|| o-Toluic acid
||o-Toluic acid (2-methylbenzoic acid, Orthotoluic acid) is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite.
||Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates.
||1,2,3,4,6-O-Pentagalloylglucose is the pentagallic acid ester of glucose. It could be used for precipitating proteins.
||1-Octacosanol (n-Octacosanol, Octacosyl alcohol, Octanosol, Montanyl alcohol, Cluytyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is used as a nutritional supplement. It is reported to possess cholesterol-lowering effects, antiaggregatory properties, cytoprotective use, and ergogenic properties.
12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of <i>Salvia microphylla</i>, is an active constituent of 5α-reductase inhibition with an IC<sup>50</sup> value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity.
2"-O-Galloylhyperin, an active compound isolated from Pyrola incarnate Fisch., possesses anti-oxidative and anti-inflammatory activities. 2"-O-Galloylhyperin has hepatoprotective effect against oxidative stress-induced liver damage.
2"-O-beta-L-galactopyranosylorientin is extracted from the flowers of Trollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug resistance protein 2 (MRP2).
2''-O-Rhamnosylicariside II is a flavonoid glycoside compound and might be beneficial for improving postmenopausal osteoporosis.
||22-Oxybis(ethylamine) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||2-O-α-D-Glucopyranosyl-l-ascorbic acid (AA-2G), which is a glucoside derivative of ascorbic acid (AA), shows vitamin C activity after enzymatic hydrolysis to ascorbic acid. The antitumor activity of AA-2G is caused by ROS generated by AA released by rapid hydrolysis of AA-2G.
2-O-β-D-Glucopyranosyl-L-ascorbic acid (AA-2βG), a bioactive compound isolated from Lycium fruit, is a stable vitamin C analog with anti-tumor activity.
||2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.
||2-Oxo-3-phenylpropanoic acid (Phenylpyruvic acid) is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase.
||2-Oxobutanoic acid (2-Oxobutyrate, 2-ketobutyric acid, 2-oxobutyric acid, alpha-ketobutyric acid, α-ketobutyric acid) is a substance that is involved in the metabolism of many amino acids as well as propanoate metabolism and C-5 branched dibasic acid metabolism.
||2OH-BNPP1 is an inhibitor of the kinase activity of BUB1 (budding uninhibited by benzimidazoles-1, BUB1 Mitotic Checkpoint Serine/Threonine Kinase) that can be used for the treatment of cancer.
||2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside.
||3,29-O-dibenzoyloxykarounidiol is a triterpenoid isolated from Trichosanthes kirilowii Maxim.
3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor.
||3-O-Acetyl-11-keto-β-boswellic acid (AKBA)
||3-O-Acetyl-11-keto-β-boswellic acid (AKBA), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.
3-O-Acetyloleanolic acid (3AOA), an oleanolic acid extracted from seeds of Vigna sinensis K., induces apoptosis of cancer cells and has the effect of anti-angiogenesis.
||3-O-Caffeoylquinic acid methyl ester
||3-O-Caffeoylquinic acid methyl ester is a chemical constituent of Pyrrosia calvata.
3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis, with IC50 ranging from 1.6-86.9 μM for PDE isozymes (PDE1-5).
||3-Oxopentanedioic acid (1,3-Acetonedicarboxylic acid; 3-Oxoglutaric acid) is an intermediate for organic compound synthesis.
4'-O-Methylbavachalcone is a chalcone separated from Psoralea corylifolia, possessing the inhibiting activity on severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro).
4-O-galloylalbiflorin discovered from Paeonia lactiflora Pall, is a potential β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor.4-O-GA could selectively inhibit the activity of BACE1 with IC50 5.11 ± 0.73 µM.
||4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs.
5-O-Caffeoylshikimic acid can be used in the study for non small cell lung cancer (NSCLC).
5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and <b>tyrosinase</b> inhibitory activities.
5-O-Methylvisamminol, a (furo) chromone identified in the extract of <i>T. glauca</i>, has a limited occurrence in the plant kingdom.
||5-O-Methylvisammioside is a naturally occuring product isolated from Saposhnikovia Divaricata and has analgesic, antipyretic, anti-inflammatory and anti-platelet aggregation effects.
6''-O-apiosyl-5-O-Methylvisammioside is one of the components of the traditional Chinese medicine Kang-Jing.
6''-O-Malonylgenistin is an isoflavone derivative.
||6'-O-galloylalbiflorin is a natural androgen receptor antagonists, with a strong androgen receptor binding
||6'-O-β-D-Glucosylgentiopicroside is a secoiridoid isolated from the roots of G. straminea, which strongly suppresses N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide generation.
||6-OAU (GTPL5846, 6-n-octylaminouracil) is a surrogate agonist of G protein-coupled receptor 84 (GPR84) that activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with EC50 of 105 nM in the PI assay. 6-OAU (GTPL5846, 6-n-octylaminouracil) increases [35S]GTPγS incorporated in Sf9 cell membranes expressing human GPR84-Gαi fusion protein with EC50 of 512 nM.
7-O-Methylaloeresin A is a 5-methylchromone glycoside isolated from Commiphora socotrana (Burseraceae), which exhibits good activity against multiple drug resistant Staphylococcus aureus (NCTC 11994) and Salmonella typhimurium (ATCC 1255), also possesses antioxidant activities.
||7-O-Methylbaicalein (Negletein) is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 and 10.8 μM, respectively.
7-O-Methylmangifer is isolated from the cortexes of <i>Polygala tenuifolia</i>.
||8-O-acetyl shanzhiside methyl ester
||8-O-acetyl shanzhiside methyl ester (Barlerin, ND01), isolated from the leaves of Lamiophlomis rotata Kudo, promotes angiogenesis, which leads to the improvement of functional outcome after stroke.8-O-Acetyl shanzhiside methyl ester can inhibts NF-κB.
8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease.
||O-304 (O-304X) is an orally available pan-activator of AMPK activated protein kinase (AMPK). O-304 (O-304X) exhibits a great potential as a novel drug to treat type 2 diabetes (T2D) and associated cardiovascular complications.
||O-3M3FBS, the negative control of m-3M3FBS, inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner, reversibly inhibits delayed rectifier K+ channels, increases in [Ca2+](i) in an agonistic manner with m-3M3FBS.
||O-Acetyl-L-carnitine (Acetyl-L-carnitine, O-acetyl-L-carnitine, O-Acetylcarnitine) can be synthesis or is naturally found in healthy humans. It could help transport fatty acids into the mitochondrial matrix where fatty acid metabolism occurs.
O-Acetyl-L-serine (OAS, O-Acetylserine, O-Acetyl-L-serine) hydrochloride (HCl) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants that displays a signalling function leading to changes in transcript levels of a specific gene set irrespective of the sulfur status of the plant.
O-acetylgalanthamine, one of acetylated alkaloids, is reported for the first time as a natural product isolated from <i>Narcissus pseudonarcissus</i> in 1995.
||O-Acetylserine is an intermediate in the biosynthesis of the common amino acid cysteine in bacteria and plants.
||o-Cresol is a widely used intermediate in the production of other chemicals which is highly toxic to both fauna and flora. o-Cresol is one of the key volatile phenolic components of wine, beechwood creosote, hardwood sawdust smoke and a flavor component of red meat. o-cresol (2-methyl phenol) is highly toxic to both fauna and flora.
||O-Desmethyl gefitinib, a major active metabolite of gefitinib, is a potent EGFR (ErbB1/HER1) inhibitor, inhibits subcellular EGFR tyrosine kinase through a mechanism similar to that of gefitinib with IC50 values of 36 and 22 nM, respectively.
O-Demethylgalanthamine is galanthamine-type alkaloid, which is an acetylcholinesterase (AChE) inhibitor.
||o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.
||O-Phospho-L-serine (Dexfosfoserine), a molecule that mimics the phosphatidylserine head group and partially blocks microglial phagocytosis of apoptotic cells, is a specific group III metabotropic glutamate receptor (mGluR) agonist.
||Phosphoethanolamine (PE) is a phosphomonoester metabolite of the phospholipid metabolism.
||o-Veratraldehyde (2,3-Dimethoxybenzaldehyde) is used as the materials for the organic synthesis intermediates.
||O4I1 is a potent Oct3/4 inducer.
||O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
||OAC1 (Oct4-activating compound 1, BAS 00287861) can enhance the efficiency of reprogramming. OAC1 can activate both Oct4 and Nanog promoter-driven luciferase reporter genes.
||OAC-2 is an Octamer-binding transcription factor 4 (OCT4) activator, enhancing iPSC reprogramming efficiency.
||Obacunone (AI3-37934, CCRIS 8657), a natural compound present in citrus fruits, has been demonstrated for various biological activities including anti-cancer and anti-inflammatory properties. It significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM; also a novel activator of Nrf2.
Obatoclax (GX15-070) is an antagonist of Bcl-2 with an Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.
||Obatoclax Mesylate (GX15-070)
||Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
||Obesity Compound Library
||A unique collection of 929 compounds used for research in obesity.
Obestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. Obestatin(human) can be used for weight loss.
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities.
||Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.
||Obinutuzumab (anti-CD20) (Gazyva, GA101, Gazyvaro, Afutuzumab) is a novel, type II, glycoengineered, humanized anti-CD20 monoclonal antibody that has been developed for lymphocytic leukemia and lymphoma of B-cell origin. MW : 146.1 kD.
Obtusifoliol is a natural product found in <i>Euphorbia chamaesyce</i> or <i>Euphorbia nicaeensis</i>.
||Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a ki of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression.
||OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM. Phase 2.
||Ocimum sanctum Extract
||Oclacitinib maleate (PF-03394197) is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. It does not inhibit a panel of 38 non-JAK kinases.
||Octaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Octaethylene glycol monomethyl ether
||Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
Octahydrocurcumin is a hydrogenated derivatives of curcumin. Octahydrocurcumin can inhibit OKT3-induced PBMC proliferation with IC50 of 82 μM. Octahydrocurcumin has a strong effect on radical scavenging with IC50 values of 12.3 mM.
||Octanedioic acid (Suberic acid) is a dicarboxylic acid used in drug syntheses and plastics manufacture.
||Octanoic acid (caprylic acid) is found naturally in the milk of various mammals, and as a minor constituent of coconut oil and palm kernel oil. It is used in the production of esters used in perfumery and also in the manufacture of dyes.
||Octenidine, a cationic surfactant, is active against gram-positive and gram-negative bacteria.
||Octinoxate (Octyl methoxycinnamate, ethylhexyl methoxycinnamate) is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage.
||Octisalate (Ethylhexyl Salicylate, Octyl salicylate) is an organic compound used as an ingredient in sunscreens and cosmetics to absorb UVB (ultraviolet) rays from the sun.
||Octocrylene is an organic compound used as an ingredient in sunscreens and cosmetics.
||Octodrine (2-Amino-6-methylheptan, 1,5-Dimethylhexylamine) is a stimulant drug that can increase blood pressure and cardiac output in animals.
||Octreotide (SMS 201-995) acetate
||Octreotide (SMS 201-995) acetate is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.
||Octyl gallate (Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester), a widely used food additive, shows antimicrobial and antioxidant activity.
||Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.
||ODM-203 is a selective inhibitor of FGFR and VEGFR with ic50s of 11 nM,16 nM,6 nM, 35 nM,26 nM,9 nM,5 nM for recombinant FGFR1, FGFR2, FGFR3,FGFR4, VEGFR1, VEGFR2 and VEGFR3, respectively.
||ODM-207 is a potent and selective BET inhibitor that is structurally unrelated to the benzodiazepine. ODM-207 also shows potent antiproliferative effects in patient-derived cancer cells and in xenograft models.
||ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells.
||Oenothera Biennis Extract
||OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with Kd of 100 nM and 500 nM, respectively.
||Ofloxacin (DL8280) is a synthetic broad-spectrum antimicrobial agent.
||OGG1-IN-08 (O8 OGG1 Inhibitor-Bio-X) is a potent inhibitor of 8-oxoguanine DNA glycosylase-1 (OGG1) with IC50 of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1.
||Oglufanide (H-Glu-Trp-OH, L-Glutamyl-L-tryptophan), a dipeptide immunomodulator isolated from calf thymus, inhibits vascular endothelial growth factor (VEGF), also stimulates the immune response to hepatitic C virus (HCV) and intracellular bacterial infections.
||OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM.
||Oil Red O
||Oil red O (ORO) is a commonly used dye for the tissue staining, which recognizes nitroglycerin and cholesterol esters. Oil red O can be fluorescently lighted up upon meeting dsDNA with emission peak localized at 600 nm, although it almost does not fluoresce by itself.
OJV-VI is isolated from <i>ophiopogonis</i>.
Okanin, the effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways.
||Okra fruit Extract
Okra fruit extract (Abelmoschus esculentus fruit extract), isolated from the fruits of <i>Abelmoschus esculentus</i>, is used as an alternative treatment because of its various medicinal properties, such as antidiabetic, antioxidant, antiplasmodial, antibacterial, anticancer, analgesic, antidiarrheal, and anti-inflammatory properties.
||Olanexidine Hydrochloride semihydrate
||Olanexidine (OPB-2045, OPB-2045G) is a monobiguanide compound with bactericidal activity.
||Olanzapine (LY170053) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.
||Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.
||Olaquindox (Bisergon, Bayernox, Bayonox, Olachindox) is an oral anti-bacterial agent used as an additive to animal food.
||Oleandrin (PBI-05204, Foliandrin, Neriolin, Neriostene, Folinerin, Corrigen, Neriol) is an inhibitor of Na+/K+-ATPase with IC50 of 0.62 μM. Oleandrin induces apoptosis and reduces migration of human glioma cells in vitro.
||Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.
||Oleanonic Acid (3-Ketooleanolic Acid, 3-Oxooleanolic acid), extracted from Pistacia terebinthus galls, is a cell cycle inhibitor and used as antitumor agents.
||Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid) is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.
||Olesoxime (TRO 19622)
Olesoxime (TRO19622) is a novel, orally active and CNS-penetrant mitochondrial-targeted neuroprotective compound.
||Oleuropein is an antioxidant polyphenol isolated from olive leaf. Oleuropein exerts antioxidant, anti-inflammatory and anti-atherogenic effects and suppresses the adipocyte differentiation in vitro. Oleuropein inhibits PPARγ activity. Oleuropein exerts anti-adipogenic effect through direct inhibition of PPARγ transcriptional activity. Oleuropein also inhibits aromatase. Oleuropein induces apoptosis. Phase 2.
||Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.
||Olitigaltin (TD-139, GB0-139) is a potent and selective inhibitor of galectin-3 with Kd of 0.036 µM over galectin-1 and galectin-7 with Kd of 2.2 µM and 32 µM, respectively. TD-139 is used potentially for the treatment of idiopathic pulmonary fibrosis (IPF).
||Olive oil comes from the fruits of Olea europae trees with a beneficial effect on human health, including the antioxidant activity and anti-inflammatory activity when olive oil is in regular diet.
||Olivetol (5-Pentylresorcinol, 5-n-Amylresorcinol) is a naturally occurring organic compound being a precursor in various syntheses of tetrahydrocannabinol. It acts as a competitive inhibitor of the cannabinoid receptors CB1 and CB2.
||Olmesartan (RNH-6270) is an an angiotensin 2 receptor antagonist with antihypertensive activity.
||Olmesartan Medoxomil (CS-866) is a selective angiotensin II type 1 (AT(1)) receptor antagonist, used in the treatment of high blood pressure.
||Olmutinib (BI 1482694)
||Olmutinib (BI 1482694) is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI). Also a potent inhibitor of Bruton's tyrosine kinase.
||Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R). Olodanrigan (EMA401) analgesic action appears to involve the inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
||Olodaterol (BI 1744)
||Olodaterol (BI 1744) is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD).
||Olodaterol hydrochloride (BI-1744) is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist.
||Olopatadine HCl is a histamine blocker and mast cell stabilizer with an IC50 of 559 μM for the release of histamine.
||Olprinone is a phosphodiesterase III (PDE3) inhibitor with IC50 values of 0.35 mM, 150 mM and 100 mM for human cardiac PDE III, PDE I and PDE II, respectively.
||Olsalazine Sodium is an anti-inflammatory prodrug, which consists of two 5-ASA moieties linked by an azo bond.
||Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). Phase 3.
||Olutasidenib is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 (mIDH1) inhibitor with IC50 of 21.1 nM, 114 nM for IDH1-R132H, IDH1-R132C, respectively.
||Olverembatinib dimesylate (HQP1351)
||Olverembatinib dimesylate (HQP1351, GZD824) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
||Omadacycline tosylate is a first-in-class aminomethylcycline antibiotic, demonstrating antimicrobial activity in vitro against a range of Gram-positive and Gram-negative aerobes and some anaerobic bacteria.
||Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research.
||Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).
||Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
||Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity.
Ombuin, an active ingredient isolated from <i>Zanthoxylum armatum</i>, displays broad spectrum antibacterial effect with minimum inhibitory concentrations (MICs) ranges from 125 to 500 μg/mL.
||Omecamtiv mecarbil (CK-1827452)
||Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.
||Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.
||Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Omeprazole Sodium is a metabolism-dependent inhibitor (MDI) of CYP2C19.
Omiganan pentahydrochloride is a cidal cationic peptide with a broad antimicrobial spectrum, including yeast.
||Omilancor (BT-11) is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM).
||Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.
||ON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM for CDK4, Ark5/NUAK1, PDGFRβ, FGFR1, RET (c-RET), and Fyn, respectively.
||Onalespib (AT13387) is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Phase 2.
||Onametostat (JNJ-64619178) is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.
||Onatasertib (CC 223)
||Onatasertib (CC 223) is a potent, selective, and orally bioavailable mTOR inhibitor with IC50 of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2.
||ONC206 is a selective antagonist of dopamine D2-like receptors (DRD2/3/4) with broad-spectrum anti-tumor activity.
||ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132. ONC212 is broadly efficacious across most solid tumors and hematological malignancies in the low nanomolar range and has robust anti-leukemic activity.
||Oncrasin-1 (Onc-1) is a potent RNA polymerase II inhibitor with antitumor activity that kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 drives abnormal aggregation of protein kinase C iota (PKCι) in nucleus of sensitive cells but not in resistant cells.
||Ondansetron (GR 38032F, GR-C507/75) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
||Ondansetron HCl (GR 38032F) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
||Ondansetron Hydrochloride Dihydrate
||Ondansetron is a highly specific and selective serotonin 5-HT3 receptor antagonist (Ki=6.16 nM), with low affinity for dopamine receptors.
||ONO-4059 analogue (ONO-WG-307) is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.
||ONO-7475 is a potent, selective, and orally active novel inhibitor of Anexelekto(Axl)/MER tyrosine kinase with IC50 of 0.7 nM and 1.0 nM for AXL and MER, respectively. ONO-7475 suppresses the emergence and maintenance of tolerant cells to the initial EGFR-TKIs, osimertinib or dacomitinib, in AXL-overexpressing EGFR-mutated NSCLC cells. ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells.
||ONO-8130 is an orally available antagonist of EP1 receptor.
||ONO-8590580 is a negative allosteric modulator of GABAA α5.
||Ononin (Formononetin glucoside, Formononetin 7-O-glucoside) is an isoflavone glycoside with anti-inflammtory effects.
||Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.
||ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome in a cell-free assay.
||Oolong tea Extract
||Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.
||Ophiopogonin D (OJV-VI, Deacetylophiopogonin C) is a steroidal glycoside isolated from Chinese herb Radix ophiopogonis and shows anti-tumor property. Ophiopogonin D could suppress TGF-β1-mediated metastatic behavior of MDA-MB-231 cells by regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis. Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells.
Ophiopogonin D', isolated from the tubers of <i>Ophiopogon japonicus</i>, is a rare naturally occurring C29 steroidal glycoside, showing cytotoxic activity against two human tumor cell lines MG-63 and SNU387.
||Opoponax oil is isolated and extracted from Commiphora erythraea (opoponax), with a promising insecticidal property.
||Oprozomib (ONX 0912)
||Oprozomib (ONX 0912, PR-047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.
||Optovin is a reversible photoactivated TRPA1 activator.
||Opuntia dillenii Extract
||Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.
||Orbifloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic.
||Orcinol (5-Methylresorcinol; 3,5-ToluenediolOrcin; 5-Methyl-1,3-benzenediol; 3,5-Dihydroxytoluene), occurs in many species of lichens including Roccella tinctoria and Lecanora, exhibits antimutagenic, antioxidant, antibacterial, radical-scavenging effects.
||Orcinol glucoside (OG, Sakakin) is an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn. It shows potent antioxidative and anxiolytic activities without sedative effects.
||Orelabrutinib (ICP-022) is a potent, orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK). Orelabrutinib has potential antineoplastic activity.
||Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, induces a CB1 receptor state that is characterized by enhanced agonist affinity and decreased inverse agonist affinity.
||Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.
||Oriental Paperbush flower Extract
||Oriental Variegated Coralbean Bark Extract
||Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
Orientin-2''-O-p-trans-coumarate is a flavonoid found in </i>Trigonella foenum-graecum</i>, with potent antioxidant activity.
||Origanum vulgare leaf Extract
||Oritavancin Diphosphate is an orally active glycopeptide antibiotic which is active against Gram-positive bacteria and also has antibacterial activity against multidrug-resistant Streptococcus pneumoniae.
||Orlistat (Ro 18-0647)
||Orlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.
||Orludodstat (BAY 2402234)
||Orludodstat (BAY 2402234) is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM.
||ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 value of 38 nM and the inhibition constant (Ki) value of 8 nM.
||Ormetoprim (OMP) is an antibiotic to prevent the spread of disease in freshwater aquaculture.
||Ornidazole (Ro7-0207, NSC 95075) is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria.
||Orotic acid (6-Carboxyuracil)
||Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.
||Oroxin A (Baicalein 7-O-glucoside), an active component isolated from the herb Oroxylum indicum (L.) Kurz, activates PPARγ and inhibits α-glucosidase, exerting antioxidant activity.
||Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.
||Oroxylin A (6-Methoxybaicalein) is a flavonoid isolated from Scutellaria root that exhibits multiple pharmacological activities, including anti-oxidative, anti-inflammatory, anti-viral and anti-tumor properties.
Oroxyloside inhibits angiogenesis through suppressing internalization of VEGFR2/Flk-1 in endothelial cells. Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation. Oroxyloside ameliorates acetaminophen-induced hepatotoxicity by inhibiting JNK related apoptosis and necroptosis.
||Oroxylum indicum seed Extract
||Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
||Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.
||Orsellinic acid ethyl ester
||Orsellinic acid (Ethyl Orsellinate), a phenolic acid, is of importance in the biochemistry of lichens, from which it can be extracted.
||Osalmid suppresses ribonucleotide reductase (RNR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.
||Oseltamivir Phosphate is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.
||OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells. Phase 1.
||OSI-420 (DesMethyl Erlotinib, CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
||OSI-930 is a potent inhibitor of Kit (c-Kit), KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl. Phase 1.
||LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase (CYP11B), an enzyme catalyzing the final step of cortisol synthesis.
||Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3.
||Osimertinib mesylate (AZD9291) is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug.
||OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with IC50 of 2.7 μM for full length human OGT (ncOGT).
||OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.
Osmundacetone ((E)-Osmundacetone) significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases. Osmundacetone has a neuroprotective effect against oxidative stress.
||Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM), used for the treatment of dyspareunia.
||OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
||Ostarine (GTx-024, MK-2866) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM, and is tissue-selective for anabolic organs. Phase 3.
||Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive inhibitor of human monoamine oxidase-A (hMAO-A) with Ki of 0.26 μM and IC50 of 0.74 μM.
||Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.
||OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.
||OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
||OSU-T315 analog (ILK-IN-1) is an inhibitor of Integrin-linked kinase (ILK) with IC50 of 0.6 μM which inhibits PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). OSU-T315 causes cell death through apoptosis and autophagy.
||OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03 nM in non-HP cancer cells and 2.89 nM in HP cancer cells, respectively.
||Otenabant (CP-945598) HCl
||Otenabant (CP-945598) HCl is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor. Phase 1.
||Otilonium bromide is an antimuscarinic.
||OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.
||OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.
||OTSSP167 (OTS167) is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor with IC50 of 0.41 nM.
||OTX008 (Calixarene 0118, PTX008), a calixarene derivative, is a selective inhibitor of galectin-1 (Gal1) with anti-tumoural activity.
||Ouabain (NSC 25485) is a selective Na+/K+, -ATPase inhibitor, binds to α2 /α3 subunit with Ki of 41 nM/15 nM.
||OX liver Extract
||OX02983 is a novel anthelmintic agent, actives against both egg and adult stages of Trichuris parasites, immobilising whipworm and reducing the ability of embryonated Trichuris muris eggs to establish infection in the mouse host.
||Oxaceprol (N-acetyl-L-hydroxyproline) is an anti-inflammatory drug used in the treatment of osteoarthritis.
||Oxacillin sodium (salt) is a narrow-spectrum β-lactam antibiotic that can be used for treatment of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia.
||Oxacillin sodium monohydrate
||Oxacillin sodium monohydrate (Methicillin) is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.
||Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.
||Oxalic acid (Ethanedioic acid, Wood bleach) is a strong dicarboxylic acid occurring in many plants and vegetables.
||Oxaliplatin (NSC 266046)
||Oxaliplatin (NSC 266046, L-OHP, Eloxatin) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.
||Oxantel Pamoate is the pamoate salt form of oxantel, a tetrahydropyrimidine anthelmintic used against intesitnal worms, particularly in a veterinary setting.
||Oxaprozin (WY-21743) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
||Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.
||Oxeladin citrate (OL), a cough suppressant, is a highly potent and effective drug applied in the treatment of all types of cough of various etiologies.
||Oxfendazole (RS-8858) is a broad spectrum benzimidazole anthelmintic.
||Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.
||Oxidative Stress Compound Library
||A unique collection of 1443 oxidative stress related compounds used for high throughput screening(HTS) and high content screening(HCS).
||Oxidopamine (6-hydroxydopamine, 6-OHDA, 2,4,5-trihydroxyphenethylamine) is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity. Solutions should be freshly prepared and protected from exposure to light.
||Oxiglutatione (Oxidized glutathione, Glutathione disulfide, GSSG, Bi(glutathion-S-yl)) is the oxidized disulfide form of glutathione (GSH) with potential protective activity.
||Oxindole (2-indolone, 2-Oxindole, Indolin-2-one) is an aromatic heterocyclic organic compound which causes sedation, muscle weakness, hypotension, and coma when dosed in excess. Oxindole has anti-cancer, anti-HIV, anti-diabetic, antibacterial and other pharmacological activities.
||Oxiracetam (ISF 2522), a cyclic derivative of gamma-aminobutyric acid (GABA), is used as a nootropic drug to improve memory and learning.
||Oxolamine (SKF-9976, AF-438) citrate, a cough suppressant, is an inhibitor of CYP2B1/2. Oxolamine citrate also exhibits anti-inflammatory effect.
||Oxolinic acid (Urinox, NSC 110364) is a quinolone antibiotic, inhibiting the enzyme DNA gyrase and DNA synthesis.It also acts as a dopamine reuptake inhibitor.
||Oxybenzone is a benzophenone derivative used as a sunscreen agent.
Oxyberberine is an alkaloid and a metabolite of the alkaloid berberine that has been found in A. mexicana and has diverse bioactivities.
||Oxybuprocaine HCl is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions
||Oxybutynin is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor, used to relieve urinary and bladder difficulties.
||Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
||Oxyclozanide (Oxiclozanidum, Zanil, Oxyclozanid, Zanilox) is a salicylanilide anthelmintic and mitochondrial uncoupling anthelmintic drug approved for veterinary use.
Oxyimperatorin ((±)-Heraclenin) is a coumarin isolated from Angelica dahurica.
||Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.
||Oxypaeoniflorin is a natural compound derived from Radix Paeoniae Rubra and Radix Paeoniae Alba.
||Oxypeucedanin hydrate is a natural coumarin compound found in several plants that exhibits anti-infective and antifungal activities.
||Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.
||Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. OSC protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.
||Oxysophoridine (Sophoridine N-oxide), a bioactive alkaloid extracted from the Sophora alopecuroides Linn, exhibits anti-inflammatory, anti-oxidative stress and anti-apoptosis effects.
||Oxytetracycline is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria.
||Oxytetracycline Dihydrate is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
||Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
||Oxytocin(Syntocinon) is a nine amino acid peptide that is synthesized in hypothalamic neurons and transported down axons of the posterior pituitary for secretion into blood.
||Oyster mushroom Extract
||Oyster Mushroom Extract
Oyster peptide is derived from oyster meat by modern bio-enzymatic hydrolysis technology, and further separation, purification, deodorization and spray drying process.
||Oyster Shell Extract
||Ozagrel (OKY-046) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
||Ozagrel HCl (OKY-046) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
||Ozagrel sodium (KCT-0809, Cataclot, Xanbo) is a thromboxane A2 synthase (CYP5) inhibitor with neuroprotective properties.
||Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3.
||Ozenoxacin is a quinolone antibiotic used for the treatment of impetigo.