Angiotensin (1-7)

Catalog No.S9820 Synonyms: Ang-(1-7), Angiotensin fragment 1-7

For research use only.

Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.

Angiotensin (1-7) Chemical Structure

CAS No. 51833-78-4

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Biological Activity

Description Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
Targets
Mas receptor [1]
()
ACE [1]
()
0.65 μM
In vitro

Angiotensin (1-7) prevents the decrease of the myotube diameter and MHC Levels Induced by myostatin in C2C12 cells. Angiotensin (1-7) decreases the myostatin-dependent increment of E3 ubiquitin ligases and ROS, the NF-κB signaling induced by myostatin, the myostatin-dependent activity through the mas receptor and Akt/PKB activity in C2C12 myotubes.[1]

In vivo

Daily Angiotensin (1-7) administration significantly reduces colitis severity observable at both gross and histological levels in DSS treated mice. The anti-inflammatory effects of Angiotensin (1-7) treatment are associated with a reduction in the phosphorylated forms of p38 MAPK, ERK1/2 and Akt post DSS induction, the anti-inflammatory properties of Angiotensin (1-7) are in part mediated through reduction of Ang II levels.[3]

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: C2C12 cells
  • Concentrations: 10 nM
  • Incubation Time: 30 min, 60 min
  • Method:

    The C2C12 cells are differentiated until day 5 by changing DMEM–FSB to DMEM supplemented with horse serum. The myotubes are incubated with 1 µg/ml of human recombinant myostatin and/or 10 nM of Angiotensin (1-7). The myotubes are treated with 10 µM of MK2206 for Akt/PKB inhibition, or 10 µM of A779 antagonist for Mas receptor inhibition. In brief, the procedure is as follows: differentiated cells are pre-treated with Angiotensin (1-7) for 30 or 60 min, depending on the experiments, and then treated with myostatin.

  • (Only for Reference)
Animal Research:

[3]

  • Animal Models: DSS treated mice
  • Dosages: 0.01 mg/kg, 0.06 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

Water 50 mg/mL
(55.61 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 899.00
Formula

C41H62N12O11

CAS No. 51833-78-4
Storage 3 years -20°C powder
2 years -80°C in solvent

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