Catalog No.S3175 Synonyms: LY 139603 HCl
Molecular Weight(MW): 291.82
Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
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|Description||Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.|
Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters. 
|In vivo||In microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold, but does not alter DAEX in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens.  Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression. |
|In vitro||DMSO||58 mg/mL (198.75 mM)|
|Ethanol||37 mg/mL (126.79 mM)|
|Water||2 mg/mL (6.85 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||LY 139603 HCl|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03460210||Recruiting||Drug: Atomoxetine||Obesity Morbid||Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital||November 2 2016||--|
|NCT01522404||Completed||Drug: Atomoxetine|Drug: Placebo||Mild Cognitive Impairment||Emory University|National Institute on Aging (NIA)||March 2012||Phase 2|
|NCT01709695||Completed||Drug: Guanfacine Hydrochloride XR|Drug: Placebo||ADHD|Attention Deficit Hyperactivity Disorder||Icahn School of Medicine at Mount Sinai||March 2011||Phase 4|
|NCT02014064||Completed||Drug: Atomoxetine|Other: Placebo||Continuous Methamphetamine Dependence|Methamphetamine Dependence in Remission||University of California Los Angeles||August 2009||Phase 1|
|NCT00529893||Unknown status||--||Attention Deficit Disorder With Hyperactivity||National Taiwan University Hospital|Eli Lilly and Company||July 2007||--|
|NCT00607568||Completed||Drug: Atomoxetine||Physiological Stress||Yale University|National Institute on Drug Abuse (NIDA)||June 2006||Phase 1|Phase 2|
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