ACSS2 inhibitor

Catalog No.S8588

For research use only.

ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).

ACSS2 inhibitor Chemical Structure

CAS No. 508186-14-9

Selleck's ACSS2 inhibitor has been cited by 8 Publications

Purity & Quality Control

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Biological Activity

Description ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).
Targets
ACSS2 [1]
(Cell-free assay)
~0.6 μM
In vitro

This quinoxaline compound inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 = 6.8 μM. The quinoxaline is also able to inhibit HepG2 utilization of [14C]acetate for histone acetylation with IC50 = 5.5 μM[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 410.51
Formula

C20H18N4O2S2

CAS No. 508186-14-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COCCNC(=O)NC1=CC2=C(C=C1)N=C(C(=N2)C3=CC=CS3)C4=CC=CS4

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
Regarding the ACSS2 inhibitor S8588, how do I prevent the formation of crystals in cell culture?

Answer:
For cell culture experiments, if there is precipitate or crystal formations after diluting to 1:1000 please reformulate. You can try the following ratio for formulation with 0.1% stock solution (in DMSO) + 1% PEG300 + 99% medium.

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