For research use only.
Catalog No.S2120 Synonyms: Umifenovir hydrochloride, Arbidol hydrochloride
CAS No. 131707-23-8
Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections.
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Choose Selective Influenza Virus Inhibitors
|Description||Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections.|
Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes.  Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5).  Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34.  Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one.  Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively. 
-  Pécheur EI, et al. Biochemistry, 2007, 46(20), 6050-6059.
-  Shi L, et al. Arch Virol, 2007, 152(8), 1447-1455.
-  Brooks MJ, et al. J Med Virol, 2012, 84(1), 170-181.
|In vitro||DMSO||103 mg/mL (200.43 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Umifenovir hydrochloride, Arbidol hydrochloride|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01651663||Unknown status||Drug: Arbidol (Umifenovir)|Other: placebo||Influenza||Pharmstandard||September 2011||Phase 4|
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