AMG-9810

Catalog No.S6934

For research use only.

AMG-9810 is potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.

AMG-9810 Chemical Structure

CAS No. 545395-94-6

Purity & Quality Control

Choose Selective TRP Channel Inhibitors

Biological Activity

Description AMG-9810 is potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.
Targets
TLR2 [2] TLR4 [2] hTRPV1 [1]
(Cell-free assay)
rTRPV1 [1]
(Cell-free assay)
24.5 nM 85.6 nM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 337.41
Formula

C21H23NO3

CAS No. 545395-94-6
Storage 3 years -20°C powder
2 years -80°C in solvent

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