For research use only. Not for use in humans.

Anti-CXCR3 / GPR9 / CD183

Cat.No.A2706 Purity:99%

Anti-CXCR3 / GPR9 / CD183 is a monoclonal antibody binds to Chemokine (C-X-C motif) receptor 3 (CXCR3, also known as G protein-coupled receptor 9 (GPR9)) . It has the potentially to be used in the treatment of diabetes mellitus type I (T1D). MW: 146.38 KD.

Anti-CXCR3 / GPR9 / CD183

Quality Control

Batch: A270601 Purity: 99% Protein concentration: 9.04mg/ml Endotoxin Level: ＜1EU/mg

99

Specificity

Name	Citation	CXCR1	CXCR2	CXCR4	CXCR3	Others
WZ811	20			++++
Mavorixafor	0			+
AMG 487	4				+++
Motixafortide (BL-8040)	1			++++		cyclin-D1,MCL-1,Bcl-2
Navarixin (SCH-527123)	7	++	+++
MSX-122	1			+++
LY2510924	2			++++
Reparixin (Repertaxin)	24	++++	+			CXCL8
SB225002	91		++
Ladarixin	0	✔
SB 265610	2		✔
Balixafortide (POL6326)	0			✔
SX-682	3	✔
TAK-779	0				✔	CCR5
MSX-130	0			✔
MSX-127	0			✔
AZD5069	3		✔
Danirixin (GSK1325756)	2		✔			CXCL8
LIT-927	5			✔		CXCL12
AMD3465 hexahydrobromide	1			✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Anti-CXCR3 / GPR9 / CD183 is a monoclonal antibody binds to Chemokine (C-X-C motif) receptor 3 (CXCR3, also known as G protein-coupled receptor 9 (GPR9)) . It has the potentially to be used in the treatment of diabetes mellitus type I (T1D). MW: 146.38 KD.
References	https://patents.google.com/patent/WO2013109974A2/en

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Molecular Weight	146.38
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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