Catalog No.S7393 Synonyms: E-64d
Molecular Weight(MW): 342.43
Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.
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Choose Selective Cysteine Protease Inhibitors
|Description||Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.|
Aloxistatin can enter the intact platelet and inhibit proteolysis by inhibiting calpain.  Aloxistatin blunts Parathyroid hormone (PTH)-induced cell proliferation and inhibits differentiation osteoblasts in vitro. 
|In vivo||Aloxistatin (100 mg/kg, p.o.) strongly inhibits the cathepsin B&L activities in the skeletal muscle, heart and liver of hamsters.  In spinal cord injury (SCI) rats, Aloxistatin provides neuroprotection in SCI lesion and penumbra.  Aloxistatin reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B activity. |
-  Tamai M, et al. J Pharmacobiodyn. 1986, 9(8), 672-677.
-  McGowan EB, et al. Biochem Biophys Res Commun. 1989, 158(2), 432-435.
-  Murray EJ, et al. Metabolism. 1997 , 46(9), 1090-1094.
|In vitro||DMSO||68 mg/mL (198.58 mM)|
|Ethanol||68 mg/mL (198.58 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+corn oil
For best results, use promptly after mixing.
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