ACY-738

ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs.

ACY-738 Chemical Structure

ACY-738 Chemical Structure

CAS: 1375465-91-0

Selleck's ACY-738 has been cited by 4 publications

Purity & Quality Control

Batch: Purity: 99.80%
99.80

ACY-738 Related Products

Signaling Pathway

Choose Selective HDAC Inhibitors

Biological Activity

Description ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs.
Targets
HDAC6 [1]
(Cell-free)
1.7 nM
In Vivo
In vivo ACY-738 induces dramatic increases in α-tubulin acetylation in brain and stimulate mouse exploratory behaviors in novel, but not familiar environments. ACY-738 has the antidepressant-like properties. Elimination of ACY-738 from plasma is rapid, with plasmatic half-life of 12 min and concentration below 10 ng/ml after 2 h. ACY-738 rapidly distributes to the brain leading to a total drug exposure in CNS comparable to that of peripheral tissues[1]. ACY-738 decreases several characteristics of SLE (Systemic lupus erythematosus) in NZB/W mice by dictating B cell development in the bone marrow. ACY-738 treatment increases the percentage of B cells in early developmental stages, while decreasing the percentage of cells in late pre-B cell fraction F. ACY-738 regulation of BM B cell development could be due to regulation developmental checkpoints known to be dysfunctional during SLE[2].
Animal Research Animal Models Male NIH Swiss mice
Dosages 5 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 270.29 Formula

C14H14N4O2

CAS No. 1375465-91-0 SDF Download ACY-738 SDF
Smiles C1CC1(C2=CC=CC=C2)NC3=NC=C(C=N3)C(=O)NO
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 54 mg/mL ( (199.78 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 1 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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