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AN-2718 Fungal inhibitor

Name: AN-2718
Brand: Selleck Chemicals
SKU: S3532
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3532

AN-2718, an inhibitor of fungal growth that blocks protein synthesis via the oxaborole tRNA trapping (OBORT) mechanism.

Chemical Structure

Molecular Weight: 168.39

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S353201 DMSO]34 mg/mL]false]Ethanol]34 mg/mL]false]Water]Insoluble]false Purity: 99.85%

99.85

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Chemical Information, Storage & Stability

Molecular Weight	168.39	Formula	C₇H₆BClO₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	174672-06-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	OB1OCC2=CC(=CC=C12)Cl

Solubility

In vitro
Batch:

DMSO : 34 mg/mL (201.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 34 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	AN2718 is a broad spectrum antifungal compound and inhibits leucyl-tRNA synthetase (LeuRS) by trapping tRNA-LEU in the editing active site, which prevents the synthesis of leucyl-tRNA-LEU, ultimately leading to a block in protein synthesis.^[2]
References	[1] https://pubmed.ncbi.nlm.nih.gov/22533461/ [2] https://idsa.confex.com/idsa/2008/webprogram/Paper27819.html

Tech Support

Handling Instructions

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