AZD7762

Catalog No.S1532

AZD7762 Chemical Structure

Molecular Weight(MW): 362.42

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.

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In DMSO USD 192 In stock
USD 70 In stock
USD 120 In stock
USD 370 In stock
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Cited by 20 Publications

9 Customer Reviews

  • CAL120 cells were either untreated or pretreated with gemcitabine for 24 hours followed by treatment with AZD7762 and/or MK-1775 for an additional 2 hours (top) or 8 hours (bottom), before lysis. Western blot analysis of Cyclin B1, CDK1 (phospho-Y15 and total) expression, and β-tubulin as loading control.

    Cancer Discov, 2012, 2: 524-539. AZD7762 purchased from Selleck.

    B, time course analysis of the mitotic index after CHK1 or WEE1 inhibition in gemcitabine-arrested CAL120 cells. C, mitotic index of CAL120 and MCF7 cells treated with AZD7762, MK-1775, or the combination for 8 h. Treatment with combination AZD7762 and MK-1775 induces unscheduled mitotic entry in cells with <4N DNA content. D, representative cell-cycle profiles of CAL120 cells treated with AZD7762, MK-1775, or the combination for 8 h assessed by pH3/PI FACS.

    Cancer Discov, 2012, 2: 524-539. AZD7762 purchased from Selleck.

  • E, CAL120 cells were either untreated or pretreated with gemcitabine for 24 hours followed by treatment with AZD7762 and /or MK-1775 for an additional 2 hours (top) or 8 hours (bottom), before lysis. Western blot analysis of Cyclin B1, CDK1 (phospho-Y15 and total) expression, and β-tubulin as loading control. F, induction of the intra–S-phase checkpoint was not affected by WEE1 inhibition. CAL120 cells were pulse-labeled with 10 μmol/L BrdU for 30 minutes, washed (W), and then treated with 1 μmol/L camptothecin (CPT) for 30 minutes. After CPT removal (0 hours), BrdU-labeled S-phase cells (BrdU+ , indicated by boxed area) were monitored at the indicated time points in the absence (iii) or presence of MK-1775 (iv) or AZD7762 as a positive control (v). Control cells (ctr) were not exposed to CPT and cultured in the absence (i) or presence of MK-1775 (ii). Arrowheads indicate delayed S-phase progression.

    Cancer Discov 2012 2, 524-39. AZD7762 purchased from Selleck.

    HNSCC cell lines have in vitro diverse sensitivities to drugs that affect mitotic progression. Fifty-nine HNSCC cell lines were treated with volasertib, AZD1775, or AZD7762 at seven concentrations ranging from 0.018 to 9.613 μM for 72 h, and their viability was estimated using a CellTiter-Glo assay. (A) Representative dose-response curves for cell lines sensitive and resistant to the drugs. (B) Distributions of the IC80 values for the 59 cell lines. The vertical orange line is the Cmax values for each drug.

    Cancer Lett, 2017, 392:71-82. AZD7762 purchased from Selleck.

  • Photomicrographs showing characteristic morphological changes in T24 cells treated with gemcitabine and AZD7762 (24 and 48 h) (c). Scale bar = 100 μm

    J Exp Clin Cancer Res, 2017, 36(1):1. AZD7762 purchased from Selleck.

    (A) GBM6 and GBM12 cells and (B) GBM5 and GBM14 cells were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 + AZD0530 for 48h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion based cell staining (±SE M, n= 3) *p < 0.05 greater than CHK1 inhibitor value. (C) GBM5 and GBM14 cells were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 +AZD0530 for 24 h and cell lysates were immunoblotted against cleaved caspase 3, PARP 1 and P-ERK1/2. (D) Medulloblastoma cell lines DAOY, VC312 and D283 were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 + AZD0530 for 48 h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion (±SE M, n = 3) *p < 0.05 greater than CHK1 inhibitor value. The cell lysates were immunoblotted against cleaved caspases-3, cleaved caspases-7 and P-ER K1/2.

    Cancer Biol Ther 2012 13. AZD7762 purchased from Selleck.

  • GBM5, 6, 12 and 14 cells were treated with AZD7762 (300nM), AZD6244 (500nM) or AZD7762 + AZD6244 for 48h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion(±SE M, n = 3) *p < 0.05 greater than CHK1 inhibitor value.

    Cancer Biol Ther 2012 13. AZD7762 purchased from Selleck.

    MCF7 cells were plated in triplicate and treated with vehicle (VEH, DMSO) , AZD0530 (125 nM), AZD7762 (50 nM) or AZD7762 and AZD0530. Cells were isolated 48 h after exposure and subjected to the indicated various cell viability assays. Data for each assay is the mean of all data points from two studies(* p < 0.05 greater than CHK1 inhibitor value).

    Cancer Biol Ther 2011 12, 215-28. AZD7762 purchased from Selleck.

  • SRC family kinases play a key role in the regulation of the ERK1/2 pathway by CHK1 inhibitors. (A) Transformed mouse embryonic fibroblasts, MEF (wild type, WT; deleted for SRC/FYN/Y es , SYF) were treated with vehicle (VE, DMSO) , UCN-01 (100 nM) or AZD7762 (50 nM). Cells were isolated at the indicated time points and subjected to SDS PAGE followed by immunoblotting to determine the phosphorylation of ERK1/2 (p-ERK1/2), the phosphorylation of SRCY461 (p -Y 416 Src ) or the expression of GAPDH . Data are from a representative of three separate studies. (B) MCF7 cells were treated with vehicle (V eh, DMSO) , UCN-01 (100 nM), pp2 (10 μM), AZD7762 (50 nM) or UCN-01+ pp2 or AZD7762+ pp2. Cells were isolated 2 h after drug exposure and subjected to SDS PAGE f ollowed by immunoblotting to determine the phosphorylation of ERK1/2 ( p-ERK1/2) or the expression of e RK2 protein. Data are from a representative of two separate studies.

    Cancer Biol Ther 2011 12, 215-28. AZD7762 purchased from Selleck.

Purity & Quality Control

Choose Selective Chk Inhibitors

Biological Activity

Description AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
Targets
Chk1 [1]
(Cell-free assay)
Chk2 [1]
(Cell-free assay)
5 nM <10 nM
In vitro

AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KASUMI-1 NVPBO2xlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXTXWt{UUN3ME2wMlAxODJ|NDFOwG0> NYX4e5RUW0GQR1XS
NKM-1 NVrafnl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGriNmZKSzVyPUCuNFAxPDF3IN88US=> NHrmclRUSU6JRWK=
MV-4-11 NEL6NHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nKcGlEPTB;MD6wNFA1OjVizszN MV3TRW5ITVJ?
NCI-H1703 M1;ZPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEC2OFMh|ryP NXfBdWdRW0GQR1XS
A204 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;mOmlEPTB;MD6wNFg2PiEQvF2= M{XjOXNCVkeHUh?=
CGTH-W-1 NIPxbnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzYcGtKSzVyPUCuNFE1OiEQvF2= M3KwSHNCVkeHUh?=
MLMA MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPlTWM2OD1yLkCyPFQ6KM7:TR?= NHvuNXVUSU6JRWK=
GOTO M3npRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3pO3JEUUN3ME2wMlA{OTJizszN NXLLSlRLW0GQR1XS
KE-37 Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LOPWlEPTB;MD6wN|E1OiEQvF2= MkjNV2FPT0WU
ES4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEOyOVEh|ryP NVXtbGNpW0GQR1XS
ATN-1 MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLFTWM2OD1yLkCzOFE4KM7:TR?= NIHLfZFUSU6JRWK=
MHH-PREB-1 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;t[mlEPTB;MD6wN|Q1OiEQvF2= MXjTRW5ITVJ?
SW756 NWftbFN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvoe5A2UUN3ME2wMlA{PTd7IN88US=> MWXTRW5ITVJ?
CTV-1 M2jlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEO4PVYh|ryP NIGySHZUSU6JRWK=
HCC1806 NVLTOXhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\jVWlEPTB;MD6wOFAzOiEQvF2= M{HXRnNCVkeHUh?=
NEC8 M3y1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHpWFhKSzVyPUCuNFQzODNizszN NUjuUJdGW0GQR1XS
P12-ICHIKAWA MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;5cGlEPTB;MD6wOFMyPiEQvF2= MkHXV2FPT0WU
DEL MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7OTWpKSzVyPUCuNFQ2QTJizszN Mo\WV2FPT0WU
KM12 NHXIeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMEWxOVgh|ryP NEXpbZlUSU6JRWK=
LB1047-RCC MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTQUlFKSzVyPUCuNFYxOjVizszN M2HzenNCVkeHUh?=
LB2241-RCC NFLtVGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGL2cHJKSzVyPUCuNFYyODJizszN MWLTRW5ITVJ?
NOMO-1 NIHDVFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwME[xNVUh|ryP MXrTRW5ITVJ?
NB14 NH3mXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17MN2lEPTB;MD6wOlE{PiEQvF2= M4HiS3NCVkeHUh?=
ONS-76 Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwME[xPVYh|ryP NVnob28yW0GQR1XS
HD-MY-Z Mof3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjSVm5[UUN3ME2wMlA3OjV3IN88US=> NH;jU|NUSU6JRWK=
G-402 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnOzTWM2OD1yLkC2OFYh|ryP NH;aWXhUSU6JRWK=
ES1 NI\lPJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkThTWM2OD1yLkC3NVQ3KM7:TR?= MkjkV2FPT0WU
L-363 Ml7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDDTWM2OD1yLkC3N|kh|ryP MWrTRW5ITVJ?
A4-Fuk NV;acJQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrVNZpKSzVyPUCuNFc1QDZizszN M4ftZnNCVkeHUh?=
OC-314 NInVOGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEe4NFch|ryP NHq5UlBUSU6JRWK=
SK-LU-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnUTWM2OD1yLkC4OFIyKM7:TR?= MV\TRW5ITVJ?
MDA-MB-157 NVHr[HROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzvWGZzUUN3ME2wMlA5PjV7IN88US=> MWHTRW5ITVJ?
HuP-T3 NU\3bpVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC0TWM2OD1yLkC4O|Eh|ryP NHLicm9USU6JRWK=
A3-KAW M4nNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEi4NFYh|ryP MWLTRW5ITVJ?
MOLT-16 NHXsWHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XiUGlEPTB;MD6wPFgxPyEQvF2= MnfpV2FPT0WU
COLO-679 NFjRfpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\qNmlEPTB;MD6wPVA6OSEQvF2= MlvZV2FPT0WU
EM-2 NUmyeXc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj5cGRKSzVyPUCuNFk6ODNizszN MWnTRW5ITVJ?
ES8 NVX6V3g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEm5NVgh|ryP Mn62V2FPT0WU
SK-MEL-2 NHLi[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7ENlVbUUN3ME2wMlExODN|IN88US=> NV[0foZnW0GQR1XS
ES3 MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3m3XmlEPTB;MD6xNFIh|ryP MXjTRW5ITVJ?
HSC-4 NFPQTZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\5TWM2OD1yLkGwOVU1KM7:TR?= M1m1fXNCVkeHUh?=
697 NELlc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnkWZRuUUN3ME2wMlEyODZ|IN88US=> NWPSdG1NW0GQR1XS
TGBC11TKB M1L2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMUGwPVMh|ryP NUPQTY9XW0GQR1XS
SK-PN-DW NYLJ[W5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe5d5VKSzVyPUCuNVE5PiEQvF2= M1G2[XNCVkeHUh?=
H9 M{HUbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2j6[WlEPTB;MD6xNlE3PSEQvF2= MXPTRW5ITVJ?
NCI-H2122 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTlZVVCUUN3ME2wMlEzOjVizszN MYfTRW5ITVJ?
ML-2 NYXnfo56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn3TWM2OD1yLkGyOFg1KM7:TR?= M1nUeXNCVkeHUh?=
MC-IXC MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMUK4OFMh|ryP M3Lj[HNCVkeHUh?=
KYSE-140 M1K2fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jYXmlEPTB;MD6xN|A1OSEQvF2= NE\5c3FUSU6JRWK=
DOHH-2 M2Hpcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonhTWM2OD1yLkGzNFY1KM7:TR?= MX7TRW5ITVJ?
MEL-JUSO MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMUOxNlgh|ryP M2nJOXNCVkeHUh?=
P30-OHK MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHf0OVhKSzVyPUCuNVMyPiEQvF2= MYrTRW5ITVJ?
CTB-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMUOzNlUh|ryP Mn3tV2FPT0WU
ACHN MmnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMUOzOlkh|ryP NX;EfmFIW0GQR1XS
ES5 NVzrOlEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMUO0O|Yh|ryP NFz4UXBUSU6JRWK=
SF539 M3HBOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXhOnhVUUN3ME2wMlE{PjhizszN NVWxO3BGW0GQR1XS
D-283MED NX7Ucoo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMUO2PFch|ryP MUfTRW5ITVJ?
OVCAR-5 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMUO4PVQh|ryP NXXKU254W0GQR1XS
RPMI-8866 NGfsSXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMUO5NlUh|ryP NELkSYpUSU6JRWK=
PANC-03-27 NV7pTZNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv0NmdKSzVyPUCuNVQzQDhizszN MXHTRW5ITVJ?
M14 M3v5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH5TWM2OD1yLkG0OFY{KM7:TR?= M{DkSXNCVkeHUh?=
D-566MG MkXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMUS2PUDPxE1? MV;TRW5ITVJ?
Ramos-2G6-4C10 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:4T2lEPTB;MD6xOFg1OiEQvF2= M323e3NCVkeHUh?=
NOS-1 Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP5ZlZKSzVyPUCuNVQ6PjdizszN NFj3fVhUSU6JRWK=
YH-13 MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGmzendKSzVyPUCuNVU3PzRizszN MnPkV2FPT0WU
NB17 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr2foRUUUN3ME2wMlE2Pzh4IN88US=> MoTTV2FPT0WU
U-2-OS NYXRPGlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMUW4OFch|ryP M3\wcHNCVkeHUh?=
ES7 M2PXeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXid2pKSzVyPUCuNVYxOTFizszN NXrScW41W0GQR1XS
LoVo MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMU[xOlYh|ryP MoHXV2FPT0WU
QIMR-WIL NIPvRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHztV5VKSzVyPUCuNVY{OTFizszN MUHTRW5ITVJ?
ESS-1 M2rOZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LaTGlEPTB;MD6xOlQyOyEQvF2= M4nlUHNCVkeHUh?=
LAMA-84 NV3OWplET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;MSWlEPTB;MD6xOlUxOyEQvF2= MX\TRW5ITVJ?
TGBC24TKB MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TIR2lEPTB;MD6xOlU{PSEQvF2= NWDMOGZiW0GQR1XS
KU812 NXOxNGU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfROGZKSzVyPUCuNVY5OyEQvF2= M3e0NHNCVkeHUh?=
KARPAS-45 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMU[4OFch|ryP MV7TRW5ITVJ?
ACN NXKyOpZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMUexO|Eh|ryP MVzTRW5ITVJ?
RPMI-8226 NXLNZoEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMUe0OlQh|ryP MlLvV2FPT0WU
GR-ST M37P[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTkTWM2OD1yLkG3PFI4KM7:TR?= NVfvXXBwW0GQR1XS
SK-UT-1 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfjTWM2OD1yLkG4OVk6KM7:TR?= NGjt[5lUSU6JRWK=
SK-N-AS M3n3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj2TWM2OD1yLkG4PFE2KM7:TR?= MnnGV2FPT0WU
EW-1 Mnm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMUi5NFUh|ryP M{HEXXNCVkeHUh?=
5637 NUK3VVhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vSWmlEPTB;MD6xPVI4QCEQvF2= Mn3KV2FPT0WU
GI-1 NXLBRVRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILwdm5KSzVyPUCuNVk2PjFizszN MVXTRW5ITVJ?
NCI-H1395 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoCwTWM2OD1yLkG5O|YyKM7:TR?= NX;PVFR1W0GQR1XS
CHP-212 MlrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjV[4JKSzVyPUCuNVk4QDJizszN NECzUGpUSU6JRWK=
A427 NUTPZ297T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M121fmlEPTB;MD6xPVg{OiEQvF2= NHSwSYxUSU6JRWK=
BE-13 NEDVSGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17HNGlEPTB;MD6yNFEyPyEQvF2= MXTTRW5ITVJ?
RS4-11 MnG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfLZ4JKSzVyPUCuNlA{OThizszN MmPRV2FPT0WU
TI-73 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMkC4O|Mh|ryP MX\TRW5ITVJ?
HAL-01 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF72T4VKSzVyPUCuNlA6PyEQvF2= NIWyRpZUSU6JRWK=
KY821 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLBTWM2OD1yLkKxOFI6KM7:TR?= NHfkT3JUSU6JRWK=
H4 NF7NZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPLfYxVUUN3ME2wMlIzODZ{IN88US=> MoKzV2FPT0WU
EPLC-272H NETLVFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HkNmlEPTB;MD6yNlA3QCEQvF2= MYTTRW5ITVJ?
COR-L105 NI\2e2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXETWM2OD1yLkKyNlM2KM7:TR?= M2HsenNCVkeHUh?=
769-P NYe3fo1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17W[2lEPTB;MD6yNlI6QCEQvF2= MVzTRW5ITVJ?
HEL NXftT4hmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPuTWM2OD1yLkKyOFU1KM7:TR?= M3zXWHNCVkeHUh?=
VA-ES-BJ NVjzbIVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;LTWM2OD1yLkKyOVU4KM7:TR?= M1f2V3NCVkeHUh?=
IST-MEL1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMkK1O{DPxE1? M2LsOHNCVkeHUh?=
KYSE-270 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLYUJNwUUN3ME2wMlIzPjN|IN88US=> NYPHUmtvW0GQR1XS
RH-1 MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi0VFJ1UUN3ME2wMlIzPjZ4IN88US=> NV74blVHW0GQR1XS
JVM-3 NXnNTGFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTTRmZKSzVyPUCuNlMxOzZizszN MYLTRW5ITVJ?
RPMI-7951 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofDTWM2OD1yLkKzNFU3KM7:TR?= NFXzXJRUSU6JRWK=
JAR MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLVTWM2OD1yLkKzNlM5KM7:TR?= NGf3e5RUSU6JRWK=
MOLT-4 NEK5eXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMkO4OUDPxE1? Mn\MV2FPT0WU
ALL-PO NV3CWVNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\ZbpRkUUN3ME2wMlI1OjR|IN88US=> NYfpR44xW0GQR1XS
SNU-387 NWTZRYpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPzTWM2OD1yLkK0N|M6KM7:TR?= NVzsbGlCW0GQR1XS
IGROV-1 NEPncZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMkS0NFEh|ryP M3:yfHNCVkeHUh?=
MPP-89 NF;2TIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf1WZR7UUN3ME2wMlI1PDVzIN88US=> NVXEUYdPW0GQR1XS
T98G MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMkS1Olgh|ryP MYXTRW5ITVJ?
NCI-H510A MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\qTWM2OD1yLkK0OlI3KM7:TR?= Mkn6V2FPT0WU
KOSC-2 Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMkS2O|Eh|ryP MYLTRW5ITVJ?
NCI-H23 NYfWTIRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXwe5I{UUN3ME2wMlI1PzZzIN88US=> NVXjdmxOW0GQR1XS
MC116 M3nmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PFVGlEPTB;MD6yOVY2PCEQvF2= M2OxO3NCVkeHUh?=
8-MG-BA MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\sZ2lEPTB;MD6yOVc3QCEQvF2= MUjTRW5ITVJ?
ABC-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvsZ5hKSzVyPUCuNlYxPjRizszN NXjPOGsyW0GQR1XS
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NCI-SNU-1 M33uU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMkewOVkh|ryP M3WxenNCVkeHUh?=
HCC1395 MkDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMkewPFkh|ryP M4T4R3NCVkeHUh?=
BB65-RCC M1i5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\McWlEPTB;MD6yO|A6PyEQvF2= MWrTRW5ITVJ?
NCI-H1755 NEPGT5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;oTWM2OD1yLkK3N|A1KM7:TR?= NXHlfpZzW0GQR1XS
OVCAR-3 M{Ti[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvVc5NsUUN3ME2wMlI4Ozh3IN88US=> MWLTRW5ITVJ?
MKN45 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{H6TWlEPTB;MD6yO|k5KM7:TR?= MWTTRW5ITVJ?
TYK-nu MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjHfmhKSzVyPUCuNlgxPiEQvF2= MVXTRW5ITVJ?
SNU-C2B M{jySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF2ze|JKSzVyPUCuNlgyOzRizszN MofpV2FPT0WU
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CAKI-1 NVO5ZVI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMki2PEDPxE1? MnPkV2FPT0WU
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RXF393 M1fuS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXewXpNkUUN3ME2wMlI6ODB6IN88US=> M2r1eXNCVkeHUh?=
CCRF-CEM MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMkmxOVQh|ryP NES3e5JUSU6JRWK=
HOP-92 NGjsd|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H2dmlEPTB;MD6yPVI4QSEQvF2= NFnhWodUSU6JRWK=
COLO-684 MkX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\aZWFKSzVyPUCuNlk1ODZizszN NWrpXJV[W0GQR1XS
NCI-H28 NXzOTWl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMkm3NFQh|ryP MmL6V2FPT0WU
HuO9 MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;iNpFyUUN3ME2wMlI6Pzl|IN88US=> Mk\QV2FPT0WU
SF295 M2PofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHL6TYxKSzVyPUCuNlk5ODJizszN Mof0V2FPT0WU
COLO-829 MnjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLJUmdKSzVyPUCuNlk5PDVizszN NGDaWYtUSU6JRWK=
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MDA-MB-361 NEf6THZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X0bGlEPTB;MD6yPVg6PiEQvF2= M{nCV3NCVkeHUh?=
FTC-133 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwM{CyOlUh|ryP NG\PRmFUSU6JRWK=
Mewo NXLTNXNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET4dnhKSzVyPUCuN|A1OzFizszN M{m1UnNCVkeHUh?=
HCC70 MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrmNGtKSzVyPUCuN|A3PjVizszN NHOybJpUSU6JRWK=
BB30-HNC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwM{G1NlUh|ryP NVTTZXY{W0GQR1XS
LCLC-97TM1 M3POb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPETIpJUUN3ME2wMlMyPTZ4IN88US=> M4XZSXNCVkeHUh?=
HCC2998 NFzKPItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXr[ZNqUUN3ME2wMlMyPjVizszN MYfTRW5ITVJ?
NBsusSR M4n0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwM{G4NVkh|ryP NWX1[|R[W0GQR1XS
OVCAR-4 NGLnWlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TGZmlEPTB;MD6zNlAzOSEQvF2= NGf6[IZUSU6JRWK=
NCI-H209 Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LybWlEPTB;MD6zNlM2OyEQvF2= M4XQfnNCVkeHUh?=
ChaGo-K-1 M{TjVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\Pbm1KSzVyPUCuN|I1QDlizszN MWfTRW5ITVJ?
KALS-1 M3;wT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvmc5B2UUN3ME2wMlMzPTl2IN88US=> NVvHVGtIW0GQR1XS
D-423MG NYK5WZljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnIUWJKSzVyPUCuN|MyPDJizszN MnjTV2FPT0WU
Detroit562 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DMRmlEPTB;MD6zN|M1OyEQvF2= NH:2R2VUSU6JRWK=
HT-144 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\D[2lEPTB;MD6zN|gyKM7:TR?= NIXpcoVUSU6JRWK=
MEG-01 NYrtNpk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwM{S1PFQh|ryP NXTp[INNW0GQR1XS
BV-173 NXvkWIZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4niSGlEPTB;MD6zOFU6PiEQvF2= M3nBRXNCVkeHUh?=
MZ7-mel Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHmdIFKSzVyPUCuN|Q3PzdizszN MnuwV2FPT0WU
C32 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XrNWlEPTB;MD6zOFY5OiEQvF2= NXzTV2N[W0GQR1XS
DU-4475 NXzEb4s1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfQd2pnUUN3ME2wMlM1QDd3IN88US=> NVfrW4EzW0GQR1XS
KP-N-YN M2DKNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIKyWGxKSzVyPUCuN|Q5QDdizszN NF65eYtUSU6JRWK=
MKN1 NXm4S3V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3qyWmlEPTB;MD6zOVAxOiEQvF2= NF\CS5FUSU6JRWK=
8505C MmXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HQSWlEPTB;MD6zOVAxOiEQvF2= MVXTRW5ITVJ?
OVCAR-8 NGGxbFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33DUmlEPTB;MD6zOVU5PCEQvF2= MUXTRW5ITVJ?
NH-12 NVXOXnI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojYTWM2OD1yLkO1Olk3KM7:TR?= M13NeHNCVkeHUh?=
COR-L88 Ml;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr0VVBKSzVyPUCuN|Y1QDJizszN MWjTRW5ITVJ?
T-24 M1vwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLtTWJ7UUN3ME2wMlM3QTh3IN88US=> MoLkV2FPT0WU
MIA-PaCa-2 MkGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwM{e0PVch|ryP NUnKbmtPW0GQR1XS
LS-411N NUDuXndJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwM{e2NFYh|ryP MUfTRW5ITVJ?
TK10 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;xSodKSzVyPUCuN|c6PDhizszN M3frV3NCVkeHUh?=
SW1990 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjSR|RKSzVyPUCuN|g{PTNizszN NGTpd4hUSU6JRWK=
GAMG M16zZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mki0TWM2OD1yLkO4OVY4KM7:TR?= Ml3MV2FPT0WU
G-361 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwM{i3NVIh|ryP NXHMPZJ1W0GQR1XS
Ca-Ski MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\VTWM2OD1yLkO4O|kzKM7:TR?= MmXHV2FPT0WU
786-0 NGLlWoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlztTWM2OD1yLkO4PFI{KM7:TR?= NGPqXYNUSU6JRWK=
MHH-NB-11 NHjsO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnmSHpKSzVyPUCuN|g6PyEQvF2= MWnTRW5ITVJ?
OE33 NY[2SXNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPFbohKSzVyPUCuN|kyOThizszN M32xN3NCVkeHUh?=
SW954 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILjeW1KSzVyPUCuOFAyOzFizszN M2OxSnNCVkeHUh?=
KYSE-180 M1e4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITV[IxKSzVyPUCuOFAyPTFizszN Ml75V2FPT0WU
NCI-H720 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULxVmhRUUN3ME2wMlQxOTlzIN88US=> NWKwboxXW0GQR1XS
COR-L23 MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLDWWJKSzVyPUCuOFAzQDZizszN MYDTRW5ITVJ?
PFSK-1 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rlc2lEPTB;MD60NVA6OiEQvF2= M1\ncHNCVkeHUh?=
FADU NX7KVZI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DOSWlEPTB;MD60NVE4OiEQvF2= MYrTRW5ITVJ?
GP5d MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwNEGyNlUh|ryP NHK2V|hUSU6JRWK=
PC-14 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\UTWM2OD1yLkSxOlYyKM7:TR?= M4jTTnNCVkeHUh?=
SJSA-1 NXnBd4Q3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkKxTWM2OD1yLkSxO|E1KM7:TR?= MV;TRW5ITVJ?
D-336MG NFnkW2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;2TWM2OD1yLkSyNVM5KM7:TR?= NHzGd2NUSU6JRWK=
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EFO-27 M2n5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fHc2lEPTB;MD60N|A1QSEQvF2= MkLrV2FPT0WU
A2780 NV7oZnAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjNS|dNUUN3ME2wMlQ{OTZ{IN88US=> MnuyV2FPT0WU
CAL-12T NHPDcFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33sc2lEPTB;MD60N|I5QCEQvF2= M1;EenNCVkeHUh?=
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HCE-T MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwNESxPFch|ryP NIKzOnJUSU6JRWK=
SK-MES-1 NYDqNFhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\0TWM2OD1yLkS0Nlk{KM7:TR?= NV3XelRrW0GQR1XS
Daoy Mk\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPPcYdKSzVyPUCuOFUyODNizszN MXrTRW5ITVJ?
A2058 M2nPR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXoTWM2OD1yLkS1NVM3KM7:TR?= M{G0N3NCVkeHUh?=
Hs-578-T MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXNTHJKSzVyPUCuOFUzPzhizszN NUXoeWRQW0GQR1XS
TE-11 NF;Hb|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4WwR2lEPTB;MD60OVI6OyEQvF2= MVrTRW5ITVJ?
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D-392MG NWHER5VxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLqTWM2OD1yLkS1OlEzKM7:TR?= NFnlZVRUSU6JRWK=
MOLT-13 NGjRd4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7vTWM2OD1yLkS2Nlk1KM7:TR?= Mm\2V2FPT0WU
SK-NEP-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEO4fmNKSzVyPUCuOFY1OTlizszN NH7WZnNUSU6JRWK=
KS-1 M4HyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTjTWM2OD1yLkS2OlA{KM7:TR?= NX7EboF4W0GQR1XS
HuP-T4 NH;sNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi5XFZpUUN3ME2wMlQ3QDZ6IN88US=> NV;uXoxVW0GQR1XS
NCI-H1563 M1TjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkS1TWM2OD1yLkS3NFM2KM7:TR?= NXnRfZRNW0GQR1XS
U031 NIH6UWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\kZWhQUUN3ME2wMlQ5OjN2IN88US=> Ml:wV2FPT0WU
HSC-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwNEi2NlYh|ryP M1mzdnNCVkeHUh?=
HT-3 Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;3[2NKSzVyPUCuOFkxOyEQvF2= MWDTRW5ITVJ?
HGC-27 M2ruVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3vTWM2OD1yLkS5NVE2KM7:TR?= M{LRc3NCVkeHUh?=
HT-1080 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjTTWM2OD1yLkS5Nlch|ryP NV;zPItqW0GQR1XS
RT-112 MorzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3BWZp7UUN3ME2wMlQ6QTJzIN88US=> NIDwfXFUSU6JRWK=
A375 NY\pPIxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXSVpdKSzVyPUCuOFk6OjJizszN NUTV[WROW0GQR1XS
SW626 NILwfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\oSnJKSzVyPUCuOVA3OzNizszN NHTkN3NUSU6JRWK=
SBC-5 M3TIU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\ST|VKSzVyPUCuOVE{PDRizszN MnLuV2FPT0WU
CAL-51 M1fSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;a[mlEPTB;MD61NVQ{PyEQvF2= MV7TRW5ITVJ?
RKO MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\1[GlEPTB;MD61NlAyQSEQvF2= NHq3OHpUSU6JRWK=
HC-1 NIjOc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7temtKSzVyPUCuOVIyOTRizszN MmnHV2FPT0WU
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OCUB-M MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXruTo5vUUN3ME21Mlc4PTZ|IN88US=> NXnvSItnW0GQR1XS
IGR-1 MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7hfGlKSzVyPUWuPFY5QTRizszN MVzTRW5ITVJ?
NCI-H747 NVjFeXlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTZwMkS1PFUh|ryP Mkn0V2FPT0WU
COLO-680N M3;vRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTZwM{m0NFMh|ryP MUnTRW5ITVJ?
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SNU-449 NILL[IFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3lemQ3UUN3ME22Mlk6PTlzIN88US=> NUm5VpViW0GQR1XS
D-542MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;H[mlEPTB;Nz6xNlI6QSEQvF2= NXGzRmF1W0GQR1XS
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NCI-H810 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLUbmpKSzVyPUiuNFI6QDRizszN NVHwVGRCW0GQR1XS
T47D M1n6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorRTWM2OD16LkG2NFI1KM7:TR?= MYLTRW5ITVJ?
Calu-3 Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XJc2lEPTB;OD6yPFg5PiEQvF2= M1vjfnNCVkeHUh?=
COLO-741 MljXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRThwOUOwPVMh|ryP MnzQV2FPT0WU
LU-135 M1Xae2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrITWM2OD17LkCzOFUzKM7:TR?= MnrWV2FPT0WU
COLO-678 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TySWlEPTB;OT6yPFg1PCEQvF2= M3LXbXNCVkeHUh?=
NCI-H2126 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;wPZNKSzVyPUmuN|M6OTlizszN MVzTRW5ITVJ?
SK-MEL-28 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7WWlJnUUN3ME25MlU{PTl4IN88US=> MUDTRW5ITVJ?
MFE-280 NX3uSZM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Ox[mlEPTB;MUCuNFIzQSEQvF2= MkHQV2FPT0WU
DBTRG-05MG M1Piemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLjTWM2OD1zMD60N|Y6KM7:TR?= MmDJV2FPT0WU
RCC10RGB MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGD6RY1KSzVyPUGwMlUzPTVizszN M2XEW3NCVkeHUh?=
NTERA-S-cl-D1 M3;1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkL1TWM2OD1zMD62PFUzKM7:TR?= NH[4bJlUSU6JRWK=
C3A M1e5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD0OVBKSzVyPUGyMlMyPzJizszN NH3OXIxUSU6JRWK=
MHH-ES-1 NHHPTHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL2XHRwUUN3ME2xNk42Ojh2IN88US=> NIDWNVhUSU6JRWK=
LU-139 NV2zRpJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTF{Lk[zN|Mh|ryP M{OwS3NCVkeHUh?=
KNS-42 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTF{Lki3O|Eh|ryP MWrTRW5ITVJ?
MCF7 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\CdWlEPTB;MUOuNlM3PSEQvF2= MmHBV2FPT0WU
SW872 NWX5XW86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILYRotKSzVyPUG0MlU1PjFizszN NEDLWnRUSU6JRWK=
HT-1376 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf0TWM2OD1zND64OVgzKM7:TR?= Mm[2V2FPT0WU
NCI-SNU-5 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLCPWlKSzVyPUG1MlE4PDFizszN M2n2WXNCVkeHUh?=
NCI-H2405 NXT2TWh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLITWM2OD1zNT60OFc1KM7:TR?= M324enNCVkeHUh?=
KYSE-150 M3vVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDieGdKSzVyPUG1Mlc3OTFizszN MXjTRW5ITVJ?
SW837 M2KydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTF4LkCxNlQh|ryP MoqxV2FPT0WU
LU-65 M{PTZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrMUFNZUUN3ME2xPU44OjZizszN NYDKXo5PW0GQR1XS
JEG-3 NGPBTnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXpTWM2OD1{MD6zOVc4KM7:TR?= MmPnV2FPT0WU
SK-MEL-1 NGPubpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTJyLke4N|Yh|ryP NHSwOXNUSU6JRWK=
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NCI-H1770 NXfVfYdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJ|LkSwPFYh|ryP NVPKToF[W0GQR1XS
MG-63 NGrafoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHKTWM2OD1{Mz63Olc{KM7:TR?= M2XSOHNCVkeHUh?=
ECC10 NWSzVnZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrySplKSzVyPUK1MlU4OSEQvF2= NY\tbYhjW0GQR1XS
SW1463 NEHmZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljxTWM2OD1{Nz64N|E3KM7:TR?= MXrTRW5ITVJ?
JVM-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP4UnZ{UUN3ME2yPE4{OjR6IN88US=> M3TKcHNCVkeHUh?=
HCT-15 NVrMZ4pkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3ITWM2OD1{OD60NVkzKM7:TR?= Ml;KV2FPT0WU
CAL-72 M2SwTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XFfGlEPTB;M{GuOFkyOiEQvF2= MlPUV2FPT0WU
HCC2218 NVruZVAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\3cXBnUUN3ME2zNk45QDV6IN88US=> NF3nXmRUSU6JRWK=
BT-474 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjIV5Z2UUN3ME2zN{4xQDR|IN88US=> NEjPNmxUSU6JRWK=
NCI-H1092 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fpRWlEPTB;M{OuOVE1PSEQvF2= M2q4OnNCVkeHUh?=
Mo-T MniwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELubHpKSzVyPUO3MlM2QDVizszN M1nsUXNCVkeHUh?=
DU-145 NFyxbmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTRyLk[yPVUh|ryP MnTLV2FPT0WU
NCI-H1666 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4P0TWlEPTB;NEKuOFQ5QCEQvF2= MnjhV2FPT0WU
IST-MES1 NFjUW4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDa[|hKSzVyPUS2MlQyQTZizszN MmrXV2FPT0WU
SW1116 NGXaenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTR6LkG3OVYh|ryP NUK0N2dTW0GQR1XS
MZ2-MEL MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTR6LkWwNlYh|ryP MXXTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Chk1 Kinase Assay:

Recombinant human Chk1 is expressed as a glutathione S-transferase fusion in insect cells using a baculovirus vector and purified by glutathione affinity chromatography. A synthetic peptide substrate (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR) for Chk1 is synthesized. Final assay concentrations of peptide and ATP (cold + 40 nCi [33P]ATP) are 0.8 and 1 μM, respectively. Different concentrations of AZD7762, buffer containing peptide and chk1 kinase and ATP, are added sequentially to a 384-well assay plate. The plate is incubated for 2 hours, reaction is stopped by the addition of buffer containing EDTA and scintillation proximity assay beads, and plates are read using a TopCount reader. Data analysis is carried out to determinate a dose response (IC50).
Cell Research:[1]
+ Expand
  • Cell lines: HT29, SW620 and MDA-MB-231 cells
  • Concentrations: Dissolved in DMSO, final concentration ~12.5 μM
  • Incubation Time: 20 or 48 hours
  • Method: For the checkpoint abrogation assay, HT29 cells are treated for 2 hours with camptothecin (topoisomerase I inhibitor; 0.07 μg/mL) to induce the G2 checkpoint. Cells are then treated for 20 hours with a 12-point titration of AZD7762 (12.5 μM to 6 nM) plus nocodazole. Cells are fixed with 3.7% formaldehyde for 1 hour, permeabilized with PBS containing 0.05% Triton X, and incubated with anti-phH3 antibody for 1 hour followed by Alexa Fluor 488 anti-rabbit and Hoechst stain for 1 hour. Mitotic index is determined on the ArrayScan and expressed as the percentage of cells undergoing mitosis. For the potentiation assays, SW620 or MDA-MB-231 cells are dosed for 24 hours with a 9-point titration of gemcitabine ranging from 0.01 to 100 nM with a constant dose of AZD7762 (300 nM). After 24 hours, medium is removed and AZD7762 alone is added back to the wells for an additional 24 hours. Cells are then incubated in AZD7762-free medium for an additional 72 hours. The effect on cell proliferation is determined by MTT.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Male NCr mice implanted s.c. with H460-DNp53 cells or SW620, and male rnu rats implanted s.c. with H460-DNp53 cells
  • Formulation: Formulated in 11.3% hydroxyproplyl-β-cyclodextrin
  • Dosages: ~25 mg/kg
  • Administration: Injection i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL (137.96 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 362.42
Formula

C17H19FN4O2S

CAS No. 860352-01-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00937664 Terminated Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca July 2009 Phase 1
NCT00937664 Terminated Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca July 2009 Phase 1
NCT00473616 Terminated Advanced Solid Tumors|Cancer|Advanced Solid Malignancies AstraZeneca May 2007 Phase 1
NCT00473616 Terminated Advanced Solid Tumors|Cancer|Advanced Solid Malignancies AstraZeneca May 2007 Phase 1
NCT00413686 Completed Solid Tumors AstraZeneca December 2006 Phase 1
NCT00413686 Completed Solid Tumors AstraZeneca December 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?

  • Answer:

    Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.

Chk Signaling Pathway Map

Chk Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID