Akti-1/2

Catalog No.S7776 Synonyms: Akt Inhibitor VIII

For research use only.

Akti-1/2 (Akt Inhibitor VIII) is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3. Akti-1/2 induces apoptosis.

Akti-1/2 Chemical Structure

CAS No. 612847-09-3

Selleck's Akti-1/2 has been cited by 13 publications

Purity & Quality Control

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Biological Activity

Description Akti-1/2 (Akt Inhibitor VIII) is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3. Akti-1/2 induces apoptosis.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
58 nM 210 nM 2119 nM
In vitro

In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. [1] In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. [2] Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. [3] In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-468 cells NITqemhEgXSxdH;4bYNqfHliYYPzZZk> MnKxNVAh|ryP NYXRe2lLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{BqdiCycnXz[Y5k\SCxZjCxNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9Nk43PiEQvF2= NUez[IdSOTh4OUG4PVQ>
MDA-MB-231 cells NXjnbZFIS3m2b4TvfIlkcXS7IHHzd4F6 Mnn5NVAh|ryP M{HDXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMUCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG|c3H5MEBIUTVyPUSuOVUh|ryP NVnyNIVIOTh4OUG4PVQ>
MCF7 cells Mkf5R5l1d3SxeHnjbZR6KGG|c3H5 MWqxNEDPxE1? MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIlvKHC{ZYPlcoNmKG:oIEGwJJVOKGOqbH;yc5F2cW6nIHL5JHNTSiCjc4PhfUwhT0l3ME2wMlQyKM7:TR?= MYixPFY6OTh7NB?=
184B5 cells M3vVVWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1i3VFIxKM7:TR?= NEDIO5REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAyQDSENTDj[YxteyCjdDCyNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9NlUvPzZizszN NVnaTVc4OTh4OUG4PVQ>
NCI-H1563 cell NXHNT3NxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHPXWmRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVU3OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwNUSyOFYh|ryP MYfTRW5ITVJ?
NCI-H1618 cel NX7MVHBWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[xPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIyNjl7OEKg{txO MX\TRW5ITVJ?
NCI-H1623 cell NV30OGhzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M37DTmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlI{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwMEW5OkDPxE1? NEPvb45USU6JRWK=
NCI-H1648 cell M3nXN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGPVbFJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwN{W1NUDPxE1? MXLTRW5ITVJ?
NCI-H1650 cell M37pNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1fpWWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwNUGzOEDPxE1? NHLYO2JUSU6JRWK=
NCI-H1651 cell M2[xV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{W5W2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlUyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwNEOzPEDPxE1? NULPSWdWW0GQR1XS
NCI-H1703 cell Mle2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3Tn[GlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|A{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwNUe3JO69VQ>? NGWzT4NUSU6JRWK=
NCI-H1734 cell Mk\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWDafG5SUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4OzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD63O|g5KM7:TR?= MoHjV2FPT0WU
NCI-H1755 cell MnX3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnSzTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3OVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB3NUOxJO69VQ>? NGLKTmNUSU6JRWK=
NCI-H1770 cell NW\Xcpk2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUe3NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM1NjF5OUOg{txO MUDTRW5ITVJ?
NCI-H1792 cell MmHTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFTUTWJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ7LkizO|kh|ryP NUfjWXpQW0GQR1XS
NCI-H1963 cell M4XBWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{j3WWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixPVY{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTlwN{S5OEDPxE1? NIjtR29USU6JRWK=
NCI-H1993 cell MkX1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUm5N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjZzNTFOwG0> NY\icVRjW0GQR1XS
NCI-H2009 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVTMUHlbUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxODliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkO5NFE6KM7:TR?= MYnTRW5ITVJ?
NCI-H2030 cell NXLqeZVRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUTKepc4UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxOzBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkm0OFg{KM7:TR?= Mn3oV2FPT0WU
NCI-H2122 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV\mN|F1UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIyOjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD6xN|g2KM7:TR?= MWLTRW5ITVJ?
NCI-H2126 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4DQNWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwM{O3NUDPxE1? Mn;UV2FPT0WU
NCI-H2170 cell MlrZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHvCNHVKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlE4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkGwNlgh|ryP NEXNfGlUSU6JRWK=
NCI-H2196 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2HjbmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVk3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjRwOECwN{DPxE1? NWTDfJVHW0GQR1XS
NCI-H2228 cell M4fVZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3;FWWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNlI5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OE[wOEDPxE1? Mlv0V2FPT0WU
NCI-H2342 cell M4rOSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MojCTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzOFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl|N{e5JO69VQ>? MVjTRW5ITVJ?
NCI-H2347 cell NX\2TpB{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHPNS4RKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlM1PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF4LkG1PFEh|ryP NFHKV2FUSU6JRWK=
NCI-H2405 cell MoHGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkSwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjR{MUKg{txO M{nPe3NCVkeHUh?=
NCI-H2452 cell NWT3ZWJpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVj4Rlh3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI1PTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Nj62OVk1KM7:TR?= NXLzTopCW0GQR1XS
NCI-H292 cell M4jYSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkmyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4xPDh|NzFOwG0> NGSzd2FUSU6JRWK=
NCI-H345 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1PvVmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVizOFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPi5{N{C2JO69VQ>? NFLvVY1USU6JRWK=
NCI-H358 cell MlrYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH[4XlhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IN|U5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTlwN{KzN{DPxE1? MVLTRW5ITVJ?
NCI-H460 cell NGDD[2dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkG3TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSES2NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvPjJ7OUOg{txO M2e3WnNCVkeHUh?=
NCI-H520 cell NGrpZmtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2TGO2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF|M{CzJO69VQ>? NWHMeYxNW0GQR1XS
NCI-H522 cell Mn\TS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoCzTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjB6N{Sg{txO NUHwXId{W0GQR1XS
NCI-H526 cell M3e2[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPjTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIzNjh6N{ROwG0> MV\TRW5ITVJ?
NCI-H596 M2fmd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUXPNGRLUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFU6PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF5LkW3NFgh|ryP M{C5RXNCVkeHUh?=
NCI-H630 cell MmfZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M120dGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi2N|Ah[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjVzMEW1JO69VQ>? MkjpV2FPT0WU
NCI-H64 cell M{jpN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXXwdldVUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwNUSzNUDPxE1? NWjsTlhkW0GQR1XS
NCI-H650 cell NVz1RmlXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4n6XGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi2OVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjV7OEe3JO69VQ>? NXjPfYhmW0GQR1XS
NCI-H661 cell M33PdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWDJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNk[xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU41OjN{NjFOwG0> M2CwbHNCVkeHUh?=
NCI-H747 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYm5TnNQUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFc1PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNkK3PVkh|ryP Mlu1V2FPT0WU
NCI-H838 cell M1vqdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KOEO4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|EvPDFzODFOwG0> NEiyVVBUSU6JRWK=
NCI-N87 cell NXnYWpZ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkntTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvTki3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlkvOzB2MjFOwG0> NFrSOJVUSU6JRWK=
NH-12 cell NG\Bc3NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG5JNTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD62NFg3PCEQvF2= NGrlbVNUSU6JRWK=
NKM-1 cell NWm2N3ZST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn3QTY5pcWKrdHnvckBw\iCqdX3hckBPU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuO|U6OjNizszN NWTuc4N4W0GQR1XS
NMC-G1 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2rOUGlvcGmkaYTpc44hd2ZiaIXtZY4hVk2FLVexJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFIvPjZ7MzFOwG0> NID3NphUSU6JRWK=
NOS-1 cell MljyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGnKU2RKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{Pjl3MzFOwG0> MX;TRW5ITVJ?
NUGC-3 cell M{Tke2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGjG[oRKdmirYnn0bY9vKG:oIHj1cYFvKE6XR1OtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjV7ME[g{txO MorZV2FPT0WU
NY cell NWr0W|FNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{THWGlvcGmkaYTpc44hd2ZiaIXtZY4hVlliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|MT6xPFY1KM7:TR?= MnXtV2FPT0WU
OAW-42 cell M3mxVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlTSTY5pcWKrdHnvckBw\iCqdX3hckBQSVdvNEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlMyPTZ3IN88US=> M2XMfnNCVkeHUh?=
OCI-AML2 cell NHz1VFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2K5emlvcGmkaYTpc44hd2ZiaIXtZY4hV0OLLVHNUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oy5{NUOxJO69VQ>? M4i0XnNCVkeHUh?=
OCUB-M cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG9EXUJvTTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuO|IyPTJizszN NVPielhyW0GQR1XS
OE19 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGeyfFhKdmirYnn0bY9vKG:oIHj1cYFvKE:HMUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23Mlc3Pjh2IN88US=> Mn6wV2FPT0WU
OE33 cell NIrqOFJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NELUUWNKdmirYnn0bY9vKG:oIHj1cYFvKE:HM{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg5QTJ4IN88US=> M1rLO3NCVkeHUh?=
OMC-1 cell M336OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYjJcohq[mm2aX;uJI9nKGi3bXHuJG9OSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT6yOVA6QCEQvF2= NXvjPGdyW0GQR1XS
OS-RC-2 cell M4njSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2nRemlvcGmkaYTpc44hd2ZiaIXtZY4hV1NvUlOtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPTJ|MEeg{txO M4nVU3NCVkeHUh?=
OVCAR-3 cell M2DJSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW\VRpVXUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk0{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS56NESxOUDPxE1? M4m0U3NCVkeHUh?=
OVCAR-4 cell M3jMXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{D6Z2lvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMxNjR4NjFOwG0> MnXhV2FPT0WU
P12-ICHIKAWA cell NWnvVJRNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mkj3TY5pcWKrdHnvckBw\iCqdX3hckBROTJvSVPITWtCX0FiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND63Olg{KM7:TR?= M1f5dnNCVkeHUh?=
P30-OHK cell M1Pqemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{\BdGlvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvPTN4IN88US=> MkPxV2FPT0WU
PA-1 cell NUP3OGl3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEPwZlVKdmirYnn0bY9vKG:oIHj1cYFvKFCDLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlA4PjF3IN88US=> M{\WXnNCVkeHUh?=
PANC-03-27 cell NV;YXmt2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUKybpdbUW6qaXLpeIlwdiCxZjDoeY1idiCSQV7DMVA{NTJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD63NVA5OiEQvF2= NGTFenBUSU6JRWK=
PANC-10-05 cell NUjUTYVKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJHBCVkNvMUCtNFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC57OUW5JO69VQ>? MofoV2FPT0WU
PC-3 cell MmPCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGXlW2hKdmirYnn0bY9vKG:oIHj1cYFvKFCFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE42OTN3IN88US=> NHvtT4VUSU6JRWK=
PF-382 cell NYHnenc1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYnJcohq[mm2aX;uJI9nKGi3bXHuJHBHNTN6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlY5OjhizszN MV;TRW5ITVJ?
RCC10RGB cell NFfZZ2xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mmi3TY5pcWKrdHnvckBw\iCqdX3hckBTS0NzMGLHRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPjV4NzFOwG0> NEDjSXNUSU6JRWK=
RD cell MnjyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnfUTY5pcWKrdHnvckBw\iCqdX3hckBTTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJyLk[wN|Yh|ryP NWrpdpJ3W0GQR1XS
REH cell NV65boJJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzZZVNKdmirYnn0bY9vKG:oIHj1cYFvKFKHSDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlQ5QDNizszN NFzlOpBUSU6JRWK=
RERF-LC-MS cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYfJcohq[mm2aX;uJI9nKGi3bXHuJHJGWkZvTFOtUXMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPi5zM{S3JO69VQ>? M322UXNCVkeHUh?=
RKO cell M4LHe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXjJcohq[mm2aX;uJI9nKGi3bXHuJHJMVyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF7LkS0N|kh|ryP NWXmdoVoW0GQR1XS
RO82-W-1 cell NVLvNGVyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYXDd29{UW6qaXLpeIlwdiCxZjDoeY1idiCUT{iyMXcuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTR5LkK3PFMh|ryP M4HY[3NCVkeHUh?=
RPMI-2650 cell M3j3Tmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkLZTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUK2OVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd5OUS3JO69VQ>? NGe4Z|lUSU6JRWK=
RPMI-8402 cell Mmi5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEj4bmhKdmirYnn0bY9vKG:oIHj1cYFvKFKSTVmtPFQxOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF4LkO0N{DPxE1? MV\TRW5ITVJ?
RS4-11 cell Mn65S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIX4bmlKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPjh4NEWg{txO MWHTRW5ITVJ?
RT-112 cell M2\xZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmDzTY5pcWKrdHnvckBw\iCqdX3hckBTXC1zMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlcyQTV{IN88US=> MXjTRW5ITVJ?
RVH-421 cell Ml\LS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIrxXXpKdmirYnn0bY9vKG:oIHj1cYFvKFKYSD20NlEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Oi5|NkC2JO69VQ>? MoqxV2FPT0WU
RXF393 cell M1\5SGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYWyWIxJUW6qaXLpeIlwdiCxZjDoeY1idiCUWF[zPVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOC53OE[zJO69VQ>? MmHNV2FPT0WU
SBC-5 cell M33ye2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJHNDSy13IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkCuPFMzPSEQvF2= M1z3[HNCVkeHUh?=
SCC-25 cell M2PRTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXTJcohq[mm2aX;uJI9nKGi3bXHuJHNESy1{NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlgyPzlizszN MVPTRW5ITVJ?
SCC-4 cell M2TlfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGTacXNKdmirYnn0bY9vKG:oIHj1cYFvKFOFQz20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU42QTJ6MzFOwG0> NX;rUnhLW0GQR1XS
SCC-9 cell M3\RSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH3scVZKdmirYnn0bY9vKG:oIHj1cYFvKFOFQz25JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xQDV|NjFOwG0> M4XMRXNCVkeHUh?=
SF126 cell NEKxT2tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHjGTXBKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvPjd2NjFOwG0> MULTRW5ITVJ?
SF268 cell MmTlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3HYfGlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z{NkigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yOzh5IN88US=> M4i1bnNCVkeHUh?=
SF295 cell NWO2[G1uT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVfJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjl3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuOlE5OyEQvF2= MlfCV2FPT0WU
SIG-M5 cell NWHYb4R7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYnJcohq[mm2aX;uJI9nKGi3bXHuJHNKTy2PNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlY3ODRizszN MU\TRW5ITVJ?
SJSA-1 cell Ml7nS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVWySWFkUW6qaXLpeIlwdiCxZjDoeY1idiCVSmPBMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Pi57MEeyJO69VQ>? Mm\oV2FPT0WU
SK-CO-1 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoXqTY5pcWKrdHnvckBw\iCqdX3hckBUUy2FTz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvPjN7NDFOwG0> NELCdHBUSU6JRWK=
SK-LMS-1 cell MkXuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJHNMNUyPUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE44PjR3MjFOwG0> MofSV2FPT0WU
SK-LU-1 cell NH7ESohIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{D5SWlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTGWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjB2MzFOwG0> MXLTRW5ITVJ?
SK-MEL-24 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUnEUZRUUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSWwuOjRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMz6xOlc2KM7:TR?= NVHTVZdTW0GQR1XS
SK-MEL-3 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJHNMNU2HTD2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvPDZ7NjFOwG0> MX;TRW5ITVJ?
SK-MES-1 cell NH;aTndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYrWXI96UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSXMuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMUCwPVYh|ryP NG\tN5BUSU6JRWK=
human SN12C cell M2D2Wmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUTJcohq[mm2aX;uJI9nKGi3bXHuJHNPOTKFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUeuNVk3PyEQvF2= NIi4TGVUSU6JRWK=
SNB75 cell M3nId2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH\nRZRKdmirYnn0bY9vKG:oIHj1cYFvKFOQQke1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{45Ojl5IN88US=> M1H3RnNCVkeHUh?=
SNU-387 cell M3S2WGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVnCSooxUW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtN|g4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5zOUW0OEDPxE1? NGX3WItUSU6JRWK=
SNU-423 cell NF:zfJZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX7ZXlBHUW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtOFI{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS57NEmzN{DPxE1? M4DWN3NCVkeHUh?=
SNU-C1 cell NF3qVmxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHNPXS2FMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFA6PDhizszN NYO1O2hZW0GQR1XS
SNU-C2B cell NVS1WlJ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mnz5TY5pcWKrdHnvckBw\iCqdX3hckBUVlVvQ{LCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvOjZ5MzFOwG0> NVHuT5EzW0GQR1XS
SR cell NWDFU4RzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzBUZBKdmirYnn0bY9vKG:oIHj1cYFvKFOUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuNFc1PiEQvF2= NYrlbXNNW0GQR1XS
SU-DHL-1 cell Moe0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFGwN21KdmirYnn0bY9vKG:oIHj1cYFvKFOXLVTIUE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi56MUW0N{DPxE1? NVvld3dpW0GQR1XS
SW1710 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXPaNIJbUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3NVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjN6OEmyJO69VQ>? M2rqNXNCVkeHUh?=
SW780 cell NFGxNZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTjTY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPFk{PThizszN NETocmRUSU6JRWK=
SW872 cell NVzx[pp6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYTDWWZkUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjF2M{Wg{txO MmD6V2FPT0WU
SW954 cell NV3SZ45{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIfKeGZKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUW0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU45PTd6MzFOwG0> MVLTRW5ITVJ?
T47D cell MnPzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGjXZ|ZKdmirYnn0bY9vKG:oIHj1cYFvKFR2N1SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlUyPjJizszN NFrsOoZUSU6JRWK=
22RV1 cell NVTFWmNVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUnycnl5UW6qaXLpeIlwdiCxZjDoeY1idiB{MmLWNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPjF2MkSg{txO M13KdXNCVkeHUh?=
23132-87 cell NUDvbG5vT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIDEdIhKdmirYnn0bY9vKG:oIHj1cYFvKDJ|MUOyMVg4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC55NUmzPEDPxE1? MnLIV2FPT0WU
639-V cell MoXES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoHrTY5pcWKrdHnvckBw\iCqdX3hckA3OzlvVjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuPFc4OyEQvF2= NGr5NXhUSU6JRWK=
697 cell NXXwXnJxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEW3cGpKdmirYnn0bY9vKG:oIHj1cYFvKDZ7NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNVc4PDZizszN MVXTRW5ITVJ?
769-P cell Mn\sS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYHJcohq[mm2aX;uJI9nKGi3bXHuJFc3QS2SIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFQ5OyEQvF2= MYDTRW5ITVJ?
8-MG-BA cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWO5PWtIUW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC54M{SwNUDPxE1? MoDVV2FPT0WU
A4-Fuk cell NVe4TppvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV\VNpc2UW6qaXLpeIlwdiCxZjDoeY1idiCDND3GeYsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh3OEOg{txO NHS3TnhUSU6JRWK=
A427 cell M3;adGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYnJcohq[mm2aX;uJI9nKGi3bXHuJGE1OjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkC3Olk{KM7:TR?= M3z2TXNCVkeHUh?=
A498 cell M4jOfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmLhTY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wPFE{PCEQvF2= MXjTRW5ITVJ?
AN3-CA cell M4\BNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX\LTHRCUW6qaXLpeIlwdiCxZjDoeY1idiCDTkOtR2Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ3NkGxJO69VQ>? NETJRlZUSU6JRWK=
AU565 cell NFvKZVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3TYSmlvcGmkaYTpc44hd2ZiaIXtZY4hSVV3NkWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI{QTF5IN88US=> NFLMNoxUSU6JRWK=
BB30-HNC cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGJDOzBvSF7DJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45PjR2OTFOwG0> NHOwfHVUSU6JRWK=
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EFO-21 cell NIT3R3VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M33tc2lvcGmkaYTpc44hd2ZiaIXtZY4hTU[RLUKxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE41OzR4ODFOwG0> MVvTRW5ITVJ?
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EW-3 cell M1jwd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnvBTY5pcWKrdHnvckBw\iCqdX3hckBGXy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT62OFQyPCEQvF2= NWnBPYdQW0GQR1XS
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HGC-27 cell M1TVc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGhISy1{NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVUxOzNizszN M{LGT3NCVkeHUh?=
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MDA-MB-361 cell M331eWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVT5XpRKUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOzZzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD60PFk6PSEQvF2= M4DITXNCVkeHUh?=
MDA-MB-415 cell MmHTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIHufYdKdmirYnn0bY9vKG:oIHj1cYFvKE2GQT3NRk01OTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkezOFQ6KM7:TR?= Ml\iV2FPT0WU
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ME-180 cell NV;RfpJNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYHpXHF4UW6qaXLpeIlwdiCxZjDoeY1idiCPRT2xPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjF3MEGxJO6ddQ>? NXy2O41oW0GQR1XS
NCI-H526 cells M3XRO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm\WTY5pcWKrdHnvckBw\iCDa4StcYVlcWG2ZXSgZY51cWGyb4D0c5Rq[yCjY4Tpeol1gSCrbjDoeY1idiCQQ1mtTFUzPiClZXzsd{Bie3Onc4Pl[EBieyCmaYPyeZB1cW:wIH;mJJBzd3SnaX6tRZBi\i1zIHPvcZBt\XhiYYSgOVAhfU1iYX\0[ZIhOjRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NGjsZVYyPzZyM{W0NC=>
Assay
Methods Test Index PMID
Western blot p-AKT / AKT / p-Foxo3a / p-GSK3β / p-p70S6K / p-S6 / p-4EBP1 / Cyclin D1 / Cyclin D2 / Cyclin D3 / p-Rb / p27 18725974
Immunofluorescence MCM2 / H3K9me2 / CD63 26637368
In vivo In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. [1]

Protocol (from reference)

Kinase Assay:[2]
  • Kinase screen:

    Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).

Cell Research:[4 ]
  • Cell lines: HCC827, NCI-H522, NCI-1651, and PC-9 cells
  • Concentrations: ~10 μM
  • Incubation Time: 96 h
  • Method: The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 22 mg/mL
(39.88 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 551.64
Formula

C34H29N7O

CAS No. 612847-09-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=C(N=C6C=C7C(=NC=N7)C=C6N5)C8=CC=CC=C8

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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