Catalog No. |
Product Name |
Information |
E2245 |
(-)-Zuonin A |
(-)-Zuonin A, a naturally occurring lignin, is a potent, selective JNKs inhibitor.
|
S8956 |
(Z)-4-Hydroxytamoxifen |
(Z)-4-Hydroxytamoxifen ((Z)-4-OHT, trans-4-Hydroxytamoxifen, 4-Monohydroxytamoxifen) is a selective modulator of estrogen receptor (SERM) with IC50 of 3.3 nM for the [3H]oestradiol binding to oestrogen receptor. |
E0765 |
(Z)-Akuammidine |
(Z)-Akuammidine is isolated from <i>Gelsemium elegans</i>.
|
S5470 |
(Z)-Ligustilide |
(Z)-Ligustilide, extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity.
|
S7312 |
Z-DEVD-FMK |
Z-DEVD-FMK (Caspase-3 Inhibitor) is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10. |
S7391 |
Z-FA-FMK |
Z-FA-FMK ((1S)-Z-FA-FMK) is an irreversible cysteine protease inhibitor, and also inhibits effector caspases. |
S6812 |
Z-Guggulsterone |
Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Z-Guggulsterone exhibits anti-inflammatory effects in microglia. Z-Guggulsterone induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway. |
S7314 |
Z-IETD-FMK |
Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK) is a specific Caspase-8 inhibitor. |
S0201 |
Z-JIB-04 (NSC 693627) |
Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. |
S7313 |
Z-LEHD-FMK TFA |
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival. |
S8102 |
Z-VAD(OH)-FMK (Caspase Inhibitor VI) |
Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor. |
S7023 |
Z-VAD-FMK |
Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells. |
S8507 |
Z-YVAD-FMK |
Z-YVAD-FMK is a cell-permeable and irreversible caspase-1 specific inhibitor with anti-inflammatory and anti-tumor activities. |
S3585 |
Z433927330 |
Z433927330 is a potent and efficacious inhibitor of mouse AQP7 (Aquaporin-7) with an IC50 of ~0.2 µM. Z433927330 also inhibits mouse AQP3 (Aquaporin-3) and mouse AQP9 (Aquaporin-9) with IC50s of ~0.7 µM and ~1.1 µM, respectively. |
E0777 |
Z944 |
Z944 is a highly selective antagonist for T-type calcium channel with IC50s of 50, 160, 110 nM for hCaV3.1, hCaV3.2, and hCaV3.3. |
E2837 |
Zabedosertib |
Zabedosertib (BAY 1834845) is a IRAK4 inhibitor with immunomodulatory potential, which is a protein kinase involved in signaling innate immune responses from Toll-like receptors. |
S1633 |
Zafirlukast (ICI-204219) |
Zafirlukast (ICI-204219) is an oral leukotriene receptor antagonist (LTRA), used to prevent asthma symptoms. |
S1719 |
Zalcitabine |
Zalcitabine (NSC 606170, Ro 24-2027/000) is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
S3008 |
Zaltoprofen |
Zaltoprofen is an inhibitor of COX-1 and COX-2 for treatment of arthritis. |
S0473 |
Zamicastat |
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH) that could cross the blood-brain barrier (BBB) and cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC50 of 73.8 μM and 17.0 μM, respectively. Zamicastat reduces high blood pressure. |
S3007 |
Zanamivir |
Zanamivir (GG167) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus. |
S3575 |
Zandelisib |
Zandelisib is a potent and selective inhibitor of phosphatidylinositol 3-kinase (PI3K) with IC50 of 3.5 nM for p110δ. Zandelisib exhibits antineoplastic activity. |
S8917 |
Zandelisib (ME-401) |
Zandelisib (ME-401, PWT-143, P110δ-IN-1, PW 143, ACC-524) is an oral, potent and selective inhibitor of Phosphatidylinositol 3-Kinase (PI3K) P110δ with IC50 of 0.6 nM in cellular assay. |
S8791 |
Zanubrutinib (BGB-3111) |
Zanubrutinib (BGB-3111) is a potent, specific and irreversible BTK inhibitor that has been shown to have a lower off-target inhibitory activity on other kinases, including ITK, JAK3 and EGFR. |
E3722 |
Zaocys dhumnades Extract |
|
E0404 |
Zapnometinib (PD0184264) |
Zapnometinib (PD0184264, ATR-002), an major active metabolite of CI-1040, is a novel MEK inhibitor with an IC50 of 5.7 nM. |
S6844 |
Zatolmilast (BPN14770) |
Zatolmilast (BPN14770) is a selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50 of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. |
S6543 |
ZD-4190 |
ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively. |
S5676 |
Zearalenone |
Zearalenone (F2 toxin, RAL) is a non-steroidal estrogenic mycotoxin that acts by binding the estrogen receptor (ER). |
S3243 |
Zeaxanthin |
Zeaxanthin, a diet-obtained carotenoid, presents in the macula region of the eye with antioxidant effects.
|
S7113 |
Zebularine (NSC 309132) |
Zebularine (NSC 309132, 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM in a cell-free assay. |
S8039 |
Zelavespib (PU-H71) |
Zelavespib (PU-H71, NSC 750424) is a potent and selective inhibitor of HSP90 with IC50 of 51 nM. Phase 1. |
S1456 |
Zibotentan (ZD4054) |
Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3. |
P1070 |
Ziconotide Acetate |
Ziconotide is a selective blocker of neuronal N-type voltage-sensitive calcium channels and antinociceptive when it is administered intrathecally.(ED50= 0.1 μg (49 pmol)) |
S2579 |
Zidovudine |
Zidovudine (ZDV, Azidothymidine, NSC 602670) is a nucleoside analogue reverse transcriptase inhibitor, used to treat HIV. It could decrease the HDR efficiency and decrease CRISPR-mediated sequence-specific genome knockin events while increaseing knockout efficiency. |
S1443 |
Zileuton (A-64077) |
Zileuton (A-64077, Abbott 64077, ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma. Zileuton induces apoptosis while inhibits ferroptosis. |
S8531 |
Zimlovisertib (PF-06650833) |
Zimlovisertib (PF-06650833) is a potent, selective inhibitor of IRAK4 with an IC50 of 0.2 nM. |
E0169 |
Zinc acetate |
Zinc acetate induces the expression of enterocyte metallothionein.
|
E0181 |
Zinc acetate dihydrate |
Zinc acetate dihydrate (Acetic acid zinc salt dihydrate, Dicarbomethoxyzinc dihydrate) contributes to the antiviral activity of microbicide gel through zinc targeting the reverse transcriptase.
|
S4075 |
Zinc Pyrithione |
Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. |
S3979 |
Zinc Undecylenate |
Zinc Undecylenate (Zinc diundec-10-enoate, Zinc 10-undecenoate) is a natural or synthetic fungistatic fatty acid, antifungal Zinc Undecylenate is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. |
E2511 |
ZINC05007751 |
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM, shows antiproliferative activity against a panel of human cancer cell lines and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. |
E3218 |
Zingiberis Rhizoma Extract |
|
S0958 |
Zingibroside R1 |
Zingibroside R1, isolated from rhizomes of Panax zingiberensis Wu et Feng (Araliaceae), has some anti-HIV-1 activity. Zingibroside R1 shows the inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells with IC50 of 91.3 µM and the growth of MT-4 cells with CC50 of 46.2 µM. |
P1083 |
ZIP |
Pkc Inhibitor |
S1444 |
Ziprasidone HCl |
Ziprasidone HCl (CP-88059) is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder. |
S8895 |
Ziritaxestat (GLPG1690) |
Ziritaxestat (GLPG1690) is a selective autotaxin inhibitor with an IC50 of 131 nM and Ki of 15 nM. |
S0479 |
ZK824859 |
ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively. |
S3378 |
ZL006 |
ZL006 is a potent nNOS/PSD-95 interaction inhibitor, and inhibits NMDA receptor-mediated NO synthesis. |
E0496 |
ZLc002 |
ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.
|
S7447 |
ZLN005 |
ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator. |
S2897 |
ZM 306416 |
ZM 306416 (CB 676475) is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM. |
S2720 |
ZM 336372 |
ZM 336372 (Zinc00581684) is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc. |
S1103 |
ZM 447439 |
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc. |
S8105 |
ZM241385 |
ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor. |
E1000 |
Zn-C3 |
ZN-c3 is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research. |
S5712 |
Zofenopril calcium |
Zofenopril calcium (SQ-26991) is an angiotensin-converting enzyme (ACE) inhibitor that protects the heart and helps reduce high blood pressure. |
S1314 |
Zoledronic acid (ZOL 446) |
Zoledronic acid (ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera, Aclasta, Reclast), a potent osteoclast inhibitor, induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho. Zoledronic acid (ZA) also induces autophagy. |
S5244 |
Zoledronic acid monohydrate |
Zoledronic acid (Zoledronate, CGP-4244) monohydrate, a nitrogen-containing bisphosphonate, is a potent osteoclast inhibitor which induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho. |
S7665 |
Zoligratinib (Debio-1347) |
Zoligratinib (Debio-1347, CH5183284, FF284) is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1.
|
S1649 |
Zolmitriptan |
Zolmitriptan is a novel and highly selective 5-HT(1B/1D) receptor agonist, used in the treatment of acute migraines. |
S1445 |
Zonisamide |
Zonisamide (CI-912) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug. |
S7971 |
Zorifertinib (AZD3759) |
Zorifertinib (AZD3759) is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. Phase 1.
|
S1481 |
Zosuquidar (LY335979) 3HCl |
Zosuquidar 3HCl (LY335979, RS 33295-198, D06387) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3. |
S7091 |
Zotarolimus (ABT-578) |
Zotarolimus (ABT-578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM. |
S7002 |
Zotiraciclib |
Zotiraciclib (SB1317; TG02) is a novel small molecule potent CDK/JAK2/FLT3 inhibitor, emerged with potent CDK (IC50 against CDKs 1, 2 and 9 = 9, 5 and 3 nM, respectively), FLT3 (IC50 = 19 nM) and JAK2 (IC50 = 19 nM) potency. |
S4233 |
Zoxazolamine |
Zoxazolamine (NSC 24995, Contrazole) is a centrally acting myorelaxant, which is formerly used as an antispasmodic and uricosuric. |
S1072 |
ZSTK474 |
ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM in a cell-free assay, mostly PI3Kδ. Phase1/2. |
S8864 |
ZT-12-037-01 |
ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM. |
S6409 |
Zucapsaicin |
Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator. |
S0049 |
Zuranolone (SAGE-217) |
Zuranolone (SAGE-217, CS-2797) is a potent agonist of GABAA receptor with EC50 of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors, respectively. |
E0958 |
ZX-29 |
ZX-29 is a potent and selective ALK inhibitor with an IC50s of 2.1, 1.3 and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. |
E1037 |
ZZW-115 |
ZZW-115 is a potent NUPR1 inhibitor with IC50s of 0.42 μM in Hep2G cells and 7.75 μM in SaOS-2 cells. ZZW-115 shows evident antitumor activity through its interaction with NUPR1.
|
E2253 |
α-Zearalanol |
α-Zearalanol, a metabolite of mycoplasma estrogen Zearalenone, is an estrogen receptor agonist.
|