Catalog No.S4019

For research use only.

Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.

Avanafil Chemical Structure

CAS No. 330784-47-9

Selleck's Avanafil has been cited by 1 Publication

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Biological Activity

Description Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
Features Highly selective for PDE5.
PDE5 [1]
1 nM
In vivo Avanafil (i.v.) potentiates penile tumescence with ED200% of 37.5 μg/kg in dogs. Furthermore, intraduodenal treatment of Avanafil potentiates pelvic nerve stimulation induced changes in intracavernous pressure and duration. [1] The cavernous injection of avanafil (1 μM) in T2DM rats results in partial improvement in erectile responses. [2]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Male mongrel dogs
  • Dosages: 1-300 μg/kg
  • Administration: Intraduodenal treatment or i.v.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 483.95


CAS No. 330784-47-9
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04374994 Completed Drug: Avanafil 50 MG|Drug: Placebo oral tablet Erectile Dysfunction University of Alexandria September 1 2018 Phase 4
NCT01095601 Completed Drug: Avanafil Healthy VIVUS LLC April 2010 Phase 1
NCT01117038 Completed Drug: avanafil and enalapril|Drug: avanafil and amlodipine Erectile Dysfunction VIVUS LLC April 2010 Phase 1
NCT01054430 Completed Drug: avanafil Erectile Dysfunction VIVUS LLC January 2010 Phase 1
NCT01054261 Completed Drug: avanafil Renal VIVUS LLC January 2010 Phase 1
NCT00914511 Completed Drug: avanafil 200mg Avanfil ADME|Semen Exposure|Sperm Function VIVUS LLC May 2009 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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