ASP7663

Catalog No.S0447

For research use only.

ASP7663 is an orally bioavailable selective activator of transient receptor potential ankyrin 1 (TRPA1). ASP7663 activates human, rat and mouse TRPA1 receptors with EC50 of 510 nM, 540 nM and 500 nM, respectively. ASP7663 acts by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo.

CAS No. 1190217-35-6

Purity & Quality Control

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Biological Activity

Description ASP7663 is an orally bioavailable selective activator of transient receptor potential ankyrin 1 (TRPA1). ASP7663 activates human, rat and mouse TRPA1 receptors with EC50 of 510 nM, 540 nM and 500 nM, respectively. ASP7663 acts by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 53 mg/mL
Ethanol 30 mg/mL
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight
Formula
CAS No. 1190217-35-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)CN1C2=C(C=CC=C2F)C(=CC(=O)O)C1=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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