Home Immunology & Inflammation TpoR agonist Avatrombopag

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Avatrombopag TpoR agonist

Cat.No.S6624

Avatrombopag (AKR-501,E5501,YM477) is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation.
Avatrombopag TpoR agonist Chemical Structure

Chemical Structure

Molecular Weight: 649.65

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Quality Control

Batch: Purity: 99.96%
99.96

Solubility

In vitro
Batch:

DMSO : 20 mg/mL (30.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 649.65 Formula

C29H34Cl2N6O3S2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 570406-98-3 -- Storage of Stock Solutions

Synonyms AKR-501,E5501,YM477 Smiles C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05772546 Recruiting
Gastrointestinal Cancer|Gastrointestinal Neoplasms|Chemotherapy-Induced Thrombocytopenia
Hanny Al-Samkari MD|Swedish Orphan Biovitrum|Massachusetts General Hospital
 November 1 2023 Phase 2
NCT04312789 Withdrawn
Platelet Disorder
Ayman Saad|Sobi Inc.|Ohio State University Comprehensive Cancer Center
 December 2022 Phase 2
NCT05518331 Recruiting
Refractory Aplastic Anemia
Institute of Hematology & Blood Diseases Hospital China|Peking University People''s Hospital|Xiyuan Hospital of China Academy of Chinese Medical Sciences|Second Hospital of Shanxi Medical University|First Affiliated Hospital of Harbin Medical University|The First Hospital of Hebei Medical University
 June 1 2022 Not Applicable
NCT05218226 Recruiting
Chemotherapy-induced Thrombocytopenia|Avatrombopag
Institute of Hematology & Blood Diseases Hospital China|Tianjin Medical University Cancer Institute and Hospital|Tianjin Medical University Second Hospital|Tianjin Third Central Hospital|Tianjin People''s Hospital|Henan Cancer Hospital|The Second Affiliated Hospital of Kunming Medical University
 February 10 2022 Phase 2
NCT04949009 Unknown status
Primary Immune Thrombocytopenia
Shandong University
 March 1 2021 --
NCT04609891 Completed
Thrombocytopenia
Anhui Provincial Cancer Hospital
 May 26 2020 Not Applicable

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