For research use only.

Catalog No.S1505 Synonyms: SQ 26776

2 publications

Aztreonam Chemical Structure

CAS No. 78110-38-0

Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.

Selleck's Aztreonam has been cited by 2 publications

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Biological Activity

Description Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.
In vitro

Aztreonam causes significant suppression of human colony forming unit-erythroid (cfu-e), burst forming unit-erythroid (bfu-e) and colony forming unit-granulocyte macrophage (cfu-gm) at both peak and trough serum concentrations in human bone marrow cells. [1] Aztreonam is hydrolyzed at measurable rates by class A beta-lactamases, a TEM-2 type penicillinase and the Proteus vulgaris cephalosporinase with a broad substraterange. Aztreonam is extremely stable as to the typical class C cephalosporinase of Citrobacter freundii, and acts as a competitive and progressive inhibitor for the beta-lactamase. [2] Aztreonam (AZT) combined with clindamycin (CLDM) has synergistic effects on Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Haemophilus influenzae, which are sensitive or quasi-sensitive to CLDM, in the presence of CLDM at MIC or sub-MIC. [3] Aztreonam reduces the cfu of some strains by 1 log unit without preserving the integrity of cystic fibrosis airway cell monolayers, while decreasing the biofilms of other clinical isolates by 4 log units and protecting the monolayers from being compromised. [4]

In vivo Aztreonam (300 mg/kg) results in a significant decrease in the content of hepatic microsomal P450, while no significant change is observed in hepatic cytochrome b5 content and NADPH-cytochrome c (P450) reductase activity. [5]


Solubility (25°C)

In vitro DMSO 87 mg/mL (199.8 mM)
Water 11 mg/mL (25.26 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 435.43


CAS No. 78110-38-0
Storage powder
in solvent
Synonyms SQ 26776
Smiles CC1C(C(=O)N1S(=O)(=O)O)NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(=N2)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04775238 Recruiting Other: Silver nanoparticles|Other: Copper nanoparticles Nosocomial Infections Sohag University February 27 2021 Not Applicable
NCT03696290 Active not recruiting Drug: Aztreonam lysine|Other: Placebo Bronchiectasis Adult University of Dundee|Gilead Sciences October 19 2019 Phase 2
NCT03867734 Completed Drug: Aztreonam Gonorrhea of Pharynx|Gonorrhea University of Washington April 5 2019 Phase 2|Phase 3
NCT02655419 Completed Drug: ATM-AVI|Drug: Metronidazole Complicated Intra-Abdominal Infections cIAIs Pfizer|Innovative Medicines Initiative (IMI) COMBACTE-CARE May 19 2016 Phase 2
NCT02449031 Active not recruiting Drug: TOBI Podhaler|Drug: TOBI|Drug: Bethkis|Drug: Cayston Pseudomonas Aeruginosa in Cystic Fibrosis Mylan Inc.|Cystic Fibrosis Foundation May 5 2015 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID