Azaguanine-8

Catalog No.S4194 Synonyms: NSC-749, SF-337, SK 1150

Azaguanine-8 Chemical Structure

Molecular Weight(MW): 152.11

Azaguanine-8 is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.

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Biological Activity

Description Azaguanine-8 is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.
In vitro

8-Azaguanine is a purine analogue that shows antineoplastic activity. It functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth.

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
H.Ep cells MofhR5l1d3SxeHnjbZR6KGG|c3H5 MnjvR5l1d3SxeHnjbZR6KGGpYXnud5QhUC6HcDDj[YxteyxiSVO1NF0zKM7:TR?= MV22OlIxOzB5

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-H3; 

PubMed: 26668215     


Analysis using optimized drug-treatment regimen in the same three HCC cell lines. Optimization of the treatment conditions increased the effect observed (20 μM, 24 hours). The untreated cell lines were compared with their treated counterparts. DP was used as positive control (5 nM). Histone acetyltransferase, GCN5, is involved in chemosensitizing drug-induced histone H3 acetylation. 

26668215
Growth inhibition assay
Cell viability; 

PubMed: 30804405     


Dose-response curve of 8-azaguanine treatment in SF3B1 cells (WT or K700E) for 5 days; plotted as % viability as ATP levels normalised to vehicle-treated controls. The table represents calculated 50% inhibitory concentrations (IC50) and 95% confidence values (n = 3, technical duplicates).

30804405
In vivo A study of the in vivo metabolism of 8-azaguanine-2-C 14 by mouse neoplasms that are susceptible or resistant to growth inhibition by 8-azagnanine have been reported. The results show that the growth of those neoplasms which convert significant amounts of 8-azaguanine to 8-azaguanylic acid is inhibited by 8-azaguanine.

Protocol

Solubility (25°C)

In vitro DMSO 6 mg/mL (39.44 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 152.11
Formula

C4H4N6O

CAS No. 134-58-7
Storage powder
in solvent
Synonyms NSC-749, SF-337, SK 1150

Bio Calculators

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID