Ademetionine

Catalog No.S5109 Synonyms: AdoMet, S-Adenosylmethionine, SAMe

For research use only.

Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.

Ademetionine Chemical Structure

CAS No. 29908-03-0

Selleck's Ademetionine has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.
In vitro

Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA[1].

In vivo SAMe is able to cross the intestinal wall and increase plasma levels. Studies in rats reveal that absorption of the drug is much better after intraduodenal administration compared to oral administration. The systemic bioavailability after oral SAMe administration appears to be low. SAMe dose-dependently (12.5, 25, 50, 100 and 200 mg/kg sc.) decreases immobility time in the forced swimming test in mice and rats. Chronic treatment with SAMe is associated with an increase in density of b-receptors, and a decrease in the affinity of a1 adrenoceptors for phenylephrine in rat cerebral membranes[1].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 79 mg/mL
(198.27 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 398.44
Formula

C15H22N6O5S

CAS No. 29908-03-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04199702 Recruiting Other: Same day discharge Atrial Fibrillation Massachusetts General Hospital December 2022 Not Applicable
NCT05126082 Not yet recruiting Behavioral: PedsBP CDS Hypertension HealthPartners Institute|Essentia Health|Agency for Healthcare Research and Quality (AHRQ) July 2022 Not Applicable
NCT02703610 Not yet recruiting Drug: Oxycodone/acetaminophen|Drug: Ibuprofen/acetaminophen Pain Albany Medical College July 1 2022 Phase 4
NCT04252768 Not yet recruiting Drug: Eftilagimod Alpha|Drug: Paclitaxel Metastatic Breast Cancer Immutep S.A.S. June 2022 Phase 1
NCT05183633 Not yet recruiting -- Patients Susceptible to Falls Curbell Medical Products Inc. February 1 2022 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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