Avanafil

For research use only.

Catalog No.S4019

Avanafil Chemical Structure

Molecular Weight(MW): 483.95

Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Biological Activity

Description Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
Features Highly selective for PDE5.
Targets
PDE5 [1]
1 nM
In vivo Avanafil (i.v.) potentiates penile tumescence with ED200% of 37.5 μg/kg in dogs. Furthermore, intraduodenal treatment of Avanafil potentiates pelvic nerve stimulation induced changes in intracavernous pressure and duration. [1] The cavernous injection of avanafil (1 μM) in T2DM rats results in partial improvement in erectile responses. [2]

Protocol

Animal Research:[1]
- Collapse
  • Animal Models: Male mongrel dogs
  • Dosages: 1-300 μg/kg
  • Administration: Intraduodenal treatment or i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (200.43 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 483.95
Formula

C23H26ClN7O3

CAS No. 330784-47-9
Storage powder
in solvent
Synonyms N/A
Smiles COC1=C(Cl)C=C(CNC2=C(C=NC(=N2)N3CCCC3CO)C(=O)NCC4=NC=CC=N4)C=C1

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04374994 Completed Drug: Avanafil 50 MG|Drug: Placebo oral tablet Erectile Dysfunction University of Alexandria September 1 2018 Phase 4
NCT01095601 Completed Drug: Avanafil Healthy VIVUS Inc. April 2010 Phase 1
NCT01117038 Completed Drug: avanafil and enalapril|Drug: avanafil and amlodipine Erectile Dysfunction VIVUS Inc. April 2010 Phase 1
NCT01054430 Completed Drug: avanafil Erectile Dysfunction VIVUS Inc. January 2010 Phase 1
NCT01054261 Completed Drug: avanafil Renal VIVUS Inc. January 2010 Phase 1
NCT00914511 Completed Drug: avanafil 200mg Avanfil ADME|Semen Exposure|Sperm Function VIVUS Inc. May 2009 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID