Alsterpaullone

Catalog No.S0354 Synonyms: Alp, 9-Nitropaullone, NSC 705701

For research use only.

Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.

Alsterpaullone Chemical Structure

CAS No. 237430-03-4

Purity & Quality Control

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Biological Activity

Description Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.
Targets
caspase-9 [2]
()
GSK-3α [1]
(Cell-free assay)
GSK-3β [1]
(Cell-free assay)
CDK2/cyclin A [1]
(Cell-free assay)
CDK1/cyclin B [1]
(Cell-free assay)
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4 nM 4 nM 15 nM 35 nM

Protocol (from reference)

Chemical Information

Molecular Weight 293.28
Formula
C16H11N3O3
CAS No. 237430-03-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-]

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03744663 Suspended Drug: Suboxone® SL|Drug: Sublocade® Opioid Use Wake Forest University Health Sciences June 2022 Phase 2
NCT05130346 Not yet recruiting Behavioral: Mindfulness Based Stress Reduction (MBSR) Non-Alcoholic Fatty Liver Disease|Fatty Liver Nonalcoholic|Obesity Virginia Commonwealth University January 2022 Not Applicable
NCT05147090 Not yet recruiting Drug: Empagliflozin 10 MG|Drug: Placebo pills Chronic Hepatitis b|NAFLD|Cirrhosis|Fibrosis Liver|Empagliflozin|SGLT2 Inhibitors The University of Hong Kong|Research Grant Council January 2 2022 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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