Aliskiren Hemifumarate

For research use only.

Catalog No.S2199

2 publications

Aliskiren Hemifumarate Chemical Structure

CAS No. 173334-58-2

Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.

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10mM (1mL in DMSO) USD 100 In stock
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Selleck's Aliskiren Hemifumarate has been cited by 2 publications

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Biological Activity

Description Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.
Renin [1]
1.5 nM
In vitro

Aliskiren hemifumarate appears to bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans. [2]

In vivo Aliskiren hemifumarate (< 10 mg/kg, oral) inhibits plasma renin activity and lowers blood pressure in sodium-depleted marmosets. [3] Once-daily oral treatment with Aliskiren hemifumarate lowers blood pressure effectively, with a safety and tolerability profile, in patients with mild-to-moderate hypertension. [4]


Solubility (25°C)

In vitro DMSO 100 mg/mL (163.98 mM)
Water 100 mg/mL (163.98 mM)
Ethanol 100 mg/mL (163.98 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 609.83


CAS No. 173334-58-2
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04432350 Not yet recruiting -- COVID|Drug Effect|Drug Interaction|Risk Reduction Tabula Rasa HealthCare June 15 2020 --
NCT01570686 Completed Drug: Aliskiren Hypertension Novartis Pharmaceuticals|Novartis April 2012 Phase 4
NCT01519635 Completed Drug: Aliskiren|Drug: Hydrochlorothiazide Hypertension Centre Hospitalier Universitaire Vaudois October 2011 Phase 4
NCT01235910 Terminated Drug: Aliskiren Hypertension|Cardiac Transplantation University of Colorado Denver|American Heart Association May 2011 Phase 4
NCT01237873 Completed Drug: Ali/Amlo 150/2.5 mg Essential Hypertension Novartis Pharmaceuticals|Novartis January 2011 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID