For research use only. Not for use in humans.

Anti-FLT3 / CD135

Synonyms: IMC-EB10 Cat.No.A2493 Purity:99%

Anti-FLT3 / CD135 (IMC-EB10) is a fully human IgG1 monoclonal antibody, targeting the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. It binds to FLT3 and blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways. MW: 145.5 KD.

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Quality Control

Batch: A249301 Purity: 99% Protein concentration: 7.932mg/ml Endotoxin Level: ＜1EU/mg

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

Specificity

Name	Citation	FLT3	FLT3-WT	FLT3-ITD	FLT3-D835Y	Others
Tozasertib (VX-680)	136	++				Aurora A,Aurora C,Aurora B
SP600125	1063	+				serine/threonine kinase,JNK2,JNK1
Foretinib	94	+++				Met,KDR,Tie-2
Quizartinib (AC220)	152	+++
Dovitinib (TKI-258)	52	++++				c-Kit,FGFR1,VEGFR3/FLT4
Linifanib (ABT-869)	33	+++				VEGFR1/FLT1,CSF-1R,VEGFR2/KDR
Crenolanib (CP-868596)	99	++++				PDGFRα,PDGFRβ
SGI-1776 free base	42	++				Pim1,Pim3,Pim2
Amuvatinib (MP-470)	21	+				RAD51,c-Met,c-RET
Tandutinib (MLN518)	14	+				c-Kit,PDGFRβ,CSF-1R
TG101209	20	++				JAK2,RET,JAK3
KW-2449	12	++++				Abl (T315I),Abl,FGFR1
ENMD-2076	9	+++				RET,Aurora A,VEGFR3/FLT4
PRT062607 (P505-15) HCl	50	+				Syk,FGR,MLK1
Pacritinib (SB1518)	22	+++				JAK2 (V617F),JAK2,TYK2
TCS 359	2	++
FN-1501	0	++++				CDK4/cyclin D1,CDK6/cyclin D1,CDK2/cyclin A
FLT3-IN-2	1	+
HM43239	0		+++	+++	++++
HPK1-IN-2	0	+				HPK1,Lck
FLT3-IN-3	0	++
MRX-2843	0	++++				MERTK
UNC2025	7	++++				Mer,Axl,TrkA
5'-Fluoroindirubinoxime	0	++
SKLB4771 (FLT3-IN-1)	1	++
AST-487 (NVP-AST487)	3	+				KDR,RET,c-Abl
FF-10101	1	++++
TAK-659 Hydrochloride	6	+++				Syk,ZAP-70,JAK3
Merestinib (LY2801653)	11	++				DDR1,AXL,Met
UNC2025 HCl	9	++++				Mer,Axl,Tyro3
AMG 925	1	++++				CDK4
Dovitinib (TKI258) Lactate monohydrate	31	++++				c-Kit,VEGFR3/FLT4,FGFR1
G-749	1	++++				Mer,Aurora B,RET
Zotiraciclib	0	++				CDK9,CDK2,CDK1
AZD2932	3	++				PDGFRβ,VEGFR-2,c-Kit
R406	124	✔				Syk
R406 (free base)	108	✔				Syk
PHI-101	0	✔
Emavusertib (CA-4948)	1	✔
SU5614	3	✔				c-Kit,VEGFR-2,RET
Isoguanosine	0	✔				HDAC6,HDAC3
Go 6976	38	✔				JAK2,PKCα,PKCβ1

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Anti-FLT3 / CD135 (IMC-EB10) is a fully human IgG1 monoclonal antibody, targeting the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. It binds to FLT3 and blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways. MW: 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Molecular Weight	145.5 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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