1-Aminobenzotriazole

For research use only.

Catalog No.S6886 Synonyms: ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987

1-Aminobenzotriazole Chemical Structure

CAS No. 1614-12-6

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

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Biological Activity

Description 1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
Targets
P450 [1]
()
NAT [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 27 mg/mL (201.28 mM)
Water 27 mg/mL (201.28 mM)
Ethanol 27 mg/mL (201.28 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 134.14
Formula
C6H6N4
CAS No. 1614-12-6
Storage powder
in solvent
Synonyms ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04006353 Not yet recruiting Drug: ABT|Drug: RIF Drug Interaction Shanghai Public Health Clinical Center July 2019 Phase 4
NCT03058198 Unknown status Diagnostic Test: 89Zr-ABT806 PET Glioma Huashan Hospital January 2017 Not Applicable
NCT02478320 Active not recruiting Drug: Ilorasertib Advanced Cancers M.D. Anderson Cancer Center|AbbVie August 5 2016 Phase 2
NCT02052349 Completed Drug: ABT-333 Relative Bioavailability AbbVie November 2013 Phase 1
NCT01495351 Completed Drug: ABT-888/Bortezomib Multiple Myeloma AHS Cancer Control Alberta|Tom Baker Cancer Centre|Abbott October 2011 Phase 1
NCT03891303 Completed Other: Allogenic blood transfusion (ABT) Blood Transfusion Clinic for Cardiovascular Diseases Magdalena January 1 2011 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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P450 (e.g. CYP17) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID