AGK2

For research use only.

Catalog No.S7577

12 publications

AGK2 Chemical Structure

CAS No. 304896-28-4

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

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Selleck's AGK2 has been cited by 12 publications

4 Customer Reviews

  • Masson trichrome staining of tubulointerstitium areas from Sham, UUO, UUO+AGK2 mice (original magnification: × 400).

    Cell Physiol Biochem, 2018, 46(2):451-460. AGK2 purchased from Selleck.

    Both HCT116 and SW480 cells were treated with 5 μM AGK2 for 12 hours, whole cell lysates were immunoblotted by the indicated antibodies. Acetylated tubulin as positive control.

    Mol Cancer Res, 2018, doi:10.1158/1541-7786.MCR-18-0637. AGK2 purchased from Selleck.

  • The effect of AGK-2 on AKT activation in HeLa cells in response to insulin.

    J Biol Chem, 2014, 289(9): 6054-66 . AGK2 purchased from Selleck.

    A549 and H1299 were treated with increasing dose of Sirtinol and AGK2. 48h later, whole cell lysates were prepared from indicated cancer cells, and subjected to immunoblotting with anti-PDHA1 antibody and phosphoS293 antibody

    Cancer Biol Ther, 2018, 19(9):835-846. AGK2 purchased from Selleck.

Purity & Quality Control

Choose Selective Sirtuin Inhibitors

Biological Activity

Description AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
Targets
SIRT2 [1]
(Cell-free assay)
3.5 μM
In vitro

In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Escherichia coli BL21 (DE3) cells NXrEV3VLTnWwY4Tpc44h[XO|YYm= NHGxNXlKdmirYnn0bY9vKG:oIH\1cIwhdGWwZ4ToJIh2dWGwIGPJVnQzKGW6cILld5Nm\CCrbjDFd4Np\XKrY3jpZUBkd2yrIFLMNlEhMESHMzmgZ4VtdHNidYPpcoch\my3b4Lv[4VvcWNiNz3hcYlvdy12LX3leIh6dGOxdX3hdolvKCiDTVOpMYxi[mWuZXSgdIVxfGmmZTDifUBndHWxcnXzZ4Vv[2ViYYPzZZktKEmFNUC9NU42PiEQvF2= NYrSXZR3OjV{N{W4NlQ>
human 30PT cells MWTDfZRwfG:6aXRCpIF{e2G7 NWPlXJJsPzJiaB?= NIPMdFREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckA{OFCWIHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuLYTpeIVzKEeObzDhd5NigSxiQ1O1NF06NjZizszN NGLOe3ozOjl|MUWyOi=>
human 30P cells M2e5[GN6fG:2b4jpZ:Kh[XO|YYm= Mor2O|IhcA>? Mlr0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gN|BRKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwKGy3bXnu[ZNk\W62IHHzd4F6NCCFQ{WwQVEzNjVizszN Mm\1NlMyQDl7Nke=
H4 cells MW\GeY5kfGmxbjDhd5NigQ>? MUiyOEBp NV;ER4l{UW6qaXLpeIlwdiCxZjDTTXJVOiCrbjDIOEBk\WyuczDjc{11emGwc3\lZ5Rm\CC5aYToJIFteGijU4nuJIFv\CC|eX7wbIltcW5zIHHzd4V{e2WmIHHzJIVvdGG{Z3XkJIFteGijU4nuJIlv[2y3c3nvcpMh[W[2ZYKgNlQhcHK| MVuxO|U5QDlyMB?=
human HCT116 cells MVjGeY5kfGmxbjDhd5NigQ>? MnPlNVAh|ryP M4iwdFghcA>? M3LPPWlvcGmkaYTpc44hd2ZiU1nSWFIhcW5iaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGGlZYT5cIF1\WRiYXzwbIEufHWkdXzpckBifCBzMDD1UUBi\nSncjC4JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> MoXJNlI3PDJ|MEC=
HeLa cells M3XsdGZ2dmO2aX;uJIF{e2G7 NGnuc3lKdmirYnn0bY9vKG:oIH;2[ZIu\XiycnXzd4VlKFOLUmSyJIludXWwb4Dy[YNqeGm2YYTl[EBnem:vIFjlUIEh[2WubIOgeJJidnOoZXP0[YQhf2m2aDDTTXJVOi2veXOg[ZhxemW|c3nvckBkd26|dIL1Z5Q> NFXQNm8yPzV6OEmwNC=>

... Click to View More Cell Line Experimental Data

In vivo In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1]

Protocol

Animal Research:

[1]

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  • Animal Models: Drosophila model of parkinson
  • Dosages: 1mM
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 10 mg/mL warmed (23.02 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
8% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
1.4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 434.27
Formula

C23H13Cl2N3O2

CAS No. 304896-28-4
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID