Atomoxetine HCl

Catalog No.S3175 Synonyms: LY 139603 HCl

Atomoxetine HCl Chemical Structure

Molecular Weight(MW): 291.82

Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.

Size Price Stock Quantity  
In DMSO USD 140 In stock
USD 110 In stock
USD 370 In stock
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Biological Activity

Description Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
Targets
Norepinephrine (NE) transporter [1] 5-HT [1] DA transporter [1]
5 nM(Ki) 77 nM(Ki) 1451 nM(Ki)
In vitro

Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters. [1]

In vivo In microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold, but does not alter DAEX in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens. [1] Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression. [2][3]

Protocol

Solubility (25°C)

In vitro DMSO 58 mg/mL (198.75 mM)
Ethanol 37 mg/mL (126.79 mM)
Water 2 mg/mL (6.85 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 291.82
Formula

C17H21NO.HCl

CAS No. 82248-59-7
Storage powder
in solvent
Synonyms LY 139603 HCl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03460210 Recruiting Drug: Atomoxetine Obesity Morbid Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital November 2 2016 --
NCT01522404 Completed Drug: Atomoxetine|Drug: Placebo Mild Cognitive Impairment Emory University|National Institute on Aging (NIA) March 2012 Phase 2
NCT01709695 Completed Drug: Guanfacine Hydrochloride XR|Drug: Placebo ADHD|Attention Deficit Hyperactivity Disorder Icahn School of Medicine at Mount Sinai March 2011 Phase 4
NCT02014064 Completed Drug: Atomoxetine|Other: Placebo Continuous Methamphetamine Dependence|Methamphetamine Dependence in Remission University of California Los Angeles August 2009 Phase 1
NCT00529893 Unknown status -- Attention Deficit Disorder With Hyperactivity National Taiwan University Hospital|Eli Lilly and Company July 2007 --
NCT00607568 Completed Drug: Atomoxetine Physiological Stress Yale University|National Institute on Drug Abuse (NIDA) June 2006 Phase 1|Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID