Home Immunology & Inflammation TpoR agonist Avatrombopag

research use only

Avatrombopag TpoR agonist

Cat.No.S6624

Avatrombopag (AKR-501,E5501,YM477) is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation.
Avatrombopag TpoR agonist Chemical Structure

Chemical Structure

Molecular Weight: 649.65

Jump to

Quality Control

Batch: Purity: 99.96%
99.96

Solubility

In vitro
Batch:

DMSO : 20 mg/mL (30.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 649.65 Formula

C29H34Cl2N6O3S2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 570406-98-3 -- Storage of Stock Solutions

Synonyms AKR-501,E5501,YM477 SMILES C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-12-12)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07278908 NOT_YET_RECRUITING
ITP - Immune Thrombocytopenia
Institute of Hematology & Blood Diseases Hospital, China
 2025-12 PHASE2; PHASE3
NCT07786922 NOT_YET_RECRUITING
Aplastic Anemia
Swedish Orphan Biovitrum
 2026-07-31 PHASE2; PHASE3
NCT07051915 NOT_YET_RECRUITING
Thrombocytopenia Purpura
Ostfold Hospital Trust
 2025-09-15 PHASE3
NCT07133659 RECRUITING
ITP - Immune Thrombocytopenia
Al-Mustansiriyah University
 2025-06-08 PHASE4
NCT05772546 COMPLETED
Gastrointestinal Cancer; Gastrointestinal Neoplasms; Chemotherapy-Induced Thrombocytopenia
Hanny Al-Samkari, MD
 2023-11-01 PHASE2
NCT06281327 RECRUITING
Immune Thrombocytopenia; Treatment
Institute of Hematology & Blood Diseases Hospital, China
 2024-03-01 PHASE2

Read more about Clinical Trials

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.