Catalog No. |
Product Name |
Information |
S6505 |
X-376 |
X-376 is an ALK inhibitor and potentially useful in non-small cell lung cancer. |
S6843 |
X-82 (Vorolanib) |
X-82 (Vorolanib, CM082) is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities. |
S6820 |
X-GAL |
X-GAL (BCIG) is a widely used chromogenic β-galactosidase substrate. β-galactosidase cleaves X-gal and produce an insoluble detectable blue compound. X-Gal is applied in blue-white selection of recombinant bacterial colonies with the lac+ genotype. |
E0644 |
X-PHOS |
X-PHOS is a palladium complex of phosphine ligand. |
E1167 |
X1 compound |
X1 compound binding reduces the conformational space of RepA, displaces cognate interacting protein factors (PRC2 and SPEN), suppresses histone H3K27 trimethylation, and blocks initiation of X-chromosome inactivation. |
S8989 |
Xanthatin |
Xanthatin is a sesquiterpene lactone isolated from Xanthium strumarium leaves, which can inhibit the nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STATs) signaling pathways. |
S4868 |
Xanthinol Nicotinate |
Xanthinol Nicotinate (Complamin, Angioamin) is a potent vasodilator that can easily pass through the cell membrane and once inside the cell it causes an increase in glucose metabolism resulting in an increased energy. |
E3074 |
Xanthium Sibiricum Extract |
|
E2231 |
Xanthoangelol |
Xanthoangelol, extracted from Angelica keiskei, which suppresses obesity-induced inflammatory responses, and possesses antibacterial activity. |
S7889 |
Xanthohumol |
Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1. |
S2372 |
Xanthone |
Xanthone (Genicide) is an organic compound, which can be prepared by the heating of phenyl salicylate. |
S5677 |
Xanthopterin Hydrate |
Xanthopterin, isolated from butterfly wings and found in many other sources, replace folic acid in the nutrition of many animal species. |
E2181 |
Xanthopurpurin |
|
S9369 |
Xanthosine |
Xanthosine (Xanthine riboside) is an intermediate in purine metabolism, formed from IMP, and forming GMP. |
S9174 |
Xanthotoxol |
Xanthotoxol (8-Hydroxypsoralen, 8-Hydroxypsoralene, 8-Hydroxyfuranocoumarin, Psoralen), a biologically active linear furocoumarin found in a large number of plants, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects. |
S4781 |
Xanthoxyline |
Xanthoxylin (Brevifolin), isolated from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree), is a cytotoxic and fungicidal compound with the characteristics of a typical phytoalexin. |
S4774 |
Xanthurenic Acid |
Xanthurenic acid (xanthurenate, 8-Hydroxykynurenic acid, 4,8-Dihydroxyquinaldic acid), a molecule arising from tryptophan metabolism by transamination of 3-hydroxykynurenine, activates mGlu2/3 Metabotropic glutamate receptors (mGlu2 and mGlu3). |
E2474 |
Xanthyletin |
Xanthyletin is a coumarin isolated from Citrus, with anti-tumor, anti-fungus and anti-bacterial activities. |
S1180 |
XAV-939 |
XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β. |
S0407 |
XCT790 |
XCT-790 (Compound 12) is a potent and selective inverse agonist for estrogen-related receptor α (ERRα) with IC50 of 0.37 μM. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ. XCT-790 (Compound 12) significantly inhibits in vivo tumor growth and angiogenesis, and induces apoptosis. |
S0395 |
XD14 |
XD14 is an inhibitor of BET bromodomain with Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively. XD14 also inhibits BRDT(1), CBP, p300 and BRDT(2) with Kd of 1.2 μM, 1.6 μM, 2.6 μM and 3.7 μM, respectively. |
S2967 |
XE991 dihydrochloride |
XE 991 (LS190926) dihydrochloride is a blocker of Kv7 (KCNQ) channels that potently inhibits KCNQ1 (Kv7.1), KCNQ2 (Kv7.2), KCNQ2 + KCNQ3 (Kv7.3) channel, and M-current with IC50 of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively. |
P1130 |
Xenin |
Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.
|
S2754 |
Xevinapant (AT406) |
Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1. |
S5076 |
Xipamide |
Xipamide is a sulfonamide-based diuretic as well as a saluretic with antihypertensive activity. |
S7036 |
XL019 |
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1. |
E0142 |
XL092 |
XL092 (JUN04542) is an ATP-competitive inhibitor of multiple RTKs including MET, VEGFR2, AXL and MER, with IC50 values of 15 nM, 1.6 nM, 3.4 nM, and 7.2 nM in cell-based assays, respectively.
|
S1118 |
XL147 analogue |
XL147 analogue (SAR245408) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. XL147 analogue induces apoptosis. Phase 1/2. |
S8967 |
XL177A |
XL177A is a potent, selective and irreversible inhibitor of Ubiquitin specific peptidase 7 (USP7) with IC50 of 0.34 nM. |
S1272 |
XL228 |
XL228 is a protein kinase inhibitor with IC50 of 5 nM, 1.4 nM, 3.1 nM, 1.6 nM, 6.1 nM and 2 nM for wild-type ABL kinase, ABL T315I, Aurora A, IGF-1R, SRC and LYN, respectively. |
S7035 |
XL388 |
XL388 is a highly potent, selective, ATP-competitive inhibitor of mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases. |
S7547 |
XL413 (BMS-863233) |
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2.
|
S7122 |
XL888 |
XL888 is an ATP-competitive inhibitor of HSP90 with IC50 of 24 nM. Phase 1. |
S0177 |
XMD-17-51 |
XMD-17-51 (XMD17-51) is a potent and highly selective inhibitor of NUAK1. |
S0726 |
XMD8-85 (ERK5-IN-1) |
XMD8-85 (ERK5-IN-1) is a selective and potent inhibitor of ERK5 and LRRK2 with IC50s of 0.162 μM and 0.339 μM, respectively. |
S8272 |
XMD8-87 |
XMD8-87 is a novel tyrosine kinase nonreceptor 2(TNK2) inhibitor with IC50s of 38 nmol/L and 113 nmol/L for the D163E and R806Q mutations. |
S7525 |
XMD8-92 |
XMD8-92 is a potent and selective dual inhibitor of big map kinase (BMK1, ERK5) and bromodomain-containing proteins (BRDs, BET) with Kd of 80 nM and 170 nM for ERK5 and BRD4(1), respectively. |
S8334 |
XMU-MP-1 |
XMU-MP-1 is an inhibitor of MST1/2 with IC50 values of 71.1±12.9 nM and 38.1±6.9 nM against MST1 and MST2, respectively. |
S0875 |
XP-59 |
XP-59 is a potent inhibitor of the SARS-CoV Mpro, with a Ki of 0.1 μM. |
S8756 |
XRK3F2 |
XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. |
S0184 |
XY1 |
XY1 is an inactive, close analog of SGC707 that can be used as the negative control for SGC707. SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively. |
S5564 |
Xylazine |
Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. |
S2516 |
Xylazine HCl |
Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant. |
S4546 |
Xylitol |
Xylitol (Adonitol, Ribitol, Xylite, D-Xylitol, Adonite) is a sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener. |
S3253 |
Xylobiose |
Xylobiose (1,4-β-D-Xylobiose, 1,4-D-Xylobiose), a disaccharide of xylose monomers, is a natural substrate that can be hydrolysed by Beta-D-Xylosidase/alpha-L-arabinofuranosidase from Selenomonas ruminantium (SXA). |
S5854 |
Xylometazoline |
Xylometazoline (Ba-11391, Otrivine, Rhinoxilin) is a nasal vasoconstricting decongestant drug which is used to improve symptoms of nasal congestion, allergic rhinitis, and sinusitis. |
S2576 |
Xylometazoline HCl |
Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. |
S2124 |
Xylose |
Xylose is a sugar first isolated from wood. |
S0934 |
Xylotetraose |
Xylotetraose is a hydrolysis product of Xylan that can be used for enzyme biochemical analysis. Xylan is a polysaccharide made from units of xylose and contains predominantly β-D-xylose units linked as in cellulose. |
S3252 |
Xylotriose |
Xylotriose (1,4-b-D-Xylotriose, 1,4-beta-D-xylotriose) is a natural xylooligosaccharide substrate that can be hydrolysed by catalytically efficient beta-D-xylosidase from Selenomonas ruminantium (SXA). |