ABX464

Catalog No.S0076 Synonyms: SPL-464

For research use only.

ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.

ABX464 Chemical Structure

CAS No. 1258453-75-6

Purity & Quality Control

Choose Selective HIV Inhibitors

Biological Activity

Description ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.
Targets
HIV-1 [1]
(Cell-free assay)
HIV-1 [1]
(Cell-free assay)
0.1 μM 0.5 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 338.71
Formula

C16H10ClF3N2O

CAS No. 1258453-75-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC2=C(C(=C1)Cl)N=C(C=C2)NC3=CC=C(C=C3)OC(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05177835 Recruiting Drug: ABX464 Ulcerative Colitis Abivax S.A. December 3 2021 Phase 2
NCT05121714 Completed Drug: Caffeine|Drug: ABX464|Drug: Fluvoxamine Healthy Abivax S.A. December 17 2020 Phase 1
NCT03905109 Unknown status Drug: ABX464|Drug: Placebo Crohn Disease Abivax S.A. April 15 2020 Phase 2
NCT04023396 Active not recruiting Drug: ABX464 Ulcerative Colitis Abivax S.A. January 13 2020 Phase 2
NCT04049448 Active not recruiting Drug: ABX464 Rheumatoid Arthritis Abivax S.A. October 24 2019 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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