AZD7762

Catalog No.S1532

AZD7762 Chemical Structure

Molecular Weight(MW): 362.42

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.

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Cited by 35 Publications

Purity & Quality Control

Choose Selective Chk Inhibitors

Biological Activity

Description AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
Targets
Chk1 [1]
(Cell-free assay)
Chk2 [1]
(Cell-free assay)
5 nM <10 nM
In vitro

AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KASUMI-1 MmPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMECwNlM1KM7:TR?= MonkV2FPT0WU
NKM-1 M1jzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3KSplKSzVyPUCuNFAxPDF3IN88US=> NFOxOXdUSU6JRWK=
MV-4-11 NGH6Zm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHMTWM2OD1yLkCwNFQzPSEQvF2= M{LrfXNCVkeHUh?=
NCI-H1703 M1PPWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33PXGlEPTB;MD6wNFY1OyEQvF2= MUfTRW5ITVJ?
A204 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vuTWlEPTB;MD6wNFg2PiEQvF2= NHzifpBUSU6JRWK=
CGTH-W-1 NIL4flZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;tUGlEPTB;MD6wNVQzKM7:TR?= M1XOU3NCVkeHUh?=
MLMA Mn3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEK4OFkh|ryP NH7ySo9USU6JRWK=
GOTO NFi4bHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHiTWM2OD1yLkCzNVIh|ryP MnHOV2FPT0WU
KE-37 Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzhRolKSzVyPUCuNFMyPDJizszN NVvqd5hEW0GQR1XS
ES4 NGHOUXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm5TWM2OD1yLkCzNlUyKM7:TR?= NW\xbW9SW0GQR1XS
ATN-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEO0NVch|ryP NIfReoNUSU6JRWK=
MHH-PREB-1 M{\3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDafnJKSzVyPUCuNFM1PDJizszN NW\FR|d5W0GQR1XS
SW756 M1q5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPxTWM2OD1yLkCzOVc6KM7:TR?= M4fuWnNCVkeHUh?=
CTV-1 M1v4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDO[VZKSzVyPUCuNFM5QTZizszN NEfuRo5USU6JRWK=
HCC1806 NGnTVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLhTWM2OD1yLkC0NFIzKM7:TR?= MYfTRW5ITVJ?
NEC8 MofES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfUS|NKSzVyPUCuNFQzODNizszN Mn3FV2FPT0WU
P12-ICHIKAWA NXj1O2JuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HZcWlEPTB;MD6wOFMyPiEQvF2= NHnQbZFUSU6JRWK=
DEL MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\vdHZtUUN3ME2wMlA1PTl{IN88US=> NEm2V5BUSU6JRWK=
KM12 NHzlXJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1uxfWlEPTB;MD6wOVE2QCEQvF2= MXzTRW5ITVJ?
LB1047-RCC M3\qUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[zXlBJUUN3ME2wMlA3ODJ3IN88US=> NXTNPZlKW0GQR1XS
LB2241-RCC MofTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfPOWtRUUN3ME2wMlA3OTB{IN88US=> MkjlV2FPT0WU
NOMO-1 M1Lrdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHOwWYpKSzVyPUCuNFYyOTVizszN MUPTRW5ITVJ?
NB14 NGDr[YdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwME[xN|Yh|ryP M1PGd3NCVkeHUh?=
ONS-76 NULZRZc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PTW2lEPTB;MD6wOlE6PiEQvF2= Mme5V2FPT0WU
HD-MY-Z MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwME[yOVUh|ryP M3XMTnNCVkeHUh?=
G-402 MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwME[0OkDPxE1? NV64W2xJW0GQR1XS
ES1 MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHNb5pRUUN3ME2wMlA4OTR4IN88US=> MnLOV2FPT0WU
L-363 Mn7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTBTWM2OD1yLkC3N|kh|ryP NF;jT5VUSU6JRWK=
A4-Fuk MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLaTWM2OD1yLkC3OFg3KM7:TR?= MXLTRW5ITVJ?
OC-314 NG[xWpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXuTWM2OD1yLkC3PFA4KM7:TR?= MVzTRW5ITVJ?
SK-LU-1 MmjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHZTWM2OD1yLkC4OFIyKM7:TR?= NGG2cHFUSU6JRWK=
MDA-MB-157 NGjpPHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;ZTWM2OD1yLkC4OlU6KM7:TR?= NInlUXpUSU6JRWK=
HuP-T3 NGLUT5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEi3NUDPxE1? MoDKV2FPT0WU
A3-KAW MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEi4NFYh|ryP NGfw[VlUSU6JRWK=
MOLT-16 M4C2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7LWFRKSzVyPUCuNFg5ODdizszN MkDOV2FPT0WU
COLO-679 NFTjbZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT4TWM2OD1yLkC5NFkyKM7:TR?= MlnaV2FPT0WU
EM-2 NV\ET|RpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEm5NFMh|ryP NULMPGs5W0GQR1XS
ES8 M4raTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1L0c2lEPTB;MD6wPVkyQCEQvF2= NFHVcIVUSU6JRWK=
SK-MEL-2 M1vnPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUC1cZRpUUN3ME2wMlExODN|IN88US=> NG\mVlFUSU6JRWK=
ES3 NH;XZWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMUCyJO69VQ>? MnP3V2FPT0WU
HSC-4 M4Hufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMUC1OVQh|ryP MkL4V2FPT0WU
697 NVP2OlNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMUGwOlMh|ryP NHjPT3NUSU6JRWK=
TGBC11TKB Mn7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDU[o1{UUN3ME2wMlEyODl|IN88US=> NVnifWlFW0GQR1XS
SK-PN-DW NVTnb5c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvDSW5TUUN3ME2wMlEyQDZizszN MXfTRW5ITVJ?
H9 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPJZmk2UUN3ME2wMlEzOTZ3IN88US=> MorOV2FPT0WU
NCI-H2122 MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnIVXRqUUN3ME2wMlEzOjVizszN MoXXV2FPT0WU
ML-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfyTWM2OD1yLkGyOFg1KM7:TR?= MVzTRW5ITVJ?
MC-IXC M3PJPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vUV2lEPTB;MD6xNlg1OyEQvF2= NHrFT2lUSU6JRWK=
KYSE-140 M4TaUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTuTWM2OD1yLkGzNFQyKM7:TR?= MXHTRW5ITVJ?
DOHH-2 NHjxSoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPQTWM2OD1yLkGzNFY1KM7:TR?= M1vxNnNCVkeHUh?=
MEL-JUSO NH;pN3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMUOxNlgh|ryP MkLoV2FPT0WU
P30-OHK M17TW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTnXlNkUUN3ME2wMlE{OTZizszN M1rtc3NCVkeHUh?=
CTB-1 M4G0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DLO2lEPTB;MD6xN|MzPSEQvF2= MWfTRW5ITVJ?
ACHN NIPHPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMUOzOlkh|ryP MUXTRW5ITVJ?
ES5 NYXXfJlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;2SoFKSzVyPUCuNVM1PzZizszN MXTTRW5ITVJ?
SF539 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fQUmlEPTB;MD6xN|Y5KM7:TR?= MnLUV2FPT0WU
D-283MED MmTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHvcW5IUUN3ME2wMlE{Pjh5IN88US=> M{PqTHNCVkeHUh?=
OVCAR-5 NVrBT5hFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXU[5oyUUN3ME2wMlE{QDl2IN88US=> NW\xWW5rW0GQR1XS
RPMI-8866 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDMfIR1UUN3ME2wMlE{QTJ3IN88US=> NW\OOJJUW0GQR1XS
PANC-03-27 M{D0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\EbJlKSzVyPUCuNVQzQDhizszN MV\TRW5ITVJ?
M14 NUL5V3dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\xeXZVUUN3ME2wMlE1PDZ|IN88US=> NGHUUIhUSU6JRWK=
D-566MG MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLwTWM2OD1yLkG0Olkh|ryP Mn35V2FPT0WU
Ramos-2G6-4C10 NETKfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rHbWlEPTB;MD6xOFg1OiEQvF2= MnnYV2FPT0WU
NOS-1 M3:wTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnSTWM2OD1yLkG0PVY4KM7:TR?= NGPCe5RUSU6JRWK=
YH-13 NF[ybGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\rTWM2OD1yLkG1Olc1KM7:TR?= M{[yOHNCVkeHUh?=
NB17 NGLUU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMUW3PFYh|ryP NWfIb2o6W0GQR1XS
U-2-OS MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMUW4OFch|ryP MoLTV2FPT0WU
ES7 NW\EdZBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLWTWM2OD1yLkG2NFEyKM7:TR?= NXizWHFVW0GQR1XS
LoVo MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPyTWM2OD1yLkG2NVY3KM7:TR?= NFHCOXZUSU6JRWK=
QIMR-WIL M1HnXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMU[zNVEh|ryP MWjTRW5ITVJ?
ESS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjjTXNKSzVyPUCuNVY1OTNizszN MYXTRW5ITVJ?
LAMA-84 M{HjTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnaenBRUUN3ME2wMlE3PTB|IN88US=> MV7TRW5ITVJ?
TGBC24TKB NUPJcItnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjkTWM2OD1yLkG2OVM2KM7:TR?= NUjRSpBKW0GQR1XS
KU812 NV76UJp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\LSm0{UUN3ME2wMlE3QDNizszN M3LScnNCVkeHUh?=
KARPAS-45 NUDwTlJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPDTWM2OD1yLkG2PFQ4KM7:TR?= NGW1ZXBUSU6JRWK=
ACN MoraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHKXHFKSzVyPUCuNVcyPzFizszN M3vTVnNCVkeHUh?=
RPMI-8226 M{nIO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMUe0OlQh|ryP Ml;PV2FPT0WU
GR-ST NHXuR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMUe4Nlch|ryP NG[wUpBUSU6JRWK=
SK-UT-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HpWWlEPTB;MD6xPFU6QSEQvF2= NYjoe2Y3W0GQR1XS
SK-N-AS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjWfZROUUN3ME2wMlE5QDF3IN88US=> NHnWfppUSU6JRWK=
EW-1 NVrsWWcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17lZWlEPTB;MD6xPFkxPSEQvF2= Mmq5V2FPT0WU
5637 NEHiN5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\SOmtKSzVyPUCuNVkzPzhizszN NF\KR3FUSU6JRWK=
GI-1 NFfUUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\lTWlEPTB;MD6xPVU3OSEQvF2= Mn7XV2FPT0WU
NCI-H1395 NH;ZO2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfYZ2F3UUN3ME2wMlE6PzZzIN88US=> MWPTRW5ITVJ?
CHP-212 M2jHNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\oTWM2OD1yLkG5O|gzKM7:TR?= NYHi[|NmW0GQR1XS
A427 NYDUVWtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTnXnMzUUN3ME2wMlE6QDN{IN88US=> NYXTR4V[W0GQR1XS
BE-13 M1Tyfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7SO|BKSzVyPUCuNlAyOTdizszN M3jkS3NCVkeHUh?=
RS4-11 MlnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjsT21KSzVyPUCuNlA{OThizszN M2LiNXNCVkeHUh?=
TI-73 M{PxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jqOWlEPTB;MD6yNFg4OyEQvF2= NFrpWY5USU6JRWK=
HAL-01 NH;1NVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjrU3dNUUN3ME2wMlIxQTdizszN MYPTRW5ITVJ?
KY821 MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTlZmVKSzVyPUCuNlE1OjlizszN NFL2N|hUSU6JRWK=
H4 NWjZWGM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEezdohKSzVyPUCuNlIxPjJizszN MoOyV2FPT0WU
EPLC-272H NG\BZ4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHhTWM2OD1yLkKyNFY5KM7:TR?= MnzvV2FPT0WU
COR-L105 M1\XSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXGeJdOUUN3ME2wMlIzOjN3IN88US=> NV23V2NlW0GQR1XS
769-P NVy3NpR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHpTWM2OD1yLkKyNlk5KM7:TR?= NIjPfnhUSU6JRWK=
HEL MlrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\CTWM2OD1yLkKyOFU1KM7:TR?= NYSzWmdVW0GQR1XS
VA-ES-BJ MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInJWZdKSzVyPUCuNlI2PTdizszN NHjKSVhUSU6JRWK=
IST-MEL1 Mk\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3P5fmlEPTB;MD6yNlU4KM7:TR?= MXTTRW5ITVJ?
KYSE-270 MoK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X6cmlEPTB;MD6yNlY{OyEQvF2= NGjVT4VUSU6JRWK=
RH-1 NHPCT3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonwTWM2OD1yLkKyOlY3KM7:TR?= MWjTRW5ITVJ?
JVM-3 MoXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH2TWM2OD1yLkKzNFM3KM7:TR?= Mn\PV2FPT0WU
RPMI-7951 NH[3coRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMkOwOVYh|ryP M1vy[nNCVkeHUh?=
JAR NG\aXW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnRUW5yUUN3ME2wMlI{OjN6IN88US=> M2fyVHNCVkeHUh?=
MOLT-4 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TRXGlEPTB;MD6yN|g2KM7:TR?= M3nL[nNCVkeHUh?=
ALL-PO MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT5TWM2OD1yLkK0NlQ{KM7:TR?= M32yXnNCVkeHUh?=
SNU-387 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfC[VNFUUN3ME2wMlI1OzN7IN88US=> MmTBV2FPT0WU
IGROV-1 Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3SSolOUUN3ME2wMlI1PDBzIN88US=> NW\ZXlJNW0GQR1XS
MPP-89 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjHZlJrUUN3ME2wMlI1PDVzIN88US=> MV;TRW5ITVJ?
T98G M3P5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMkS1Olgh|ryP NUTneHcyW0GQR1XS
NCI-H510A NIXuTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fnUGlEPTB;MD6yOFYzPiEQvF2= NX3zfG9bW0GQR1XS
KOSC-2 MmLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrEW3c4UUN3ME2wMlI1PjdzIN88US=> MmHLV2FPT0WU
NCI-H23 NGG1S2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3XTWM2OD1yLkK0O|YyKM7:TR?= MUfTRW5ITVJ?
MC116 MnfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXJUWd4UUN3ME2wMlI2PjV2IN88US=> MYLTRW5ITVJ?
8-MG-BA M1HsPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH1[283UUN3ME2wMlI2PzZ6IN88US=> NVu0UIpPW0GQR1XS
ABC-1 MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMk[wOlQh|ryP NEKwPW1USU6JRWK=
J-RT3-T3-5 NUnodJRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3WxTmlEPTB;MD6yOlY4QCEQvF2= MYPTRW5ITVJ?
NCI-SNU-1 MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnNUGpKSzVyPUCuNlcxPTlizszN MYjTRW5ITVJ?
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BB65-RCC M{Cx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMkewPVch|ryP M4mzPXNCVkeHUh?=
NCI-H1755 NILhXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3neW5VUUN3ME2wMlI4OzB2IN88US=> NYHG[4VqW0GQR1XS
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COLO-829 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXr5dGpFUUN3ME2wMlI6QDR3IN88US=> M1\pU3NCVkeHUh?=
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OVCAR-4 M2nQeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTMTWM2OD1yLkOyNFIyKM7:TR?= M3fXb3NCVkeHUh?=
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Detroit562 M1rFWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHBWm9KSzVyPUCuN|M{PDNizszN MXfTRW5ITVJ?
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NH-12 NHzHS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnhR2FWUUN3ME2wMlM2Pjl4IN88US=> NF3leGRUSU6JRWK=
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G-361 Ml\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwM{i3NVIh|ryP MnXrV2FPT0WU
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A2780 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TCeGlEPTB;MD60N|E3OiEQvF2= NHXRToJUSU6JRWK=
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NCI-H661 Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwNkO3NVIh|ryP NHP5dFZUSU6JRWK=
ETK-1 NX;2OlJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHrdI9uUUN3ME2wMlY{PzJzIN88US=> MWrTRW5ITVJ?
SW1710 NGK5VnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TZT2lEPTB;MD62OFAzOyEQvF2= MkjqV2FPT0WU
GCT NFXxeGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIflZYhKSzVyPUCuOlQ6OzVizszN NGfDdHlUSU6JRWK=
SKG-IIIa MoXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3PemtKSzVyPUCuOlUxOzZizszN NES5[|NUSU6JRWK=
LU-134-A MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe3fXBKSzVyPUCuOlU3PSEQvF2= M1zmSXNCVkeHUh?=
Becker MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LYfGlEPTB;MD62OVgxPSEQvF2= MkLpV2FPT0WU
PANC-08-13 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwNk[wOlgh|ryP M4[4N3NCVkeHUh?=
SW620 M4rBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPxVWxHUUN3ME2wMlY3OjJ|IN88US=> MkPIV2FPT0WU
AsPC-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HGPWlEPTB;MD62OlM3OSEQvF2= MWXTRW5ITVJ?
LXF-289 M1PTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoL4TWM2OD1yLk[3OlI2KM7:TR?= Mn;hV2FPT0WU
RERF-LC-MS MmfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEW0dHZKSzVyPUCuOlc3PzFizszN NVXOTJZmW0GQR1XS
NCI-H1355 NU\VR4l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHvOGxKSzVyPUCuOlc5PTJizszN M1vMTHNCVkeHUh?=
23132-87 NITPPIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDzUpVKSzVyPUCuOlg{ODZizszN NUPSWY9vW0GQR1XS
BHY NH31bnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\5UWlEPTB;MD62PFgxPCEQvF2= NV7aN5RQW0GQR1XS
C2BBe1 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TKU2lEPTB;MD62PFkzQCEQvF2= MVvTRW5ITVJ?
A172 MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzuTWM2OD1yLk[5NlE4KM7:TR?= MVLTRW5ITVJ?
NCI-H727 NF\i[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:1cHIzUUN3ME2wMlY6QDF{IN88US=> M33JR3NCVkeHUh?=
NB69 NIHNeXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLTelVbUUN3ME2wMlcxPTR7IN88US=> NHXCVFZUSU6JRWK=
HCC1937 MlTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwN{C2N|Eh|ryP MlfkV2FPT0WU
HuCCT1 NUjOflg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\ZZmlEPTB;MD63NFc3PSEQvF2= MmfaV2FPT0WU
HH MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XmfmlEPTB;MD63NFc5OSEQvF2= M3jOPHNCVkeHUh?=
MN-60 NWHNVXFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwN{KxNlQh|ryP M4faR3NCVkeHUh?=
CFPAC-1 NHvKNndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHGRYVtUUN3ME2wMlczOjV5IN88US=> NV3XdJQ4W0GQR1XS
HOP-62 NYXHOWY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfGbWlkUUN3ME2wMlczPjJizszN M{GwXXNCVkeHUh?=
EW-3 NXniXXI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HnemlEPTB;MD63N|U2OiEQvF2= M1KxRXNCVkeHUh?=
SW1417 NVu0XG9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwN{O1PVMh|ryP MlPtV2FPT0WU
NCI-H1155 MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTtTWM2OD1yLkezPFY1KM7:TR?= NVewU202W0GQR1XS
CAL-54 NHLsW|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fWfmlEPTB;MD63OFA{KM7:TR?= Mnn0V2FPT0WU
Saos-2 NVfnO2VyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PsbWlEPTB;MD63OFU5PCEQvF2= MkS2V2FPT0WU
NCI-H446 M2TtVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLhR2hkUUN3ME2wMlc1QDB4IN88US=> M37uSXNCVkeHUh?=
LS-513 M{X1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXTTWM2OD1yLke0PVA5KM7:TR?= MYLTRW5ITVJ?
PA-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwN{S5Olgh|ryP MlTxV2FPT0WU
HCC38 MnqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jNN2lEPTB;MD63OFk5PCEQvF2= M4X6NXNCVkeHUh?=
DMS-273 NF\XclBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;tWIVKSzVyPUCuO|U1PTZizszN NWK4NHBNW0GQR1XS
U-266 M{HjV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\HTWM2OD1yLke2NlYzKM7:TR?= MYrTRW5ITVJ?
HL-60 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfsUGVKSzVyPUCuO|c{PTVizszN NIDsV|RUSU6JRWK=
UACC-62 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\JR2lEPTB;MD63O|U2OyEQvF2= NGe1d4lUSU6JRWK=
DoTc2-4510 M4m2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LC[2lEPTB;MD63PFIyOSEQvF2= NEixWZdUSU6JRWK=
SW982 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HmNmlEPTB;MD63PFQ{OiEQvF2= Mk\2V2FPT0WU
8305C Ml7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXtTWM2OD1yLke4PVM6KM7:TR?= M{O0NXNCVkeHUh?=
SW48 NHjNUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfDTWM2OD1yLke5NlQh|ryP Mn\HV2FPT0WU
NB5 M{K2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWezOHN4UUN3ME2wMlc6PjVzIN88US=> MmLqV2FPT0WU
J82 NInvPVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwOEC0PFch|ryP M2HIdXNCVkeHUh?=
HDLM-2 M2ryRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTlTWM2OD1yLkixN|Q6KM7:TR?= M1PQS3NCVkeHUh?=
HEC-1 M1\tTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjMTWM2OD1yLkixN|cyKM7:TR?= NWLnU2RlW0GQR1XS
AU565 NUnyfoh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;CPHRKSzVyPUCuPFI1PCEQvF2= Ml75V2FPT0WU
KYSE-520 NXG2bnBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\PTWM2OD1yLkiyOlM3KM7:TR?= NW\2PFhZW0GQR1XS
HTC-C3 NFH5ZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LySGlEPTB;MD64N|Q4PCEQvF2= NInuOGdUSU6JRWK=
AN3-CA NIHvXnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzpTWM2OD1yLkizO|EyKM7:TR?= MX;TRW5ITVJ?
KG-1 M{jyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWSxZlBtUUN3ME2wMlg1PDh2IN88US=> NWrJ[4dEW0GQR1XS
NCI-N87 MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLyOpBlUUN3ME2wMlg1PTV4IN88US=> MonsV2FPT0WU
HN NIn3VlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFWyRVBKSzVyPUCuPFQ2QTFizszN NHPIVJhUSU6JRWK=
SiHa M3\4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fFeWlEPTB;MD64OVg5OiEQvF2= NXG3doVPW0GQR1XS
C-33-A NGjJR41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPnTWM2OD1yLki2NVg2KM7:TR?= MWPTRW5ITVJ?
A673 M13hcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwOE[1N|Yh|ryP MYfTRW5ITVJ?
HSC-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT2c29KSzVyPUCuPFc{OzRizszN M3vmcnNCVkeHUh?=
LN-405 MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwOEe3N|Eh|ryP NG\lcnpUSU6JRWK=
HOS MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\kTWM2OD1yLki3PVk2KM7:TR?= M4jjUnNCVkeHUh?=
SF268 M2rZeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwOEiwPVch|ryP NWH4XXF{W0GQR1XS
DJM-1 NEL6[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPJTWM2OD1yLki4OlAzKM7:TR?= NXztVGczW0GQR1XS
HT-29 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwOEm0NVch|ryP M2\P[3NCVkeHUh?=
NCI-H292 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfyTWM2OD1yLki5O|c4KM7:TR?= MWHTRW5ITVJ?
UM-UC-3 NGS4TVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rZOmlEPTB;MD65NFMyPiEQvF2= NHSybIVUSU6JRWK=
VMRC-RCZ MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwOUC1O|gh|ryP M1Xac3NCVkeHUh?=
D-263MG MoLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TsO2lEPTB;MD65NFk1OyEQvF2= NFnqd5ZUSU6JRWK=
TE-10 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrVTWM2OD1yLkmwPVg1KM7:TR?= MWrTRW5ITVJ?
SW1088 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwOUG1OVIh|ryP M2HLd3NCVkeHUh?=
NCI-H1048 NGn1cG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPiTGVKSzVyPUCuPVE5PTJizszN NVTvTGx[W0GQR1XS
A431 NIm0RphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzGTWM2OD1yLkmyOFUzKM7:TR?= MU\TRW5ITVJ?
SW1783 M1\VPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwOUOyOVEh|ryP MWfTRW5ITVJ?
NCI-H2452 NXrQOmd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP3TWM2OD1yLkmzOVU4KM7:TR?= M4\meXNCVkeHUh?=
OAW-42 MnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnaV2dtUUN3ME2wMlk{PjZ3IN88US=> M3m5T3NCVkeHUh?=
HuO-3N1 NE\YT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnlUVZXUUN3ME2wMlk1ODl{IN88US=> MkHIV2FPT0WU
K5 M4LG[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvDTWM2OD1yLkm0NVI4KM7:TR?= NYr0S416W0GQR1XS
SW1573 NGPWUIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rtN2lEPTB;MD65OFIzPyEQvF2= M4fQXnNCVkeHUh?=
NCI-H1792 M1PiR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj4Sm9UUUN3ME2wMlk1OjN5IN88US=> Mn7XV2FPT0WU
HCC1187 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDSRo5KSzVyPUCuPVY4PDlizszN M1\FZnNCVkeHUh?=
HCE-4 Mn20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXLTWM2OD1yLkm2PVYh|ryP Mk\vV2FPT0WU
HPAF-II MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPXTWM2OD1yLkm3NFI5KM7:TR?= M2fnWXNCVkeHUh?=
MEL-HO M1\aTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nxTGlEPTB;MD65O|k1PSEQvF2= NWju[mh4W0GQR1XS
LCLC-103H M2\i[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LaNGlEPTB;MD65PFAzPyEQvF2= MkDUV2FPT0WU
CAL-33 NEjWO5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvVTWM2OD1yLkm4N|c5KM7:TR?= MVHTRW5ITVJ?
NB6 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[3TmlEPTB;MD65PFQ3OiEQvF2= MYDTRW5ITVJ?
BFTC-905 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLsTWM2OD1yLkm4OFc{KM7:TR?= NFnXdXFUSU6JRWK=
NMC-G1 M{TDfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwOUi1PVIh|ryP M3rJcnNCVkeHUh?=
RCM-1 NX7FNpBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;UeJpKSzVyPUCuPVkzPThizszN MUHTRW5ITVJ?
COLO-320-HSR M1nIOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFiw[GxKSzVyPUGuNFA1OTJizszN NETFPZdUSU6JRWK=
NCI-H2030 NIrObo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTFwMEG4NVMh|ryP M4Lqb3NCVkeHUh?=
SCC-4 NYDXU3J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHQTHRKSzVyPUGuNFE5PTlizszN NITZNlNUSU6JRWK=
KYSE-410 NImwNHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKwZoROUUN3ME2xMlA{PTJizszN M2fXNXNCVkeHUh?=
NCI-H1650 MlLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHmToxKSzVyPUGuNFM6PzFizszN M1u3VXNCVkeHUh?=
S-117 MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFwMESg{txO M{TwenNCVkeHUh?=
GAK MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLmR4VRUUN3ME2xMlA2ODd3IN88US=> M{LKW3NCVkeHUh?=
KYSE-450 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljLTWM2OD1zLkC1N|M3KM7:TR?= NIH4cVNUSU6JRWK=
M059J Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEftZVhKSzVyPUGuNFY5OjhizszN Ml;KV2FPT0WU
LAN-6 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPHTWM2OD1zLkC3O|c{KM7:TR?= NIDUVJdUSU6JRWK=
NCI-H1651 M{jjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jKVWlEPTB;MT6wPVM2OiEQvF2= M3PrO3NCVkeHUh?=
KMOE-2 NH3ybnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC5fHdKSzVyPUGuNVA6PzNizszN Mn3TV2FPT0WU
SN12C MmDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlL0TWM2OD1zLkGxO|g2KM7:TR?= NFLrRXRUSU6JRWK=
SW900 M3jOOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XPS2lEPTB;MT6xNlI2OSEQvF2= NVLLRm9xW0GQR1XS
TE-8 NIrDOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFwMUKyPVEh|ryP NEjMelZUSU6JRWK=
HO-1-N-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jXd2lEPTB;MT6xOFM2OyEQvF2= NUe0cWc4W0GQR1XS
BHT-101 NESyPXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljxTWM2OD1zLkG0O|E1KM7:TR?= MkfaV2FPT0WU
639-V M4\aO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPTTWM2OD1zLkG2Olch|ryP NEe1TVhUSU6JRWK=
RVH-421 M3viOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33IcmlEPTB;MT6xPVM1PyEQvF2= NF3udWZUSU6JRWK=
SW780 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\ETWM2OD1zLkG5OVE2KM7:TR?= MUHTRW5ITVJ?
SNB75 MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T5TGlEPTB;MT6xPVgyQSEQvF2= MXjTRW5ITVJ?
U-87-MG MnrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjOdGh6UUN3ME2xMlIyOzN2IN88US=> MlLOV2FPT0WU
TE-1 M4TpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnPW3BkUUN3ME2xMlIyOzZ5IN88US=> NUH5[IplW0GQR1XS
CAS-1 MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HTc2lEPTB;MT6yNVQyQCEQvF2= NYWwZYhGW0GQR1XS
MKN7 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD1bG1KSzVyPUGuNlE1PzhizszN NWTpWo5yW0GQR1XS
KM-H2 M2DCPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjZR5NNUUN3ME2xMlIyPzd|IN88US=> NHH2UVhUSU6JRWK=
NCI-H1693 NEe1d|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jVZWlEPTB;MT6yNlc2QCEQvF2= NFXTUGRUSU6JRWK=
KGN M3j2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwMkOzOVkh|ryP MorrV2FPT0WU
NCI-H2347 NFHxR2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVny[4ZTUUN3ME2xMlI{PTJ3IN88US=> NWfHW5Q4W0GQR1XS
MFM-223 NGDLdG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzKTWM2OD1zLkK0N|Q{KM7:TR?= NGrLdoFUSU6JRWK=
OCI-AML2 M{K0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwMk[2OlYh|ryP NF;oOoJUSU6JRWK=
SAS NULaV3NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HrXWlEPTB;MT6yOlY4OiEQvF2= MXvTRW5ITVJ?
BT-549 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFwMk[3PFIh|ryP MmHSV2FPT0WU
NCI-H2228 MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTFwMki2OEDPxE1? MWXTRW5ITVJ?
BxPC-3 NVfXV2d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fkWWlEPTB;MT6zNFY4OiEQvF2= NWr6OYRKW0GQR1XS
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GMS-10 MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTFwM{S1OVEh|ryP MUXTRW5ITVJ?
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NCI-H226 MnvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorMTWM2OD12LkW0PFcyKM7:TR?= NELOUGpUSU6JRWK=
CAL-27 MlXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHriZplKSzVyPUSuO|E3QTRizszN M2mzeHNCVkeHUh?=
G-401 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfpTWM2OD12LkizPFQyKM7:TR?= NXLvTZFEW0GQR1XS
CAL-120 Mk\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHqS41KSzVyPUSuPFQ6QTFizszN NWr3Oo1yW0GQR1XS
DMS-114 NUjHfINCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X3[2lEPTB;NT6xOFUxPiEQvF2= NW\J[|IyW0GQR1XS
KYSE-70 NYnmSHIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[0TWlEPTB;NT6xOFg2QSEQvF2= M4fHRnNCVkeHUh?=
NCI-H1648 NYXic3R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPlS|d5UUN3ME21MlI6Pzh{IN88US=> M2\yN3NCVkeHUh?=
MDA-MB-175-VII NV\6flE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTVwNESwNVQh|ryP NVrpZpBkW0GQR1XS
NCI-H2029 NX;1T5lHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\KTWM2OD13LkS4NFIzKM7:TR?= NH7hfFRUSU6JRWK=
LS-1034 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnPUI1KSzVyPUWuOlY5QDlizszN NUnBfXp1W0GQR1XS
LB831-BLC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3SyfWlEPTB;NT63NFM1PSEQvF2= NXzFW4xoW0GQR1XS
MDA-MB-415 Mo\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XqW2lEPTB;NT63NFgyKM7:TR?= M33RSnNCVkeHUh?=
TE-6 NW[3W4lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTVwN{SxPFIh|ryP NWTwcms2W0GQR1XS
SK-MEL-24 NFXiU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTVwN{S1OlQh|ryP NILvUHJUSU6JRWK=
HUTU-80 M1rUW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFmxWWtKSzVyPUWuO|U{OzNizszN Mo\iV2FPT0WU
OCUB-M NIH4PY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nZU2lEPTB;NT63O|U3OyEQvF2= NGPNSYhUSU6JRWK=
IGR-1 NED2PXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTMTWM2OD13Lki2PFk1KM7:TR?= MXfTRW5ITVJ?
NCI-H747 MnuyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTZwMkS1PFUh|ryP MVfTRW5ITVJ?
COLO-680N MmHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2SzcWlEPTB;Nj6zPVQxOyEQvF2= MV3TRW5ITVJ?
NB12 MkftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\QfJM1UUN3ME22Mlc6PzJ{IN88US=> MlvwV2FPT0WU
SNU-449 NITyR3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTZwOUm1PVEh|ryP Ml3BV2FPT0WU
D-542MG MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn2TWM2OD15LkGyNlk6KM7:TR?= M1PWPHNCVkeHUh?=
COLO-792 NHLxTZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO3N|RKSzVyPUeuPFcyOjdizszN MYfTRW5ITVJ?
NCI-H810 M4fyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;xTWM2OD16LkCyPVg1KM7:TR?= M{f4TXNCVkeHUh?=
T47D M4DyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLFTWM2OD16LkG2NFI1KM7:TR?= NInNUIFUSU6JRWK=
Calu-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRThwMki4PFYh|ryP M1Ha[XNCVkeHUh?=
COLO-741 NF7USmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;FV2lEPTB;OD65N|A6OyEQvF2= MWXTRW5ITVJ?
LU-135 Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUiwcZJnUUN3ME25MlA{PDV{IN88US=> NVHxV5d2W0GQR1XS
COLO-678 NFPpNZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTlwMki4OFQh|ryP NHLKelRUSU6JRWK=
NCI-H2126 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfxV5NKSzVyPUmuN|M6OTlizszN M3fodnNCVkeHUh?=
SK-MEL-28 NYr3SYZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m2[WlEPTB;OT61N|U6PiEQvF2= NEG1[JVUSU6JRWK=
MFE-280 M3Pkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LzemlEPTB;MUCuNFIzQSEQvF2= NHfPR4ZUSU6JRWK=
DBTRG-05MG M4i3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfNTWM2OD1zMD60N|Y6KM7:TR?= NXS5PIxjW0GQR1XS
RCC10RGB MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nnc2lEPTB;MUCuOVI2PSEQvF2= NFvpcHRUSU6JRWK=
NTERA-S-cl-D1 M3jheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrqTWM2OD1zMD62PFUzKM7:TR?= MkXPV2FPT0WU
C3A NGTVbW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlf5TWM2OD1zMj6zNVczKM7:TR?= MlK1V2FPT0WU
MHH-ES-1 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTldWhKSzVyPUGyMlUzQDRizszN NG\kSWlUSU6JRWK=
LU-139 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm2dVFIUUN3ME2xNk43OzN|IN88US=> NInvc5BUSU6JRWK=
KNS-42 NYT1NWdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGO0UZpKSzVyPUGyMlg4PzFizszN NYLBXmJUW0GQR1XS
MCF7 NHrJOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rnOGlEPTB;MUOuNlM3PSEQvF2= NYfaWZlOW0GQR1XS
SW872 M{[0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vlWmlEPTB;MUSuOVQ3OSEQvF2= MYnTRW5ITVJ?
HT-1376 MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37lcWlEPTB;MUSuPFU5OiEQvF2= NVuxU3k{W0GQR1XS
NCI-SNU-5 M{DBR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP6TWM2OD1zNT6xO|QyKM7:TR?= MX3TRW5ITVJ?
NCI-H2405 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTF3LkS0O|Qh|ryP NGLpV|JUSU6JRWK=
KYSE-150 NETpcHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDKUllnUUN3ME2xOU44PjFzIN88US=> NXT0fHJVW0GQR1XS
SW837 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm4SFZsUUN3ME2xOk4xOTJ2IN88US=> MWjTRW5ITVJ?
LU-65 MkfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\nPItKSzVyPUG5MlczPiEQvF2= MnXaV2FPT0WU
JEG-3 M1m4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJyLkO1O|ch|ryP MnXXV2FPT0WU
SK-MEL-1 NWTZRYF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPEeJRKSzVyPUKwMlc5OzZizszN MoXqV2FPT0WU
SK-HEP-1 NEHjWplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPV[4ZIUUN3ME2yNU42PTRzIN88US=> MUfTRW5ITVJ?
NCI-H1770 M3S5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G3bWlEPTB;MkOuOFA5PiEQvF2= Mm\OV2FPT0WU
MG-63 M3q2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ|Lke2O|Mh|ryP NGj0UYJUSU6JRWK=
ECC10 M2DjZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJ3LkW3NUDPxE1? NVT1U4t6W0GQR1XS
SW1463 NULXNZRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjGXWdwUUN3ME2yO{45OzF4IN88US=> MXPTRW5ITVJ?
JVM-2 NFrCdmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj1TWM2OD1{OD6zNlQ5KM7:TR?= MXTTRW5ITVJ?
HCT-15 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3xNmRKSzVyPUK4MlQyQTJizszN NVexb4RDW0GQR1XS
CAL-72 NVH1U4txT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTNzLkS5NVIh|ryP M{L6fXNCVkeHUh?=
HCC2218 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHqbFVrUUN3ME2zNk45QDV6IN88US=> M3LVU3NCVkeHUh?=
BT-474 NVnTeZB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvRTWM2OD1|Mz6wPFQ{KM7:TR?= NX7uVnVqW0GQR1XS
NCI-H1092 NITFRZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LmWmlEPTB;M{OuOVE1PSEQvF2= NF\rOoJUSU6JRWK=
Mo-T M2rjRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPyTWM2OD1|Nz6zOVg2KM7:TR?= MXHTRW5ITVJ?
DU-145 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLidlZqUUN3ME20NE43Ojl3IN88US=> MVLTRW5ITVJ?
NCI-H1666 MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTR{LkS0PFgh|ryP NGPJVHpUSU6JRWK=
IST-MES1 NU\s[Hd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTR4LkSxPVYh|ryP Mnv3V2FPT0WU
SW1116 Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTR6LkG3OVYh|ryP NUW2WnNnW0GQR1XS
MZ2-MEL MnLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPvTWM2OD12OD61NFI3KM7:TR?= Mn;XV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pChk1 / Chk1 / Wee1 / p21 / p53 ; 

PubMed: 29963769     


Immunoblotting analysis of CAL39 and SW954 cells showing increase in CHK1 phosphorylation after exposure to AZD7762 for 24 hours. β‐actin is used as loading control. Representative data from n = 3 experiments.

29963769
Growth inhibition assay
Cell viability; 

PubMed: 23715154     


Lkb1-wt (634, 855, and 857) and Lkb1-null (t2, t4, and t5) cell lines were plated into 96-well plates at 2000 cells/well in 150 ml medium containing the indicated concentrations of AZD7762 or CHIR124 for 3 days. Viable cells were then counted with Dojindo’s Cell Counting Kit-8 assay. The data represent mean ± SD for 3 repeats. GI50 was calculated with GraphPad.

23715154
In vivo AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Chk1 Kinase Assay:

Recombinant human Chk1 is expressed as a glutathione S-transferase fusion in insect cells using a baculovirus vector and purified by glutathione affinity chromatography. A synthetic peptide substrate (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR) for Chk1 is synthesized. Final assay concentrations of peptide and ATP (cold + 40 nCi [33P]ATP) are 0.8 and 1 μM, respectively. Different concentrations of AZD7762, buffer containing peptide and chk1 kinase and ATP, are added sequentially to a 384-well assay plate. The plate is incubated for 2 hours, reaction is stopped by the addition of buffer containing EDTA and scintillation proximity assay beads, and plates are read using a TopCount reader. Data analysis is carried out to determinate a dose response (IC50).
Cell Research:[1]
+ Expand
  • Cell lines: HT29, SW620 and MDA-MB-231 cells
  • Concentrations: Dissolved in DMSO, final concentration ~12.5 μM
  • Incubation Time: 20 or 48 hours
  • Method: For the checkpoint abrogation assay, HT29 cells are treated for 2 hours with camptothecin (topoisomerase I inhibitor; 0.07 μg/mL) to induce the G2 checkpoint. Cells are then treated for 20 hours with a 12-point titration of AZD7762 (12.5 μM to 6 nM) plus nocodazole. Cells are fixed with 3.7% formaldehyde for 1 hour, permeabilized with PBS containing 0.05% Triton X, and incubated with anti-phH3 antibody for 1 hour followed by Alexa Fluor 488 anti-rabbit and Hoechst stain for 1 hour. Mitotic index is determined on the ArrayScan and expressed as the percentage of cells undergoing mitosis. For the potentiation assays, SW620 or MDA-MB-231 cells are dosed for 24 hours with a 9-point titration of gemcitabine ranging from 0.01 to 100 nM with a constant dose of AZD7762 (300 nM). After 24 hours, medium is removed and AZD7762 alone is added back to the wells for an additional 24 hours. Cells are then incubated in AZD7762-free medium for an additional 72 hours. The effect on cell proliferation is determined by MTT.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Male NCr mice implanted s.c. with H460-DNp53 cells or SW620, and male rnu rats implanted s.c. with H460-DNp53 cells
  • Formulation: Formulated in 11.3% hydroxyproplyl-β-cyclodextrin
  • Dosages: ~25 mg/kg
  • Administration: Injection i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL (137.96 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 362.42
Formula

C17H19FN4O2S

CAS No. 860352-01-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?

  • Answer:

    Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID