AZD7762

Catalog No.S1532

Molecular Weight(MW): 362.42

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.

Cited by 20 Publications

Haematologica, 2017, 102(5):826-834

PubMed: 28154085 ( click the link to review the publication )

Cancer Lett, 2017, 392:71-82

PubMed: 28126323 ( click the link to review the publication )

J Exp Clin Cancer Res, 2017, 36(1):1

PubMed: 28049532 ( click the link to review the publication )

Cancer Res, 2016, 76(11):3319-31

PubMed: 26988986 ( click the link to review the publication )

J Pathol, 2015, 10.1002/path.4528

PubMed: 25757065 ( click the link to review the publication )

Biochem Pharmacol, 2015, 93(2):210-20

PubMed: ( click the link to review the publication )

Cell Rep, 2014, 10.1016/j.celrep.2014.10.024

PubMed: ( click the link to review the publication )

Sci Signal, 2014, 7(326):ra47

PubMed: 24847116 ( click the link to review the publication )

Cell Death Dis, 2014, 5:e1253

PubMed: 24853431 ( click the link to review the publication )

Int J Oncol, 2014, 45(3):1159-66

PubMed: 24969815 ( click the link to review the publication )

Int J Gynecol Cancer, 2014, 24(5):838-43

PubMed: 24804869 ( click the link to review the publication )

Oncotarget, 2014, 5(21):10546-57

PubMed: 25301733 ( click the link to review the publication )

Br J Cancer, 2013, 110(2):510-9

PubMed: 24327015 ( click the link to review the publication )

J Cell Mol Med, 2013, 18(1):143-55

PubMed: 24238094 ( click the link to review the publication )

PLoS One, 2013, 8(2):e55493

PubMed: 23405159 ( click the link to review the publication )

Cancer Discov, 2012, 2(6):524-39

PubMed: 22628408 ( click the link to review the publication )

Cancer Biol Ther, 2012, 13(6):379-88

PubMed: 22313687 ( click the link to review the publication )

Nat Biotechnol, 2011, 29(6):542-6

PubMed: 21623355 ( click the link to review the publication )

Cancer Biol Ther, 2011, 12(3):215-28

PubMed: 21642769 ( click the link to review the publication )

PLoS One, 2010, 5(12):e14335

PubMed: 21179472 ( click the link to review the publication )

Purity & Quality Control

Choose Selective Chk Inhibitors

Biological Activity

Description

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.

Targets

Chk1 ^[1] (Cell-free assay)	Chk2 ^[1] (Cell-free assay)
5 nM	<10 nM

In vitro

AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and K_i of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. ^[1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. ^[2]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
KASUMI-1	MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXjqO4p{UUN3ME2wMlAxODJ\|NDFOwG0>	NI[0UGdUSU6JRWK=
NKM-1	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlLHTWM2OD1yLkCwNFQyPSEQvF2=	NXXB[5JJW0GQR1XS
MV-4-11	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NITNc5NKSzVyPUCuNFAxPDJ3IN88US=>	NYHHR5pMW0GQR1XS
NCI-H1703	NVrEWFFGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2HUSWlEPTB;MD6wNFY1OyEQvF2=	MVzTRW5ITVJ?
A204	M2m0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2TxNmlEPTB;MD6wNFg2PiEQvF2=	MVzTRW5ITVJ?
CGTH-W-1	MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1fNcGlEPTB;MD6wNVQzKM7:TR?=	NHH4SJpUSU6JRWK=
MLMA	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXq2c\|FDUUN3ME2wMlAzQDR7IN88US=>	NWHVfWx4W0GQR1XS
GOTO	M4PXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFr0eI9KSzVyPUCuNFMyOiEQvF2=	MUjTRW5ITVJ?
KE-37	NXrWd\|R5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEnpcplKSzVyPUCuNFMyPDJizszN	NWfQV3Z6W0GQR1XS
ES4	M3iwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFHIUoFKSzVyPUCuNFMzPTFizszN	MmHmV2FPT0WU
ATN-1	M2H0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1Tl[mlEPTB;MD6wN\|QyPyEQvF2=	MUHTRW5ITVJ?
MHH-PREB-1	Mn;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH;FOVhKSzVyPUCuNFM1PDJizszN	NVHaNlFpW0GQR1XS
SW756	M2XJcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M37QdWlEPTB;MD6wN\|U4QSEQvF2=	MVrTRW5ITVJ?
CTV-1	NV:0N2w4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4TGcWlEPTB;MD6wN\|g6PiEQvF2=	Mk\rV2FPT0WU
HCC1806	M1zrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{\RdGlEPTB;MD6wOFAzOiEQvF2=	NWHnTlBEW0GQR1XS
NEC8	M162XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2rr[mlEPTB;MD6wOFIxOyEQvF2=	NVzhXJhLW0GQR1XS
P12-ICHIKAWA	NUG4fYFYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUC1UJFXUUN3ME2wMlA1OzF4IN88US=>	NFjnO3JUSU6JRWK=
DEL	Ml\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTBwMES1PVIh\|ryP	MXHTRW5ITVJ?
KM12	M1PF[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M172ZmlEPTB;MD6wOVE2QCEQvF2=	NF3VRWpUSU6JRWK=
LB1047-RCC	NHe0V3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVfROIw3UUN3ME2wMlA3ODJ3IN88US=>	M2r5fXNCVkeHUh?=
LB2241-RCC	NYXUdYg2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MULJR\|UxRTBwME[xNFIh\|ryP	MljkV2FPT0WU
NOMO-1	M1LwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF7ObmJKSzVyPUCuNFYyOTVizszN	MV;TRW5ITVJ?
NB14	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXOxc4NRUUN3ME2wMlA3OTN4IN88US=>	MVXTRW5ITVJ?
ONS-76	NULVVFZOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEH1U3VKSzVyPUCuNFYyQTZizszN	NYjmeo1wW0GQR1XS
HD-MY-Z	MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFPsS2hKSzVyPUCuNFYzPTVizszN	M3\5R3NCVkeHUh?=
G-402	MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4LxTWlEPTB;MD6wOlQ3KM7:TR?=	M2DFXXNCVkeHUh?=
ES1	NEfCOmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYjJR\|UxRTBwMEexOFYh\|ryP	MoD2V2FPT0WU
L-363	MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTBwMEezPUDPxE1?	NG\DTFdUSU6JRWK=
A4-Fuk	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYHJR\|UxRTBwMEe0PFYh\|ryP	MoXzV2FPT0WU
OC-314	M3:5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1H3XmlEPTB;MD6wO\|gxPyEQvF2=	Mmf2V2FPT0WU
SK-LU-1	MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{D3R2lEPTB;MD6wPFQzOSEQvF2=	MWLTRW5ITVJ?
MDA-MB-157	MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGS5NFVKSzVyPUCuNFg3PTlizszN	Ml24V2FPT0WU
HuP-T3	Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkPmTWM2OD1yLkC4O\|Eh\|ryP	Mon5V2FPT0WU
A3-KAW	M1HFdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUW5[2lqUUN3ME2wMlA5QDB4IN88US=>	MYHTRW5ITVJ?
MOLT-16	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{C4TWlEPTB;MD6wPFgxPyEQvF2=	M2rQVHNCVkeHUh?=
COLO-679	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF;U[5FKSzVyPUCuNFkxQTFizszN	M1\iV3NCVkeHUh?=
EM-2	NX23VFd3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGWxd3RKSzVyPUCuNFk6ODNizszN	NULFTohRW0GQR1XS
ES8	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTBwMEm5NVgh\|ryP	M3vyZXNCVkeHUh?=
SK-MEL-2	NIDDVlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3HBbGlEPTB;MD6xNFA{OyEQvF2=	NIfPOlJUSU6JRWK=
ES3	NX3oUZJkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVTJR\|UxRTBwMUCyJO69VQ>?	M4jpOHNCVkeHUh?=
HSC-4	M4HNfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4LjNmlEPTB;MD6xNFU2PCEQvF2=	MXjTRW5ITVJ?
697	NYXXOo5[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEK5SZhKSzVyPUCuNVExPjNizszN	MkO1V2FPT0WU
TGBC11TKB	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1n2OGlEPTB;MD6xNVA6OyEQvF2=	NFPNeodUSU6JRWK=
SK-PN-DW	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mk\TTWM2OD1yLkGxPFYh\|ryP	NY\QUJZ5W0GQR1XS
H9	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mlr2TWM2OD1yLkGyNVY2KM7:TR?=	M4fwU3NCVkeHUh?=
NCI-H2122	NFvk[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1POWmlEPTB;MD6xNlI2KM7:TR?=	M2HxUHNCVkeHUh?=
ML-2	NHTpR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV[2d3h2UUN3ME2wMlEzPDh2IN88US=>	NHm4T4JUSU6JRWK=
MC-IXC	NVrKeVN2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;rTWM2OD1yLkGyPFQ{KM7:TR?=	M3SxV3NCVkeHUh?=
KYSE-140	NIK4cJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVPJR\|UxRTBwMUOwOFEh\|ryP	M3jpdnNCVkeHUh?=
DOHH-2	NXTBWJFXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEPiN3VKSzVyPUCuNVMxPjRizszN	M{jFUnNCVkeHUh?=
MEL-JUSO	NVLPT5p1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYjMSnhUUUN3ME2wMlE{OTJ6IN88US=>	NG\F[lRUSU6JRWK=
P30-OHK	MkW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXnI[ZBWUUN3ME2wMlE{OTZizszN	M4DKRnNCVkeHUh?=
CTB-1	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTBwMUOzNlUh\|ryP	MomyV2FPT0WU
ACHN	M37uZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mo\VTWM2OD1yLkGzN\|Y6KM7:TR?=	M37D[3NCVkeHUh?=
ES5	MoTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MonHTWM2OD1yLkGzOFc3KM7:TR?=	MVLTRW5ITVJ?
SF539	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1mx[2lEPTB;MD6xN\|Y5KM7:TR?=	NYrsWZg{W0GQR1XS
D-283MED	MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVTQbJY{UUN3ME2wMlE{Pjh5IN88US=>	MUfTRW5ITVJ?
OVCAR-5	NUXrUHdXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NITsb3RKSzVyPUCuNVM5QTRizszN	NXXFbFE{W0GQR1XS
RPMI-8866	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH;NelBKSzVyPUCuNVM6OjVizszN	NHvtRolUSU6JRWK=
PANC-03-27	M1HJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVrve2ZxUUN3ME2wMlE1Ojh6IN88US=>	NEmyUYVUSU6JRWK=
M14	M2\HO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXrJR\|UxRTBwMUS0OlMh\|ryP	NUDGS5hEW0GQR1XS
D-566MG	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVLJR\|UxRTBwMUS2PUDPxE1?	M1j0VHNCVkeHUh?=
Ramos-2G6-4C10	M1vFfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn\3TWM2OD1yLkG0PFQzKM7:TR?=	M1G4UXNCVkeHUh?=
NOS-1	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUXJR\|UxRTBwMUS5Olch\|ryP	MV\TRW5ITVJ?
YH-13	Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGPFO4JKSzVyPUCuNVU3PzRizszN	MX3TRW5ITVJ?
NB17	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWrJR\|UxRTBwMUW3PFYh\|ryP	MXLTRW5ITVJ?
U-2-OS	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFTSe5RKSzVyPUCuNVU5PDdizszN	NU\YNFNKW0GQR1XS
ES7	NIHVdVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWTJR\|UxRTBwMU[wNVEh\|ryP	MnfrV2FPT0WU
LoVo	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1faV2lEPTB;MD6xOlE3PiEQvF2=	MUnTRW5ITVJ?
QIMR-WIL	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MW\JR\|UxRTBwMU[zNVEh\|ryP	NV3GOItkW0GQR1XS
ESS-1	MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkPyTWM2OD1yLkG2OFE{KM7:TR?=	MkfaV2FPT0WU
LAMA-84	M4r4Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHr3Z4FKSzVyPUCuNVY2ODNizszN	M4\re3NCVkeHUh?=
TGBC24TKB	NHTkdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnfaTWM2OD1yLkG2OVM2KM7:TR?=	NF;EWIlUSU6JRWK=
KU812	NX76TVQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXTJR\|UxRTBwMU[4N{DPxE1?	MXvTRW5ITVJ?
KARPAS-45	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn3pTWM2OD1yLkG2PFQ4KM7:TR?=	NHSyXJJUSU6JRWK=
ACN	NH\od\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYq3WFMzUUN3ME2wMlE4OTdzIN88US=>	MmrMV2FPT0WU
RPMI-8226	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnLwTWM2OD1yLkG3OFY1KM7:TR?=	Mk\JV2FPT0WU
GR-ST	NEH3emtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoPQTWM2OD1yLkG3PFI4KM7:TR?=	NGO4PJJUSU6JRWK=
SK-UT-1	NHPGXJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUnJR\|UxRTBwMUi1PVkh\|ryP	MnPTV2FPT0WU
SK-N-AS	M1PON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVWzb5RRUUN3ME2wMlE5QDF3IN88US=>	M3PmenNCVkeHUh?=
EW-1	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEm1VJhKSzVyPUCuNVg6ODVizszN	NX\sfnFUW0GQR1XS
5637	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIm2fXhKSzVyPUCuNVkzPzhizszN	NUDYe2Y3W0GQR1XS
GI-1	NEH6UYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{PHVWlEPTB;MD6xPVU3OSEQvF2=	NFnu[5pUSU6JRWK=
NCI-H1395	M{jPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFnNZ3RKSzVyPUCuNVk4PjFizszN	M2rvfXNCVkeHUh?=
CHP-212	M{nIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlTGTWM2OD1yLkG5O\|gzKM7:TR?=	MUXTRW5ITVJ?
A427	MlPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVPoVGhpUUN3ME2wMlE6QDN{IN88US=>	NWOwWXI6W0GQR1XS
BE-13	NX\mWIlUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHTrSVhKSzVyPUCuNlAyOTdizszN	M3fib3NCVkeHUh?=
RS4-11	NWXxUY5ST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEjsNI1KSzVyPUCuNlA{OThizszN	MkTOV2FPT0WU
TI-73	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUW3d4RuUUN3ME2wMlIxQDd\|IN88US=>	NED2PGxUSU6JRWK=
HAL-01	MlvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn3MTWM2OD1yLkKwPVch\|ryP	M1n5OnNCVkeHUh?=
KY821	M2Tac2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTBwMkG0Nlkh\|ryP	M33oWHNCVkeHUh?=
H4	NYj2c3FvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmfJTWM2OD1yLkKyNFYzKM7:TR?=	Ml\2V2FPT0WU
EPLC-272H	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoH1TWM2OD1yLkKyNFY5KM7:TR?=	M4TrW3NCVkeHUh?=
COR-L105	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkLhTWM2OD1yLkKyNlM2KM7:TR?=	NYrRXWl6W0GQR1XS
769-P	M3LobWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGHISW5KSzVyPUCuNlIzQThizszN	NInQNlJUSU6JRWK=
HEL	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{jMU2lEPTB;MD6yNlQ2PCEQvF2=	NEm1WoNUSU6JRWK=
VA-ES-BJ	M{HrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M17VTGlEPTB;MD6yNlU2PyEQvF2=	NWjXNG57W0GQR1XS
IST-MEL1	M3ewXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoH5TWM2OD1yLkKyOVch\|ryP	M3HqRXNCVkeHUh?=
KYSE-270	M2\ISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUXIVohwUUN3ME2wMlIzPjN\|IN88US=>	NITYSmJUSU6JRWK=
RH-1	MlXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWL3ZoNwUUN3ME2wMlIzPjZ4IN88US=>	NWLwfXdKW0GQR1XS
JVM-3	NWDabohZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGDEO\|dKSzVyPUCuNlMxOzZizszN	MXfTRW5ITVJ?
RPMI-7951	NX;LPHpjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH\XcZVKSzVyPUCuNlMxPTZizszN	NVXpRpNqW0GQR1XS
JAR	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3LpS2lEPTB;MD6yN\|I{QCEQvF2=	M2jodHNCVkeHUh?=
MOLT-4	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkC1TWM2OD1yLkKzPFUh\|ryP	NWHGWItjW0GQR1XS
ALL-PO	NGjrPHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1n4T2lEPTB;MD6yOFI1OyEQvF2=	MkXuV2FPT0WU
SNU-387	NWD0O\|ByT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4DTVmlEPTB;MD6yOFM{QSEQvF2=	NE\LOGZUSU6JRWK=
IGROV-1	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHP4OW1KSzVyPUCuNlQ1ODFizszN	MkCyV2FPT0WU
MPP-89	NUD2PXJNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF70WZdKSzVyPUCuNlQ1PTFizszN	M36xT3NCVkeHUh?=
T98G	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2LzSGlEPTB;MD6yOFU3QCEQvF2=	NETvTIFUSU6JRWK=
NCI-H510A	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlnVTWM2OD1yLkK0OlI3KM7:TR?=	NGjUfFhUSU6JRWK=
KOSC-2	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MljQTWM2OD1yLkK0OlcyKM7:TR?=	M1e1bXNCVkeHUh?=
NCI-H23	MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3\qVWlEPTB;MD6yOFc3OSEQvF2=	NVXrOJJjW0GQR1XS
MC116	NIDoXXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWLMToxEUUN3ME2wMlI2PjV2IN88US=>	MkCyV2FPT0WU
8-MG-BA	M1jETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXrJR\|UxRTBwMkW3Olgh\|ryP	M3vudnNCVkeHUh?=
ABC-1	NX;Cd5puT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXjJR\|UxRTBwMk[wOlQh\|ryP	NGi1PIlUSU6JRWK=
J-RT3-T3-5	NF\JOGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3HhZWlEPTB;MD6yOlY4QCEQvF2=	Ml7EV2FPT0WU
NCI-SNU-1	Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NG\0elZKSzVyPUCuNlcxPTlizszN	M1;pSHNCVkeHUh?=
HCC1395	NYrVR4ZZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEfDNGhKSzVyPUCuNlcxQDlizszN	MnezV2FPT0WU
BB65-RCC	NH62c2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4\tOmlEPTB;MD6yO\|A6PyEQvF2=	NHTRUItUSU6JRWK=
NCI-H1755	NYnCUFNvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXvwUolIUUN3ME2wMlI4OzB2IN88US=>	MVvTRW5ITVJ?
OVCAR-3	MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVHJR\|UxRTBwMkezPFUh\|ryP	M3zXd3NCVkeHUh?=
MKN45	M2XOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGS2[nFKSzVyPUCuNlc6QCEQvF2=	MW\TRW5ITVJ?
TYK-nu	NW\WOm5vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml;4TWM2OD1yLkK4NFYh\|ryP	M{LFfHNCVkeHUh?=
SNU-C2B	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlLlTWM2OD1yLkK4NVM1KM7:TR?=	NUPLVmd5W0GQR1XS
H-EMC-SS	M2HBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4excmlEPTB;MD6yPFM2PCEQvF2=	MoXFV2FPT0WU
CAKI-1	M4L4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX;ZWlJGUUN3ME2wMlI5PjhizszN	MorKV2FPT0WU
EW-24	NWPKWmd4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXfJR\|UxRTBwMki5NUDPxE1?	MmnYV2FPT0WU
RXF393	NInZdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV;5c406UUN3ME2wMlI6ODB6IN88US=>	MkXxV2FPT0WU
CCRF-CEM	NXr4cHozT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEPZdXZKSzVyPUCuNlkyPTRizszN	MoPhV2FPT0WU
HOP-92	M4DaN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1TYSWlEPTB;MD6yPVI4QSEQvF2=	NXTYWFdyW0GQR1XS
COLO-684	NEjt[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoPtTWM2OD1yLkK5OFA3KM7:TR?=	NI\mRolUSU6JRWK=
NCI-H28	MlfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIHrW45KSzVyPUCuNlk4ODRizszN	NIX5bHBUSU6JRWK=
HuO9	M33EZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3vBcWlEPTB;MD6yPVc6OyEQvF2=	Mnv5V2FPT0WU
SF295	M3z6bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlvJTWM2OD1yLkK5PFAzKM7:TR?=	NVvoNpZLW0GQR1XS
COLO-829	MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTBwMkm4OFUh\|ryP	NHnLfppUSU6JRWK=
MSTO-211H	NEC1VmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUPJR\|UxRTBwMkm4OVUh\|ryP	NVWxTXRIW0GQR1XS
MDA-MB-361	NVn6eGNXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYrtR\|lEUUN3ME2wMlI6QDl4IN88US=>	MoL6V2FPT0WU
FTC-133	M2DKVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M17wR2lEPTB;MD6zNFI3PSEQvF2=	NXvkSFlRW0GQR1XS
Mewo	NHjOSWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M13VPGlEPTB;MD6zNFQ{OSEQvF2=	NYHBenY5W0GQR1XS
HCC70	MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml;pTWM2OD1yLkOwOlY2KM7:TR?=	MonnV2FPT0WU
BB30-HNC	NXHtZpczT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYrjbFdsUUN3ME2wMlMyPTJ3IN88US=>	MnPvV2FPT0WU
LCLC-97TM1	M{PJNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3\2e2lEPTB;MD6zNVU3PiEQvF2=	MmGwV2FPT0WU
HCC2998	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUHtU5JHUUN3ME2wMlMyPjVizszN	NHv3W2JUSU6JRWK=
NBsusSR	M{fM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M135dGlEPTB;MD6zNVgyQSEQvF2=	MkfLV2FPT0WU
OVCAR-4	NFKxOXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3OzS2lEPTB;MD6zNlAzOSEQvF2=	M1LzfHNCVkeHUh?=
NCI-H209	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlnMTWM2OD1yLkOyN\|U{KM7:TR?=	MkLBV2FPT0WU
ChaGo-K-1	NVjNPGd2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlHMTWM2OD1yLkOyOFg6KM7:TR?=	NFvMZ3RUSU6JRWK=
KALS-1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTBwM{K1PVQh\|ryP	Mnz6V2FPT0WU
D-423MG	NH7KSXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUDmNlYxUUN3ME2wMlM{OTR{IN88US=>	NV35NVVuW0GQR1XS
Detroit562	NVq2PVRKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTBwM{OzOFMh\|ryP	Mn;vV2FPT0WU
HT-144	NF:4bJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml\qTWM2OD1yLkOzPFEh\|ryP	MUjTRW5ITVJ?
MEG-01	MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWHJR\|UxRTBwM{S1PFQh\|ryP	MVPTRW5ITVJ?
BV-173	M2rFPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{jU[2lEPTB;MD6zOFU6PiEQvF2=	M4jKSHNCVkeHUh?=
MZ7-mel	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{LIXmlEPTB;MD6zOFY4PyEQvF2=	MonaV2FPT0WU
C32	NGrVSG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVexZ\|J3UUN3ME2wMlM1Pjh{IN88US=>	M2roTHNCVkeHUh?=
DU-4475	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoqwTWM2OD1yLkO0PFc2KM7:TR?=	NFyxWJdUSU6JRWK=
KP-N-YN	NHLldXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTBwM{S4PFch\|ryP	NFjSeYxUSU6JRWK=
MKN1	MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVPxSlZ2UUN3ME2wMlM2ODB{IN88US=>	NXXi[pdIW0GQR1XS
8505C	MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkjrTWM2OD1yLkO1NFAzKM7:TR?=	MmrYV2FPT0WU
OVCAR-8	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTBwM{W1PFQh\|ryP	MlS5V2FPT0WU
NH-12	M4fVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1LRbGlEPTB;MD6zOVY6PiEQvF2=	MWPTRW5ITVJ?
COR-L88	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmfQTWM2OD1yLkO2OFgzKM7:TR?=	NGr6NHRUSU6JRWK=
T-24	M1XhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYDSR5MyUUN3ME2wMlM3QTh3IN88US=>	NFTXZmpUSU6JRWK=
MIA-PaCa-2	M2rKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoXCTWM2OD1yLkO3OFk4KM7:TR?=	NVX5XmFSW0GQR1XS
LS-411N	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{m4W2lEPTB;MD6zO\|YxPiEQvF2=	MUTTRW5ITVJ?
TK10	NWf3[Hg5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXe2OXVMUUN3ME2wMlM4QTR6IN88US=>	NX\x[WhMW0GQR1XS
SW1990	NXjtc5NZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYPtNmQ1UUN3ME2wMlM5OzV\|IN88US=>	M2nieXNCVkeHUh?=
GAMG	NIHTeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTBwM{i1Olch\|ryP	Mk[wV2FPT0WU
G-361	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlT0TWM2OD1yLkO4O\|EzKM7:TR?=	M4XBVXNCVkeHUh?=
Ca-Ski	NXHRbWY6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlPTTWM2OD1yLkO4O\|kzKM7:TR?=	NF3uXmVUSU6JRWK=
786-0	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoDKTWM2OD1yLkO4PFI{KM7:TR?=	NFnYeXFUSU6JRWK=
MHH-NB-11	MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYPsN4lXUUN3ME2wMlM5QTdizszN	NVPPTXZRW0GQR1XS
OE33	NGrRbXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkjOTWM2OD1yLkO5NVE5KM7:TR?=	NY[0N2FUW0GQR1XS
SW954	MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH3HWWdKSzVyPUCuOFAyOzFizszN	MXrTRW5ITVJ?
KYSE-180	NHzPTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXmTWM2OD1yLkSwNVUyKM7:TR?=	MorNV2FPT0WU
NCI-H720	MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkiyTWM2OD1yLkSwNVkyKM7:TR?=	NXrBNWtkW0GQR1XS
COR-L23	MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWjJR\|UxRTBwNECyPFYh\|ryP	MWfTRW5ITVJ?
PFSK-1	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU[4O\|BVUUN3ME2wMlQyODl{IN88US=>	NXn3OI01W0GQR1XS
FADU	M3rkO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWjq[3dZUUN3ME2wMlQyOTd{IN88US=>	MnHZV2FPT0WU
GP5d	NInW[XlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn:zTWM2OD1yLkSxNlI2KM7:TR?=	NWn6cnl6W0GQR1XS
PC-14	NGTSdWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmLnTWM2OD1yLkSxOlYyKM7:TR?=	NGDON\|VUSU6JRWK=
SJSA-1	NYrhPFZUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NG\XT5FKSzVyPUCuOFE4OTRizszN	M4q2VnNCVkeHUh?=
D-336MG	NIjleY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MorsTWM2OD1yLkSyNVM5KM7:TR?=	NVriW3B7W0GQR1XS
LOXIMVI	M3X1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHXSSZdKSzVyPUCuOFI5QDVizszN	M2P2cXNCVkeHUh?=
EFO-27	NHzVWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYnROYVQUUN3ME2wMlQ{ODR7IN88US=>	MYnTRW5ITVJ?
A2780	NU\ZS4xqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUjHV2M3UUN3ME2wMlQ{OTZ{IN88US=>	M13O[HNCVkeHUh?=
CAL-12T	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlTsTWM2OD1yLkSzNlg5KM7:TR?=	MVnTRW5ITVJ?
ES6	M{LV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIf2e4lKSzVyPUCuOFQyQDVizszN	MkLDV2FPT0WU
HCE-T	MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTBwNESxPFch\|ryP	M4e1dXNCVkeHUh?=
SK-MES-1	MmH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWPJR\|UxRTBwNESyPVMh\|ryP	M1jMNXNCVkeHUh?=
Daoy	NWrt[oVUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXTB[IV[UUN3ME2wMlQ2OTB\|IN88US=>	M{LuVHNCVkeHUh?=
A2058	NGrKSoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4i1fmlEPTB;MD60OVE{PiEQvF2=	MlLZV2FPT0WU
Hs-578-T	M4XzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTBwNEWyO\|gh\|ryP	M2PKNXNCVkeHUh?=
TE-11	NGj6TG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlnXTWM2OD1yLkS1Nlk{KM7:TR?=	Ml\NV2FPT0WU
GI-ME-N	NVHzVXU2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{LqUmlEPTB;MD60OVQ3KM7:TR?=	NFfCU5ZUSU6JRWK=
D-392MG	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVSwdWx2UUN3ME2wMlQ2PjF{IN88US=>	NHPFZYVUSU6JRWK=
MOLT-13	NEfWUYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYrvfJZWUUN3ME2wMlQ3Ojl2IN88US=>	NYnUTIg1W0GQR1XS
SK-NEP-1	M3Tvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3u0ZmlEPTB;MD60OlQyQSEQvF2=	Mmr4V2FPT0WU
KS-1	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn\qTWM2OD1yLkS2OlA{KM7:TR?=	MlO4V2FPT0WU
HuP-T4	MkW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH\qempKSzVyPUCuOFY5PjhizszN	M2f0RXNCVkeHUh?=
NCI-H1563	MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFnDbGVKSzVyPUCuOFcxOzVizszN	NVPGcmFlW0GQR1XS
U031	NVr1NIZiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIHjdVJKSzVyPUCuOFgzOzRizszN	MY\TRW5ITVJ?
HSC-3	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2nVXGlEPTB;MD60PFYzPiEQvF2=	M3X3OHNCVkeHUh?=
HT-3	MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MljuTWM2OD1yLkS5NFMh\|ryP	M4G5OHNCVkeHUh?=
HGC-27	NYG5cJZnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3noV2lEPTB;MD60PVEyPSEQvF2=	NHW5O2tUSU6JRWK=
HT-1080	NFHXV\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXPJR\|UxRTBwNEmyO{DPxE1?	NUD0cZpXW0GQR1XS
RT-112	NHTOVYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{LmSGlEPTB;MD60PVkzOSEQvF2=	NH\4To9USU6JRWK=
A375	NX[5OFdyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjlTWM2OD1yLkS5PVIzKM7:TR?=	M3m1WHNCVkeHUh?=
SW626	MnX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUHJR\|UxRTBwNUC2N\|Mh\|ryP	NUTaXVJiW0GQR1XS
SBC-5	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYnJR\|UxRTBwNUGzOFQh\|ryP	NX3qZY5CW0GQR1XS
CAL-51	MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmmwTWM2OD1yLkWxOFM4KM7:TR?=	MkfxV2FPT0WU
RKO	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlHXTWM2OD1yLkWyNFE6KM7:TR?=	Mn21V2FPT0WU
HC-1	NELSSIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX3VZ282UUN3ME2wMlUzOTF2IN88US=>	NUfDOG5vW0GQR1XS
CHL-1	NXXlWYV1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVLJR\|UxRTBwNUK1OVEh\|ryP	NIfTUGxUSU6JRWK=
SK-N-DZ	M2[1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1HKPWlEPTB;MD61N\|A4QCEQvF2=	M2\Ke3NCVkeHUh?=
SNU-423	Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4DHZWlEPTB;MD61N\|Q3PiEQvF2=	MWrTRW5ITVJ?
NB13	M1KwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXvJR\|UxRTBwNUO2OVch\|ryP	MUPTRW5ITVJ?
EW-16	M1jLW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWXNOWwzUUN3ME2wMlU{Pzd2IN88US=>	Mlv4V2FPT0WU
A704	MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnjlTWM2OD1yLkWzPFgyKM7:TR?=	MkHLV2FPT0WU
Ca9-22	NIfifZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVfJR\|UxRTBwNUSwO\|ch\|ryP	NUGwSld{W0GQR1XS
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NCI-H1581	M1\afmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXLB[mk6UUN3ME2yMlE6PTl4IN88US=>	NFHsXGFUSU6JRWK=
COLO-668	MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIHFc29KSzVyPUKuNlk6PzNizszN	M3PUenNCVkeHUh?=
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RO82-W-1	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVLJR\|UxRTJwNEO3Nlch\|ryP	MXrTRW5ITVJ?
NCI-H2291	M3vWeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV;YSlBrUUN3ME2yMlQ3QTl2IN88US=>	M4DwUHNCVkeHUh?=
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NCI-H2126	MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHHUS4pKSzVyPUmuN\|M6OTlizszN	NVTwUm9QW0GQR1XS
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NTERA-S-cl-D1	MkPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXjPNXNJUUN3ME2xNE43QDV{IN88US=>	MnzYV2FPT0WU
C3A	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlnZTWM2OD1zMj6zNVczKM7:TR?=	MVTTRW5ITVJ?
MHH-ES-1	M37zZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmH1TWM2OD1zMj61Nlg1KM7:TR?=	NV3qcWR{W0GQR1XS
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MCF7	NFTKXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{Dz[GlEPTB;MUOuNlM3PSEQvF2=	NGXzeoxUSU6JRWK=
SW872	MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MY\JR\|UxRTF2LkW0OlEh\|ryP	MmDpV2FPT0WU
HT-1376	NX;SV2hCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3\wcGlEPTB;MUSuPFU5OiEQvF2=	NF;MeGRUSU6JRWK=
NCI-SNU-5	M1;OO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{W1S2lEPTB;MUWuNVc1OSEQvF2=	MlywV2FPT0WU
NCI-H2405	NHvBdXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoPDTWM2OD1zNT60OFc1KM7:TR?=	MmP6V2FPT0WU
KYSE-150	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFHHUnJKSzVyPUG1Mlc3OTFizszN	NIjnN5pUSU6JRWK=
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JEG-3	Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTJyLkO1O\|ch\|ryP	MUXTRW5ITVJ?
SK-MEL-1	NEjpbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4\JcmlEPTB;MkCuO\|g{PiEQvF2=	MVjTRW5ITVJ?
SK-HEP-1	NFvPPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkSxTWM2OD1{MT61OVQyKM7:TR?=	M1LHXnNCVkeHUh?=
NCI-H1770	MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4XobmlEPTB;MkOuOFA5PiEQvF2=	Mm\BV2FPT0WU
MG-63	NIrQSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYLCR5Y6UUN3ME2yN{44Pjd\|IN88US=>	MoHEV2FPT0WU
ECC10	M2i2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4HtVGlEPTB;MkWuOVcyKM7:TR?=	MnTLV2FPT0WU
SW1463	NWLlNXVpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\YV3ljUUN3ME2yO{45OzF4IN88US=>	MoDlV2FPT0WU
JVM-2	M1rRPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mnv1TWM2OD1{OD6zNlQ5KM7:TR?=	NHi1Z4NUSU6JRWK=
HCT-15	NG\JR\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUHEVIlIUUN3ME2yPE41OTl{IN88US=>	NXXzVGUzW0GQR1XS
CAL-72	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUjXNldPUUN3ME2zNU41QTF{IN88US=>	NIPiOINUSU6JRWK=
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NCI-H1092	NWrr[ZE{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWqx[ZlkUUN3ME2zN{42OTR3IN88US=>	MXXTRW5ITVJ?
Mo-T	Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXnOSXd6UUN3ME2zO{4{PTh3IN88US=>	MXfTRW5ITVJ?
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MZ2-MEL	NU\MOGJMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmOyTWM2OD12OD61NFI3KM7:TR?=	NIDONXdUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo

AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively. ^[1]

Protocol

Kinase Assay:^[1]	+ Expand Chk1 Kinase Assay: Recombinant human Chk1 is expressed as a glutathione S-transferase fusion in insect cells using a baculovirus vector and purified by glutathione affinity chromatography. A synthetic peptide substrate (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR) for Chk1 is synthesized. Final assay concentrations of peptide and ATP (cold + 40 nCi [³³P]ATP) are 0.8 and 1 μM, respectively. Different concentrations of AZD7762, buffer containing peptide and chk1 kinase and ATP, are added sequentially to a 384-well assay plate. The plate is incubated for 2 hours, reaction is stopped by the addition of buffer containing EDTA and scintillation proximity assay beads, and plates are read using a TopCount reader. Data analysis is carried out to determinate a dose response (IC50).
Cell Research:^[1]	+ Expand Cell lines: HT29, SW620 and MDA-MB-231 cells Concentrations: Dissolved in DMSO, final concentration ~12.5 μM Incubation Time: 20 or 48 hours Method: For the checkpoint abrogation assay, HT29 cells are treated for 2 hours with camptothecin (topoisomerase I inhibitor; 0.07 μg/mL) to induce the G2 checkpoint. Cells are then treated for 20 hours with a 12-point titration of AZD7762 (12.5 μM to 6 nM) plus nocodazole. Cells are fixed with 3.7% formaldehyde for 1 hour, permeabilized with PBS containing 0.05% Triton X, and incubated with anti-phH3 antibody for 1 hour followed by Alexa Fluor 488 anti-rabbit and Hoechst stain for 1 hour. Mitotic index is determined on the ArrayScan and expressed as the percentage of cells undergoing mitosis. For the potentiation assays, SW620 or MDA-MB-231 cells are dosed for 24 hours with a 9-point titration of gemcitabine ranging from 0.01 to 100 nM with a constant dose of AZD7762 (300 nM). After 24 hours, medium is removed and AZD7762 alone is added back to the wells for an additional 24 hours. Cells are then incubated in AZD7762-free medium for an additional 72 hours. The effect on cell proliferation is determined by MTT. (Only for Reference)
Animal Research:^[1]	+ Expand Animal Models: Male NCr mice implanted s.c. with H460-DNp53 cells or SW620, and male rnu rats implanted s.c. with H460-DNp53 cells Formulation: Formulated in 11.3% hydroxyproplyl-β-cyclodextrin Dosages: ~25 mg/kg Administration: Injection i.v. (Only for Reference)

References

[1] Zabludoff SD, et al. Mol Cancer Ther, 2008, 7(9), 2955-2966.

Solubility (25°C)

In vitro	DMSO	50 mg/mL (137.96 mM)
	Water	Insoluble
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download AZD7762 SDF

Molecular Weight	362.42
Formula	C₁₇H₁₉FN₄O₂S
CAS No.	860352-01-8
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00937664	Terminated	Cancer\|Solid Tumors\|Advanced Solid Malignancies	AstraZeneca	July 2009	Phase 1
NCT00937664	Terminated	Cancer\|Solid Tumors\|Advanced Solid Malignancies	AstraZeneca	July 2009	Phase 1
NCT00473616	Terminated	Advanced Solid Tumors\|Cancer\|Advanced Solid Malignancies	AstraZeneca	May 2007	Phase 1
NCT00473616	Terminated	Advanced Solid Tumors\|Cancer\|Advanced Solid Malignancies	AstraZeneca	May 2007	Phase 1
NCT00413686	Completed	Solid Tumors	AstraZeneca	December 2006	Phase 1
NCT00413686	Completed	Solid Tumors	AstraZeneca	December 2006	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?
Answer:
Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.

Chk Signaling Pathway Map

Chk Inhibitors with Unique Features

Selective CHK Inhibitor

MK-8776 (SCH 900776) : Chk1-selective, IC50=3 nM.
Most Potent CHK Inhibitor

CHIR-124 : Chk1, IC50=0.3 nM.
CHK Inhibitor in Clinical Trial

MK-8776 (SCH 900776) : Phase II for Relapsed Acute Myeloid Leukemia.
Classic CHK Inhibitor

PF-477736 : Selective, potent and ATP-competitive Chk1 inhibitor with K_i of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes.

Related Chk Products4

Ro-3306 ^New

RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with K_i of 20 nM, >15-fold selectivity against a diverse panel of human kinases.
CCG-1423 ^New

CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.
ML141 ^New

ML141 (CID-2950007), is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7).
Rabusertib (LY2603618)

Rabusertib (LY2603618) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated.
CHIR-124

CHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM in a cell-free assay. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.
MK-8776 (SCH 900776)

MK-8776 (SCH 900776) is a selective Chk1 inhibitor with IC50 of 3 nM in a cell-free assay. It shows 500-fold selectivity against Chk2. Phase 2.
PF-477736

PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with K_i of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2. Phase 1.
Y-27632 2HCl

Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with K_i of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
Palbociclib (PD-0332991) HCl

Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.

Features:Non-cytotoxic, and halts cancer cell growth & could be used in glioblastoma that has relapsed after temozolomide treatment (a chemotherapeutic used to treat many cancers).
Alisertib (MLN8237)

Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.

Features:First orally available inhibitor of Aurora A.

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AZD7762

Cited by 20 Publications

Purity & Quality Control

Choose Selective Chk Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download AZD7762 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

Tech Support

Frequently Asked Questions

Chk Signaling Pathway Map

Chk Inhibitors with Unique Features

Related Chk Products4

Choose Your Country or Region

By Signaling Pathways

By product type

AZD7762

Cited by 20 Publications

Purity & Quality Control

Choose Selective Chk Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download AZD7762 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2019-03-27)

Tech Support

Frequently Asked Questions

Chk Signaling Pathway Map

Chk Inhibitors with Unique Features

Related Chk Products4

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)