Akti-1/2

Catalog No.S7776 Synonyms: Akt Inhibitor VIII

Akti-1/2 Chemical Structure

Molecular Weight(MW): 551.64

Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.

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  • AKTi-1/2 inhibits human HCC cells in vitro. Human HCC HepG2 cells (A–F), Huh-7 cells (G), primary human HCC cells (“Pri HCC”, G) or the primary liver cells (“Pri liver cells”, G) were treated with/out applied concentrations of AKTi-1/2 for indicated time; Cell survival (A, B and G), proliferation (C and D) and apoptosis (E and F) were tested by the listed assays. Data were shown as the mean (n = 5) with the standard deviation (SD). Experiments in this figure were repeated three times, with similar results were obtained. *P < 0.05 vs. “C” (untreated control) group.

    Biochem Biophys Res Commun, 2016, 480(3):334-340. Akti-1/2 purchased from Selleck.

    Autophagy inhibitors sensitize AKTi-1/2-induced cytotoxicity against HCC cells. HepG2 cells were treated with/out AKTi-1/2 (5/10 μM) for indicated time; Listed proteins were tested by Western blot assay (A); The percentage of LC3B-II GFP puncta positive cells ("autophagic cells") was calculated (B). HepG2 cells, pretreated with 3-methyladenine (“3 MA”, 10 mM), ammonium chloride (“NH4Cl”, 1 mM) or bafilomycin A1 (“BafA1”, 1 μM) for 1 h, were treated with AKTi-1/2 (10 μM) for applied time; Cell survival (CCK-8 assay, C) were tested. The IC50 was also determined (D).

    Biochem Biophys Res Commun, 2016, 480(3):334-340.. Akti-1/2 purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
58 nM 210 nM 2119 nM
In vitro

In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. [1] In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. [2] Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. [3] In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-468 cells NHfvOI1EgXSxdH;4bYNqfHliYYPzZZk> M2jGWlExKM7:TR?= M1raTGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20Olgh[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMUCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG|c3H5MEBIUTVyPUKuOlYh|ryP MnTzNVg3QTF6OUS=
MDA-MB-231 cells MX7DfZRwfG:6aXPpeJkh[XO|YYm= MUexNEDPxE1? M2nTcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMUCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG|c3H5MEBIUTVyPUSuOVUh|ryP NF7wfWMyQDZ7MUi5OC=>
MCF7 cells NF;lb2hEgXSxdH;4bYNqfHliYYPzZZk> MnK5NVAh|ryP M3;ldGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMhcW5icILld4Vv[2Vib3[gNVAhfU1iY3jsc5JweXWrbnWgZpkhW1KEIHHzd4F6NCCJSUWwQVAvPDFizszN MYmxPFY6OTh7NB?=
184B5 cells NU\zO2JWS3m2b4TvfIlkcXS7IHHzd4F6 Mn7INlAh|ryP NFP1PXpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAyQDSENTDj[YxteyCjdDCyNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9NlUvPzZizszN M2OyOFE5PjlzOEm0
NCI-H1563 cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoK5TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG1OlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjV2MkS2JO69VQ>? NH;ze4NUSU6JRWK=
NCI-H1618 cel NFzHUWZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[xPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIyNjl7OEKg{txO NFj0dXBUSU6JRWK=
NCI-H1623 cell NXPJPGhuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoDDTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2NlMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS5yNUm2JO69VQ>? NGDoPIFUSU6JRWK=
NCI-H1648 cell Mn\hS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH3UfppKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwN{W1NUDPxE1? NEfWUlRUSU6JRWK=
NCI-H1650 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMU[1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjVzM{Sg{txO MVfTRW5ITVJ?
NCI-H1651 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1zoeWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlUyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwNEOzPEDPxE1? M{XDN3NCVkeHUh?=
NCI-H1703 cell M37CUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUewN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjV5NzFOwG0> MVfTRW5ITVJ?
NCI-H1734 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXTHbpl3UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4OzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD63O|g5KM7:TR?= M1;yZ3NCVkeHUh?=
NCI-H1755 cell NH6wXYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoHYTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3OVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB3NUOxJO69VQ>? MX;TRW5ITVJ?
NCI-H1770 cell NXfifGhwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1XtOmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|cxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzRwMUe5N{DPxE1? MkPUV2FPT0WU
NCI-H1792 cell M{Ozfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFLWSpdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ7LkizO|kh|ryP MnjWV2FPT0WU
NCI-H1963 cell NFzsco1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVGxSpQ{UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE6PjNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zOT63OFk1KM7:TR?= M3vrRXNCVkeHUh?=
NCI-H1993 cell Mlj0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIfjXlVKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVk6OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lk[xOUDPxE1? MWjTRW5ITVJ?
NCI-H2009 cell M1;Fdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkCwPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOzlyMUmg{txO MVvTRW5ITVJ?
NCI-H2030 cell NILCNlBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2L6SWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNFMxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NES4N{DPxE1? M{LnVnNCVkeHUh?=
NCI-H2122 cell NV\pTpFNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkGyNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjF|OEWg{txO Moj4V2FPT0WU
NCI-H2126 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4DQc2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwM{O3NUDPxE1? NUnMb49lW0GQR1XS
NCI-H2170 cell NFfRdlFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIHEd2ZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlE4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF6LkGwNlgh|ryP NEfWU5pUSU6JRWK=
NCI-H2196 cell NGnTVmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2rtTmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVk3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjRwOECwN{DPxE1? M{fEWXNCVkeHUh?=
NCI-H2228 cell M4qwe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkKyPEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjh4MESg{txO NVzWW5BoW0GQR1XS
NCI-H2342 cell M3vpZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIj5XmhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlM1OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOUO3O|kh|ryP MVrTRW5ITVJ?
NCI-H2347 cell NX\iWoNzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4TlOGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyN|Q4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwMUW4NUDPxE1? M{HvR3NCVkeHUh?=
NCI-H2405 cell Mo[1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{jlWWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyOFA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwNEKxNkDPxE1? MoDEV2FPT0WU
NCI-H2452 cell NXvuTZRQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHnmR4xKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlQ2OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ4Lk[1PVQh|ryP NF23ZmNUSU6JRWK=
NCI-H292 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFzHb2pKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlkzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi5yNEizO{DPxE1? MUHTRW5ITVJ?
NCI-H345 cell NImwdlVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGfBfnRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IN|Q2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwMkewOkDPxE1? MlvMV2FPT0WU
NCI-H358 cell MnzYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkjCTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEO1PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE6Njd{M{Og{txO MkLkV2FPT0WU
NCI-H460 cell MoraS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2P1VmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjZ{OUmzJO69VQ>? NIrPW|NUSU6JRWK=
NCI-H520 cell NEHKc5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX;Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUKwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yOzNyMzFOwG0> MmXwV2FPT0WU
NCI-H522 cell M1PJemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWP1WGxSUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUzOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFzLkC4O|Qh|ryP NGrrdJpUSU6JRWK=
NCI-H526 cell NHz0O2NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYPEUJQzUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUzPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ{Lki4O|PPxE1? MnXHV2FPT0WU
NCI-H596 M2n3c2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUm2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvPTdyODFOwG0> NV7tOWlvW0GQR1XS
NCI-H630 cell NGnNUYpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1r1PWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi2N|Ah[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjVzMEW1JO69VQ>? NXnqZXVRW0GQR1XS
NCI-H64 cell NYnNRYw3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV\HbFZ[UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwNUSzNUDPxE1? NVHFelZ6W0GQR1XS
NCI-H650 cell M{XOe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfHTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPTl6N{eg{txO M37FR3NCVkeHUh?=
NCI-H661 cell M1\sT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVjMTGxuUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY3OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNEKzNlYh|ryP NETIdXJUSU6JRWK=
NCI-H747 cell MlOyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXrmV4o4UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFc1PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNkK3PVkh|ryP M{PpbXNCVkeHUh?=
NCI-H838 cell NILVW3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFT0Tm1KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IPFM5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzFwNEGxPEDPxE1? MoHLV2FPT0WU
NCI-N87 cell MleyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2QOEegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPU4{ODR{IN88US=> Mk\NV2FPT0WU
NH-12 cell M13NbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVHCenR2UW6qaXLpeIlwdiCxZjDoeY1idiCQSD2xNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPjB6NkSg{txO M3r2W3NCVkeHUh?=
NKM-1 cell NGfaR|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrMVow4UW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzV7MkOg{txO MXnTRW5ITVJ?
NMC-G1 cell NHi4dY5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2fLcWlvcGmkaYTpc44hd2ZiaIXtZY4hVk2FLVexJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFIvPjZ7MzFOwG0> NVvBepBbW0GQR1XS
NOS-1 cell MnnjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NU\xXmdTUW6qaXLpeIlwdiCxZjDoeY1idiCQT2OtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzZ7NUOg{txO MUjTRW5ITVJ?
NUGC-3 cell NFPw[JRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NES2ZXBKdmirYnn0bY9vKG:oIHj1cYFvKE6XR1OtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE3NjV7ME[g{txO M1jmOXNCVkeHUh?=
NY cell M1rIeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV[y[VlTUW6qaXLpeIlwdiCxZjDoeY1idiCQWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOxMlE5PjRizszN NH[wPGNUSU6JRWK=
OAW-42 cell NX;LOIxoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF3CSHNKdmirYnn0bY9vKG:oIHj1cYFvKE:DVz20NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOzF3NkWg{txO NFjxT41USU6JRWK=
OCI-AML2 cell NFfRWGxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYrJcohq[mm2aX;uJI9nKGi3bXHuJG9EUS2DTVyyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|MvOjV|MTFOwG0> NXrGZ25pW0GQR1XS
OCUB-M cell M3KybWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUPhcJoyUW6qaXLpeIlwdiCxZjDoeY1idiCRQ2XCMW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04Njd{MUWyJO69VQ>? NWXC[XpjW0GQR1XS
OE19 cell NFW1PIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlT0TY5pcWKrdHnvckBw\iCqdX3hckBQTTF7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz63OlY5PCEQvF2= MW\TRW5ITVJ?
OE33 cell NHfvUXJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWjJcohq[mm2aX;uJI9nKGi3bXHuJG9GOzNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLki4PVI3KM7:TR?= M17ueXNCVkeHUh?=
OMC-1 cell MnHWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFr0ZmtKdmirYnn0bY9vKG:oIHj1cYFvKE:PQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4zPTB7ODFOwG0> NYXpVFVoW0GQR1XS
OS-RC-2 cell M4PJ[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVvJcohq[mm2aX;uJI9nKGi3bXHuJG9UNVKFLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlUzOzB5IN88US=> MV7TRW5ITVJ?
OVCAR-3 cell NIXufY1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NELDWVZKdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh2NEG1JO69VQ>? M4\YW3NCVkeHUh?=
OVCAR-4 cell NIX6fGlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYTpOIxbUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk01KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzBwNE[2JO69VQ>? M1L1R3NCVkeHUh?=
P12-ICHIKAWA cell NITDPFRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFfDd3VKdmirYnn0bY9vKG:oIHj1cYFvKFBzMj3JR2hKU0GZQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0Mlc3QDNizszN M2TPRnNCVkeHUh?=
P30-OHK cell NULITmExT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUjJcohq[mm2aX;uJI9nKGi3bXHuJHA{OC2RSFugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlU{PiEQvF2= Ml7SV2FPT0WU
PA-1 cell NYK1N4s{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkfiTY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT6wO|YyPSEQvF2= NFfrVGFUSU6JRWK=
PANC-03-27 cell M3LCUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUDsOJJJUW6qaXLpeIlwdiCxZjDoeY1idiCSQV7DMVA{NTJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD63NVA5OiEQvF2= MWrTRW5ITVJ?
PANC-10-05 cell NVPj[FVHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MofETY5pcWKrdHnvckBw\iCqdX3hckBRSU6FLUGwMVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwOUm1PUDPxE1? NH7xe5BUSU6JRWK=
PC-3 cell MlLNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NI[zV|FKdmirYnn0bY9vKG:oIHj1cYFvKFCFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE42OTN3IN88US=> NHmx[IdUSU6JRWK=
PF-382 cell NW\5bI15T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYP0NYZsUW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS54OEK4JO69VQ>? MVPTRW5ITVJ?
RCC10RGB cell Ml\MS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGjvZYJKdmirYnn0bY9vKG:oIHj1cYFvKFKFQ{GwVmdDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC54NU[3JO69VQ>? MXjTRW5ITVJ?
RD cell MojtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlnLTY5pcWKrdHnvckBw\iCqdX3hckBTTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJyLk[wN|Yh|ryP NVzr[2pUW0GQR1XS
REH cell M{XrPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\BT3VKdmirYnn0bY9vKG:oIHj1cYFvKFKHSDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlQ5QDNizszN NUfQWXhpW0GQR1XS
RERF-LC-MS cell MmXES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3X3dGlvcGmkaYTpc44hd2ZiaIXtZY4hWkWURj3MR{1OWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ4LkGzOFch|ryP NVW4Um1TW0GQR1XS
RKO cell NHnxOINIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXLVWmNKUW6qaXLpeIlwdiCxZjDoeY1idiCUS1:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xPU41PDN7IN88US=> M2rkdHNCVkeHUh?=
RO82-W-1 cell Ml\TS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mmr2TY5pcWKrdHnvckBw\iCqdX3hckBTVzh{LWetNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQ4NjJ5OEOg{txO NXG0O|N{W0GQR1XS
RPMI-2650 cell NEniR|FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYLJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvMk[1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzd7NEeg{txO M1;EWHNCVkeHUh?=
RPMI-8402 cell NWW5[YdHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkfTTY5pcWKrdHnvckBw\iCqdX3hckBTWE2LLUi0NFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPi5|NEOg{txO MlXTV2FPT0WU
RS4-11 cell NF7vZ2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHfRXZZKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPjh4NEWg{txO NU[4OldwW0GQR1XS
RT-112 cell MojOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXPJcohq[mm2aX;uJI9nKGi3bXHuJHJVNTFzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uO|E6PTJizszN NG\mUoJUSU6JRWK=
RVH-421 cell M{[wR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlXDTY5pcWKrdHnvckBw\iCqdX3hckBTXkhvNEKxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|IvOzZyNjFOwG0> NIDiRW1USU6JRWK=
RXF393 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoWxTY5pcWKrdHnvckBw\iCqdX3hckBTYEZ|OUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNE42QDZ|IN88US=> MUfTRW5ITVJ?
SBC-5 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2nndWlvcGmkaYTpc44hd2ZiaIXtZY4hW0KFLUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNE45OzJ3IN88US=> NYD1doNpW0GQR1XS
SCC-25 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHvl[HBKdmirYnn0bY9vKG:oIHj1cYFvKFOFQz2yOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjhzN{mg{txO M1:1SHNCVkeHUh?=
SCC-4 cell NE\0So1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVPJTXZvUW6qaXLpeIlwdiCxZjDoeY1idiCVQ1OtOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvPTl{OEOg{txO MmK4V2FPT0WU
SCC-9 cell NFr6d2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4i4R2lvcGmkaYTpc44hd2ZiaIXtZY4hW0OFLUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlA5PTN4IN88US=> MXHTRW5ITVJ?
SF126 cell M1vuVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2jPOmlvcGmkaYTpc44hd2ZiaIXtZY4hW0ZzMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43PzR4IN88US=> M2fMPXNCVkeHUh?=
SF268 cell Mki1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2fKVGlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z{NkigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yOzh5IN88US=> NXrvUFU4W0GQR1XS
SF295 cell MmrLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1;jVGlvcGmkaYTpc44hd2ZiaIXtZY4hW0Z{OUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{43OTh|IN88US=> MnHKV2FPT0WU
SIG-M5 cell NFfKbmdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NI\lWpRKdmirYnn0bY9vKG:oIHj1cYFvKFOLRz3NOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjZ4MESg{txO MnnkV2FPT0WU
SJSA-1 cell MoXrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWrqfZJTUW6qaXLpeIlwdiCxZjDoeY1idiCVSmPBMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Pi57MEeyJO69VQ>? Mkf2V2FPT0WU
SK-CO-1 cell NVnNRmUzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVmzXll3UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3DU{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwNkO5OEDPxE1? M2m4O3NCVkeHUh?=
SK-LMS-1 cell M4P5ZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkPGTY5pcWKrdHnvckBw\iCqdX3hckBUUy2OTWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPzZ2NUKg{txO MVTTRW5ITVJ?
SK-LU-1 cell NFHoV4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVPTc3hYUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3MWU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwMESzJO69VQ>? M{C0e3NCVkeHUh?=
SK-MEL-24 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3v3NmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXMMVI1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwMU[3OUDPxE1? NIC4V4VUSU6JRWK=
SK-MEL-3 cell NETQRVFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH\zVYdKdmirYnn0bY9vKG:oIHj1cYFvKFONLV3FUE0{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjFwNE[5OkDPxE1? MWDTRW5ITVJ?
SK-MES-1 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYnNS4VVUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSXMuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMUCwPVYh|ryP MVvTRW5ITVJ?
human SN12C cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mo\iTY5pcWKrdHnvckBw\iCqdX3hckBUVjF{QzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG3MlE6PjdizszN MnnTV2FPT0WU
SNB75 cell NHTu[2tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlLGTY5pcWKrdHnvckBw\iCqdX3hckBUVkJ5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuPFI6PyEQvF2= NV3lc4tFW0GQR1XS
SNU-387 cell M{PCcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWnmd5l4UW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtN|g4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC5zOUW0OEDPxE1? NYDFPJFFW0GQR1XS
SNU-423 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYH1NIRUUW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtOFI{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS57NEmzN{DPxE1? NVLaU3JDW0GQR1XS
SNU-C1 cell M4nifWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX;wUmE6UW6qaXLpeIlwdiCxZjDoeY1idiCVTmWtR|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjByOUS4JO69VQ>? MorqV2FPT0WU
SNU-C2B cell NILWN5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MorITY5pcWKrdHnvckBw\iCqdX3hckBUVlVvQ{LCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvOjZ5MzFOwG0> NYrBd21mW0GQR1XS
SR cell M3fxeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVnQXYFlUW6qaXLpeIlwdiCxZjDoeY1idiCVUjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlA4PDZizszN MXPTRW5ITVJ?
SU-DHL-1 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlnHTY5pcWKrdHnvckBw\iCqdX3hckBUXS2GSFytNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvQDF3NEOg{txO NYK0Z2hOW0GQR1XS
SW1710 cell MlLMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFHTbIxKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUexNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzh6OUKg{txO NX3LXY1pW0GQR1XS
SW780 cell M{\LTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUHJcohq[mm2aX;uJI9nKGi3bXHuJHNYPzhyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND64PVM2QCEQvF2= MnzXV2FPT0WU
SW872 cell M{fFbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFKzcJdKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvOTR|NTFOwG0> M2f4d3NCVkeHUh?=
SW954 cell M3jRZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXjSNnI5UW6qaXLpeIlwdiCxZjDoeY1idiCVV{m1OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQDV5OEOg{txO MWPTRW5ITVJ?
T47D cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1XRNWlvcGmkaYTpc44hd2ZiaIXtZY4hXDR5RDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOVE3OiEQvF2= M{[wOXNCVkeHUh?=
22RV1 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJFIzWlZzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj62NVQzPCEQvF2= NYPwepMzW0GQR1XS
23132-87 cell NX;FfFRTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml\FTY5pcWKrdHnvckBw\iCqdX3hckAzOzF|Mj24O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzV7M{ig{txO MlPNV2FPT0WU
639-V cell MnX5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWXRfJhTUW6qaXLpeIlwdiCxZjDoeY1idiB4M{mtWkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQDd5MzFOwG0> M3KyTnNCVkeHUh?=
697 cell M4r4cWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3rldWlvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz6xO|c1PiEQvF2= Mm\QV2FPT0WU
769-P cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVPYelZiUW6qaXLpeIlwdiCxZjDoeY1idiB5NkmtVEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTB2OEOg{txO M1jQU3NCVkeHUh?=
8-MG-BA cell NGT6R4RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3fZXWlvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPjN2MEGg{txO MVfTRW5ITVJ?
A4-Fuk cell M1\xSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIDnOW1KdmirYnn0bY9vKG:oIHj1cYFvKEF2LV\1b{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDV6MzFOwG0> M1PsSnNCVkeHUh?=
A427 cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJGE1OjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkC3Olk{KM7:TR?= NVvzdZNMW0GQR1XS
A498 cell MnTwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2flVmlvcGmkaYTpc44hd2ZiaIXtZY4hSTR7ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFgyOzRizszN M3vFdHNCVkeHUh?=
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... Click to View More Cell Line Experimental Data

In vivo In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. [1]

Protocol

Kinase Assay:[2]
+ Expand

Kinase screen:

Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).
Cell Research:[4 ]
+ Expand
  • Cell lines: HCC827, NCI-H522, NCI-1651, and PC-9 cells
  • Concentrations: ~10 μM
  • Incubation Time: 96 h
  • Method: The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 22 mg/mL (39.88 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 551.64
Formula

C34H29N7O

CAS No. 612847-09-3
Storage powder
in solvent
Synonyms Akt Inhibitor VIII

Bio Calculators

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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