For research use only.
Catalog No.S1505 Synonyms: SQ 26776
CAS No. 78110-38-0
Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.
Selleck's Aztreonam has been cited by 2 publications
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|Description||Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.|
Aztreonam causes significant suppression of human colony forming unit-erythroid (cfu-e), burst forming unit-erythroid (bfu-e) and colony forming unit-granulocyte macrophage (cfu-gm) at both peak and trough serum concentrations in human bone marrow cells.  Aztreonam is hydrolyzed at measurable rates by class A beta-lactamases, a TEM-2 type penicillinase and the Proteus vulgaris cephalosporinase with a broad substraterange. Aztreonam is extremely stable as to the typical class C cephalosporinase of Citrobacter freundii, and acts as a competitive and progressive inhibitor for the beta-lactamase.  Aztreonam (AZT) combined with clindamycin (CLDM) has synergistic effects on Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Haemophilus influenzae, which are sensitive or quasi-sensitive to CLDM, in the presence of CLDM at MIC or sub-MIC.  Aztreonam reduces the cfu of some strains by 1 log unit without preserving the integrity of cystic fibrosis airway cell monolayers, while decreasing the biofilms of other clinical isolates by 4 log units and protecting the monolayers from being compromised. 
|In vivo||Aztreonam (300 mg/kg) results in a significant decrease in the content of hepatic microsomal P450, while no significant change is observed in hepatic cytochrome b5 content and NADPH-cytochrome c (P450) reductase activity. |
-  Charak BS, et al. J Antimicrob Chemother,?991, 27(1), 95-104.
-  Sakurai Y, et al. J Antibiot (Tokyo),?990, 43(4), 403-410.
-  Deguchi K, et al. Jpn J Antibiot,?991, 44(5), 529-537.
|In vitro||DMSO||87 mg/mL (199.8 mM)|
|Water||11 mg/mL (25.26 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04775238||Recruiting||Other: Silver nanoparticles|Other: Copper nanoparticles||Nosocomial Infections||Sohag University||February 27 2021||Not Applicable|
|NCT03696290||Active not recruiting||Drug: Aztreonam lysine|Other: Placebo||Bronchiectasis Adult||University of Dundee|Gilead Sciences||October 19 2019||Phase 2|
|NCT03867734||Completed||Drug: Aztreonam||Gonorrhea of Pharynx|Gonorrhea||University of Washington||April 5 2019||Phase 2|Phase 3|
|NCT02655419||Completed||Drug: ATM-AVI|Drug: Metronidazole||Complicated Intra-Abdominal Infections cIAIs||Pfizer|Innovative Medicines Initiative (IMI) COMBACTE-CARE||May 19 2016||Phase 2|
|NCT02449031||Active not recruiting||Drug: TOBI Podhaler|Drug: TOBI|Drug: Bethkis|Drug: Cayston||Pseudomonas Aeruginosa in Cystic Fibrosis||Mylan Inc.|Cystic Fibrosis Foundation||May 5 2015||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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