Amiodarone HCl

For research use only.

Catalog No.S1979

4 publications

Amiodarone HCl Chemical Structure

CAS No. 19774-82-4

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Selleck's Amiodarone HCl has been cited by 4 publications

1 Customer Review

  • Drugs across therapeutic indications induce lipid formation in hiPS-CM. Lipid accumulation was detected in cardiac cells using the LipidTox plate-based fluorescent assay on the Thermo Scientific CellInsight High Content platform. A) Ten drugs increased lipid levels in hiPS-CM following 48 h treatment. The lowest drug dose that induced a N1.5-fold increase in lipid formation is shown. B) Representative images (20×) from the assay are shown to the right. All drugs had >55% cell viability at 48 h at these tested concentrations. C) Of these 10 drugs, 8 significantly increased lipid accumulation following only 24 h treatment (images not shown). All drugs had >80% cell viability at 24 h at these drug doses. The graphs represent the mean fold-change of the lowest concentration of drug that significantly induced lipid formation >1.5-fold more than vehicle control. *P<0.05, **P<0.01, and ***P<0.0001.

    Toxicol Appl Pharmacol, 2015, 285(1):51-60.. Amiodarone HCl purchased from Selleck.

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Biological Activity

Description Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
Potassium channel [1]
In vitro

Amiodarone possesses an inhibitory effect on the fast sodium channel as well as on the slow calcium channel. Amiodarone also has non-competitive antisympathetic effects, and modulates thyroid function and phospholipid metabolism. Amiodarone penetrates deeply into the lipid matrix of the membrane, and is released from cardiac tissues very slowly when washed out. Amiodarone (44–88 μM) depresses Vmax of guinea pig papillary muscle without affecting the resting membrane potential, and that this Vmax inhibition is enhanced in a frequency- or use-dependent manner like Class I antiarrhythmic drugs. Amiodarone (50–88 μM) is also found to suppress the depolarization-induced spontaneous action potentials (abnormal automaticity) in ventricular muscles and in Purkinje fibers. [1]

In vivo Amiodarone (1.25–25 mg/kg) results in a decrease in sinus rate, a prolongation of effective and functional refractory periods of the atrioventricular node, and a frequency-dependent conduction delay in the atrioventricular node and in the ventricle of anesthetized dogs. Amiodarone (50 mg/kg/day, i.p. for 3–4 weeks) results in significant decreases in the current density of iK and ito in ventricular cells without affecting iCa and iK1 densities in rabbit. Amiodarone (AM) inhibits intracellular conversion from thyroxine (T4) to triiodothyronine (T3) via 5′-deiodination (5′DI) without affecting intracellular conversion from T4 to reverse T3 (rT3). [1]


Solubility (25°C)

In vitro DMSO 23 mg/mL (33.73 mM)
Ethanol 11 mg/mL (16.13 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 681.77


CAS No. 19774-82-4
Storage powder
in solvent
Synonyms N/A
Smiles CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03991754 Not yet recruiting Procedure: transcatheter aortic valve implantation Atrial Fibrillation New Onset Luis Nombela Franco|Hospital San Carlos Madrid June 30 2019 Phase 3
NCT03842020 Recruiting Other: Blood pharmacokinetic samples Heart Rhythm Disorder Assistance Publique - Hôpitaux de Paris|URC-CIC Paris Descartes Necker Cochin February 13 2019 Not Applicable
NCT03919097 Recruiting Other: Medical Data extraction Flutter José Castro|Brugmann University Hospital January 8 2019 --
NCT02783976 Completed Drug: Sovaldi HCV Infection Gilead Sciences October 28 2016 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID