For research use only.
Catalog No.S0354 Synonyms: Alp, 9-Nitropaullone, NSC 705701
CAS No. 237430-03-4
Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.
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|Description||Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.|
|Synonyms||Alp, 9-Nitropaullone, NSC 705701|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03744663||Suspended||Drug: Suboxone® SL|Drug: Sublocade®||Opioid Use||Wake Forest University Health Sciences||June 2022||Phase 2|
|NCT05033145||Not yet recruiting||Drug: AZVUDINE|Drug: AZVUDINE placebo||COVID-19||HRH Holdngs Limited|GALZU INSTITUTE OF RESEARCH TEACHING APPLIED SCIENCE AND TECHNOLOGY Brazil|SANTA CASA DE MISERICORDIA DE CAMPOS HOSPITAL (SCMCH) Brazil|UNIVERSIDADE ESTADUAL DO NORTE FLUMINENSE (UENF) Brazil||October 2021||Phase 3|
|NCT04783428||Recruiting||Other: No intervention||Tumor-induced Osteomalacia (TIO)||Ultragenyx Pharmaceutical Inc||September 2021||--|
|NCT04908826||Recruiting||Procedure: Indocyanine Green (ICG) administration||Laparoscopic; Cholecystectomy|Cholelithiasis; Bile Duct|Choledocholithiasis|Stone - Biliary|Post-Op Complication|Cholangiography|Indocyanine Green|Intraoperative Complications|Bile Duct Injury||Aristotle University Of Thessaloniki|George Papanicolaou Hospital||September 1 2021||Not Applicable|
|NCT05011370||Not yet recruiting||--||Intestinal Failure-associated Liver Disease||Protara Therapeutics||August 13 2021||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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