research use only

AZD1656 Carbohydrate Metabolism activator

Name: AZD1656
Brand: Selleck Chemicals
SKU: E1353
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1353

AZD1656 is a potent, selective and orally active activator of glucokinase. This compound has the potential for type 2 diabetes research.

Chemical Structure

Molecular Weight: 478.50

Jump to

Quality Control

Batch: E135301 DMSO]96 mg/mL]false]Ethanol]96 mg/mL]false]Water]Insoluble]false Purity: 99.03%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS
Datasheet

99.03

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Mitochondrial Metabolism Drug Metabolite
Other Carbohydrate Metabolism Inhibitors	2-DG (2-Deoxy-D-glucose) Lonidamine Bromopyruvic acid (3-BP) LY2608204 1-Deoxynojirimycin Dorzagliatin 4',7-Dimethoxy-5-Hydroxyflavone Voglibose BI-9787 Eleutherol

Solubility

In vitro
Batch:

DMSO : 96 mg/mL (200.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 96 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	478.50	Formula	C₂₄H₂₆N₆O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	919783-22-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/24753370/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01221545	Completed	Type 2 Diabetes Mellitus	AstraZeneca	October 2010	Phase 1
NCT01221519	Completed	Type 2 Diabetes Mellitus\|High Blood Sugar	AstraZeneca	September 2010	Phase 1
NCT01103622	Completed	Type 2 Diabetes Mellitus	AstraZeneca	June 2010	Phase 1
NCT01103609	Completed	Type 2 Diabetes Mellitus	AstraZeneca	April 2010	Phase 1
NCT01095991	Completed	Type 2 Diabetes Mellitus	AstraZeneca	March 2010	Phase 1
NCT01096940	Completed	Type 2 Diabetes Mellitus	AstraZeneca	March 2010	Phase 1

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):