Artemisinin

Catalog No.S1282 Synonyms: Qinghaosu,Artemisinine

Artemisinin Chemical Structure

Molecular Weight(MW): 282.33

Artemisinin is a sesquiterpene endoperoxide which is a potent antimalarial agent.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
USD 127 In stock
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Biological Activity

Description Artemisinin is a sesquiterpene endoperoxide which is a potent antimalarial agent.
In vitro

Artemisinin's antimalarial activity has been shown to be mediated by activated oxygen (i.e., superoxide, hydrogen peroxide, and/or hydroxyl radicals). Artemisinin and heroin appear to be forming an adduct whose behavior resembles the behavior of the parasite Artemisinin product. [1] Artemisinin activity can be potentiated by oxygen and oxidizing agents and attenuated by reducing agents. Artemisinin susceptibility can be influenced by genetic changes in the loci encoding P. falciparum multidrug resistance protein 1 (PfMDR1) and P. falciparum chloroquine resistance transporter (PfCRT). [2] Artemisinins are effective not only against multi-resistant strains of P. falciparum, but have broad stage specificity against the Plasmodium life cycle including activity throughout the asexual blood stages and also the sexual gametocyte stages which may reduce the spread of the disease in areas of low transmission. Artemisinins have also been investigated for their antiproliferative effects against a wide range of cancer cell lines. Artemisinin is active against other parasite species such as Toxoplasma and Babesia that do not contain hematin. Artemisinin results in decreased proliferation, increased levels of oxidative stress, induction of apoptosis and inhibition of angiogenesis in cancer cells. Artemisinins have also been shown to inhibit the falcipains, a papain family cysteine protease that aid hemoglobin degradation. [3]

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (201.89 mM)
Ethanol 24 mg/mL (85.0 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 282.33
Formula

C15H22O5

CAS No. 63968-64-9
Storage powder
in solvent
Synonyms Qinghaosu,Artemisinine

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03640403 Not yet recruiting MalariaFalciparum|Anemia National Institute for Medical Research Tanzania|Universiteit Antwerpen March 2019 Phase 3
NCT03640403 Not yet recruiting MalariaFalciparum|Anemia National Institute for Medical Research Tanzania|Universiteit Antwerpen March 2019 Phase 3
NCT03671109 Not yet recruiting Malaria|HIV/AIDS|Pregnancy Related Barcelona Institute for Global Health|Medicines for Malaria Venture|Universität Tübingen|Centre de Recherche Médicale de Lambaréné|Medical University of Vienna|Bernhard Nocht Institute for Tropical Medicine|Centro de Investigação em Saúde de Manhiça February 2019 Phase 3
NCT03671109 Not yet recruiting Malaria|HIV/AIDS|Pregnancy Related Barcelona Institute for Global Health|Medicines for Malaria Venture|Universität Tübingen|Centre de Recherche Médicale de Lambaréné|Medical University of Vienna|Bernhard Nocht Institute for Tropical Medicine|Centro de Investigação em Saúde de Manhiça February 2019 Phase 3
NCT03576313 Recruiting Malaria London School of Hygiene and Tropical Medicine|Institute of Tropical Medicine Belgium|National Malaria Control Programme The Gambia|Liverpool School of Tropical Medicine|Radboud University|University of Durham|Imperial College London August 11 2018 Phase 3
NCT03576313 Recruiting Malaria London School of Hygiene and Tropical Medicine|Institute of Tropical Medicine Belgium|National Malaria Control Programme The Gambia|Liverpool School of Tropical Medicine|Radboud University|University of Durham|Imperial College London August 11 2018 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID