Home Immunology & Inflammation NOS inhibitor Aminoguanidine hydrochloride For research use only.

Aminoguanidine hydrochloride

Synonyms: Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine

Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.

Aminoguanidine hydrochloride Chemical Structure

Aminoguanidine hydrochloride Chemical Structure

CAS: 1937-19-5

Selleck's Aminoguanidine hydrochloride has been cited by 7 publications

Purity & Quality Control

Batch: S454801 DMSO] 22 mg/mL] false] Water] 22 mg/mL] false] Ethanol] Insoluble] false Purity: 98.19%
98.19

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Biological Activity

Description Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.
Targets
Diamine oxidase [1] NOS [2] advanced glycation end products (AGE) [3]
In Vivo
In vivo Aminoguanidine ameliorates neonatal hypoxic-ischemic brain damage and that temporal profiles of NO correlated with the neuroprotective effect of aminoguanidine. Neuroprotection by AG is attributable to suppression of NO produced by iNOS after the end of the hypoxic period, during the reoxygenation phase. The half-life of AG is estimated to be between 6 and 8 h in vivo and approximately 4.4 h in human with normal renal function.AG is also an inhibitor of the formation of advanced glycation end products. Systematically administered advanced glycation end product–modified BSA increases cerebral infarct size in an adult rat, which is attenuated by AG[2].
Animal Research Animal Models Wister rat pups 
Dosages 300 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 110.55 Formula

CH6N4.HCl
CAS No. 1937-19-5 SDF Download Aminoguanidine hydrochloride SDF
Smiles C(=NN)(N)N.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 22 mg/mL ( (199.0 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 22 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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