Synonyms: TNFRSF9, CD137 Clone No.:3H3
Anti-mouse 4-1BB (CD137)-InVivo reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137.
Shimon Sakaguchi
Nature Communications 2025,16, Article number:1325
David Baker
Dev Cell 2023, 58(20):2163-2180.e9.
David Julius
Cell 2017, 185-198.e16
Michael Houghton
Cell Chem Biol, 2020, 27(7):780-792.e5
Charles M. Rice
Cell 2018, 172(3):423-438.e25
| Featured Inhibitors | Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933 |
|---|
| Clone | 3H3 |
|---|---|
| Isotype | Rat IgG2a |
| Application | Anti-mouse 4-1BB (CD137)-InVivo |
| Source | CHO |
| Purification | Protein G |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Murine Pathogen Screening Panel | all targets tested yielded Negative Results: Theiler’s Murine Encephalomyelitis Virus, Ectromelia (Mousepox) Virus, Hantavirus, Polyomavirus, Sendai Virus, Mycoplasma pulmonis, Pneumonia Virus of Mice, K Virus, Mouse Parvovirus, Mouse Hepatitis Virus, Mouse Norovirus, Mouse Minute Virus, Mouse Cytomegalovirus, Mouse Adenovirus, Lactate Dehydrogenase-Elevating Virus, Reovirus Panel, Lymphocytic Choriomeningitis Virus, Mouse Rotavirus. |
| Storage (From the date of receipt) |
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles |
*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT07720180 | NOT_YET_RECRUITING | Drug: Fludarabine|Drug: Cyclophosphamide | Ovarian Cancer | Medical University of South Carolina | 2026-12-01 | PHASE2 |
| NCT06782932 | RECRUITING | Drug: AGEN2373|Drug: Balstilimab|Drug: Cyclophosphamide|Drug | Pancreatic Cancer | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2025-05-27 | PHASE1; PHASE2 |
| NCT04740424 | RECRUITING | Drug: FS222 | Advanced Cancer; Metastatic Cancer | invoX Pharma Limited | 2020-12-14 | PHASE1 |
| NCT06410131 | RECRUITING | Drug: FTL008.16 | Solid Tumors | Sound Biopharmaceuticals Ltd. | 2025-05-27 | PHASE1 |
| NCT04648202 | ACTIVE_NOT_RECRUITING | Drug: FS120 | Advanced Cancer; Metastatic Cancer | invoX Pharma Limited | 2020-11-18 | PHASE1 |
| NCT04635995 | COMPLETED | Cancer | Lyvgen Biopharma Holdings Limited | 2020-12-11 | PHASE1 |
(data from https://clinicaltrials.gov, updated on 2026-07-22)
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