Anidulafungin (LY303366)

Catalog No.S4286

For research use only.

Anidulafungin (LY303366), an echinocandin derivative, inhibits glucan synthase activity, used as an antifungal drug.

Anidulafungin (LY303366) Chemical Structure

CAS No. 166663-25-8

Selleck's Anidulafungin (LY303366) has been cited by 11 Publications

1 Customer Review

Purity & Quality Control

Choose Selective Fungal Inhibitors

Biological Activity

Description Anidulafungin (LY303366), an echinocandin derivative, inhibits glucan synthase activity, used as an antifungal drug.
Targets
glucan synthase [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL warmed
(87.7 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1140.24
Formula

C58H73N7O17

CAS No. 166663-25-8
Storage 3 years -20°C(in the dark) powder
2 years -80°C(in the dark) in solvent
Smiles CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC=C(C=C7)O)O)O)C(C)O)C)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04876716 Recruiting Drug: Azole|Drug: Anidulafungin Invasive Aspergillosis Erasmus Medical Center|ZonMw: The Netherlands Organisation for Health Research and Development|Stichting Hemato-Oncologie voor Volwassenen Nederland May 11 2021 Phase 3
NCT02021123 Completed Drug: Anidulafungin 100mg single dose iv Obesity Morbid Radboud University August 2014 Phase 4
NCT01236261 Completed Other: Non intervention Fungemia Fundacion SEIMC-GESIDA|Astellas Pharma Inc|Gilead Sciences|Merck Sharp & Dohme Corp.|Pfizer March 2013 --
NCT01734525 Completed Drug: Anidulafungin Candidemia Universidade Federal do Rio de Janeiro November 2012 Phase 4
NCT01188759 Withdrawn Drug: Voriconazole|Drug: Anidulafungin Aspergillosis|Invasive Pulmonary Aspergillosis|Neuroaspergillosis Pfizer May 2012 Phase 3
NCT01438216 Unknown status -- Invasive Candidiasis|Candidemia VU University Medical Center|Radboud University September 2011 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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