For research use only. Not for use in humans.
Catalog No.S7393 Synonyms: E-64d
Molecular Weight(MW): 342.43
Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.
Purity & Quality Control
Choose Selective Cysteine Protease Inhibitors
|Description||Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.|
Aloxistatin can enter the intact platelet and inhibit proteolysis by inhibiting calpain.  Aloxistatin blunts Parathyroid hormone (PTH)-induced cell proliferation and inhibits differentiation osteoblasts in vitro. 
|In vivo||Aloxistatin (100 mg/kg, p.o.) strongly inhibits the cathepsin B&L activities in the skeletal muscle, heart and liver of hamsters.  In spinal cord injury (SCI) rats, Aloxistatin provides neuroprotection in SCI lesion and penumbra.  Aloxistatin reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B activity. |
-  Tamai M, et al. J Pharmacobiodyn. 1986, 9(8), 672-677.
-  McGowan EB, et al. Biochem Biophys Res Commun. 1989, 158(2), 432-435.
-  Murray EJ, et al. Metabolism. 1997 , 46(9), 1090-1094.
|In vitro||DMSO||68 mg/mL (198.58 mM)|
|Ethanol||68 mg/mL (198.58 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+corn oil
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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