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Angiotensin (1-7) RAAS inhibitor

Cat.No.S9820

Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. This compound is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
Angiotensin (1-7) RAAS inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 899.00

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Quality Control

Batch: S982001 Water]50 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.30%
99.30

Chemical Information, Storage & Stability

Molecular Weight 899.00 Formula

C41H62N12O11

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 51833-78-4 -- Storage of Stock Solutions

Synonyms Ang-(1-7), Angiotensin fragment 1-7 Smiles CCC(C)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(CC2=CN=C[NH]2)C(=O)N3CCCC3C(O)=O

Solubility

In vitro
Batch:

Water : 50 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Mechanism of Action

Targets/IC50/Ki
Mas receptor [1]
ACE [1]
0.65 μM
In vitro

This compound prevents the decrease of the myotube diameter and MHC Levels Induced by myostatin in C2C12 cells. Angiotensin (1-7) decreases the myostatin-dependent increment of E3 ubiquitin ligases and ROS, the NF-κB signaling induced by myostatin, the myostatin-dependent activity through the mas receptor and Akt/PKB activity in C2C12 myotubes.[1]
In vivo

Daily administration of Angiotensin (1-7) significantly reduces colitis severity observable at both gross and histological levels in DSS treated mice. The anti-inflammatory effects of this compound treatment are associated with a reduction in the phosphorylated forms of p38 MAPK, ERK1/2 and Akt post DSS induction, and its anti-inflammatory properties are in part mediated through reduction of Ang II levels.[3]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06282965 Not yet recruiting
Traumatic Brain Injury
University of Arizona|United States Department of Defense
 March 2024 Phase 1|Phase 2

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