Ademetionine

Catalog No.S5109 Synonyms: AdoMet, S-Adenosylmethionine, SAMe

For research use only.

Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.

Ademetionine Chemical Structure

CAS No. 29908-03-0

Selleck's Ademetionine has been cited by 3 Publications

Purity & Quality Control

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Biological Activity

Description Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.
In vitro

Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA[1].

In vivo SAMe is able to cross the intestinal wall and increase plasma levels. Studies in rats reveal that absorption of the drug is much better after intraduodenal administration compared to oral administration. The systemic bioavailability after oral SAMe administration appears to be low. SAMe dose-dependently (12.5, 25, 50, 100 and 200 mg/kg sc.) decreases immobility time in the forced swimming test in mice and rats. Chronic treatment with SAMe is associated with an increase in density of b-receptors, and a decrease in the affinity of a1 adrenoceptors for phenylephrine in rat cerebral membranes[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 398.44
Formula

C15H22N6O5S

CAS No. 29908-03-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04199702 Recruiting Other: Same day discharge Atrial Fibrillation Massachusetts General Hospital December 2022 Not Applicable
NCT05359146 Not yet recruiting Drug: 161Tb-DOTA-LM3|Drug: 177Lu-DOTATOC Neuroendocrine Neoplasia''s (NENs)|Gastroenteropancreatic Neuroendocrine Tumour (GEP-NET) University Hospital Basel Switzerland|Swiss National Science Foundation|Paul Scherrer Institute (PSI) December 2022 Early Phase 1
NCT05470686 Not yet recruiting Biological: blood gas via arterial catheter Heart Surgery Central Hospital Nancy France October 2022 Not Applicable
NCT05279196 Not yet recruiting Other: Quadriceps microbiopsy and blood collection Muscle Injury University Hospital Montpellier September 2022 Not Applicable
NCT05132504 Not yet recruiting Drug: Pembrolizumab|Drug: Folfirinox Pancreatic Ductal Adenocarcinoma Baylor College of Medicine|Merck Sharp & Dohme LLC September 30 2022 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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