Artemisinin

Catalog No.S1282 Synonyms: Qinghaosu,Artemisinine,Coartem,NSC 369397

For research use only.

Artemisinin (Qinghaosu,Artemisinine,Coartem,NSC 369397) is a sesquiterpene endoperoxide which is a potent antimalarial agent.

Artemisinin Chemical Structure

CAS No. 63968-64-9

Selleck's Artemisinin has been cited by 6 Publications

Purity & Quality Control

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Biological Activity

Description Artemisinin (Qinghaosu,Artemisinine,Coartem,NSC 369397) is a sesquiterpene endoperoxide which is a potent antimalarial agent.
In vitro

Artemisinin's antimalarial activity has been shown to be mediated by activated oxygen (i.e., superoxide, hydrogen peroxide, and/or hydroxyl radicals). Artemisinin and heroin appear to be forming an adduct whose behavior resembles the behavior of the parasite Artemisinin product. [1] Artemisinin activity can be potentiated by oxygen and oxidizing agents and attenuated by reducing agents. Artemisinin susceptibility can be influenced by genetic changes in the loci encoding P. falciparum multidrug resistance protein 1 (PfMDR1) and P. falciparum chloroquine resistance transporter (PfCRT). [2] Artemisinins are effective not only against multi-resistant strains of P. falciparum, but have broad stage specificity against the Plasmodium life cycle including activity throughout the asexual blood stages and also the sexual gametocyte stages which may reduce the spread of the disease in areas of low transmission. Artemisinins have also been investigated for their antiproliferative effects against a wide range of cancer cell lines. Artemisinin is active against other parasite species such as Toxoplasma and Babesia that do not contain hematin. Artemisinin results in decreased proliferation, increased levels of oxidative stress, induction of apoptosis and inhibition of angiogenesis in cancer cells. Artemisinins have also been shown to inhibit the falcipains, a papain family cysteine protease that aid hemoglobin degradation. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 282.33
Formula

C15H22O5

CAS No. 63968-64-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05343312 Recruiting Drug: AL (Coartem)|Drug: AS-AQ (Carsucam)|Drug: DHP|Drug: PA Malaria Centro de Investigacao em Saude de Manhica|United States Agency for International Development (USAID) March 16 2022 Phase 4
NCT05070520 Completed Drug: Artemether-lumefantrine MALARIA Programme National de Lutte contre le Paludisme Niger September 1 2020 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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