For research use only.
CAS No. 1623416-31-8
AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity.
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Choose Selective Dehydrogenase Inhibitors
|Description||AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity.|
AG-636 reveals a strong enrichment in sensitivity to a novel dihydroorotate dehydrogenase (DHODH) in cancer cell lines of hematologic versus solid tumor origin.
AG-636 results in robust tumor growth inhibition in xenograft lymphoma tumor models, with comparably poor activity in solid tumor models.
|In vitro||DMSO||35 mg/mL (101.92 mM)|
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|% DMSO % % Tween 80 % ddH2O|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03834584||Terminated||Drug: AG-636||Lymphoma||Agios Pharmaceuticals Inc.||May 24 2019||Phase 1|
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