Catalog No.S7029

AZD2461 Chemical Structure

Molecular Weight(MW): 395.43

AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.

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  • (b) Hoechst-positive cell quantification of caspase and PARP inhibitors and their effect on ARPE-19 cells undergoing UOS in the presence and absence of NPD1 (lower panel). Bars represent data averages of three repeats (technical replicas) of three independent experiments (biological replicas). *P<0.05

    Cell Death Differ, 2017, 24(6):1091-1099. AZD2461 purchased from Selleck.

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Biological Activity

Description AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.
PARP [1]
In vitro

AZD2461 has lower affinity for Pgp than does Olaparib. [1]

In vivo AZD2461 has an 80-fold increased Mdr1b expression on Olaparib-resistant KB1P tumor T6-28, without inhibition of Pgp. AZD2461 induces loss of 53BP1 expression in mice with KB1P tumors with short-term treatment. Long-term AZD2461 treatment is well tolerated and doubled the median relapse-free survival. [1]


Animal Research:[1]
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  • Animal Models: Olaparib-resistant tumors from KB1PM1, KB1PM3, and KB1PM4 in female mice
  • Formulation: 0.5% w/v hydroxypropyl methylcellulose
  • Dosages: 100 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 79 mg/mL (199.78 mM)
Ethanol 31 mg/mL (78.39 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 395.43


CAS No. 1174043-16-3
Storage powder
in solvent
Synonyms N/A

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01247168 Completed Refractory Solid Tumors|Cancer Tumor AstraZeneca November 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    I need to formulate the drug for in vivo use. How to dissolve the drug for injections?

  • Answer:

    The IP formula of S702901 is 3% DMSO+40% PEG+2% Tween-80+H2O, the concentration of which can be up to 5 mg/ml. And you must add solvents to the product in order and individually.

PARP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID