1-Aminobenzotriazole

Catalog No.S6886 Synonyms: ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987

For research use only.

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

1-Aminobenzotriazole Chemical Structure

CAS No. 1614-12-6

Purity & Quality Control

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Biological Activity

Description 1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
Targets
P450 [1] NAT [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 134.14
Formula
C6H6N4
CAS No. 1614-12-6
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05532696 Recruiting Drug: ABT-101 Advanced Solid Tumor|Non Small Cell Lung Cancer|HER2 Mutations Anbogen Therapeutics Inc. September 2022 Phase 1|Phase 2
NCT05449249 Not yet recruiting Procedure: Long-term fasting Healthy|Periodontitis Buchinger Wilhelmi Development & Holding GmbH|Buchinger Wilhelmi Clinic|University of Geneva Switzerland|King''s College London|ETH Zurich (Switzerland) September 1 2022 Not Applicable
NCT04053569 Active not recruiting Dietary Supplement: Table Grape supplement Metabolic Syndrome Protection Against Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis October 1 2019 Not Applicable
NCT04006353 Completed Drug: ABT|Drug: RIF Drug Interaction Shanghai Public Health Clinical Center July 11 2019 Phase 4
NCT03935022 Completed Other: Rice Healthy University of Milan March 6 2019 Not Applicable
NCT03719664 Recruiting Drug: Albuvirtide|Drug: 3BNC117|Drug: Baseline ART HIV-1-infection Frontier Biotechnologies Inc. December 17 2018 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-11-29)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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