Atomoxetine HCl

Catalog No.S3175 Synonyms: LY 139603 HCl

Atomoxetine HCl Chemical Structure

Molecular Weight(MW): 291.82

Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.

Size Price Stock Quantity  
In DMSO USD 140 In stock
USD 110 In stock
USD 370 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective 5-HT Receptor Inhibitors

Biological Activity

Description Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
Targets
Norepinephrine (NE) transporter [1] 5-HT [1] DA transporter [1]
5 nM(Ki) 77 nM(Ki) 1451 nM(Ki)
In vitro

Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters. [1]

In vivo In microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HTEX levels. Atomoxetine also increases DAEX concentrations in PFC 3-fold, but does not alter DAEX in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens. [1] Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression. [2][3]

Protocol

Solubility (25°C)

In vitro DMSO 58 mg/mL (198.75 mM)
Ethanol 37 mg/mL (126.79 mM)
Water 2 mg/mL (6.85 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 291.82
Formula

C17H21NO.HCl

CAS No. 82248-59-7
Storage powder
in solvent
Synonyms LY 139603 HCl

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03781765 Not yet recruiting ADHD|Attention Deficit Hyperactivity Disorder Icahn School of Medicine at Mount Sinai|National Institute on Drug Abuse (NIDA) April 2019 Phase 4
NCT03781765 Not yet recruiting ADHD|Attention Deficit Hyperactivity Disorder Icahn School of Medicine at Mount Sinai|National Institute on Drug Abuse (NIDA) April 2019 Phase 4
NCT03808740 Recruiting Orthostatic Intolerance Vanderbilt University Medical Center July 1 2018 Phase 1
NCT03808740 Recruiting Orthostatic Intolerance Vanderbilt University Medical Center July 1 2018 Phase 1
NCT03350659 Recruiting Neurogenic Orthostatic Hypotension Seoul National University Hospital|Kyung Hee University Hospital at Gangdong January 1 2018 Phase 4
NCT03350659 Recruiting Neurogenic Orthostatic Hypotension Seoul National University Hospital|Kyung Hee University Hospital at Gangdong January 1 2018 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

5-HT Receptor Signaling Pathway Map

Related 5-HT Receptor Products0

Tags: buy Atomoxetine HCl | Atomoxetine HCl supplier | purchase Atomoxetine HCl | Atomoxetine HCl cost | Atomoxetine HCl manufacturer | order Atomoxetine HCl | Atomoxetine HCl distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID