AZD7762

Catalog No.S1532

AZD7762 Chemical Structure

Molecular Weight(MW): 362.42

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.

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In DMSO USD 192 In stock
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Cited by 20 Publications

Purity & Quality Control

Choose Selective Chk Inhibitors

Biological Activity

Description AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
Targets
Chk1 [1]
(Cell-free assay)
Chk2 [1]
(Cell-free assay)
5 nM <10 nM
In vitro

AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KASUMI-1 MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjqO4p{UUN3ME2wMlAxODJ|NDFOwG0> NI[0UGdUSU6JRWK=
NKM-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLHTWM2OD1yLkCwNFQyPSEQvF2= NXXB[5JJW0GQR1XS
MV-4-11 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITNc5NKSzVyPUCuNFAxPDJ3IN88US=> NYHHR5pMW0GQR1XS
NCI-H1703 NVrEWFFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HUSWlEPTB;MD6wNFY1OyEQvF2= MVzTRW5ITVJ?
A204 M2m0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TxNmlEPTB;MD6wNFg2PiEQvF2= MVzTRW5ITVJ?
CGTH-W-1 MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fNcGlEPTB;MD6wNVQzKM7:TR?= NHH4SJpUSU6JRWK=
MLMA MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXq2c|FDUUN3ME2wMlAzQDR7IN88US=> NWHVfWx4W0GQR1XS
GOTO M4PXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr0eI9KSzVyPUCuNFMyOiEQvF2= MUjTRW5ITVJ?
KE-37 NXrWd|R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnpcplKSzVyPUCuNFMyPDJizszN NWfQV3Z6W0GQR1XS
ES4 M3iwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHIUoFKSzVyPUCuNFMzPTFizszN MmHmV2FPT0WU
ATN-1 M2H0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Tl[mlEPTB;MD6wN|QyPyEQvF2= MUHTRW5ITVJ?
MHH-PREB-1 Mn;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;FOVhKSzVyPUCuNFM1PDJizszN NVHaNlFpW0GQR1XS
SW756 M2XJcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37QdWlEPTB;MD6wN|U4QSEQvF2= MVrTRW5ITVJ?
CTV-1 NV:0N2w4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TGcWlEPTB;MD6wN|g6PiEQvF2= Mk\rV2FPT0WU
HCC1806 M1zrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\RdGlEPTB;MD6wOFAzOiEQvF2= NWHnTlBEW0GQR1XS
NEC8 M162XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rr[mlEPTB;MD6wOFIxOyEQvF2= NVzhXJhLW0GQR1XS
P12-ICHIKAWA NUG4fYFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC1UJFXUUN3ME2wMlA1OzF4IN88US=> NFjnO3JUSU6JRWK=
DEL Ml\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMES1PVIh|ryP MXHTRW5ITVJ?
KM12 M1PF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M172ZmlEPTB;MD6wOVE2QCEQvF2= NF3VRWpUSU6JRWK=
LB1047-RCC NHe0V3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfROIw3UUN3ME2wMlA3ODJ3IN88US=> M2r5fXNCVkeHUh?=
LB2241-RCC NYXUdYg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwME[xNFIh|ryP MljkV2FPT0WU
NOMO-1 M1LwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7ObmJKSzVyPUCuNFYyOTVizszN MV;TRW5ITVJ?
NB14 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOxc4NRUUN3ME2wMlA3OTN4IN88US=> MVXTRW5ITVJ?
ONS-76 NULVVFZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH1U3VKSzVyPUCuNFYyQTZizszN NYjmeo1wW0GQR1XS
HD-MY-Z MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPsS2hKSzVyPUCuNFYzPTVizszN M3\5R3NCVkeHUh?=
G-402 MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LxTWlEPTB;MD6wOlQ3KM7:TR?= M2DFXXNCVkeHUh?=
ES1 NEfCOmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEexOFYh|ryP MoD2V2FPT0WU
L-363 MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMEezPUDPxE1? NG\DTFdUSU6JRWK=
A4-Fuk MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEe0PFYh|ryP MoXzV2FPT0WU
OC-314 M3:5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H3XmlEPTB;MD6wO|gxPyEQvF2= Mmf2V2FPT0WU
SK-LU-1 MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D3R2lEPTB;MD6wPFQzOSEQvF2= MWLTRW5ITVJ?
MDA-MB-157 MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS5NFVKSzVyPUCuNFg3PTlizszN Ml24V2FPT0WU
HuP-T3 Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPmTWM2OD1yLkC4O|Eh|ryP Mon5V2FPT0WU
A3-KAW M1HFdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW5[2lqUUN3ME2wMlA5QDB4IN88US=> MYHTRW5ITVJ?
MOLT-16 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C4TWlEPTB;MD6wPFgxPyEQvF2= M2rQVHNCVkeHUh?=
COLO-679 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;U[5FKSzVyPUCuNFkxQTFizszN M1\iV3NCVkeHUh?=
EM-2 NX23VFd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGWxd3RKSzVyPUCuNFk6ODNizszN NULFTohRW0GQR1XS
ES8 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEm5NVgh|ryP M3vyZXNCVkeHUh?=
SK-MEL-2 NIDDVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HBbGlEPTB;MD6xNFA{OyEQvF2= NIfPOlJUSU6JRWK=
ES3 NX3oUZJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMUCyJO69VQ>? M4jpOHNCVkeHUh?=
HSC-4 M4HNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LjNmlEPTB;MD6xNFU2PCEQvF2= MXjTRW5ITVJ?
697 NYXXOo5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK5SZhKSzVyPUCuNVExPjNizszN MkO1V2FPT0WU
TGBC11TKB MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1n2OGlEPTB;MD6xNVA6OyEQvF2= NFPNeodUSU6JRWK=
SK-PN-DW MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\TTWM2OD1yLkGxPFYh|ryP NY\QUJZ5W0GQR1XS
H9 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlr2TWM2OD1yLkGyNVY2KM7:TR?= M4fwU3NCVkeHUh?=
NCI-H2122 NFvk[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1POWmlEPTB;MD6xNlI2KM7:TR?= M2HxUHNCVkeHUh?=
ML-2 NHTpR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[2d3h2UUN3ME2wMlEzPDh2IN88US=> NHm4T4JUSU6JRWK=
MC-IXC NVrKeVN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;rTWM2OD1yLkGyPFQ{KM7:TR?= M3SxV3NCVkeHUh?=
KYSE-140 NIK4cJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMUOwOFEh|ryP M3jpdnNCVkeHUh?=
DOHH-2 NXTBWJFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPiN3VKSzVyPUCuNVMxPjRizszN M{jFUnNCVkeHUh?=
MEL-JUSO NVLPT5p1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjMSnhUUUN3ME2wMlE{OTJ6IN88US=> NG\F[lRUSU6JRWK=
P30-OHK MkW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnI[ZBWUUN3ME2wMlE{OTZizszN M4DKRnNCVkeHUh?=
CTB-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMUOzNlUh|ryP MomyV2FPT0WU
ACHN M37uZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\VTWM2OD1yLkGzN|Y6KM7:TR?= M37D[3NCVkeHUh?=
ES5 MoTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonHTWM2OD1yLkGzOFc3KM7:TR?= MVLTRW5ITVJ?
SF539 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1mx[2lEPTB;MD6xN|Y5KM7:TR?= NYrsWZg{W0GQR1XS
D-283MED MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTQbJY{UUN3ME2wMlE{Pjh5IN88US=> MUfTRW5ITVJ?
OVCAR-5 NUXrUHdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITsb3RKSzVyPUCuNVM5QTRizszN NXXFbFE{W0GQR1XS
RPMI-8866 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;NelBKSzVyPUCuNVM6OjVizszN NHvtRolUSU6JRWK=
PANC-03-27 M1HJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrve2ZxUUN3ME2wMlE1Ojh6IN88US=> NEmyUYVUSU6JRWK=
M14 M2\HO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMUS0OlMh|ryP NUDGS5hEW0GQR1XS
D-566MG MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMUS2PUDPxE1? M1j0VHNCVkeHUh?=
Ramos-2G6-4C10 M1vFfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\3TWM2OD1yLkG0PFQzKM7:TR?= M1G4UXNCVkeHUh?=
NOS-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMUS5Olch|ryP MV\TRW5ITVJ?
YH-13 Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPFO4JKSzVyPUCuNVU3PzRizszN MX3TRW5ITVJ?
NB17 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwMUW3PFYh|ryP MXLTRW5ITVJ?
U-2-OS MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTSe5RKSzVyPUCuNVU5PDdizszN NU\YNFNKW0GQR1XS
ES7 NIHVdVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMU[wNVEh|ryP MnfrV2FPT0WU
LoVo MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1faV2lEPTB;MD6xOlE3PiEQvF2= MUnTRW5ITVJ?
QIMR-WIL MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMU[zNVEh|ryP NV3GOItkW0GQR1XS
ESS-1 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPyTWM2OD1yLkG2OFE{KM7:TR?= MkfaV2FPT0WU
LAMA-84 M4r4Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHr3Z4FKSzVyPUCuNVY2ODNizszN M4\re3NCVkeHUh?=
TGBC24TKB NHTkdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfaTWM2OD1yLkG2OVM2KM7:TR?= NF;EWIlUSU6JRWK=
KU812 NX76TVQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMU[4N{DPxE1? MXvTRW5ITVJ?
KARPAS-45 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3pTWM2OD1yLkG2PFQ4KM7:TR?= NHSyXJJUSU6JRWK=
ACN NH\od|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq3WFMzUUN3ME2wMlE4OTdzIN88US=> MmrMV2FPT0WU
RPMI-8226 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLwTWM2OD1yLkG3OFY1KM7:TR?= Mk\JV2FPT0WU
GR-ST NEH3emtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPQTWM2OD1yLkG3PFI4KM7:TR?= NGO4PJJUSU6JRWK=
SK-UT-1 NHPGXJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMUi1PVkh|ryP MnPTV2FPT0WU
SK-N-AS M1PON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWzb5RRUUN3ME2wMlE5QDF3IN88US=> M3PmenNCVkeHUh?=
EW-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEm1VJhKSzVyPUCuNVg6ODVizszN NX\sfnFUW0GQR1XS
5637 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm2fXhKSzVyPUCuNVkzPzhizszN NUDYe2Y3W0GQR1XS
GI-1 NEH6UYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PHVWlEPTB;MD6xPVU3OSEQvF2= NFnu[5pUSU6JRWK=
NCI-H1395 M{jPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnNZ3RKSzVyPUCuNVk4PjFizszN M2rvfXNCVkeHUh?=
CHP-212 M{nIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTGTWM2OD1yLkG5O|gzKM7:TR?= MUXTRW5ITVJ?
A427 MlPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPoVGhpUUN3ME2wMlE6QDN{IN88US=> NWOwWXI6W0GQR1XS
BE-13 NX\mWIlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTrSVhKSzVyPUCuNlAyOTdizszN M3fib3NCVkeHUh?=
RS4-11 NWXxUY5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjsNI1KSzVyPUCuNlA{OThizszN MkTOV2FPT0WU
TI-73 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW3d4RuUUN3ME2wMlIxQDd|IN88US=> NED2PGxUSU6JRWK=
HAL-01 MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3MTWM2OD1yLkKwPVch|ryP M1n5OnNCVkeHUh?=
KY821 M2Tac2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwMkG0Nlkh|ryP M33oWHNCVkeHUh?=
H4 NYj2c3FvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfJTWM2OD1yLkKyNFYzKM7:TR?= Ml\2V2FPT0WU
EPLC-272H MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH1TWM2OD1yLkKyNFY5KM7:TR?= M4TrW3NCVkeHUh?=
COR-L105 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLhTWM2OD1yLkKyNlM2KM7:TR?= NYrRXWl6W0GQR1XS
769-P M3LobWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHISW5KSzVyPUCuNlIzQThizszN NInQNlJUSU6JRWK=
HEL MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jMU2lEPTB;MD6yNlQ2PCEQvF2= NEm1WoNUSU6JRWK=
VA-ES-BJ M{HrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17VTGlEPTB;MD6yNlU2PyEQvF2= NWjXNG57W0GQR1XS
IST-MEL1 M3ewXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH5TWM2OD1yLkKyOVch|ryP M3HqRXNCVkeHUh?=
KYSE-270 M2\ISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXIVohwUUN3ME2wMlIzPjN|IN88US=> NITYSmJUSU6JRWK=
RH-1 MlXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL3ZoNwUUN3ME2wMlIzPjZ4IN88US=> NWLwfXdKW0GQR1XS
JVM-3 NWDabohZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDEO|dKSzVyPUCuNlMxOzZizszN MXfTRW5ITVJ?
RPMI-7951 NX;LPHpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\XcZVKSzVyPUCuNlMxPTZizszN NVXpRpNqW0GQR1XS
JAR MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LpS2lEPTB;MD6yN|I{QCEQvF2= M2jodHNCVkeHUh?=
MOLT-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC1TWM2OD1yLkKzPFUh|ryP NWHGWItjW0GQR1XS
ALL-PO NGjrPHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n4T2lEPTB;MD6yOFI1OyEQvF2= MkXuV2FPT0WU
SNU-387 NWD0O|ByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DTVmlEPTB;MD6yOFM{QSEQvF2= NE\LOGZUSU6JRWK=
IGROV-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP4OW1KSzVyPUCuNlQ1ODFizszN MkCyV2FPT0WU
MPP-89 NUD2PXJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF70WZdKSzVyPUCuNlQ1PTFizszN M36xT3NCVkeHUh?=
T98G MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LzSGlEPTB;MD6yOFU3QCEQvF2= NETvTIFUSU6JRWK=
NCI-H510A MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnVTWM2OD1yLkK0OlI3KM7:TR?= NGjUfFhUSU6JRWK=
KOSC-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljQTWM2OD1yLkK0OlcyKM7:TR?= M1e1bXNCVkeHUh?=
NCI-H23 MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\qVWlEPTB;MD6yOFc3OSEQvF2= NVXrOJJjW0GQR1XS
MC116 NIDoXXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLMToxEUUN3ME2wMlI2PjV2IN88US=> MkCyV2FPT0WU
8-MG-BA M1jETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMkW3Olgh|ryP M3vudnNCVkeHUh?=
ABC-1 NX;Cd5puT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMk[wOlQh|ryP NGi1PIlUSU6JRWK=
J-RT3-T3-5 NF\JOGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HhZWlEPTB;MD6yOlY4QCEQvF2= Ml7EV2FPT0WU
NCI-SNU-1 Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\0elZKSzVyPUCuNlcxPTlizszN M1;pSHNCVkeHUh?=
HCC1395 NYrVR4ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfDNGhKSzVyPUCuNlcxQDlizszN MnezV2FPT0WU
BB65-RCC NH62c2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\tOmlEPTB;MD6yO|A6PyEQvF2= NHTRUItUSU6JRWK=
NCI-H1755 NYnCUFNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvwUolIUUN3ME2wMlI4OzB2IN88US=> MVvTRW5ITVJ?
OVCAR-3 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMkezPFUh|ryP M3zXd3NCVkeHUh?=
MKN45 M2XOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS2[nFKSzVyPUCuNlc6QCEQvF2= MW\TRW5ITVJ?
TYK-nu NW\WOm5vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;4TWM2OD1yLkK4NFYh|ryP M{LFfHNCVkeHUh?=
SNU-C2B MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLlTWM2OD1yLkK4NVM1KM7:TR?= NUPLVmd5W0GQR1XS
H-EMC-SS M2HBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4excmlEPTB;MD6yPFM2PCEQvF2= MoXFV2FPT0WU
CAKI-1 M4L4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;ZWlJGUUN3ME2wMlI5PjhizszN MorKV2FPT0WU
EW-24 NWPKWmd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMki5NUDPxE1? MmnYV2FPT0WU
RXF393 NInZdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;5c406UUN3ME2wMlI6ODB6IN88US=> MkXxV2FPT0WU
CCRF-CEM NXr4cHozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPZdXZKSzVyPUCuNlkyPTRizszN MoPhV2FPT0WU
HOP-92 M4DaN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TYSWlEPTB;MD6yPVI4QSEQvF2= NXTYWFdyW0GQR1XS
COLO-684 NEjt[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPtTWM2OD1yLkK5OFA3KM7:TR?= NI\mRolUSU6JRWK=
NCI-H28 MlfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHrW45KSzVyPUCuNlk4ODRizszN NIX5bHBUSU6JRWK=
HuO9 M33EZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vBcWlEPTB;MD6yPVc6OyEQvF2= Mnv5V2FPT0WU
SF295 M3z6bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvJTWM2OD1yLkK5PFAzKM7:TR?= NVvoNpZLW0GQR1XS
COLO-829 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMkm4OFUh|ryP NHnLfppUSU6JRWK=
MSTO-211H NEC1VmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMkm4OVUh|ryP NVWxTXRIW0GQR1XS
MDA-MB-361 NVn6eGNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrtR|lEUUN3ME2wMlI6QDl4IN88US=> MoL6V2FPT0WU
FTC-133 M2DKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17wR2lEPTB;MD6zNFI3PSEQvF2= NXvkSFlRW0GQR1XS
Mewo NHjOSWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13VPGlEPTB;MD6zNFQ{OSEQvF2= NYHBenY5W0GQR1XS
HCC70 MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;pTWM2OD1yLkOwOlY2KM7:TR?= MonnV2FPT0WU
BB30-HNC NXHtZpczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrjbFdsUUN3ME2wMlMyPTJ3IN88US=> MnPvV2FPT0WU
LCLC-97TM1 M{PJNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\2e2lEPTB;MD6zNVU3PiEQvF2= MmGwV2FPT0WU
HCC2998 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHtU5JHUUN3ME2wMlMyPjVizszN NHv3W2JUSU6JRWK=
NBsusSR M{fM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M135dGlEPTB;MD6zNVgyQSEQvF2= MkfLV2FPT0WU
OVCAR-4 NFKxOXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3OzS2lEPTB;MD6zNlAzOSEQvF2= M1LzfHNCVkeHUh?=
NCI-H209 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnMTWM2OD1yLkOyN|U{KM7:TR?= MkLBV2FPT0WU
ChaGo-K-1 NVjNPGd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHMTWM2OD1yLkOyOFg6KM7:TR?= NFvMZ3RUSU6JRWK=
KALS-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwM{K1PVQh|ryP Mnz6V2FPT0WU
D-423MG NH7KSXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDmNlYxUUN3ME2wMlM{OTR{IN88US=> NV35NVVuW0GQR1XS
Detroit562 NVq2PVRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwM{OzOFMh|ryP Mn;vV2FPT0WU
HT-144 NF:4bJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\qTWM2OD1yLkOzPFEh|ryP MUjTRW5ITVJ?
MEG-01 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwM{S1PFQh|ryP MVPTRW5ITVJ?
BV-173 M2rFPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jU[2lEPTB;MD6zOFU6PiEQvF2= M4jKSHNCVkeHUh?=
MZ7-mel MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LIXmlEPTB;MD6zOFY4PyEQvF2= MonaV2FPT0WU
C32 NGrVSG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVexZ|J3UUN3ME2wMlM1Pjh{IN88US=> M2roTHNCVkeHUh?=
DU-4475 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqwTWM2OD1yLkO0PFc2KM7:TR?= NFyxWJdUSU6JRWK=
KP-N-YN NHLldXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwM{S4PFch|ryP NFjSeYxUSU6JRWK=
MKN1 MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPxSlZ2UUN3ME2wMlM2ODB{IN88US=> NXXi[pdIW0GQR1XS
8505C MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjrTWM2OD1yLkO1NFAzKM7:TR?= MmrYV2FPT0WU
OVCAR-8 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwM{W1PFQh|ryP MlS5V2FPT0WU
NH-12 M4fVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LRbGlEPTB;MD6zOVY6PiEQvF2= MWPTRW5ITVJ?
COR-L88 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfQTWM2OD1yLkO2OFgzKM7:TR?= NGr6NHRUSU6JRWK=
T-24 M1XhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDSR5MyUUN3ME2wMlM3QTh3IN88US=> NFTXZmpUSU6JRWK=
MIA-PaCa-2 M2rKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXCTWM2OD1yLkO3OFk4KM7:TR?= NVX5XmFSW0GQR1XS
LS-411N MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m4W2lEPTB;MD6zO|YxPiEQvF2= MUTTRW5ITVJ?
TK10 NWf3[Hg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe2OXVMUUN3ME2wMlM4QTR6IN88US=> NX\x[WhMW0GQR1XS
SW1990 NXjtc5NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPtNmQ1UUN3ME2wMlM5OzV|IN88US=> M2nieXNCVkeHUh?=
GAMG NIHTeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwM{i1Olch|ryP Mk[wV2FPT0WU
G-361 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT0TWM2OD1yLkO4O|EzKM7:TR?= M4XBVXNCVkeHUh?=
Ca-Ski NXHRbWY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPTTWM2OD1yLkO4O|kzKM7:TR?= NF3uXmVUSU6JRWK=
786-0 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDKTWM2OD1yLkO4PFI{KM7:TR?= NFnYeXFUSU6JRWK=
MHH-NB-11 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPsN4lXUUN3ME2wMlM5QTdizszN NVPPTXZRW0GQR1XS
OE33 NGrRbXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjOTWM2OD1yLkO5NVE5KM7:TR?= NY[0N2FUW0GQR1XS
SW954 MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3HWWdKSzVyPUCuOFAyOzFizszN MXrTRW5ITVJ?
KYSE-180 NHzPTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXmTWM2OD1yLkSwNVUyKM7:TR?= MorNV2FPT0WU
NCI-H720 MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkiyTWM2OD1yLkSwNVkyKM7:TR?= NXrBNWtkW0GQR1XS
COR-L23 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwNECyPFYh|ryP MWfTRW5ITVJ?
PFSK-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[4O|BVUUN3ME2wMlQyODl{IN88US=> NXn3OI01W0GQR1XS
FADU M3rkO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjq[3dZUUN3ME2wMlQyOTd{IN88US=> MnHZV2FPT0WU
GP5d NInW[XlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:zTWM2OD1yLkSxNlI2KM7:TR?= NWn6cnl6W0GQR1XS
PC-14 NGTSdWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLnTWM2OD1yLkSxOlYyKM7:TR?= NGDON|VUSU6JRWK=
SJSA-1 NYrhPFZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\XT5FKSzVyPUCuOFE4OTRizszN M4q2VnNCVkeHUh?=
D-336MG NIjleY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorsTWM2OD1yLkSyNVM5KM7:TR?= NVriW3B7W0GQR1XS
LOXIMVI M3X1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXSSZdKSzVyPUCuOFI5QDVizszN M2P2cXNCVkeHUh?=
EFO-27 NHzVWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnROYVQUUN3ME2wMlQ{ODR7IN88US=> MYnTRW5ITVJ?
A2780 NU\ZS4xqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjHV2M3UUN3ME2wMlQ{OTZ{IN88US=> M13O[HNCVkeHUh?=
CAL-12T MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTsTWM2OD1yLkSzNlg5KM7:TR?= MVnTRW5ITVJ?
ES6 M{LV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf2e4lKSzVyPUCuOFQyQDVizszN MkLDV2FPT0WU
HCE-T MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwNESxPFch|ryP M4e1dXNCVkeHUh?=
SK-MES-1 MmH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwNESyPVMh|ryP M1jMNXNCVkeHUh?=
Daoy NWrt[oVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTB[IV[UUN3ME2wMlQ2OTB|IN88US=> M{LuVHNCVkeHUh?=
A2058 NGrKSoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i1fmlEPTB;MD60OVE{PiEQvF2= MlLZV2FPT0WU
Hs-578-T M4XzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwNEWyO|gh|ryP M2PKNXNCVkeHUh?=
TE-11 NGj6TG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnXTWM2OD1yLkS1Nlk{KM7:TR?= Ml\NV2FPT0WU
GI-ME-N NVHzVXU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LqUmlEPTB;MD60OVQ3KM7:TR?= NFfCU5ZUSU6JRWK=
D-392MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVSwdWx2UUN3ME2wMlQ2PjF{IN88US=> NHPFZYVUSU6JRWK=
MOLT-13 NEfWUYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrvfJZWUUN3ME2wMlQ3Ojl2IN88US=> NYnUTIg1W0GQR1XS
SK-NEP-1 M3Tvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3u0ZmlEPTB;MD60OlQyQSEQvF2= Mmr4V2FPT0WU
KS-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\qTWM2OD1yLkS2OlA{KM7:TR?= MlO4V2FPT0WU
HuP-T4 MkW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\qempKSzVyPUCuOFY5PjhizszN M2f0RXNCVkeHUh?=
NCI-H1563 MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnDbGVKSzVyPUCuOFcxOzVizszN NVPGcmFlW0GQR1XS
U031 NVr1NIZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHjdVJKSzVyPUCuOFgzOzRizszN MY\TRW5ITVJ?
HSC-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nVXGlEPTB;MD60PFYzPiEQvF2= M3X3OHNCVkeHUh?=
HT-3 MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljuTWM2OD1yLkS5NFMh|ryP M4G5OHNCVkeHUh?=
HGC-27 NYG5cJZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3noV2lEPTB;MD60PVEyPSEQvF2= NHW5O2tUSU6JRWK=
HT-1080 NFHXV|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwNEmyO{DPxE1? NUD0cZpXW0GQR1XS
RT-112 NHTOVYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LmSGlEPTB;MD60PVkzOSEQvF2= NH\4To9USU6JRWK=
A375 NX[5OFdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjlTWM2OD1yLkS5PVIzKM7:TR?= M3m1WHNCVkeHUh?=
SW626 MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwNUC2N|Mh|ryP NUTaXVJiW0GQR1XS
SBC-5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwNUGzOFQh|ryP NX3qZY5CW0GQR1XS
CAL-51 MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmmwTWM2OD1yLkWxOFM4KM7:TR?= MkfxV2FPT0WU
RKO MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHXTWM2OD1yLkWyNFE6KM7:TR?= Mn21V2FPT0WU
HC-1 NELSSIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3VZ282UUN3ME2wMlUzOTF2IN88US=> NUfDOG5vW0GQR1XS
CHL-1 NXXlWYV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwNUK1OVEh|ryP NIfTUGxUSU6JRWK=
SK-N-DZ M2[1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HKPWlEPTB;MD61N|A4QCEQvF2= M2\Ke3NCVkeHUh?=
SNU-423 Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DHZWlEPTB;MD61N|Q3PiEQvF2= MWrTRW5ITVJ?
NB13 M1KwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwNUO2OVch|ryP MUPTRW5ITVJ?
EW-16 M1jLW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXNOWwzUUN3ME2wMlU{Pzd2IN88US=> Mlv4V2FPT0WU
A704 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjlTWM2OD1yLkWzPFgyKM7:TR?= MkHLV2FPT0WU
Ca9-22 NIfifZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwNUSwO|ch|ryP NUGwSld{W0GQR1XS
NCI-H1299 NFzFR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXXSoxlUUN3ME2wMlU2PThizszN MkXVV2FPT0WU
LB771-HNC NIXXc45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTVXJRKSzVyPUCuOVU6OzNizszN NW\I[plFW0GQR1XS
EW-11 NV\zU4xTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIG1TIxKSzVyPUCuOVY{OjZizszN NHn0VItUSU6JRWK=
LC-2-ad MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:0VWlEPTB;MD61OlUzOiEQvF2= NVG2SWZbW0GQR1XS
KNS-62 NETHcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwNU[1OVMh|ryP M2SyV3NCVkeHUh?=
CAL-62 M{PJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwNUexNlEh|ryP MmTlV2FPT0WU
SF126 NIfDUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnmxTWM2OD1yLkW3OFIyKM7:TR?= NHzIUIpUSU6JRWK=
OMC-1 NEX5fWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwNUe0PVch|ryP NHHOWWhUSU6JRWK=
AGS NYjjfYJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPoO5VuUUN3ME2wMlU5OTZ{IN88US=> NYTZSWRtW0GQR1XS
EW-22 M4HRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPpTWM2OD1yLkW4N|c2KM7:TR?= MUPTRW5ITVJ?
KP-N-YS M13sUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3wWWxwUUN3ME2wMlU5Ozh{IN88US=> NUjCN2lxW0GQR1XS
BFTC-909 MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLmTWM2OD1yLkW4PFM{KM7:TR?= M37tPXNCVkeHUh?=
PSN1 NHzBOJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DPS2lEPTB;MD61PVEyQCEQvF2= NFXFdVZUSU6JRWK=
NB10 NUL1RoVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zrR2lEPTB;MD61PVEzQSEQvF2= MX;TRW5ITVJ?
COLO-800 MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXkSmVUUUN3ME2wMlYxOzJ6IN88US=> MmPnV2FPT0WU
647-V NGrXSZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjMTWM2OD1yLk[xO|g4KM7:TR?= MmPJV2FPT0WU
VM-CUB-1 NHS2WJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXuTWM2OD1yLk[xPFYyKM7:TR?= M2HxR3NCVkeHUh?=
OS-RC-2 M4HYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TFe2lEPTB;MD62NlAyKM7:TR?= MUjTRW5ITVJ?
IST-SL1 M2rRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HPVWlEPTB;MD62Nlc5QCEQvF2= NUfFR5E2W0GQR1XS
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G-401 MnTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHOVGNKSzVyPUSuPFM5PDFizszN NUTUWWtVW0GQR1XS
CAL-120 M1LOV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrkTWM2OD12Lki0PVkyKM7:TR?= MnrWV2FPT0WU
DMS-114 M372XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXFTWM2OD13LkG0OVA3KM7:TR?= M2nPNnNCVkeHUh?=
KYSE-70 NUfIbIVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjVVWNKSzVyPUWuNVQ5PTlizszN M1zXe3NCVkeHUh?=
NCI-H1648 Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jROWlEPTB;NT6yPVc5OiEQvF2= MYDTRW5ITVJ?
MDA-MB-175-VII MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jFcGlEPTB;NT60OFAyPCEQvF2= NUe0bY5VW0GQR1XS
NCI-H2029 NGP2NnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3jT2RqUUN3ME21MlQ5ODJ{IN88US=> M2HSfnNCVkeHUh?=
LS-1034 M4[3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTVwNk[4PFkh|ryP NFHFNWZUSU6JRWK=
LB831-BLC M1zOeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXaTWM2OD13LkewN|Q2KM7:TR?= NF\yT3pUSU6JRWK=
MDA-MB-415 NYGzZZZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnDS5FYUUN3ME21MlcxQDFizszN MnzxV2FPT0WU
TE-6 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTVwN{SxPFIh|ryP NFXqWoRUSU6JRWK=
SK-MEL-24 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e2N2lEPTB;NT63OFU3PCEQvF2= NInOXGRUSU6JRWK=
HUTU-80 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfuOJBEUUN3ME21Mlc2OzN|IN88US=> M2fwbXNCVkeHUh?=
OCUB-M Moe4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3VTWM2OD13Lke3OVY{KM7:TR?= MnW5V2FPT0WU
IGR-1 NGrUZlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPYNHBKSzVyPUWuPFY5QTRizszN NV;CV2tyW0GQR1XS
NCI-H747 M2TjS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX73NmhiUUN3ME22MlI1PTh3IN88US=> M{HtZ3NCVkeHUh?=
COLO-680N NHHydopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTzellCUUN3ME22MlM6PDB|IN88US=> Mlv4V2FPT0WU
NB12 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUK1[JlkUUN3ME22Mlc6PzJ{IN88US=> MVTTRW5ITVJ?
SNU-449 M{P5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTZwOUm1PVEh|ryP NYq2dlRXW0GQR1XS
D-542MG M1PF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTdwMUKyPVkh|ryP MlHNV2FPT0WU
COLO-792 NWn0WoN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPKR|lnUUN3ME23Mlg4OTJ5IN88US=> MkLmV2FPT0WU
NCI-H810 NEjwOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHoNJRGUUN3ME24MlAzQTh2IN88US=> NVf6TZBWW0GQR1XS
T47D MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnL5TWM2OD16LkG2NFI1KM7:TR?= MmnYV2FPT0WU
Calu-3 NVHRT4p2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRThwMki4PFYh|ryP MUTTRW5ITVJ?
COLO-741 NXjUfmgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRThwOUOwPVMh|ryP MYnTRW5ITVJ?
LU-135 NVK5OGd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS1bItxUUN3ME25MlA{PDV{IN88US=> NHO1eJBUSU6JRWK=
COLO-678 M1PNSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIX4TIlKSzVyPUmuNlg5PDRizszN MmHuV2FPT0WU
NCI-H2126 MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHUS4pKSzVyPUmuN|M6OTlizszN NVTwUm9QW0GQR1XS
SK-MEL-28 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTlwNUO1PVYh|ryP Ml;lV2FPT0WU
MFE-280 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj0Z|FKSzVyPUGwMlAzOjlizszN NYLOblBwW0GQR1XS
DBTRG-05MG NXLGS3dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFyLkSzOlkh|ryP NX:0S2R4W0GQR1XS
RCC10RGB NIm0PZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnwNIpEUUN3ME2xNE42OjV3IN88US=> MkLoV2FPT0WU
NTERA-S-cl-D1 MkPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjPNXNJUUN3ME2xNE43QDV{IN88US=> MnzYV2FPT0WU
C3A MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnZTWM2OD1zMj6zNVczKM7:TR?= MVTTRW5ITVJ?
MHH-ES-1 M37zZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH1TWM2OD1zMj61Nlg1KM7:TR?= NV3qcWR{W0GQR1XS
LU-139 NYrONpBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj5TWM2OD1zMj62N|M{KM7:TR?= MXHTRW5ITVJ?
KNS-42 MnG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT4TWM2OD1zMj64O|cyKM7:TR?= NECw[4NUSU6JRWK=
MCF7 NFTKXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Dz[GlEPTB;MUOuNlM3PSEQvF2= NGXzeoxUSU6JRWK=
SW872 MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTF2LkW0OlEh|ryP MmDpV2FPT0WU
HT-1376 NX;SV2hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\wcGlEPTB;MUSuPFU5OiEQvF2= NF;MeGRUSU6JRWK=
NCI-SNU-5 M1;OO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W1S2lEPTB;MUWuNVc1OSEQvF2= MlywV2FPT0WU
NCI-H2405 NHvBdXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPDTWM2OD1zNT60OFc1KM7:TR?= MmP6V2FPT0WU
KYSE-150 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHHUnJKSzVyPUG1Mlc3OTFizszN NIjnN5pUSU6JRWK=
SW837 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTJPZVKSzVyPUG2MlAyOjRizszN NUf4O4VmW0GQR1XS
LU-65 MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnkfZJKSzVyPUG5MlczPiEQvF2= Ml63V2FPT0WU
JEG-3 Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJyLkO1O|ch|ryP MUXTRW5ITVJ?
SK-MEL-1 NEjpbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\JcmlEPTB;MkCuO|g{PiEQvF2= MVjTRW5ITVJ?
SK-HEP-1 NFvPPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkSxTWM2OD1{MT61OVQyKM7:TR?= M1LHXnNCVkeHUh?=
NCI-H1770 MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XobmlEPTB;MkOuOFA5PiEQvF2= Mm\BV2FPT0WU
MG-63 NIrQSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLCR5Y6UUN3ME2yN{44Pjd|IN88US=> MoHEV2FPT0WU
ECC10 M2i2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HtVGlEPTB;MkWuOVcyKM7:TR?= MnTLV2FPT0WU
SW1463 NWLlNXVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\YV3ljUUN3ME2yO{45OzF4IN88US=> MoDlV2FPT0WU
JVM-2 M1rRPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv1TWM2OD1{OD6zNlQ5KM7:TR?= NHi1Z4NUSU6JRWK=
HCT-15 NG\JR|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHEVIlIUUN3ME2yPE41OTl{IN88US=> NXXzVGUzW0GQR1XS
CAL-72 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjXNldPUUN3ME2zNU41QTF{IN88US=> NIPiOINUSU6JRWK=
HCC2218 NXHzXplLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfxTWM2OD1|Mj64PFU5KM7:TR?= M136VHNCVkeHUh?=
BT-474 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjrS3RKSzVyPUOzMlA5PDNizszN NUDCW|k1W0GQR1XS
NCI-H1092 NWrr[ZE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWqx[ZlkUUN3ME2zN{42OTR3IN88US=> MXXTRW5ITVJ?
Mo-T Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnOSXd6UUN3ME2zO{4{PTh3IN88US=> MXfTRW5ITVJ?
DU-145 NU\xfnU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTxTWM2OD12MD62Nlk2KM7:TR?= NIrKe|BUSU6JRWK=
NCI-H1666 Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELzSWRKSzVyPUSyMlQ1QDhizszN MmnZV2FPT0WU
IST-MES1 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLXUItKSzVyPUS2MlQyQTZizszN MlXiV2FPT0WU
SW1116 M{LTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofMTWM2OD12OD6xO|U3KM7:TR?= MkjWV2FPT0WU
MZ2-MEL NU\MOGJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmOyTWM2OD12OD61NFI3KM7:TR?= NIDONXdUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Chk1 Kinase Assay:

Recombinant human Chk1 is expressed as a glutathione S-transferase fusion in insect cells using a baculovirus vector and purified by glutathione affinity chromatography. A synthetic peptide substrate (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR) for Chk1 is synthesized. Final assay concentrations of peptide and ATP (cold + 40 nCi [33P]ATP) are 0.8 and 1 μM, respectively. Different concentrations of AZD7762, buffer containing peptide and chk1 kinase and ATP, are added sequentially to a 384-well assay plate. The plate is incubated for 2 hours, reaction is stopped by the addition of buffer containing EDTA and scintillation proximity assay beads, and plates are read using a TopCount reader. Data analysis is carried out to determinate a dose response (IC50).
Cell Research:[1]
+ Expand
  • Cell lines: HT29, SW620 and MDA-MB-231 cells
  • Concentrations: Dissolved in DMSO, final concentration ~12.5 μM
  • Incubation Time: 20 or 48 hours
  • Method: For the checkpoint abrogation assay, HT29 cells are treated for 2 hours with camptothecin (topoisomerase I inhibitor; 0.07 μg/mL) to induce the G2 checkpoint. Cells are then treated for 20 hours with a 12-point titration of AZD7762 (12.5 μM to 6 nM) plus nocodazole. Cells are fixed with 3.7% formaldehyde for 1 hour, permeabilized with PBS containing 0.05% Triton X, and incubated with anti-phH3 antibody for 1 hour followed by Alexa Fluor 488 anti-rabbit and Hoechst stain for 1 hour. Mitotic index is determined on the ArrayScan and expressed as the percentage of cells undergoing mitosis. For the potentiation assays, SW620 or MDA-MB-231 cells are dosed for 24 hours with a 9-point titration of gemcitabine ranging from 0.01 to 100 nM with a constant dose of AZD7762 (300 nM). After 24 hours, medium is removed and AZD7762 alone is added back to the wells for an additional 24 hours. Cells are then incubated in AZD7762-free medium for an additional 72 hours. The effect on cell proliferation is determined by MTT.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Male NCr mice implanted s.c. with H460-DNp53 cells or SW620, and male rnu rats implanted s.c. with H460-DNp53 cells
  • Formulation: Formulated in 11.3% hydroxyproplyl-β-cyclodextrin
  • Dosages: ~25 mg/kg
  • Administration: Injection i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL (137.96 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 362.42
Formula

C17H19FN4O2S

CAS No. 860352-01-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00937664 Terminated Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca July 2009 Phase 1
NCT00937664 Terminated Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca July 2009 Phase 1
NCT00473616 Terminated Advanced Solid Tumors|Cancer|Advanced Solid Malignancies AstraZeneca May 2007 Phase 1
NCT00473616 Terminated Advanced Solid Tumors|Cancer|Advanced Solid Malignancies AstraZeneca May 2007 Phase 1
NCT00413686 Completed Solid Tumors AstraZeneca December 2006 Phase 1
NCT00413686 Completed Solid Tumors AstraZeneca December 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?

  • Answer:

    Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.

Chk Signaling Pathway Map

Chk Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID