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(-)-Corynoxidine is an <b>acetylcholinesterase</b> inhibitor with an IC⁵⁰ value of 89.0 μM, isolated from the aerial parts of <i>Corydalis speciosa</i>. (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.

(3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) is an intermediary metabolite by gut microbes from dietary L-carnitine in mice.

2-Chlorotrityl chloride resin can be cleaved under extremely mild acid conditions that leave Boc/tBu based protecting groups in place. It is used to prepare protected peptide fragments.

5-Cholesten-3β-ol-7-one (7-ketocholesterol) is a cholestanoid that consists of cholesterol bearing an oxo substituent at position 7. 5-Cholesten-3β-ol-7-one has a role as a neuroprotective agent. 5-Cholesten-3β-ol-7-one is a 3beta-sterol, a cholestanoid, a 7-oxo steroid and a 3beta-hydroxy-Delta(5)-steroid.

C-170 is a covalent small-molecule inhibitor of STING. C-170 efficiently inhibits both hsSTING and mmSTING through the same covalent modification with C-171.

C-171 is a covalent small-molecule inhibitor of STING. C-171 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.

Cadralazine (ISF 2469) is an orally active anti-hypertensive agent. Cadralazine is a peripheral arteriolar vasodilator.

Calcium 2-hydroxy-4-(methylthio)butanoate is an active endogenous metabolite.

Calenduloside E is a natural triterpenoid saponin isolated from Aralia elata (Miq.) Seem., has anti-cardiovascular disease effects and inhibits LPS-induced inflammatory response by blocking ROS-mediated activation of JAK1-stat3 signaling pathway in RAW264.7 cells.

Calycanthine, the principal alkaloid of the order Calycanthaceae, has been isolated from a species of the genus <i>Psychotria</i>, and is a central nervous system toxin, causing convulsions.

Campesterol is a phytosterol. Though an analogue of cholesterol, it is poorly absorbed in humans and competitively inhibits the absorption of cholesterol. Campesterol decreases the transcription of genes involved in cholesterol metabolism in hepatocytes and enterocytes and has positive impact in treatment of cardiovascular disease.

Cannabichromene (DL-cannabichromene), a 2,2-dimethyl-2H-chromene derivative, is found in <i>Cannabis sativa</i> L.

Cannabichromevarinic acid, a kind of cannabichromene (CBC)-related phytocannabinoids isolated from <i>Cannabis sativa</i> L., is anticonvulsant against hyperthermia-induced seizures in Scn1a^+/- mice.

Cannabisin B, a lignanamide from hempseed, possesses considerable antiproliferative activity.

Capsiate, a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1.

Carboxyatractyloside dipotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport.

Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. Carrageenan shows anticoagulant activity, antithrombotic activity, antiviral activity, anti-tumour activity and immunomodulatory activity.

Cassiaside C (Toralactone 9-O-β-D-gentiobioside) is a naphthopyrone isolated from the seed of Cassia tora and has inhibitory activity on advanced glycation end products (AGE) formation in vitro.

CB-103 is an orally active inhibitor of the Notch transcription activation complex. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts.

CB41235515 (3-oxo-4,6-choladien-24-oic acid) is an endogenous metabolite. 3-Oxo-4,6-choladien-24-oic acid exsists in the urine of patients with hepatobiliary disease.

CB51315232 (3-oxo-7-hydroxychol-4-enoic acid) has a role as a human urinary metabolite.

CB82657736 (KCNQ2/3 activator-1) is an activator of Kv7.2/Kv7.3 (KCNQ2/3) potassium channel. KCNQ2/3 activator-1 has the potential in relieving pain (extracted from patent WO2021113757A1, compound A).

CBP/EP300-IN-1 is an inhibitor of CBP/EP300 bromodomain.

CC-885 is a novel cereblon (CRBN) modulator. CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation.

CCT020312 is a selective PERK (EIF2AK3) activator with an EC50 of 5.1 μM. CCT020312 can be used for the selective activation of EIF2A-mediated translation control.

Ceapin-A7 is a selective and highly potent inhibitor of the ATF6α, which can activate the response to ER stress, with IC50 of 0.59 μM.

Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA).

Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. Chebulagic acid shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. Chebulagic acid also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.

Chebulic acid, a phenolcarboxylic acid compound isolated from <i>Terminalia chebula</i>, has potent anti-oxidant activity, which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits the formation of AGEs.

Chebulinic acid, a phenolic compound isolated from Terminalia chebula fruit, is a novel Influenza viral neuraminidase inhibitor. Chebulinic acid is a antiangiogenic agent through inhibiting the actions of VEGF. Chebulinic acid shows antitumour activity.

Cheilanthifoline, an alkaloid isolated from <i>Corydalis calliantha</i>, exhibits antiplasmodial activities against <i>Plasmodium falciparum</i> with IC50s of 0.90 and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively.

Chelerythrine (Toddaline, Broussonpapyrine) is a potent, selective antagonist of PKC with an IC50 of 0.66 μM. Chelerythrine also inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1.5 μM. Chelerythrine shows antitumor, antidiabetic and anti-inflammatory activity.

Chiauranib selectively inhibits multiple kinase targets such as aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit, thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.

Cholesta-4,6-dien-3beta-ol is a cholestanoid.

Cholesteryl linoleate is less polar lipid in human nasal fluid that contributes to the inherent antibacterial activity.

Chrysin 7-O-β-gentiobioside is the glycosylation product of Chrysin.

Chrysin-7-O-glucuronide is a flavonoid extracted from Scutellaria baicalensis, with antioxidant activity.

Chrysosplenol D is a kind of methoxyflavonoids, which can induce ERK1/2-mediated apoptosis in triple negative human breast cancer cells and has anti-inflammatory and anti-trypanosomal activities.

CID-1067700 (ML282) is a pan-GTPase inhibitor with a ki of 12.89 nM for Rab7wt.

CID1231538, a benzothiazole analogue, is a potent GPR35 antagonist (IC50=0.55 μM). GPR35 is a G protein-coupled receptor (GPCR).

Cimiracemoside C is an active component of Cimicifuga racemosa, which can activate AMPK and has the potential activity against diabetes.

Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. 

A novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.

Cinitapride Tartrate is the salt analogue of Cinitapride (C441990), a novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.

Cinobufotalin, extracted from the skin secretion of the giant toad, is a novel SREBP1 inhibitor that suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.

Cirsimarin is a potent antilipogenic flavonoid isolated from <i>Microtea debilis</i>. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on <b>adenosin A1 receptor</b> and its inhibitory effect on <b>phosphodiesterase</b>.

Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.

Cis-3-Hexenyl hexanoate ((Z)-3-hexenyl hexanoate) is a kind of plant volatile that brings tropical and pulpy profile with citrus and green nuances to all kinds of fruit flavors.

cis-4-Hydroxy-D-proline (H-D-cis-Hyp-OH) is an endogenous metabolite that can be used to study the specificity and kinetics of D-alanine dehydrogenase.

Cistus Incanus Extract, isolated from Mediterranean shrub species Cistus incanus L., is rich in polyphenolic compounds, possesses significant antioxidant activity, and may be effective active ingredients for the cosmetic industry. 

CITCO is a potent and selective constitutive androstane receptor (CAR) agonist with EC50 of 49 nM. CITCO displays >50-fold selectivity for CAR over PXR in the transient transfection assay.

Citraconic acid (CA) is a kind of methyl-branched fatty acids that exists in wild soybean.

Clematichinenoside AR is a major active ingredient extracted from <i>Clematis chinensis</i>, and has potent pharmacological effects on various diseases, including atherosclerosis (AS).

Clenbuterol (CST-103) Hydrochloride is a potent and selective adrenergic beta 2-receptor agonist.

Cochinchinenin A, an active component extracted from dragon's blood, suppresses the peak tetrodotoxin-resistant (TTX-R) sodium currents in a dose-dependent way and affects the activations of TTX-R sodium currents.

Colesevelam Hydrochloride is an orally administered, non-absorbable, polymeric, bile-acid-binding agent with a higher affinity for glycocholic acid in vitro.

Columbamine is a quaternary isoquinoline alkaloid extracted from plants.

Columbianetin acetate is an isomer of columbianetin that is a phytoalexin associated with celery (<i>Apium graveolens</i>) resistance to pathogens during storage and possesses excellent anti-fungal and anti-inflammatory activity.

Coniferin (Laricin), a glucoside of coniferyl alcohol, inhibits fungal growth and melanization.

Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST), reverses multidrug resistance and downregulates P-glycoprotein.

Conoidin A is a covalent inhibitor of peroxiredoxin II with an IC50 of 25.1 mM for recombinant T. gondii enzyme peroxiredoxin II (rTgPrxII).

Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive indoleamine 2,3-dioxygenase (IDO) inhibitor.

Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive <b>IDO</b> inhibitor with a Kⁱ value of 5.8 μM and an IC⁵⁰ value of 6.3 μM.

Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. et ZUCC. Cornuside suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting NF-κB activation in RAW 264.7 macrophages. Cornuside attenuates apoptosis in rat cortical neurons.

Cotoin is a natural product isolated from the stem bark of Garcinia virgate.

CP-31398 Dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

CPI-455 is a specific KDM5 inhibitor with an IC50 of 10 nM for full-length KDM5A in enzymatic assays. CPI-455 shows over 200-fold selectivity for KDM5 relative to KDM2, 3, 4, 6, and 7 enzymes.

CU-CPT9a is a potent and specific antagonist of Toll-like receptor 8 (TLR8) with IC50 of 0.5 nM.

Cubebin, a dibenzylbutyrolactone lignan isolated from <i>Piper cubeba</i>, shows promising protective activity in scopolamine-induced spatial memory impairment in mice.

Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. 

Cucurbitacin E is a natural compound which from the climbing stem of Cucumic melo L. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

Cucurbitacin-I (Elatericin B, JSI 124, NSC 521777), a natural cell-permeable triterpenoid isolated from Cucurbitaceae, is a novel selective inhibitor of JAK2/STAT3.

Cy5.5 is a near-infrared fluorescent dye (Ex=673 nm, Em=707 nm) used to label biological molecules, such as peptides, proteins, and oligonucleotides.

Cy7 bis-acid is a free non-activated NIR (near-infrared fluorescent) dye.

Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds, and has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease.

Cyclosporin C, a fungal metabolite found in <i>T. inflatum</i>, has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. 

CYM50358 is a potent S1PR4 antagonist with an IC50 of 25 nM.

Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. 

CyPPA is a subtype-selective positive modulator of SK channels with EC50s of 5.6 μM and 14 μM for hSK3 and hSK2, repectively. CyPPA is inactive on both hSK1 and hIK channels.