Home Biosimilar Antibodies Angiogenesis FLT3 Anti-FLT3 / CD135
For research use only. Not for use in humans.

Anti-FLT3 / CD135

Synonyms: IMC-EB10

Anti-FLT3 / CD135 (IMC-EB10) is a fully human IgG1 monoclonal antibody, targeting the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. It binds to FLT3 and blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways. MW: 145.5 KD.

Anti-FLT3 / CD135

Click to purchase the isotype control of Anti-FLT3 / CD135

Quality Control

Batch: A249301 Purity: 99% Protein concentration: 7.932mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation FLT3 FLT3-WT FLT3-ITD FLT3-D835Y Others
Tozasertib (VX-680, MK-0457) 136 Aurora A,Aurora C,Aurora B
SP600125 1063 serine/threonine kinase,JNK2,JNK1
Foretinib (GSK1363089, XL880) 94 Met,KDR,Tie-2
Quizartinib (AC220) 152
Dovitinib (TKI-258) 52 c-Kit,FGFR1,VEGFR3/FLT4
Linifanib (ABT-869) 33 VEGFR1/FLT1,CSF-1R,VEGFR2/KDR
Crenolanib (CP-868596) 99 PDGFRα,PDGFRβ
SGI-1776 free base 42 Pim1,Pim3,Pim2
Amuvatinib (MP-470) 21 RAD51,c-Met,c-RET
Tandutinib (MLN518) 14 c-Kit,PDGFRβ,CSF-1R
TG101209 20 JAK2,RET,JAK3
KW-2449 12 Abl (T315I),Abl,FGFR1
ENMD-2076 13 RET,Aurora A,VEGFR3/FLT4
PRT062607 (P505-15) HCl 50 Syk,FGR,MLK1
Pacritinib (SB1518) 22 JAK2 (V617F),JAK2,TYK2
TCS 359 2
FN-1501 0 CDK4/cyclin D1,CDK6/cyclin D1,CDK2/cyclin A
FLT3-IN-2 1
HM43239 0
HPK1-IN-2 0 HPK1,Lck
FLT3-IN-3 0
MRX-2843 0 MERTK
UNC2025 7 Mer,Axl,TrkA
5'-Fluoroindirubinoxime 0
SKLB4771 (FLT3-IN-1) 1
AST-487 (NVP-AST487) 3 KDR,RET,c-Abl
FF-10101 3
TAK-659 Hydrochloride 8 Syk,ZAP-70,JAK3
Merestinib (LY2801653) 14 DDR1,AXL,Met
UNC2025 HCl 12 Mer,Axl,Tyro3
AMG 925 1 CDK4
Dovitinib (TKI258) Lactate monohydrate 31 c-Kit,VEGFR3/FLT4,FGFR1
G-749 1 Mer,Aurora B,RET
Zotiraciclib 0 CDK9,CDK2,CDK1
AZD2932 5 PDGFRβ,VEGFR-2,c-Kit
R406 124 Syk
R406 (free base) 108 Syk
PHI-101 0
Emavusertib (CA-4948) 1
SU5614 5 c-Kit,VEGFR-2,RET
Isoguanosine 0 HDAC6,HDAC3
Go 6976 38 JAK2,PKCα,PKCβ1
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Anti-FLT3 / CD135 (IMC-EB10) is a fully human IgG1 monoclonal antibody, targeting the FLT3 tyrosine kinase receptor (CD135) with potential antineoplastic activity. It binds to FLT3 and blocks FLT3 ligand binding to FLT3 and subsequent FLT3 phosphorylation, which may result in the inhibition of FLT3-mediated signal transduction pathways. MW: 145.5 KD.

Product Details

Molecular Weight 145.5 kDa
Isotype Human IgG1
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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