=> MlmxV2FPT0WU
GOTO NGm4ZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvkfW5KSzVyPUCuNFMyOiEQvF2= MVvTRW5ITVJ?
KE-37 NV3SUYxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEOxOFIh|ryP M4LSenNCVkeHUh?=
ES4 NEPQbXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rVVWlEPTB;MD6wN|I2OSEQvF2= MknVV2FPT0WU
ATN-1 NE\wWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEO0NVch|ryP M2WzV3NCVkeHUh?=
MHH-PREB-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\qfIlKSzVyPUCuNFM1PDJizszN NFTXUZVUSU6JRWK=
SW756 MkXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlGwTWM2OD1yLkCzOVc6KM7:TR?= NVfyV5BJW0GQR1XS
CTV-1 NYG5ZXY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEO4PVYh|ryP NEOybpBUSU6JRWK=
HCC1806 M17id2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr0TWM2OD1yLkC0NFIzKM7:TR?= MUjTRW5ITVJ?
NEC8 M2rVT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTTTFlKSzVyPUCuNFQzODNizszN MkDoV2FPT0WU
P12-ICHIKAWA NVyzUXBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMESzNVYh|ryP MVnTRW5ITVJ?
DEL MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jWPWlEPTB;MD6wOFU6OiEQvF2= M{TRdXNCVkeHUh?=
KM12 M{nsPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;ZSnRKSzVyPUCuNFUyPThizszN NGL0VXFUSU6JRWK=
LB1047-RCC NVrTcnY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULIdlhiUUN3ME2wMlA3ODJ3IN88US=> M1O3U3NCVkeHUh?=
LB2241-RCC MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD6bIdFUUN3ME2wMlA3OTB{IN88US=> NEXX[ohUSU6JRWK=
NOMO-1 NGnzOHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPoZYZKSzVyPUCuNFYyOTVizszN NHTWelNUSU6JRWK=
NB14 MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwME[xN|Yh|ryP NYXWR4hMW0GQR1XS
ONS-76 NFHmVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjkTWM2OD1yLkC2NVk3KM7:TR?= M{ixeHNCVkeHUh?=
HD-MY-Z MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwME[yOVUh|ryP MWTTRW5ITVJ?
G-402 MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrlUYdOUUN3ME2wMlA3PDZizszN M1L1TnNCVkeHUh?=
ES1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG1dHdKSzVyPUCuNFcyPDZizszN NHjtbYhUSU6JRWK=
L-363 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnTVoVKSzVyPUCuNFc{QSEQvF2= MYjTRW5ITVJ?
A4-Fuk M{PtdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEe0PFYh|ryP NVjBWWxjW0GQR1XS
OC-314 NYfwcG1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nJVmlEPTB;MD6wO|gxPyEQvF2= M2XVN3NCVkeHUh?=
SK-LU-1 NGDrRm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LyXmlEPTB;MD6wPFQzOSEQvF2= MljMV2FPT0WU
MDA-MB-157 M{SzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTu[ZM4UUN3ME2wMlA5PjV7IN88US=> M33PPXNCVkeHUh?=
HuP-T3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PTNWlEPTB;MD6wPFcyKM7:TR?= MmG1V2FPT0WU
A3-KAW MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXuTWM2OD1yLkC4PFA3KM7:TR?= MX7TRW5ITVJ?
MOLT-16 Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEi4NFch|ryP NHfCOohUSU6JRWK=
COLO-679 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HNO2lEPTB;MD6wPVA6OSEQvF2= M{jvU3NCVkeHUh?=
EM-2 M2jLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEm5NFMh|ryP MnftV2FPT0WU
ES8 NILJR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7VWJBKSzVyPUCuNFk6OThizszN MorGV2FPT0WU
SK-MEL-2 M1vFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDHZnZvUUN3ME2wMlExODN|IN88US=> NHOzfZdUSU6JRWK=
ES3 M4H0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvQO|FKSzVyPUCuNVAzKM7:TR?= NYHMXoVNW0GQR1XS
HSC-4 MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMUC1OVQh|ryP NYjzTotsW0GQR1XS
697 NH[3T3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjpN4JKSzVyPUCuNVExPjNizszN NGjSTnFUSU6JRWK=
TGBC11TKB MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzaUJliUUN3ME2wMlEyODl|IN88US=> MXLTRW5ITVJ?
SK-PN-DW MmTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMUG4OkDPxE1? NVnQXJFMW0GQR1XS
H9 NHf1WGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMUKxOlUh|ryP NGHZb5FUSU6JRWK=
NCI-H2122 NHvONHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXhTpFKSzVyPUCuNVIzPSEQvF2= NH7HTFVUSU6JRWK=
ML-2 NULld3NUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr3XY51UUN3ME2wMlEzPDh2IN88US=> M4LnbXNCVkeHUh?=
MC-IXC NVnrPZk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPnTWM2OD1yLkGyPFQ{KM7:TR?= MX\TRW5ITVJ?
KYSE-140 MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUmxc|JbUUN3ME2wMlE{ODRzIN88US=> NFLWdmpUSU6JRWK=
DOHH-2 MknVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjJb5dJUUN3ME2wMlE{ODZ2IN88US=> NYfPOGVpW0GQR1XS
MEL-JUSO MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M165SWlEPTB;MD6xN|EzQCEQvF2= MlriV2FPT0WU
P30-OHK Mn3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMUOxOkDPxE1? NYH3R5l{W0GQR1XS
CTB-1 NXvzco44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMUOzNlUh|ryP M4G4R3NCVkeHUh?=
ACHN NIfqSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHNSHVKSzVyPUCuNVM{PjlizszN NHfWSGxUSU6JRWK=
ES5 NGDSUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMUO0O|Yh|ryP NVrDXmVHW0GQR1XS
SF539 NULzOFBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[zPJJKSzVyPUCuNVM3QCEQvF2= NX3WTZpmW0GQR1XS
D-283MED Mo\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DkRWlEPTB;MD6xN|Y5PyEQvF2= MVvTRW5ITVJ?
OVCAR-5 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUO4PVQh|ryP Ml;YV2FPT0WU
RPMI-8866 NILCcXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK2[GxHUUN3ME2wMlE{QTJ3IN88US=> MkDOV2FPT0WU
PANC-03-27 MlrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPUNFNlUUN3ME2wMlE1Ojh6IN88US=> MlPoV2FPT0WU
M14 M3u4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDxSmtTUUN3ME2wMlE1PDZ|IN88US=> NWnTTI1[W0GQR1XS
D-566MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMUS2PUDPxE1? NXLke5R7W0GQR1XS
Ramos-2G6-4C10 M373Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;1TWM2OD1yLkG0PFQzKM7:TR?= NGTPXFZUSU6JRWK=
NOS-1 M2S3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLuVXdlUUN3ME2wMlE1QTZ5IN88US=> MnfGV2FPT0WU
YH-13 M3;zZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMUW2O|Qh|ryP MYjTRW5ITVJ?
NB17 M3LU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMUW3PFYh|ryP MmTuV2FPT0WU
U-2-OS M2nwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMUW4OFch|ryP M{\1XXNCVkeHUh?=
ES7 M4q0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTuXWVKSzVyPUCuNVYxOTFizszN NGnxT3BUSU6JRWK=
LoVo NF72[|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrhZYJVUUN3ME2wMlE3OTZ4IN88US=> MnrFV2FPT0WU
QIMR-WIL M1Sxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7lWoNKSzVyPUCuNVY{OTFizszN M2jCTnNCVkeHUh?=
ESS-1 NVzqZZZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMU[0NVMh|ryP M3r2bXNCVkeHUh?=
LAMA-84 M1PtNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfKTWM2OD1yLkG2OVA{KM7:TR?= NWfsOJdFW0GQR1XS
TGBC24TKB MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv3SnFKSzVyPUCuNVY2OzVizszN M1nGPHNCVkeHUh?=
KU812 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMU[4N{DPxE1? NELkWZFUSU6JRWK=
KARPAS-45 NV3C[3g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfKTWM2OD1yLkG2PFQ4KM7:TR?= Ml:4V2FPT0WU
ACN M3;LN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMUexO|Eh|ryP M2\FenNCVkeHUh?=
RPMI-8226 NEHXd4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrXRnhLUUN3ME2wMlE4PDZ2IN88US=> Mn\aV2FPT0WU
GR-ST Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzScoVKSzVyPUCuNVc5OjdizszN MUjTRW5ITVJ?
SK-UT-1 NYqxZYFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TiWGlEPTB;MD6xPFU6QSEQvF2= M4Ptb3NCVkeHUh?=
SK-N-AS MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXjTWM2OD1yLkG4PFE2KM7:TR?= M1T3[3NCVkeHUh?=
EW-1 NX2zOlB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml2yTWM2OD1yLkG4PVA2KM7:TR?= MmSwV2FPT0WU
5637 NXj4Unk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z1dGlEPTB;MD6xPVI4QCEQvF2= NEHpPFZUSU6JRWK=
GI-1 NHvwXFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMUm1OlEh|ryP MoXNV2FPT0WU
NCI-H1395 M37yNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMUm3OlEh|ryP NFW4d2RUSU6JRWK=
CHP-212 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXoVoJKSzVyPUCuNVk4QDJizszN MYDTRW5ITVJ?
A427 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP0cHBKSzVyPUCuNVk5OzJizszN MVfTRW5ITVJ?
BE-13 Ml;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPmTWM2OD1yLkKwNVE4KM7:TR?= MYLTRW5ITVJ?
RS4-11 NWXiR5c2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH2TmNMUUN3ME2wMlIxOzF6IN88US=> NWTS[lVFW0GQR1XS
TI-73 NXK1U|RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\VbGlEPTB;MD6yNFg4OyEQvF2= MofkV2FPT0WU
HAL-01 NXf6d2RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn6WplKUUN3ME2wMlIxQTdizszN NIGxNVVUSU6JRWK=
KY821 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3HR5p3UUN3ME2wMlIyPDJ7IN88US=> NFThN5dUSU6JRWK=
H4 NUmzbpVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMkKwOlIh|ryP MmXwV2FPT0WU
EPLC-272H NIPCe2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHaRZNKSzVyPUCuNlIxPjhizszN NWK2fIJxW0GQR1XS
COR-L105 NVu0S2ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMkKyN|Uh|ryP NFzGUXpUSU6JRWK=
769-P NXLyOIRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMkKyPVgh|ryP M3;BN3NCVkeHUh?=
HEL NF:5PVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX2RY5mUUN3ME2wMlIzPDV2IN88US=> MmrsV2FPT0WU
VA-ES-BJ NF;jOWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvTTWM2OD1yLkKyOVU4KM7:TR?= NEns[VBUSU6JRWK=
IST-MEL1 NYG0V2lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMkK1O{DPxE1? NWLJ[lh2W0GQR1XS
KYSE-270 MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jzSWlEPTB;MD6yNlY{OyEQvF2= MnHnV2FPT0WU
RH-1 NGi4SoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMkK2OlYh|ryP NITiTHdUSU6JRWK=
JVM-3 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPMTWM2OD1yLkKzNFM3KM7:TR?= M3G0fHNCVkeHUh?=
RPMI-7951 M36wSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH60[XBKSzVyPUCuNlMxPTZizszN NF\NS|dUSU6JRWK=
JAR NWP1SZAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMkOyN|gh|ryP NVLjVm9DW0GQR1XS
MOLT-4 NHjndGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvjTWM2OD1yLkKzPFUh|ryP MnnsV2FPT0WU
ALL-PO MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fwc2lEPTB;MD6yOFI1OyEQvF2= NUT5VlVmW0GQR1XS
SNU-387 NGjHUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG2cWFKSzVyPUCuNlQ{OzlizszN MX7TRW5ITVJ?
IGROV-1 MoLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTZRo05UUN3ME2wMlI1PDBzIN88US=> M2Hs[XNCVkeHUh?=
MPP-89 M4rINWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX4TWM2OD1yLkK0OFUyKM7:TR?= NFvUU21USU6JRWK=
T98G MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP6NJgzUUN3ME2wMlI1PTZ6IN88US=> M3:0U3NCVkeHUh?=
NCI-H510A MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHVTWM2OD1yLkK0OlI3KM7:TR?= MYHTRW5ITVJ?
KOSC-2 MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMkS2O|Eh|ryP NEXVVG1USU6JRWK=
NCI-H23 M1;PPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMkS3OlEh|ryP NFHZTpdUSU6JRWK=
MC116 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDifWZIUUN3ME2wMlI2PjV2IN88US=> MnT4V2FPT0WU
8-MG-BA MmrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHCdpp1UUN3ME2wMlI2PzZ6IN88US=> MXTTRW5ITVJ?
ABC-1 NGe0cGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMk[wOlQh|ryP NX\QdHFCW0GQR1XS
J-RT3-T3-5 NUPUS4hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETtOYVKSzVyPUCuNlY3PzhizszN NXPz[I53W0GQR1XS
NCI-SNU-1 NGnZdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMkewOVkh|ryP NWrGZ|c1W0GQR1XS
HCC1395 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMkewPFkh|ryP Ml\CV2FPT0WU
BB65-RCC M2nmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfCO3dIUUN3ME2wMlI4ODl5IN88US=> M3;iNnNCVkeHUh?=
NCI-H1755 MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP6TWM2OD1yLkK3N|A1KM7:TR?= MXrTRW5ITVJ?
OVCAR-3 MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoSzTWM2OD1yLkK3N|g2KM7:TR?= MYfTRW5ITVJ?
MKN45 NI\6SoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfuTWM2OD1yLkK3PVgh|ryP MWXTRW5ITVJ?
TYK-nu M3q3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITTbVhKSzVyPUCuNlgxPiEQvF2= Mom2V2FPT0WU
SNU-C2B MoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTJSnRSUUN3ME2wMlI5OTN2IN88US=> MkO2V2FPT0WU
H-EMC-SS Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHJTWM2OD1yLkK4N|U1KM7:TR?= NGrxd4RUSU6JRWK=
CAKI-1 Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\0TWM2OD1yLkK4Olgh|ryP Moq5V2FPT0WU
EW-24 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMki5NUDPxE1? NUi5b5hzW0GQR1XS
RXF393 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMkmwNFgh|ryP NV2wS3hZW0GQR1XS
CCRF-CEM NGK5R|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMkmxOVQh|ryP NFO5UHVUSU6JRWK=
HOP-92 NIPXSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rpZ2lEPTB;MD6yPVI4QSEQvF2= MV\TRW5ITVJ?
COLO-684 M4Txe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjaclhKSzVyPUCuNlk1ODZizszN M1vmfnNCVkeHUh?=
NCI-H28 NXvqdphzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y3e2lEPTB;MD6yPVcxPCEQvF2= M{fzbnNCVkeHUh?=
HuO9 M1;3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\3O|VKSzVyPUCuNlk4QTNizszN NVLPRVVSW0GQR1XS
SF295 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMkm4NFIh|ryP NVPQOXR{W0GQR1XS
COLO-829 M3Xte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMkm4OFUh|ryP MmLZV2FPT0WU
MSTO-211H NY\WO|Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHQTWM2OD1yLkK5PFU2KM7:TR?= NU[xcGp[W0GQR1XS
MDA-MB-361 MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXKzXo53UUN3ME2wMlI6QDl4IN88US=> NGK4WFhUSU6JRWK=
FTC-133 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz6SGZKSzVyPUCuN|AzPjVizszN MXPTRW5ITVJ?
Mewo M2LCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3yTWM2OD1yLkOwOFMyKM7:TR?= M1qzdnNCVkeHUh?=
HCC70 NGnJ[2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHZTWM2OD1yLkOwOlY2KM7:TR?= MkHGV2FPT0WU
BB30-HNC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwM{G1NlUh|ryP M4ezRnNCVkeHUh?=
LCLC-97TM1 M{PsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjyNGdKSzVyPUCuN|E2PjZizszN M3\qTXNCVkeHUh?=
HCC2998 NVPLVY0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwM{G2OUDPxE1? MojKV2FPT0WU
NBsusSR Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr2U|RHUUN3ME2wMlMyQDF7IN88US=> NETvWG5USU6JRWK=
OVCAR-4 NUHZT21pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGWzZ3hKSzVyPUCuN|IxOjFizszN NHy3RohUSU6JRWK=
NCI-H209 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe4WmJJUUN3ME2wMlMzOzV|IN88US=> MlLNV2FPT0WU
ChaGo-K-1 NIjVdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLHTWM2OD1yLkOyOFg6KM7:TR?= MoPGV2FPT0WU
KALS-1 MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG2Uo9KSzVyPUCuN|I2QTRizszN NW[1SY5tW0GQR1XS
D-423MG NVzLXYhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PjZ2lEPTB;MD6zN|E1OiEQvF2= Ml:xV2FPT0WU
Detroit562 NED4eIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S0SmlEPTB;MD6zN|M1OyEQvF2= Mo[4V2FPT0WU
HT-144 NVq4NFRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fkV2lEPTB;MD6zN|gyKM7:TR?= MVfTRW5ITVJ?
MEG-01 NHftVGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[4TWM2OD1yLkO0OVg1KM7:TR?= NUTmfmVlW0GQR1XS
BV-173 NG\DWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHmWldKSzVyPUCuN|Q2QTZizszN MkG3V2FPT0WU
MZ7-mel NV7ROodoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;BZXVlUUN3ME2wMlM1Pjd5IN88US=> MmDJV2FPT0WU
C32 NUTybJlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfMfIo2UUN3ME2wMlM1Pjh{IN88US=> M3fkWXNCVkeHUh?=
DU-4475 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknyTWM2OD1yLkO0PFc2KM7:TR?= NGnRS|lUSU6JRWK=
KP-N-YN NEnl[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfhTWM2OD1yLkO0PFg4KM7:TR?= NGXs[ZZUSU6JRWK=
MKN1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT6U|hKSzVyPUCuN|UxODJizszN MY\TRW5ITVJ?
8505C NEHvN29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwM{WwNFIh|ryP MXjTRW5ITVJ?
OVCAR-8 M4jnTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnJZZFZUUN3ME2wMlM2PTh2IN88US=> NULJOpJ6W0GQR1XS
NH-12 MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXJTWM2OD1yLkO1Olk3KM7:TR?= NWnZeopoW0GQR1XS
COR-L88 NWP6U|gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmThTWM2OD1yLkO2OFgzKM7:TR?= MlL2V2FPT0WU
T-24 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTKd5JDUUN3ME2wMlM3QTh3IN88US=> NF\2WpVUSU6JRWK=
MIA-PaCa-2 NHrGPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvENmRKSzVyPUCuN|c1QTdizszN NHTxXnVUSU6JRWK=
LS-411N MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwM{e2NFYh|ryP NWizb4pUW0GQR1XS
TK10 MmXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULtOWhvUUN3ME2wMlM4QTR6IN88US=> MY\TRW5ITVJ?
SW1990 NXLUUVhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwM{izOVMh|ryP M{XkSXNCVkeHUh?=
GAMG NUfQTHQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoewTWM2OD1yLkO4OVY4KM7:TR?= MkHyV2FPT0WU
G-361 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;JZoNKSzVyPUCuN|g4OTJizszN M2XsW3NCVkeHUh?=
Ca-Ski M2LjPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;qTWM2OD1yLkO4O|kzKM7:TR?= NWnt[HBuW0GQR1XS
786-0 MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwM{i4NlMh|ryP MYrTRW5ITVJ?
MHH-NB-11 NFHWT|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXSzfo9zUUN3ME2wMlM5QTdizszN M3Hac3NCVkeHUh?=
OE33 NFHwPXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwM{mxNVgh|ryP NUW5XXhKW0GQR1XS
SW954 NXrXdFRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXUVnNKSzVyPUCuOFAyOzFizszN MoC1V2FPT0WU
KYSE-180 NF\2V5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwNECxOVEh|ryP M33lcHNCVkeHUh?=
NCI-H720 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLZTZBKSzVyPUCuOFAyQTFizszN MlmwV2FPT0WU
COR-L23 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOxXZZYUUN3ME2wMlQxOjh4IN88US=> M3S2ZXNCVkeHUh?=
PFSK-1 M{\4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwNEGwPVIh|ryP MkC3V2FPT0WU
FADU NVrGbmtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq0TWM2OD1yLkSxNVczKM7:TR?= NFXn[3FUSU6JRWK=
GP5d NGL2V5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXv[G9KSzVyPUCuOFEzOjVizszN M4PFS3NCVkeHUh?=
PC-14 MnXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfzTWM2OD1yLkSxOlYyKM7:TR?= NUnMU|JIW0GQR1XS
SJSA-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jyWmlEPTB;MD60NVcyPCEQvF2= NV\E[VJPW0GQR1XS
D-336MG M{ewS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkO0TWM2OD1yLkSyNVM5KM7:TR?= NEDyO4NUSU6JRWK=
LOXIMVI NVewb4xtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HlSWlEPTB;MD60Nlg5PSEQvF2= M{jFNXNCVkeHUh?=
EFO-27 NVXqWZFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwNEOwOFkh|ryP NIPSeJZUSU6JRWK=
A2780 NU\C[ZQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwNEOxOlIh|ryP NIDQd3JUSU6JRWK=
CAL-12T M2XLW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwNEOyPFgh|ryP NEPHdWxUSU6JRWK=
ES6 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzh[pFyUUN3ME2wMlQ1OTh3IN88US=> MWHTRW5ITVJ?
HCE-T M{Pxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwNESxPFch|ryP Mlu2V2FPT0WU
SK-MES-1 NGPlNoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrsTWM2OD1yLkS0Nlk{KM7:TR?= M3XSbnNCVkeHUh?=
Daoy NIPzb2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4T2T2lEPTB;MD60OVExOyEQvF2= M2DENXNCVkeHUh?=
A2058 M{PR[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PJ[GlEPTB;MD60OVE{PiEQvF2= MXfTRW5ITVJ?
Hs-578-T M3G2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;wRpJKSzVyPUCuOFUzPzhizszN NWP6XJEzW0GQR1XS
TE-11 M3X1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnzTWM2OD1yLkS1Nlk{KM7:TR?= NUnjPY96W0GQR1XS
GI-ME-N NGXNPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PGPWlEPTB;MD60OVQ3KM7:TR?= NUDlUmZbW0GQR1XS
D-392MG MmXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2SyTWlEPTB;MD60OVYyOiEQvF2= MorTV2FPT0WU
MOLT-13 M2KxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwNE[yPVQh|ryP NUfMZVZCW0GQR1XS
SK-NEP-1 M2flTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrsTWM2OD1yLkS2OFE6KM7:TR?= M2nyVHNCVkeHUh?=
KS-1 NHztRYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFuyfoxKSzVyPUCuOFY3ODNizszN MVPTRW5ITVJ?
HuP-T4 NEfXbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwNE[4Olgh|ryP M3HNWnNCVkeHUh?=
NCI-H1563 NYPIZZQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwNEewN|Uh|ryP NY\z[JFHW0GQR1XS
U031 M1r2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmToTWM2OD1yLkS4NlM1KM7:TR?= MUTTRW5ITVJ?
HSC-3 M4\0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[wTWM2OD1yLkS4OlI3KM7:TR?= M{jVeHNCVkeHUh?=
HT-3 NUizeIJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXITWM2OD1yLkS5NFMh|ryP NV3h[nlUW0GQR1XS
HGC-27 M4nWSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LXSWlEPTB;MD60PVEyPSEQvF2= NGP3R2VUSU6JRWK=
HT-1080 NF7WT3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\TTWM2OD1yLkS5Nlch|ryP NEDKRllUSU6JRWK=
RT-112 NV\wXWdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzsTWM2OD1yLkS5PVIyKM7:TR?= MmDlV2FPT0WU
A375 MojtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\zTWM2OD1yLkS5PVIzKM7:TR?= MnHtV2FPT0WU
SW626 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjUeXVKSzVyPUCuOVA3OzNizszN NVLnXHk5W0GQR1XS
SBC-5 Ml7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwNUGzOFQh|ryP MoDmV2FPT0WU
CAL-51 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m4XmlEPTB;MD61NVQ{PyEQvF2= NUnTWFVtW0GQR1XS
RKO NEXoUlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwNUKwNVkh|ryP MY\TRW5ITVJ?
HC-1 NYX3UHg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3u5PWlEPTB;MD61NlEyPCEQvF2= NXvXOFlxW0GQR1XS
CHL-1 NEn4S3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLrNGRpUUN3ME2wMlUzPTVzIN88US=> MnGxV2FPT0WU
SK-N-DZ MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\TfnVxUUN3ME2wMlU{ODd6IN88US=> MW\TRW5ITVJ?
SNU-423 NI\5WYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\kTWM2OD1yLkWzOFY3KM7:TR?= MUjTRW5ITVJ?
NB13 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nQN2lEPTB;MD61N|Y2PyEQvF2= M1z0ZnNCVkeHUh?=
EW-16 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLSdWhKSzVyPUCuOVM4PzRizszN Mm\mV2FPT0WU
A704 NILK[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwNUO4PFEh|ryP M1fvZnNCVkeHUh?=
Ca9-22 M{fUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXrUoY2UUN3ME2wMlU1ODd5IN88US=> M3i1ZXNCVkeHUh?=
NCI-H1299 NIrlVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwNUW1PEDPxE1? NHLpSYJUSU6JRWK=
LB771-HNC MlnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPFTWM2OD1yLkW1PVM{KM7:TR?= NUTYWW9xW0GQR1XS
EW-11 M3fPeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrFfnRKSzVyPUCuOVY{OjZizszN MnjGV2FPT0WU
LC-2-ad NYDa[XJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDXZoRKSzVyPUCuOVY2OjJizszN M3P6ZnNCVkeHUh?=
KNS-62 M1e3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml25TWM2OD1yLkW2OVU{KM7:TR?= MWfTRW5ITVJ?
CAL-62 M325O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELxV2hKSzVyPUCuOVcyOjFizszN NXz3[HRFW0GQR1XS
SF126 NUPGRmNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTrSoxKSzVyPUCuOVc1OjFizszN MWHTRW5ITVJ?
OMC-1 MkPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LDdGlEPTB;MD61O|Q6PyEQvF2= Mn3LV2FPT0WU
AGS MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvaTWM2OD1yLkW4NVYzKM7:TR?= Mn\yV2FPT0WU
EW-22 M3i1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNUizO|Uh|ryP MmrpV2FPT0WU
KP-N-YS MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LsdGlEPTB;MD61PFM5OiEQvF2= NYXsepBUW0GQR1XS
BFTC-909 M1:4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwNUi4N|Mh|ryP NYnlW3dSW0GQR1XS
PSN1 NUj6NJBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjmTWM2OD1yLkW5NVE5KM7:TR?= Mk[4V2FPT0WU
NB10 MlnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnlTWM2OD1yLkW5NVI6KM7:TR?= NUHHbGxqW0GQR1XS
COLO-800 M{DLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPLOIZKSzVyPUCuOlA{OjhizszN M{DjRnNCVkeHUh?=
647-V NVnoVlkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwNkG3PFch|ryP MnHOV2FPT0WU
VM-CUB-1 MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHPNIFpUUN3ME2wMlYyQDZzIN88US=> NIrtXZRUSU6JRWK=
OS-RC-2 Ml\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwNkKwNUDPxE1? NVHldW9nW0GQR1XS
IST-SL1 NYCyWY9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHFTWM2OD1yLk[yO|g5KM7:TR?= NF76fVhUSU6JRWK=
NCI-H661 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLhXXBKSzVyPUCuOlM4OTJizszN NFHweHZUSU6JRWK=
ETK-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwNkO3NlEh|ryP NHzlVoVUSU6JRWK=
SW1710 M{O3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjVN|ZlUUN3ME2wMlY1ODJ|IN88US=> NV3RWGlQW0GQR1XS
GCT Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;DUmlEPTB;MD62OFk{PSEQvF2= MXzTRW5ITVJ?
SKG-IIIa MlPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTFdHQ2UUN3ME2wMlY2ODN4IN88US=> MV3TRW5ITVJ?
LU-134-A NHj3[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwNkW2OUDPxE1? MlPIV2FPT0WU
Becker NH7LUYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFmwUI5KSzVyPUCuOlU5ODVizszN M4fpUHNCVkeHUh?=
PANC-08-13 M3jWXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nCW2lEPTB;MD62OlA3QCEQvF2= M1fUOXNCVkeHUh?=
SW620 NUHuNYNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLrTWM2OD1yLk[2NlI{KM7:TR?= MY\TRW5ITVJ?
AsPC-1 NXnHSo5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnm2TWM2OD1yLk[2N|YyKM7:TR?= NHmzT2RUSU6JRWK=
LXF-289 M1Hme2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPzbW1KSzVyPUCuOlc3OjVizszN MmG3V2FPT0WU
RERF-LC-MS M{DpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKyd|NsUUN3ME2wMlY4PjdzIN88US=> MkXUV2FPT0WU
NCI-H1355 NXnid4xqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwNke4OVIh|ryP MlvDV2FPT0WU
23132-87 NGfn[XRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\yTWM2OD1yLk[4N|A3KM7:TR?= M3joU3NCVkeHUh?=
BHY NIPyZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwNki4NFQh|ryP MX3TRW5ITVJ?
C2BBe1 M1PJfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwNki5Nlgh|ryP NX\u[ItmW0GQR1XS
A172 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlP0TWM2OD1yLk[5NlE4KM7:TR?= NIXmXnFUSU6JRWK=
NCI-H727 NHvKXnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PScmlEPTB;MD62PVgyOiEQvF2= MnfjV2FPT0WU
NB69 NIH4VVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwN{C1OFkh|ryP NIDId5RUSU6JRWK=
HCC1937 NFfjOXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwN{C2N|Eh|ryP MmnKV2FPT0WU
HuCCT1 NIXHUI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7uTWM2OD1yLkewO|Y2KM7:TR?= NGHOSJlUSU6JRWK=
HH NF3Ld|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTvd|dFUUN3ME2wMlcxPzhzIN88US=> MVjTRW5ITVJ?
MN-60 M2fCN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwN{KxNlQh|ryP MYPTRW5ITVJ?
CFPAC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XScmlEPTB;MD63NlI2PyEQvF2= MUTTRW5ITVJ?
HOP-62 M4nURWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrER3BHUUN3ME2wMlczPjJizszN NEHzO|BUSU6JRWK=
EW-3 MnWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHWTWM2OD1yLkezOVUzKM7:TR?= MVLTRW5ITVJ?
SW1417 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHGTWM2OD1yLkezOVk{KM7:TR?= MULTRW5ITVJ?
NCI-H1155 M3vQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zOeWlEPTB;MD63N|g3PCEQvF2= M4LMV3NCVkeHUh?=
CAL-54 NIj6[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnld5FKSzVyPUCuO|QxOyEQvF2= M1u5OXNCVkeHUh?=
Saos-2 NH[4eZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXmUlZXUUN3ME2wMlc1PTh2IN88US=> NG[xUmNUSU6JRWK=
NCI-H446 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\uTWM2OD1yLke0PFA3KM7:TR?= MXLTRW5ITVJ?
LS-513 Ml\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXiTWM2OD1yLke0PVA5KM7:TR?= NHq5foJUSU6JRWK=
PA-1 MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[3XnRKSzVyPUCuO|Q6PjhizszN MmXMV2FPT0WU
HCC38 MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmflTWM2OD1yLke0PVg1KM7:TR?= MknkV2FPT0WU
DMS-273 M4LXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LWfWlEPTB;MD63OVQ2PiEQvF2= M{TEcXNCVkeHUh?=
U-266 NH3nW2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HNXGlEPTB;MD63OlI3OiEQvF2= NETxPHFUSU6JRWK=
HL-60 NFHoW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vocGlEPTB;MD63O|M2PSEQvF2= MknDV2FPT0WU
UACC-62 NWq0RVg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjHTWM2OD1yLke3OVU{KM7:TR?= MVrTRW5ITVJ?
DoTc2-4510 NYDsSHhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEWyb3dKSzVyPUCuO|gzOTFizszN M4rtdHNCVkeHUh?=
SW982 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO3d3pEUUN3ME2wMlc5PDN{IN88US=> MXjTRW5ITVJ?
8305C MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX3e2lKSzVyPUCuO|g6OzlizszN NVrUXpZkW0GQR1XS
SW48 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHBTWM2OD1yLke5NlQh|ryP NWm0N|lNW0GQR1XS
NB5 NVLLdWRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwN{m2OVEh|ryP M1LWXHNCVkeHUh?=
J82 NFX6PHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm1VmJKSzVyPUCuPFA1QDdizszN MVfTRW5ITVJ?
HDLM-2 NVHSW2NiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwOEGzOFkh|ryP NXThSlQ{W0GQR1XS
HEC-1 NYG2NJVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LCbWlEPTB;MD64NVM4OSEQvF2= M4fJO3NCVkeHUh?=
AU565 M1;lUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorhTWM2OD1yLkiyOFQh|ryP NXLhbFJZW0GQR1XS
KYSE-520 Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwOEK2N|Yh|ryP MlT1V2FPT0WU
HTC-C3 M2C4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXF[GFxUUN3ME2wMlg{PDd2IN88US=> MVXTRW5ITVJ?
AN3-CA NIi2SHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwOEO3NVEh|ryP NFnjO21USU6JRWK=
KG-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G4V2lEPTB;MD64OFQ5PCEQvF2= M4rubnNCVkeHUh?=
NCI-N87 NEjiTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPKTWM2OD1yLki0OVU3KM7:TR?= MVLTRW5ITVJ?
HN NHLOS4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwOES1PVEh|ryP M1;mT3NCVkeHUh?=
SiHa NW\ZeYhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3hTWM2OD1yLki1PFgzKM7:TR?= NGTFWVRUSU6JRWK=
C-33-A MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Lh[2lEPTB;MD64OlE5PSEQvF2= M162cnNCVkeHUh?=
A673 MnPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwOE[1N|Yh|ryP MV;TRW5ITVJ?
HSC-2 M2fhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwOEezN|Qh|ryP MmThV2FPT0WU
LN-405 M2\5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33JemlEPTB;MD64O|c{OSEQvF2= NYfVZYlUW0GQR1XS
HOS NXHCe4t[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4m5O2lEPTB;MD64O|k6PSEQvF2= NXT5fJlLW0GQR1XS
SF268 NX62PYNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWm2ZVdOUUN3ME2wMlg5ODl5IN88US=> NIjCZnVUSU6JRWK=
DJM-1 NEW0VlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCzTWM2OD1yLki4OlAzKM7:TR?= NVi0cWt6W0GQR1XS
HT-29 NGLpe4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwOEm0NVch|ryP MlnMV2FPT0WU
NCI-H292 M4nsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4ixSWlEPTB;MD64PVc4PyEQvF2= M1\sSnNCVkeHUh?=
UM-UC-3 M3m2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzHTWM2OD1yLkmwN|E3KM7:TR?= M{nERnNCVkeHUh?=
VMRC-RCZ NY\wZXIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwOUC1O|gh|ryP MX\TRW5ITVJ?
D-263MG NIfnVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwOUC5OFMh|ryP MVLTRW5ITVJ?
TE-10 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwOUC5PFQh|ryP M17XVHNCVkeHUh?=
SW1088 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XXcmlEPTB;MD65NVU2OiEQvF2= NELrdoNUSU6JRWK=
NCI-H1048 MlzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTk[2lvUUN3ME2wMlkyQDV{IN88US=> M3nXfXNCVkeHUh?=
A431 Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwOUK0OVIh|ryP Mlq2V2FPT0WU
SW1783 NYLDPHdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:xfnRKSzVyPUCuPVMzPTFizszN NEK1cm9USU6JRWK=
NCI-H2452 NW\RWWRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NImwbmtKSzVyPUCuPVM2PTdizszN M2\XO3NCVkeHUh?=
OAW-42 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwOUO2OlUh|ryP M{fvdnNCVkeHUh?=
HuO-3N1 NYDtVmZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X5N2lEPTB;MD65OFA6OiEQvF2= MUDTRW5ITVJ?
K5 MojhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{OwdWlEPTB;MD65OFEzPyEQvF2= NFf2SHlUSU6JRWK=
SW1573 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDPN|I3UUN3ME2wMlk1OjJ5IN88US=> NWL2PGN[W0GQR1XS
NCI-H1792 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\kcGlEPTB;MD65OFI{PyEQvF2= NV7W[5J[W0GQR1XS
HCC1187 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;PT3VjUUN3ME2wMlk3PzR7IN88US=> NH3le4pUSU6JRWK=
HCE-4 NF3o[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTZTWM2OD1yLkm2PVYh|ryP MVnTRW5ITVJ?
HPAF-II NYi4Rmg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\nOWRKSzVyPUCuPVcxOjhizszN Mn3yV2FPT0WU
MEL-HO M4DBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwOUe5OFUh|ryP M2DtXnNCVkeHUh?=
LCLC-103H NVK5RY56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTJc|dKSzVyPUCuPVgxOjdizszN NFSwOXZUSU6JRWK=
CAL-33 M1\uPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHNTWM2OD1yLkm4N|c5KM7:TR?= MoTJV2FPT0WU
NB6 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfUe|NKSzVyPUCuPVg1PjJizszN MYnTRW5ITVJ?
BFTC-905 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDhNVA3UUN3ME2wMlk5PDd|IN88US=> NYHDVYIxW0GQR1XS
NMC-G1 M3HjZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwOUi1PVIh|ryP M4XE[HNCVkeHUh?=
RCM-1 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfCTWM2OD1yLkm5NlU5KM7:TR?= NHHEWJdUSU6JRWK=
COLO-320-HSR M1;xcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXOfGZrUUN3ME2xMlAxPDF{IN88US=> MVnTRW5ITVJ?
NCI-H2030 NE\VVWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDHPWZwUUN3ME2xMlAyQDF|IN88US=> NIXDUlZUSU6JRWK=
SCC-4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XIemlEPTB;MT6wNVg2QSEQvF2= MV7TRW5ITVJ?
KYSE-410 MlXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTofpRbUUN3ME2xMlA{PTJizszN MXTTRW5ITVJ?
NCI-H1650 M1m5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXBUZAyUUN3ME2xMlA{QTdzIN88US=> MoLjV2FPT0WU
S-117 M3m0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnaTo5FUUN3ME2xMlA1KM7:TR?= M{nUT3NCVkeHUh?=
GAK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDQTWM2OD1zLkC1NFc2KM7:TR?= NGPE[JFUSU6JRWK=
KYSE-450 NEjPb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHReI9SUUN3ME2xMlA2OzN4IN88US=> NIfPeXNUSU6JRWK=
M059J NFj1N5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFwME[4Nlgh|ryP M{KzXHNCVkeHUh?=
LAN-6 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DPU2lEPTB;MT6wO|c4OyEQvF2= M1v1NXNCVkeHUh?=
NCI-H1651 M1TScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXGbY1KSzVyPUGuNFk{PTJizszN NH73S3RUSU6JRWK=
KMOE-2 M3noVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfhdmJKSzVyPUGuNVA6PzNizszN NUTFUYZsW0GQR1XS
SN12C NFTF[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknhTWM2OD1zLkGxO|g2KM7:TR?= Mo\GV2FPT0WU
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BEN Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3uTWM2OD12LkWyN|YzKM7:TR?= M3vuc3NCVkeHUh?=
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DMS-114 M2PQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHPTWM2OD13LkG0OVA3KM7:TR?= NYPBV5JPW0GQR1XS
KYSE-70 M13mXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvsRVRKSzVyPUWuNVQ5PTlizszN MYDTRW5ITVJ?
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MDA-MB-175-VII M4PlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7pUnJKSzVyPUWuOFQxOTRizszN NWDDVVdVW0GQR1XS
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LS-1034 M{juWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLaTWM2OD13Lk[2PFg6KM7:TR?= M{\abnNCVkeHUh?=
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MDA-MB-415 M{jnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfHWJhKSzVyPUWuO|A5OSEQvF2= MknrV2FPT0WU
TE-6 M{fINmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2S1NWlEPTB;NT63OFE5OiEQvF2= MkDlV2FPT0WU
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OCUB-M NHXF[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTVwN{e1OlMh|ryP NUXYR3VmW0GQR1XS
IGR-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4f6W2lEPTB;NT64Olg6PCEQvF2= NHXyN4tUSU6JRWK=
NCI-H747 NHOzWo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPKdHZKSzVyPU[uNlQ2QDVizszN M3rabHNCVkeHUh?=
COLO-680N NEO0TlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljYTWM2OD14LkO5OFA{KM7:TR?= M4fhU3NCVkeHUh?=
NB12 M3;kOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzGS2RNUUN3ME22Mlc6PzJ{IN88US=> NXzTbW1nW0GQR1XS
SNU-449 M{f1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjxfnNKSzVyPU[uPVk2QTFizszN NYDKUG02W0GQR1XS
D-542MG MkW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mki1TWM2OD15LkGyNlk6KM7:TR?= Mn;2V2FPT0WU
COLO-792 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL5N|ZYUUN3ME23Mlg4OTJ5IN88US=> NXnuOJp3W0GQR1XS
NCI-H810 MonOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRThwMEK5PFQh|ryP Ml\vV2FPT0WU
T47D NFLBRnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[5TWM2OD16LkG2NFI1KM7:TR?= NEHzT|NUSU6JRWK=
Calu-3 NG\MUIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRThwMki4PFYh|ryP NVzVbIdbW0GQR1XS
COLO-741 MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRThwOUOwPVMh|ryP NEHQXWlUSU6JRWK=
LU-135 M3zRXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTlwMEO0OVIh|ryP NELVNnZUSU6JRWK=
COLO-678 NWDSZWRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Psc2lEPTB;OT6yPFg1PCEQvF2= M{m5cnNCVkeHUh?=
NCI-H2126 NGrZOldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTlwM{O5NVkh|ryP NUiweFVQW0GQR1XS
SK-MEL-28 NInJfm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[5TWM2OD17LkWzOVk3KM7:TR?= NFHqO49USU6JRWK=
MFE-280 NX\xS4RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvFTWM2OD1zMD6wNlI6KM7:TR?= NUPkXXpLW0GQR1XS
DBTRG-05MG NYO3WHZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zNSmlEPTB;MUCuOFM3QSEQvF2= NHfpOZFUSU6JRWK=
RCC10RGB M2PoZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;JTWM2OD1zMD61NlU2KM7:TR?= MYfTRW5ITVJ?
NTERA-S-cl-D1 NYHPeIZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHve|c2UUN3ME2xNE43QDV{IN88US=> MYDTRW5ITVJ?
C3A M3\wXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jCTGlEPTB;MUKuN|E4OiEQvF2= MUDTRW5ITVJ?
MHH-ES-1 M2DD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTF{LkWyPFQh|ryP MYLTRW5ITVJ?
LU-139 MlGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTF{Lk[zN|Mh|ryP M4fSdnNCVkeHUh?=
KNS-42 NEPkNmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3OUIxjUUN3ME2xNk45PzdzIN88US=> M4fpfHNCVkeHUh?=
MCF7 NHHJO|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLvTWM2OD1zMz6yN|Y2KM7:TR?= NWLJXXcxW0GQR1XS
SW872 NFrnW2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnL4TWM2OD1zND61OFYyKM7:TR?= M2W2OnNCVkeHUh?=
HT-1376 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fYWmlEPTB;MUSuPFU5OiEQvF2= NUHVOWhrW0GQR1XS
NCI-SNU-5 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfpV2ZoUUN3ME2xOU4yPzRzIN88US=> NVvITIFPW0GQR1XS
NCI-H2405 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTkTWM2OD1zNT60OFc1KM7:TR?= MnP4V2FPT0WU
KYSE-150 MoSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1u2PGlEPTB;MUWuO|YyOSEQvF2= NYjMS3UxW0GQR1XS
SW837 NVTkfYNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXkTWM2OD1zNj6wNVI1KM7:TR?= Mn3kV2FPT0WU
LU-65 M2\RR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;Xfo9KSzVyPUG5MlczPiEQvF2= MlS2V2FPT0WU
JEG-3 M37QVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4GzPGlEPTB;MkCuN|U4PyEQvF2= NVTl[ndGW0GQR1XS
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NCI-H1770 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4KzfmlEPTB;MkOuOFA5PiEQvF2= NWPHXW13W0GQR1XS
MG-63 NHnQVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJ|Lke2O|Mh|ryP NE\FV5dUSU6JRWK=
ECC10 NGP0[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH74fJBKSzVyPUK1MlU4OSEQvF2= M4LkSnNCVkeHUh?=
SW1463 Mne2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnGWZNVUUN3ME2yO{45OzF4IN88US=> M3HCWnNCVkeHUh?=
JVM-2 M13CbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTnPJo4UUN3ME2yPE4{OjR6IN88US=> MoO4V2FPT0WU
HCT-15 M3TQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ6LkSxPVIh|ryP NILjbpZUSU6JRWK=
CAL-72 M2fNeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTNzLkS5NVIh|ryP NF\UW3FUSU6JRWK=
HCC2218 MmmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPocZJJUUN3ME2zNk45QDV6IN88US=> MWnTRW5ITVJ?
BT-474 NV\ufXFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnpVmtGUUN3ME2zN{4xQDR|IN88US=> Mlq1V2FPT0WU
NCI-H1092 NEjEbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[xOWlEPTB;M{OuOVE1PSEQvF2= NGmycGdUSU6JRWK=
Mo-T NXXm[2hlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\ZVXpKSzVyPUO3MlM2QDVizszN M4Xr[XNCVkeHUh?=
DU-145 NGLudplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH4ZY9IUUN3ME20NE43Ojl3IN88US=> NYLDe5hQW0GQR1XS
NCI-H1666 NEHnXolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TmR2lEPTB;NEKuOFQ5QCEQvF2= MoP0V2FPT0WU
IST-MES1 NUPsdGFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mki1TWM2OD12Nj60NVk3KM7:TR?= M3;FS3NCVkeHUh?=
SW1116 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWeyU|FIUUN3ME20PE4yPzV4IN88US=> MWrTRW5ITVJ?
MZ2-MEL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH3SmpKSzVyPUS4MlUxOjZizszN MX7TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Chk1 Kinase Assay:

Recombinant human Chk1 is expressed as a glutathione S-transferase fusion in insect cells using a baculovirus vector and purified by glutathione affinity chromatography. A synthetic peptide substrate (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR) for Chk1 is synthesized. Final assay concentrations of peptide and ATP (cold + 40 nCi [33P]ATP) are 0.8 and 1 μM, respectively. Different concentrations of AZD7762, buffer containing peptide and chk1 kinase and ATP, are added sequentially to a 384-well assay plate. The plate is incubated for 2 hours, reaction is stopped by the addition of buffer containing EDTA and scintillation proximity assay beads, and plates are read using a TopCount reader. Data analysis is carried out to determinate a dose response (IC50).
Cell Research:[1]
+ Expand
  • Cell lines: HT29, SW620 and MDA-MB-231 cells
  • Concentrations: Dissolved in DMSO, final concentration ~12.5 μM
  • Incubation Time: 20 or 48 hours
  • Method: For the checkpoint abrogation assay, HT29 cells are treated for 2 hours with camptothecin (topoisomerase I inhibitor; 0.07 μg/mL) to induce the G2 checkpoint. Cells are then treated for 20 hours with a 12-point titration of AZD7762 (12.5 μM to 6 nM) plus nocodazole. Cells are fixed with 3.7% formaldehyde for 1 hour, permeabilized with PBS containing 0.05% Triton X, and incubated with anti-phH3 antibody for 1 hour followed by Alexa Fluor 488 anti-rabbit and Hoechst stain for 1 hour. Mitotic index is determined on the ArrayScan and expressed as the percentage of cells undergoing mitosis. For the potentiation assays, SW620 or MDA-MB-231 cells are dosed for 24 hours with a 9-point titration of gemcitabine ranging from 0.01 to 100 nM with a constant dose of AZD7762 (300 nM). After 24 hours, medium is removed and AZD7762 alone is added back to the wells for an additional 24 hours. Cells are then incubated in AZD7762-free medium for an additional 72 hours. The effect on cell proliferation is determined by MTT.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Male NCr mice implanted s.c. with H460-DNp53 cells or SW620, and male rnu rats implanted s.c. with H460-DNp53 cells
  • Formulation: Formulated in 11.3% hydroxyproplyl-β-cyclodextrin
  • Dosages: ~25 mg/kg
  • Administration: Injection i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL (137.96 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 362.42
Formula

C17H19FN4O2S

CAS No. 860352-01-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00937664 Terminated Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca July 2009 Phase 1
NCT00473616 Terminated Advanced Solid Tumors|Cancer|Advanced Solid Malignancies AstraZeneca May 2007 Phase 1
NCT00413686 Completed Solid Tumors AstraZeneca December 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?

  • Answer:

    Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.

Chk Signaling Pathway Map

Chk Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID