AGK2

For research use only.

Catalog No.S7577

20 publications

AGK2 Chemical Structure

CAS No. 304896-28-4

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

Selleck's AGK2 has been cited by 20 publications

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Biological Activity

Description AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
Targets
SIRT2 [1]
(Cell-free assay)
3.5 μM
In vitro

In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa NEPLVJFHfW6ldHnvckBie3OjeR?= NHKxe5NKdmirYnn0bY9vKG:oIH;2[ZIu\XiycnXzd4VlKFOLUmSyJIludXWwb4Dy[YNqeGm2YYTl[EBnem:vIFjlUIEh[2WubIOgeJJidnOoZXP0[YQhf2m2aDDTTXJVOi2veXOg[ZhxemW|c3nvckBkd26|dIL1Z5Q> NXXGOFY{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1PFg6ODBpPkG3OVg5QTByPD;hQi=>
H4 M3rGd2Z2dmO2aX;uJIF{e2G7 MVSyOEBpenN? Mk\KTY5pcWKrdHnvckBw\iCVSWLUNkBqdiCKNDDj[YxteyClbz30doFve2[nY4Tl[EB4cXSqIHHsdIhiW3mwIHHu[EB{gW6yaHnsbY4yKGG|c3Xzd4VlKGG|IHXucIFz\2WmIHHsdIhiW3mwIHnuZ4x2e2mxboOgZYZ1\XJiMkSgbJJ{ MmPmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3OEi5NFAoRjF5NUi4PVAxRC:jPh?=
rat embryo midbrain NWCxfZkxTnWwY4Tpc44h[XO|YYm= NETpUXFRem:2ZXP0bY9vKG:oIHTvdIFucW6ncnfpZ{Bk\WyuIHTlZZRpKGmwIILheEBmdWK{eX:gcYll[nKjaX6geJJidnOmdXPl[EB4cXSqIHzlcpRqfmm{dYOg[Y5kd2SrbnegZYxxcGGVeX6tRVU{XCCvdYThcpQh[XO|ZYPz[YQh[XNidInyc5NqdmViaInkdo95gWyjc3WgdI9{cXSrdnWgZ4VtdHN? NHPYWm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W4PFkxOCd-MUe1PFg6ODB:L3G+
HCT116 NYD3SI9{TnWwY4Tpc44h[XO|YYm= MYexNEB2VQ>? NUD5XFhIQCCqcoO= M2HSUGlvcGmkaYTpc44hd2ZiU1nSWFIhcW5iaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGGlZYT5cIF1\WRiYXzwbIEufHWkdXzpckBifCBzMDD1UUBi\nSncjC4JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NYDq[JpwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2OFI{ODBpPkKyOlQzOzByPD;hQi=>
Escherichia coli cells NFvqfXRHfW6ldHnvckBie3OjeR?= MYjJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFOLUmSyJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKGOnbHzzJJV{cW6pIHHj[ZR6dGG2ZXSgUJl{KHOrZHWgZ4hicW5iYX3pco8h[WOrZIOgN|c6NTN6MjCoRZJoNUircz3MfZMuVHm|KFHjLUkheDV|IHPvcop2\2G2ZXSge4l1cCCjbXnuc41mfGi7bHPveY1iemmwIHHzJJN2[nO2cnH0[UBjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVA:PS53zszN NVHGRVIxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5N|E2OjZpPkKyPVMyPTJ4PD;hQi=>
30PT MWHDfZRwfG:6aXPpeJkh[XO|YYm= NGO2N2o4OiCqcoO= MmTZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gN|BRXCClZXzsd{Bi\nSncjC3NkBpenNiYomgR4VtdC22aYTldkBIVG9iYYPzZZktKEOFNUC9PU43|ryP MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl|MUWyOkc,OjJ7M{G1NlY9N2F-
30P MWnDfZRwfG:6aXPpeJkh[XO|YYm= MmjXO|IhcHK| M2LPW2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFMxWCClZXzsd{Bi\nSncjC3NkBpenNiYomgR4VtdC22aYTldkBIVG9iYYPzZZktKEOFNUC9NVIvPc7:TR?= MkPNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7M{G1NlYoRjJ{OUOxOVI3RC:jPh?=
Escherichia coli cells MXfGeY5kfGmxbjDhd5NigQ>? MmLGTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCVSWLUNUBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSClZXzsd{B2e2mwZzDhZ4V1gWyjdHXkJGx6eyC|aXTlJINp[WmwIHHtbY5wKGGlaXTzJFM4QS1|OEKgLGFz\y2KaYOtUJl{NUy7czjBZ{kqKHB3MzDjc45rfWejdHXkJJdqfGhiYX3pco9u\XSqeXzjc5Vu[XKrbjDhd{B{fWK|dILheIUh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTN6zszN NIX4Xo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmzNVUzPid-MkK5N|E2OjZ:L3G+
30PT NH\lOIVEgXSxdH;4bYNqfHliYYPzZZk> NEe3NY04OiCqcoO= NYHPeJZSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hOzCSVDDj[YxteyCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubzDseY1qdmW|Y3XueEBie3OjeTygR2M2OD17LkdOwG0> MlT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzOEm5OlcoRjJ|MUi5PVY4RC:jPh?=
30P NGHaWWtEgXSxdH;4bYNqfHliYYPzZZk> MXm3NkBpenN? NE\aWpZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckA{OFBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JINmdGy2aYTldk1odG9ibIXtbY5me2OnboSgZZN{[XluIFPDOVA:OTJwNd88US=> NUnPPW9VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPFk6PjdpPkKzNVg6QTZ5PD;hQi=>
Escherichia coli BL21 (DE3) M{jJcmZ2dmO2aX;uJIF{e2G7 NUHnVJh[UW6qaXLpeIlwdiCxZjDmeYxtKGynbnf0bEBpfW2jbjDTTXJVOiCneIDy[ZN{\WRiaX6gSZNkcGW{aXPobYEh[2:uaTDCUFIyKCiGRUOpJINmdGy|IIXzbY5oKG[udX;yc4dmdmmlIEetZY1qdm9vND3t[ZRpgWylb4XtZZJqdiBqQV3DLU1t[WKnbHXkJJBmeHSrZHWgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVEvPTcQvF2= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ5NUiyOEc,OjV{N{W4NlQ9N2F-
SH-SY5Y MYPO[ZVzd3C{b4TlZ5RqfmViYYPzZZk> MlfPNUB1dyBzMDD1US=> NHPtcZk{OCCvaX7z NIjLR5NP\XW{b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZYdicW6|dDDvcIlod22ncnnjJIFteGijLYP5cpVkdGWrbj3pcoR2[2WmIHP5eI91d3irY3n0fUBqdiCqdX3hckBUUC2VWUXZJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHyg[5Jwf3SqIHH0JFEhfG9iMUCgeW0heHKnaX7jeYJifGWmIH\vdkA{OCCvaX7zJIZwdGyxd3XkJIJ6KGGucHjhMZN6dnWlbHXpckBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5 M4T2RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUiyNlM1Lz5{Nkm4NlI{PDxxYU6=
MCF7 M2jrVmZ2dmO2aX;uJIF{e2G7 NHrGcGEyOCC2bzC1NEB2VQ>? MkjHNlQhcHK| M3G0TmlvcGmkaYTpc44hd2ZiU1nSWFIhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBidHCqYT30eYJ2dGmwIFu0NEBi[2W2eXzheIlwdiCuZY\lcEBifCBzMDD0c{A2OCC3TTDh[pRmeiB{NDDodpMhcW5icILld4Vv[2Vib3[gWHNCKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> NIfaV5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEGzOVA5Pid-MkixN|UxQDZ:L3G+
U373 MkHHRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mn3wO|IhcHK| NXq4[YNKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVN|c{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NEeuOu69VQ>? M13D[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEe1N|MxLz5{OES3OVM{ODxxYU6=
Hs683 NU\UdndsS2WubDDjfYNt\SCjc4PhfS=> MW[yOEB1dyB2ODDodpM> Mn7WR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gTJM3QDNiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KHO3Yj3HNUBxcGG|ZTDheEBKSzVyIH\vdkBOXFRiYYPzZZkh[W[2ZYKgNlQhfG9iNEigbJJ{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\myxdzDjfZRwdWW2com= NYCxUXNtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0O|U{OzBpPkK4OFc2OzNyPD;hQi=>
U373 Mm\GR4VtdCCleXPs[UBie3OjeR?= M2XIPVI1KHSxIES4JIhzew>? NVXZOJJES2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hXTN5MzDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRic4XiMWcyKHCqYYPlJIF1KEmFNUCg[o9zKE2WVDDhd5NigSCjZoTldkAzPCC2bzC0PEBpenNiYomgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZz3iZZNm\CCobH;3JIN6fG:vZYTyfS=> Mn7iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2N{WzN|AoRjJ6NEe1N|MxRC:jPh?=
Hs683 NY\lN2RCS2WubDDjfYNt\SCjc4PhfS=> MX2yOEB1dyB2ODDodpM> MUfD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDId|Y5OyClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzJxTTDwbIF{\SCjdDDJR|UxKGGodHXyJFI1KHSxIES4JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[ub4egZ5l1d22ndIL5 M3TjTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEe1N|MxLz5{OES3OVM{ODxxYU6=
U373 MnL5R4VtdCCleXPs[UBie3OjeR?= M3\BT|I1KHSxIES4JIhzew>? MmXkR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gWVM4OyClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzJxTTDwbIF{\SCjdDDJR|UxKGGodHXyJFI1KHSxIES4JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[ub4egZ5l1d22ndIL5 NEGzb289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES3OVM{OCd-Mki0O|U{OzB:L3G+

... Click to View More Cell Line Experimental Data

In vivo In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1]

Protocol

Animal Research:

[1]

- Collapse
  • Animal Models: Drosophila model of parkinson
  • Dosages: 1mM
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 10 mg/mL warmed (23.02 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
8% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
1.4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 434.27
Formula

C23H13Cl2N3O2

CAS No. 304896-28-4
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID