Name: 1-Aminobenzotriazole
Brand: Selleck Chemicals
SKU: S6886

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

1-Aminobenzotriazole Chemical Structure

CAS: 1614-12-6

Purity & Quality Control

Batch: S688601 DMSO] 27 mg/mL] false] Water] 27 mg/mL] false] Ethanol] 27 mg/mL] false Purity: 99.99%

99.99

1-Aminobenzotriazole Related Products

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Signaling Pathway

P450 (e.g. CYP17) Signaling Pathway

Choose Selective P450 (e.g. CYP17) Inhibitors

Biological Activity

Description

1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).

Targets

P450 ^[1]

NAT ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05532696	Recruiting	Advanced Solid Tumor\|Non Small Cell Lung Cancer\|HER2 Mutations	Anbogen Therapeutics Inc.	September 27 2022	Phase 1\|Phase 2
NCT05449249	Completed	Healthy\|Periodontitis	Buchinger Wilhelmi Development & Holding GmbH\|Buchinger Wilhelmi Clinic\|University of Geneva Switzerland\|King''s College London\|ETH Zurich (Switzerland)	September 1 2022	Not Applicable
NCT06108869	Suspended	Chronic Spontaneous Urticaria	Royal College of Surgeons Ireland	June 1 2022	Not Applicable
NCT04053569	Active not recruiting	Metabolic Syndrome Protection Against	Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis	October 1 2019	Not Applicable
NCT04006353	Completed	Drug Interaction	Shanghai Public Health Clinical Center	July 11 2019	Phase 4
NCT03935022	Completed	Healthy	University of Milan	March 6 2019	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	134.14	Formula	C₆H₆N₄
CAS No.	1614-12-6	SDF	--
Smiles	N[N]1N=NC2=CC=CC=C12
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 27 mg/mL ( (201.28 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 27 mg/mL

Ethanol : 27 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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