For research use only.

Catalog No.S8054

3 publications

ASP3026 Chemical Structure

CAS No. 1097917-15-1

ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. Phase 1.

Selleck's ASP3026 has been cited by 3 publications

Purity & Quality Control

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Biological Activity

Description ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. Phase 1.
Features ALK-selective inhibitor that has been tested in Phase I clinical trials for treatment of solid tumors and B-cell lymphoma.
ALK [1]
3.5 nM
In vitro

ASP3026 shows more selective ALK inhibition in a Tyr-kinase panel than PF02341066. ASP3026 inhibits the growth of NCI-H2228, a human NSCLC tumor cell line endogenously expressing EML4-ALK variant 3, with an IC50 value of 64.8 nM. [1]

In vivo ASP3026, administered to mice bearing subcutaneous NCI-H2228 tumor xenografts as twice daily oral dosing for 14 days, induces dose dependent anti-tumor effects starting at 1 mg/kg with strong regression at 10, 30 and 100 mg/kg. [1]


Solubility (25°C)

In vitro DMSO 14 mg/mL (24.1 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 580.74


CAS No. 1097917-15-1
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

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Molarity Calculator

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Dilution Calculator

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01401504 Completed Drug: ASP3026 Solid Tumor Astellas Pharma Inc May 2011 Phase 1
NCT01284192 Completed Drug: ASP3026 Advanced Malignancies|Positive for Anaplastic Lymphoma Kinase|Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS|Solid Tumor|B-Cell Lymphoma Astellas Pharma Inc December 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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ALK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID