Home MAPK ERK inhibitor ASN007

research use only

ASN007 ERK inhibitor

Cat.No.S9975

ASN007(ERAS 007, ERK-IN-3) is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with 2 nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations.
ASN007 ERK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 473.93

Jump to

Quality Control

Batch: S997501 DMSO]95 mg/mL]false]Ethanol]95 mg/mL]false]Water]Insoluble]false Purity: 99.05%
99.05

Solubility

In vitro
Batch:

DMSO : 95 mg/mL (200.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 95 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 473.93 Formula

C22H25ClFN7O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2055597-12-9 -- Storage of Stock Solutions

Synonyms ERAS 007,ERK-IN-3 Smiles CC1=CN=C(NC2CCOCC2)N=C1[N]3C=NC(=C3)C(=O)NC(CN)C4=CC(=CC(=C4)F)Cl

Mechanism of Action

Targets/IC50/Ki
ERK1/2
2 nM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04866134 Active not recruiting
Advanced or Metastatic Solid Tumors
Erasca Inc.
 May 7 2021 Phase 1|Phase 2
NCT03415126 Completed
Cancer|Malignancy|Neoplasia|Neoplasm|Neoplasm Metastasis|Colon Cancer|Colonic Neoplasms|Colon Cancer Liver Metastasis|Metastatic Cancer|Metastatic Melanoma|Metastatic Colon Cancer|Metastatic Lung Cancer|Non Small Cell Lung Cancer Metastatic|Pancreatic Cancer|Pancreas Cancer|Pancreas Adenocarcinoma|Pancreas Neoplasm|Metastatic Nonsmall Cell Lung Cancer|Metastatic Pancreatic Cancer
Asana BioSciences
 January 19 2018 Phase 1

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Signaling Pathway Map