Azoramide

For research use only.

Catalog No.S8304

Azoramide Chemical Structure

CAS No. 932986-18-0

Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.

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Biological Activity

Description Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.
Targets
UPR [1]
()
In vitro

Azoramide may have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis. Azoramide may require the presence of intact IRE1 and PERK branches of the UPR to fully increase chaperone capacity. Azoramide is found to be a kind of compound with the dual property of not only boosting ER folding acutely but also activating ER chaperone capacity chronically to promote ER homeostasis. Its treatment potently protects cells against chemically-induced ER stress conditions. Azoramide preserves beta cell function and survival during metabolic ER stress. Azoramide pretreatment does not impair ER function as part of its initial action. Azoramide treatment leads to increased SERCA expression, resulting in enhanced retention of Ca+2 within the ER. Azoramide interacts with UPR pathways to promote resolution of ER stress and improve ER function[1].

In vivo Azoramide improves glucose homeostasis in mice with genetic obesity and diet-induced obesity. Remarkably, azoramide treatment significantly improves insulin sensitivity and glucose tolerance and beta cell function in obese mice in multiple preclinical models[1].

Protocol

Cell Research:

[1]

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  • Cell lines: INS1 cells
  • Concentrations: 20 µM
  • Incubation Time: 60 h
  • Method:

    INS1 cells are treated with 25 mM Glucose and 500 µM Palmitate (G/P) in the absence or presence of 20 µM azoramide for 60 hours. At the end of the incubation, viability is measured using the CellTiter-Glo cell viability assay system.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: ob/ob mice
  • Dosages: 150mg/kg
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 61 mg/mL (197.51 mM)
Ethanol 61 mg/mL (197.51 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 308.83
Formula

C15H17ClN2OS

CAS No. 932986-18-0
Storage powder
in solvent
Synonyms N/A
Smiles CCCC(=O)NCCC1=CSC(=N1)C2=CC=C(C=C2)Cl

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID