Akti-1/2

Catalog No.S7776 Synonyms: Akt Inhibitor VIII

Akti-1/2 Chemical Structure

Molecular Weight(MW): 551.64

Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.

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Cited by 3 Publications

2 Customer Reviews

  • AKTi-1/2 inhibits human HCC cells in vitro. Human HCC HepG2 cells (A–F), Huh-7 cells (G), primary human HCC cells (“Pri HCC”, G) or the primary liver cells (“Pri liver cells”, G) were treated with/out applied concentrations of AKTi-1/2 for indicated time; Cell survival (A, B and G), proliferation (C and D) and apoptosis (E and F) were tested by the listed assays. Data were shown as the mean (n = 5) with the standard deviation (SD). Experiments in this figure were repeated three times, with similar results were obtained. *P < 0.05 vs. “C” (untreated control) group.

    Biochem Biophys Res Commun, 2016, 480(3):334-340. Akti-1/2 purchased from Selleck.

    Autophagy inhibitors sensitize AKTi-1/2-induced cytotoxicity against HCC cells. HepG2 cells were treated with/out AKTi-1/2 (5/10 μM) for indicated time; Listed proteins were tested by Western blot assay (A); The percentage of LC3B-II GFP puncta positive cells ("autophagic cells") was calculated (B). HepG2 cells, pretreated with 3-methyladenine (“3 MA”, 10 mM), ammonium chloride (“NH4Cl”, 1 mM) or bafilomycin A1 (“BafA1”, 1 μM) for 1 h, were treated with AKTi-1/2 (10 μM) for applied time; Cell survival (CCK-8 assay, C) were tested. The IC50 was also determined (D).

    Biochem Biophys Res Commun, 2016, 480(3):334-340.. Akti-1/2 purchased from Selleck.

Purity & Quality Control

Choose Selective Akt Inhibitors

Biological Activity

Description Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.
Targets
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
58 nM 210 nM 2119 nM
In vitro

In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. [1] In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. [2] Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. [3] In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-468 cells NFy4WpFEgXSxdH;4bYNqfHliYYPzZZk> MlHmNVAh|ryP NX65ZodoS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{BqdiCycnXz[Y5k\SCxZjCxNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9Nk43PiEQvF2= MYOxPFY6OTh7NB?=
MDA-MB-231 cells MnvnR5l1d3SxeHnjbZR6KGG|c3H5 M{XKfVExKM7:TR?= M2e5UWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgbY4heHKnc3XuZ4Uhd2ZiMUCgeW0h[2iub4LvdZVqdmViYomgV3JDKGG|c3H5MEBIUTVyPUSuOVUh|ryP NGjlc44yQDZ7MUi5OC=>
MCF7 cells NIGwTZhEgXSxdH;4bYNqfHliYYPzZZk> M3nqe|ExKM7:TR?= Mn7qR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BqdiCycnXz[Y5k\SCxZjCxNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9NE41OSEQvF2= M{TqR|E5PjlzOEm0
184B5 cells NXr5R3hiS3m2b4TvfIlkcXS7IHHzd4F6 NEHGfpYzOCEQvF2= NEjodIxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckAyQDSENTDj[YxteyCjdDCyNEB2VSClaHzvdo9yfWmwZTDifUBUWkJiYYPzZZktKEeLNUC9NlUvPzZizszN MkLjNVg3QTF6OUS=
NCI-H1563 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYfJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUW2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPTR{NE[g{txO M17ndHNCVkeHUh?=
NCI-H1618 cel M3jTcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3zrNWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixOlE5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjFwOUm4NkDPxE1? NYnK[JZ[W0GQR1XS
NCI-H1623 cell NH3HRnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF7UeFVKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVYzOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF3LkC1PVYh|ryP NULD[opCW0GQR1XS
NCI-H1648 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoP3TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njd3NUGg{txO MUjTRW5ITVJ?
NCI-H1650 cell NEDKb3BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmS4TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS53MUO0JO69VQ>? NWDFU4xEW0GQR1XS
NCI-H1651 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnzzTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG2OVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPi52M{O4JO69VQ>? Mnn6V2FPT0WU
NCI-H1703 cell Mk\4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVjv[IJVUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4ODNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNT61O|ch|ryP MYfTRW5ITVJ?
NCI-H1734 cell M{DYV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV3yR2JiUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4OzRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD63O|g5KM7:TR?= M1XWVHNCVkeHUh?=
NCI-H1755 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoPhTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3OVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB3NUOxJO69VQ>? Mn;aV2FPT0WU
NCI-H1770 cell NI\LcWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYPLXGJMUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4PzBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|ND6xO|k{KM7:TR?= MnviV2FPT0WU
NCI-H1792 cell NUXpSGp{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUe5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI6Njh|N{mg{txO Mkj5V2FPT0WU
NCI-H1963 cell NWrjdGZZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVPO[nZjUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE6PjNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zOT63OFk1KM7:TR?= MkToV2FPT0WU
NCI-H1993 cell NX7KdVVGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYH4O|VxUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE6QTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Mj62NVUh|ryP MkLHV2FPT0WU
NCI-H2009 cell NVPF[HNmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmrNTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKwNFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjN7MEG5JO69VQ>? MlqyV2FPT0WU
NCI-H2030 cell NXnqNIt2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX7QUY45UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxOzBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkm0OFg{KM7:TR?= M3vL[HNCVkeHUh?=
NCI-H2122 cell NE\3U25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{T2VWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVIzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwMUO4OUDPxE1? NWjqNphzW0GQR1XS
NCI-H2126 cell NEmz[ZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH\FfVBKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlEzPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF{LkOzO|Eh|ryP NFjVNHVUSU6JRWK=
NCI-H2170 cell MlLZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{XjN2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNVcxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OThwMUCyPEDPxE1? MY\TRW5ITVJ?
NCI-H2196 cell NGGycnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYfJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkG5OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI1NjhyMEOg{txO MUPTRW5ITVJ?
NCI-H2228 cell M1fxOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXXvZnA4UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIzOjhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkK4OlA1KM7:TR?= MVzTRW5ITVJ?
NCI-H2342 cell NUD5dHJMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml\GTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzOFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl|N{e5JO69VQ>? MV\TRW5ITVJ?
NCI-H2347 cell MnTOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYS3VnhsUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI{PDdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNj6xOVgyKM7:TR?= M4e4TXNCVkeHUh?=
NCI-H2405 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHlTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK0NFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC52MkGyJO69VQ>? M1XNWHNCVkeHUh?=
NCI-H2452 cell NETNNFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmeyTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK0OVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPi54NUm0JO69VQ>? MoXyV2FPT0WU
NCI-H292 cell MoTDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mnj5TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvODR6M{eg{txO NF\WOHRUSU6JRWK=
NCI-H345 cell NFHUcFdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KM{S1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVYvOjdyNjFOwG0> NGfVc|dUSU6JRWK=
NCI-H358 cell NYDNZWxZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV;MT|htUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFM2QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF7LkeyN|Mh|ryP M33OdHNCVkeHUh?=
NCI-H460 cell NV;PUFNXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXXJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE43Ojl7MzFOwG0> MoTMV2FPT0WU
NCI-H520 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoXXTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWyNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTN|MEOg{txO NUP4XpY4W0GQR1XS
NCI-H522 cell NXH4OG5vT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUKyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvODh5NDFOwG0> M1[3dnNCVkeHUh?=
NCI-H526 cell NH3KNpJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\DTWxKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjJwOEi3N:69VQ>? NEP1T5dUSU6JRWK=
NCI-H596 NHXtbFJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVfJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUm2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVcvPTdyODFOwG0> MUTTRW5ITVJ?
NCI-H630 cell NVjMWFZjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEnrT2NKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlMxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS53MUC1OUDPxE1? NWnHZ4FPW0GQR1XS
NCI-H64 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVLqZ5ZyUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTJwNUSzNUDPxE1? Mn25V2FPT0WU
NCI-H650 cell M{fVVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGfzc2FKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOlUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py53OUi3O{DPxE1? MVjTRW5ITVJ?
NCI-H661 cell M4fwbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNk[xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU41OjN{NjFOwG0> MlvIV2FPT0WU
NCI-H747 cell MnPrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYfJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{S3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{43Ojd7OTFOwG0> MYnTRW5ITVJ?
NCI-H838 cell NIDOcWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4HIfGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi4N|gh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{OS52MUG4JO69VQ>? MYLTRW5ITVJ?
NCI-N87 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkDqTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvTki3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlkvOzB2MjFOwG0> MX\TRW5ITVJ?
NH-12 cell M17zWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2LWW2lvcGmkaYTpc44hd2ZiaIXtZY4hVkhvMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYxQDZ2IN88US=> NEjwUYdUSU6JRWK=
NKM-1 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYrDN2Z6UW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzV7MkOg{txO NX7rPHl3W0GQR1XS
NMC-G1 cell NWnlTXA{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIP6SYZKdmirYnn0bY9vKG:oIHj1cYFvKE6PQz3HNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQzNjZ4OUOg{txO MVXTRW5ITVJ?
NOS-1 cell NWHnV3oxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlfGTY5pcWKrdHnvckBw\iCqdX3hckBPV1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|Y6PTNizszN M17ES3NCVkeHUh?=
NUGC-3 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mm\KTY5pcWKrdHnvckBw\iCqdX3hckBPXUeFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOk42QTB4IN88US=> Mkn2V2FPT0WU
NY cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkTzTY5pcWKrdHnvckBw\iCqdX3hckBPYSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNzLkG4OlQh|ryP NGTWb|dUSU6JRWK=
OAW-42 cell M3TvOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFG2NZVKdmirYnn0bY9vKG:oIHj1cYFvKE:DVz20NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOzF3NkWg{txO MUDTRW5ITVJ?
OCI-AML2 cell NXLKUIFqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHjlbIpKdmirYnn0bY9vKG:oIHj1cYFvKE:FST3BUWwzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzNwMkWzNUDPxE1? NWqwd3ZYW0GQR1XS
OCUB-M cell NUnVXlFPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXrIZoVHUW6qaXLpeIlwdiCxZjDoeY1idiCRQ2XCMW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04Njd{MUWyJO69VQ>? MmfGV2FPT0WU
OE19 cell NY\oeYx5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGj1NYtKdmirYnn0bY9vKG:oIHj1cYFvKE:HMUmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23Mlc3Pjh2IN88US=> M{nlcnNCVkeHUh?=
OE33 cell NHXqR2ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUWxSWNVUW6qaXLpeIlwdiCxZjDoeY1idiCRRUOzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45QDl{NjFOwG0> NGTiS2lUSU6JRWK=
OMC-1 cell NULJUXZPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYnHcJI5UW6qaXLpeIlwdiCxZjDoeY1idiCRTVOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvOjVyOUig{txO NGi1bI5USU6JRWK=
OS-RC-2 cell NEjaO5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVLKZ3F7UW6qaXLpeIlwdiCxZjDoeY1idiCRUz3SR{0zKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC53MkOwO{DPxE1? M2LVd3NCVkeHUh?=
OVCAR-3 cell MnXRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NITjcGtKdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh2NEG1JO69VQ>? NFXyWVhUSU6JRWK=
OVCAR-4 cell M2G2c2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYHJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNE41PjZizszN MUXTRW5ITVJ?
P12-ICHIKAWA cell M{frdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWHuZVVYUW6qaXLpeIlwdiCxZjDoeY1idiCSMUKtTWNJUUuDV1GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE44Pjh|IN88US=> MYXTRW5ITVJ?
P30-OHK cell M2fTV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXnJcohq[mm2aX;uJI9nKGi3bXHuJHA{OC2RSFugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlU{PiEQvF2= MXTTRW5ITVJ?
PA-1 cell M1nJbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYjBNXNSUW6qaXLpeIlwdiCxZjDoeY1idiCSQT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4xPzZzNTFOwG0> Mn20V2FPT0WU
PANC-03-27 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NULyOWx4UW6qaXLpeIlwdiCxZjDoeY1idiCSQV7DMVA{NTJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD63NVA5OiEQvF2= NXmyO2pDW0GQR1XS
PANC-10-05 cell MlW1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkfYTY5pcWKrdHnvckBw\iCqdX3hckBRSU6FLUGwMVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwOUm1PUDPxE1? MXHTRW5ITVJ?
PC-3 cell NVLONYpYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJHBENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD61NVM2KM7:TR?= NFrkbo1USU6JRWK=
PF-382 cell MlfJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXvzeGVDUW6qaXLpeIlwdiCxZjDoeY1idiCSRj2zPFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS54OEK4JO69VQ>? MkfOV2FPT0WU
RCC10RGB cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3rBV2lvcGmkaYTpc44hd2ZiaIXtZY4hWkOFMUDSS2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjZ3Nkeg{txO MWnTRW5ITVJ?
RD cell M4K3U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHXkTYlKdmirYnn0bY9vKG:oIHj1cYFvKFKGIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkCuOlA{PiEQvF2= MUTTRW5ITVJ?
REH cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3S4NmlvcGmkaYTpc44hd2ZiaIXtZY4hWkWKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuOFg5OyEQvF2= MknJV2FPT0WU
RERF-LC-MS cell M3jDcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XaTGlvcGmkaYTpc44hd2ZiaIXtZY4hWkWURj3MR{1OWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ4LkGzOFch|ryP NUjjbJI2W0GQR1XS
RKO cell NF:yUJNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF:2eHdKdmirYnn0bY9vKG:oIHj1cYFvKFKNTzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG5MlQ1OzlizszN NVy4fmNrW0GQR1XS
RO82-W-1 cell M37qV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHrjcXRKdmirYnn0bY9vKG:oIHj1cYFvKFKROEKtW{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDdwMke4N{DPxE1? M3THPXNCVkeHUh?=
RPMI-2650 cell M3S1RWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13PUGlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST2yOlUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS55N{m0O{DPxE1? M3q5SnNCVkeHUh?=
RPMI-8402 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2eyb2lvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST24OFAzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTZwM{SzJO69VQ>? MlvRV2FPT0WU
RS4-11 cell NXzLNYJmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4fQNmlvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok43QDZ2NTFOwG0> MkLiV2FPT0WU
RT-112 cell NHjERZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIj3O49KdmirYnn0bY9vKG:oIHj1cYFvKFKWLUGxNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvPzF7NUKg{txO NVHwR3V2W0GQR1XS
RVH-421 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX3Jcohq[mm2aX;uJI9nKGi3bXHuJHJXUC12MkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk4{PjB4IN88US=> NYXuTo5mW0GQR1XS
RXF393 cell M1POSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXnJcohq[mm2aX;uJI9nKGi3bXHuJHJZTjN7MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKwMlU5PjNizszN M3;iSXNCVkeHUh?=
SBC-5 cell NHK2fI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJHNDSy13IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkCuPFMzPSEQvF2= MYrTRW5ITVJ?
SCC-25 cell NH7nNWdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGL6NGRKdmirYnn0bY9vKG:oIHj1cYFvKFOFQz2yOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjhzN{mg{txO MoriV2FPT0WU
SCC-4 cell NWXtdpA{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoHpTY5pcWKrdHnvckBw\iCqdX3hckBUS0NvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuOVkzQDNizszN Moe0V2FPT0WU
SCC-9 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJHNESy17IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wPFU{PiEQvF2= NYXhc4xpW0GQR1XS
SF126 cell NEjXSnBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3y0UWlvcGmkaYTpc44hd2ZiaIXtZY4hW0ZzMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43PzR4IN88US=> MXLTRW5ITVJ?
SF268 cell NH\ocZFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlHTTY5pcWKrdHnvckBw\iCqdX3hckBUTjJ4ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlE{QDdizszN NFXubYFUSU6JRWK=
SF295 cell MkP5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVLJcohq[mm2aX;uJI9nKGi3bXHuJHNHOjl3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuOlE5OyEQvF2= Mn\pV2FPT0WU
SIG-M5 cell M{\qeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXnQRmhrUW6qaXLpeIlwdiCxZjDoeY1idiCVSVetUVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi54NkC0JO69VQ>? MkPRV2FPT0WU
SJSA-1 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoroTY5pcWKrdHnvckBw\iCqdX3hckBUUlODLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk46ODd{IN88US=> M2ix[XNCVkeHUh?=
SK-CO-1 cell MlewS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4r4XGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvQ1:tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjZ|OUSg{txO Mm\TV2FPT0WU
SK-LMS-1 cell NFSyUmpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{fqbWlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTF3TMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05Njd4NEWyJO69VQ>? M1fzU3NCVkeHUh?=
SK-LU-1 cell MlTkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWTXXGVwUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3MWU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwMESzJO69VQ>? NVzxZpVsW0GQR1XS
SK-MEL-24 cell Mn21S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVfJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU2HTD2yOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjF4N{Wg{txO NUS4Wph1W0GQR1XS
SK-MEL-3 cell NGfVboFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV\hcI54UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSWwuOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJzLkS2PVYh|ryP NYrLXWM5W0GQR1XS
SK-MES-1 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlW4TY5pcWKrdHnvckBw\iCqdX3hckBUUy2PRWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTByOU[g{txO Mlv3V2FPT0WU
human SN12C cell MmnIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV\afGlCUW6qaXLpeIlwdiCxZjDoeY1idiCVTkGyR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE4NjF7Nkeg{txO NF7lZoNUSU6JRWK=
SNB75 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWHJcohq[mm2aX;uJI9nKGi3bXHuJHNPSjd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz64Nlk4KM7:TR?= MkfmV2FPT0WU
SNU-387 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkHMTY5pcWKrdHnvckBw\iCqdX3hckBUVlVvM{i3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQTV2NDFOwG0> M4Lqd3NCVkeHUh?=
SNU-423 cell M{DQeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2C4R2lvcGmkaYTpc44hd2ZiaIXtZY4hW06XLUSyN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvQTR7M{Og{txO MYXTRW5ITVJ?
SNU-C1 cell M1\3PWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkDPTY5pcWKrdHnvckBw\iCqdX3hckBUVlVvQ{GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlAxQTR6IN88US=> MVzTRW5ITVJ?
SNU-C2B cell MnnZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoHWTY5pcWKrdHnvckBw\iCqdX3hckBUVlVvQ{LCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlIvOjZ5MzFOwG0> NVT1ZYFzW0GQR1XS
SR cell NUjHWZBFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnPETY5pcWKrdHnvckBw\iCqdX3hckBUWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF|LkC3OFYh|ryP NVWwZZpKW0GQR1XS
SU-DHL-1 cell NYfYPII5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFjoOYtKdmirYnn0bY9vKG:oIHj1cYFvKFOXLVTIUE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi56MUW0N{DPxE1? Ml23V2FPT0WU
SW1710 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIG4VllKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUexNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzh6OUKg{txO MVfTRW5ITVJ?
SW780 cell NFi2dHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoXETY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuPFk{PThizszN NGD3TYtUSU6JRWK=
SW872 cell M2T4NWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2f6NWlvcGmkaYTpc44hd2ZiaIXtZY4hW1d6N{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE4yPDN3IN88US=> MmHpV2FPT0WU
SW954 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEfpVoNKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUW0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU45PTd6MzFOwG0> NWTQfXp6W0GQR1XS
T47D cell NF7XPXlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXrFOVJTUW6qaXLpeIlwdiCxZjDoeY1idiCWNEfEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE42OTZ{IN88US=> MVPTRW5ITVJ?
22RV1 cell NEHyNlhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1e4OGlvcGmkaYTpc44hd2ZiaIXtZY4hOjKUVkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlYyPDJ2IN88US=> MXPTRW5ITVJ?
23132-87 cell NV74VnB3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3HPfmlvcGmkaYTpc44hd2ZiaIXtZY4hOjNzM{KtPFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd3OUO4JO69VQ>? MUnTRW5ITVJ?
639-V cell NUnHRm5qT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3zhVmlvcGmkaYTpc44hd2ZiaIXtZY4hPjN7LW[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Mlg4PzNizszN MUHTRW5ITVJ?
697 cell NI\LR2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMUe3OFYh|ryP NV\Qcol3W0GQR1XS
769-P cell MmK4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVfJcohq[mm2aX;uJI9nKGi3bXHuJFc3QS2SIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFQ5OyEQvF2= M3q4XnNCVkeHUh?=
8-MG-BA cell NUD0VGo4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXy1bWd[UW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QC54M{SwNUDPxE1? M1ThenNCVkeHUh?=
A4-Fuk cell M4mzUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYi3dJpRUW6qaXLpeIlwdiCxZjDoeY1idiCDND3GeYsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh3OEOg{txO NVjNdFlZW0GQR1XS
A427 cell M3W0dWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFy5U29KdmirYnn0bY9vKG:oIHj1cYFvKEF2MkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlA4Pjl|IN88US=> M4XvXXNCVkeHUh?=
A498 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHzCSYVKdmirYnn0bY9vKG:oIHj1cYFvKEF2OUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA5OTN2IN88US=> NIK3b3FUSU6JRWK=
AN3-CA cell NUXNd3o6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NI\Vb45KdmirYnn0bY9vKG:oIHj1cYFvKEGQMz3DRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjV4MUGg{txO MnvMV2FPT0WU
AU565 cell MlX3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4HIfGlvcGmkaYTpc44hd2ZiaIXtZY4hSVV3NkWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI{QTF5IN88US=> Mom5V2FPT0WU
BB30-HNC cell NILqUFJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGC2dHZKdmirYnn0bY9vKG:oIHj1cYFvKEKEM{CtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi56NkS0PUDPxE1? Ml;SV2FPT0WU
BxPC-3 cell Ml;FS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{DrfGlvcGmkaYTpc44hd2ZiaIXtZY4hSniSQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zOjR2MjFOwG0> NILZOJFUSU6JRWK=
C-33-A cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXrmWmFLUW6qaXLpeIlwdiCxZjDoeY1idiCFLUOzMWEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi52N{izJO69VQ>? MkLUV2FPT0WU
C2BBe1 cell M2ToU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3\mU2lvcGmkaYTpc44hd2ZiaIXtZY4hSzKEQnWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPjZ5OTFOwG0> M3TyeXNCVkeHUh?=
C3A cell NFq3[nhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{X4RmlvcGmkaYTpc44hd2ZiaIXtZY4hSzODIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND60NlE6OiEQvF2= M4XBRXNCVkeHUh?=
CAL-33 cell Mnv3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmDaTY5pcWKrdHnvckBw\iCqdX3hckBESUxvM{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlQ{OTJ3IN88US=> Mo\3V2FPT0WU
CAL-51 cell NFHpUGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuOlI5PDFizqzt MoLYV2FPT0WU
CAL-54 cell NVLTNFBbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHXrNmNKdmirYnn0bY9vKG:oIHj1cYFvKEODTD21OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvQDh4MkWg{txO NHTXV2lUSU6JRWK=
CAL-85-1 cell NVHxOYdET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHjZVFFKdmirYnn0bY9vKG:oIHj1cYFvKEODTD24OU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PS57NUOwPUDPxE1? NIfOUFJUSU6JRWK=
TE-10 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXn2d4g6UW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvODR{MkWg{txO M4j0S3NCVkeHUh?=
TE-15 cell NUHmO29NT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJHRGNTF3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj60PVM6OyEQvF2= NHz1U25USU6JRWK=
TE-5 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlXNTY5pcWKrdHnvckBw\iCqdX3hckBVTS13IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND64NlQ2OiEQvF2= MnnUV2FPT0WU
TE-8 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVXJcohq[mm2aX;uJI9nKGi3bXHuJHRGNThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{ND61NlQ{KM7:TR?= NFvhUXBUSU6JRWK=
TT cell NE\Sc|hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGj4O2tKdmirYnn0bY9vKG:oIHj1cYFvKFSWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NT6zNlczPCEQvF2= MYDTRW5ITVJ?
U-118-MG cell NXXlSlZ4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXnJcohq[mm2aX;uJI9nKGi3bXHuJHUuOTF6LV3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU46ODJ3ODFOwG0> NFj1eolUSU6JRWK=
U-698-M cell M3TzSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYfne5NjUW6qaXLpeIlwdiCxZjDoeY1idiCXLU[5PE1OKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzlwMECxOUDPxE1? Mmr5V2FPT0WU
U251 cell NHz6NmJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFSwW4RKdmirYnn0bY9vKG:oIHj1cYFvKFV{NUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xPU4zODRizszN NEPrOYJUSU6JRWK=
UACC-62 cell NXLPbmo4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJHVCS0NvNkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yO{4xPTR3IN88US=> MlnhV2FPT0WU
UACC-893 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1mzcGlvcGmkaYTpc44hd2ZiaIXtZY4hXUGFQz24PVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02NjJ7M{O5JO69VQ>? Ml;jV2FPT0WU
VMRC-RCZ cell NF\Yd2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV\UcIF6UW6qaXLpeIlwdiCxZjDoeY1idiCYTWLDMXJEYiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwN{C5OVUh|ryP MWHTRW5ITVJ?
YKG-1 cell NHe1dIlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJHlMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNVgxPiEQvF2= NHLq[HFUSU6JRWK=
CCF-STTG1 cell NFjISFNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGfVTIhKdmirYnn0bY9vKG:oIHj1cYFvKEOFRj3TWHRIOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZwOEG1NFEh|ryP NXr5OJExW0GQR1XS
CCRF-CEM cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVvJcohq[mm2aX;uJI9nKGi3bXHuJGNEWkZvQ1XNJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE46OzV2MTFOwG0> M1\m[nNCVkeHUh?=
CESS cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGK0OoNKdmirYnn0bY9vKG:oIHj1cYFvKEOHU2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlcxODh7IN88US=> NYD0cllPW0GQR1XS
CHP-212 cell M17BTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVzWcHdpUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNlEzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC53NUi2O{DPxE1? M1T6RnNCVkeHUh?=
COLO-205 cell NY\JbZZ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmrDTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUKwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTl5ME[g{txO M{HnVXNCVkeHUh?=
COR-L279 cell NYfr[2lsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXrld3dHUW6qaXLpeIlwdiCxZjDoeY1idiCFT2KtUFI4QSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwNkiwOlQh|ryP M{X4fnNCVkeHUh?=
CTB-1 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{jqOGlvcGmkaYTpc44hd2ZiaIXtZY4hS1SELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlU6PzVzIN88US=> M{fMNHNCVkeHUh?=
Ca-Ski cell MlzwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1z0cmlvcGmkaYTpc44hd2ZiaIXtZY4hS2FvU3vpJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OU4{PDFzIN88US=> M3W5U3NCVkeHUh?=
Ca9-22 cell M2PEXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV;rVm8xUW6qaXLpeIlwdiCxZjDoeY1idiCFYUmtNlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Njl5M{OzJO69VQ>? NXX0OFJxW0GQR1XS
Calu-1 cell NFXuZ4RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF3iOVBKdmirYnn0bY9vKG:oIHj1cYFvKEOjbIWtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvOjV4MUOg{txO MW\TRW5ITVJ?
Calu-3 cell NH\GUodIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF\h[4NKdmirYnn0bY9vKG:oIHj1cYFvKEOjbIWtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvPjV|MkGg{txO NWnIfGtIW0GQR1XS
DMS-273 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEC2V4xKdmirYnn0bY9vKG:oIHj1cYFvKESPUz2yO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjF3MUO0JO69VQ>? M2i2S3NCVkeHUh?=
DOK cell Mnn3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3LjUGlvcGmkaYTpc44hd2ZiaIXtZY4hTE:NIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xOVE{PCEQvF2= MnThV2FPT0WU
DSH1 cell M{G2UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUDJcohq[mm2aX;uJI9nKGi3bXHuJGRUUDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkm4O|IzKM7:TR?= MXPTRW5ITVJ?
DV-90 cell Mk[5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4myZ2lvcGmkaYTpc44hd2ZiaIXtZY4hTFZvOUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlA{OTJ{IN88US=> MnvJV2FPT0WU
Detroit562 cell M3rFZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWLJcohq[mm2aX;uJI9nKGi3bXHuJGRmfHKxaYS1OlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01Njd7NE[1JO69VQ>? NXWxfFNQW0GQR1XS
DoTc2-4510 cell MmqyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NInrNmZKdmirYnn0bY9vKG:oIHj1cYFvKESxVHOyMVQ2OTBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkSzNlAzKM7:TR?= M2H0bnNCVkeHUh?=
EB2 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUPJcohq[mm2aX;uJI9nKGi3bXHuJGVDOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwN{W0Olgh|ryP MUXTRW5ITVJ?
ECC12 cell NUS2S5M{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWfJcohq[mm2aX;uJI9nKGi3bXHuJGVESzF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD64PFU3QSEQvF2= NWfreI5SW0GQR1XS
EFM-19 cell NYnubZpuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2jpTGlvcGmkaYTpc44hd2ZiaIXtZY4hTU[PLUG5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE42PjRyODFOwG0> M4HPTHNCVkeHUh?=
EFO-21 cell NU[1XlhkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MknaTY5pcWKrdHnvckBw\iCqdX3hckBGTk9vMkGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ{PDZ6IN88US=> MWDTRW5ITVJ?
ES7 cell MnK5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3;MV2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zOFUyOSEQvF2= MV7TRW5ITVJ?
ETK-1 NH64SZJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUX6e24xUW6qaXLpeIlwdiCxZjDoeY1idiCHVFutNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVQvPTd|OEOg{txO NVPofHpwW0GQR1XS
EW-3 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NInZNYdKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21MlY1PDF2IN88US=> NIDoT|NUSU6JRWK=
HCC70 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4ntbGlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFN{CgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlc2ODd6IN88US=> NYrHb2NuW0GQR1XS
HGC-27 cell NYfIboVyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFzodIlKdmirYnn0bY9vKG:oIHj1cYFvKEiJQz2yO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTVyM{Og{txO MYLTRW5ITVJ?
IGROV-1 cell NXHyblhYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEXtXmpKdmirYnn0bY9vKG:oIHj1cYFvKEmJUl;WMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd{M{K4JO6ddQ>? NEXSc5FUSU6JRWK=
MDA-MB-361 cell NVH1c3BMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVf0UFVkUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOzZzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD60PFk6PSEQvF2= M{DHOHNCVkeHUh?=
MDA-MB-415 cell NVTkVGRlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mki5TY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtOFE2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55M{S0PUDPxE1? M1\SR3NCVkeHUh?=
MDA-MB-468 cell NWrId3dqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1fpN2lvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVQ3QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwN{C3O|Mh|ryP M{XvenNCVkeHUh?=
ME-180 cell NHSzfW1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrPfI5MUW6qaXLpeIlwdiCxZjDoeY1idiCPRT2xPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjF3MEGxJO6ddQ>? MkfiV2FPT0WU
NCI-H526 cells MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWLJcohq[mm2aX;uJI9nKEGtdD3t[YRq[XSnZDDhcpRq[XCxcITveIlkKGGldHn2bZR6KGmwIHj1cYFvKE6FST3IOVI3KGOnbHzzJIF{e2W|c3XkJIF{KGSrc4L1dJRqd25ib3[gdJJwfGWrbj3BdIFnNTFiY3;tdIxmgCCjdDC1NEB2VSCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| Mmn0NVc3ODN3NEC=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-Foxo3a / p-GSK3β / p-p70S6K / p-S6 / p-4EBP1 / Cyclin D1 / Cyclin D2 / Cyclin D3 / p-Rb / p27; 

PubMed: 18725974     


HCC1806 and T47D cells were treated with 1 µM AKTi-1/2 for the indicated times and cell lysates were immunoblotted with the indicated antibodies. 

18725974
Immunofluorescence
MCM2 / H3K9me2 / CD63 ; 

PubMed: 26637368     


Immunofluorescence images for both HCT116 and MCF7 cells, treated either with DMSO or Akti-1/2. Cells were stained for DAPI, MCM2, H3K9me2 and CD63. Merged images represent respective stains merged with underlying DAPI stain. Size bar = 10μm.

26637368
In vivo In mice, Akti-1/2 (50 mg/kg, i.p.) inhibits basal and IGF-stimulated Akt1 and Akt2 phosphorylation in lung. [1]

Protocol

Kinase Assay:[2]
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Kinase screen:

Briefly, all assays (25.5 μl at 21°C for 30 min) are performed using a Biomek 2000 Laboratory Automation Workstation in a 96-well format. Reactions contains 5–20 mU purified kinase along with substrate peptide or protein and are initiated by the addition of 10 mM MgAcetate and 5, 20, or 50 μM ATP ([γ-33P]-ATP, 800 cpm/pmol).
Cell Research:[4 ]
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  • Cell lines: HCC827, NCI-H522, NCI-1651, and PC-9 cells
  • Concentrations: ~10 μM
  • Incubation Time: 96 h
  • Method: The cell growth inhibitory effect of AKTi-1/2 is studied using the 96 h sulforhodamine B assay (SRB). Drug concentrations that inhibited 50% of cell growth (IC50) are calculated for each compound in GraphPad Prism 6.0 using non-linear regression analysis and sigmoidal dose–response (variable slope) equation.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 22 mg/mL (39.88 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 551.64
Formula

C34H29N7O

CAS No. 612847-09-3
Storage powder
in solvent
Synonyms Akt Inhibitor VIII

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Akt Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID