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ASP7663

Cat.No.S0447

ASP7663 is an orally bioavailable selective activator of transient receptor potential ankyrin 1 (TRPA1). This compound activates human, rat and mouse TRPA1 receptors with EC50 of 510 nM, 540 nM and 500 nM, respectively. It acts by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo.
ASP7663 Chemical Structure

Chemical Structure

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Quality Control

Batch: S044701 DMSO]53 mg/mL]false]Ethanol]30 mg/mL]false]Water]Insoluble]false Purity: 99.47%
99.47

Solubility

In vitro
Batch:

DMSO : 53 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 30 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight Formula Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1190217-35-6 -- Storage of Stock Solutions

Synonyms N/A Smiles CC(C)CN1C2=C(C=CC=C2F)C(=CC(=O)O)C1=O

Mechanism of Action

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