Ampicillin sodium

Catalog No.S3170

For research use only.

Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.

Ampicillin sodium Chemical Structure

CAS No. 69-52-3

Selleck's Ampicillin sodium has been cited by 2 Publications

Purity & Quality Control

Choose Selective Selection Antibiotics for Transfected Cell Inhibitors

Biological Activity

Description Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.
Targets
beta-lactamase [1]
In vitro

Belonging to the penicillin group of beta-lactam antibiotics, ampicillin is able to penetrate Gram-positive and some Gram-negative bacteria. Ampicillin acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Ampicillin inhibits the third and final stage of bacterial cell wall synthesis in binary fission, which ultimately leads to cell lysis.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 371.39
Formula

C16H18N3NaO4S

CAS No. 69-52-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)[O-])C.[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04647331 Recruiting -- Infective Endocarditis Uppsala University June 1 2021 --
NCT03129620 Completed -- Hypothermia Drexel University March 2013 --
NCT01433757 Completed Drug: Ampicillin|Drug: Sugar pill DYT-1|Dystonia University of Florida|Tyler''s Hope for a Dystonia Cure Inc September 2011 Phase 1
NCT01118403 Withdrawn Drug: Sultamicillin Ventilator Associated Pneumonia Hospital Pablo Tobón Uribe March 2011 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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