Arbidol HCl

Catalog No.S2120 Synonyms: Umifenovir hydrochloride, Arbidol hydrochloride

For research use only.

Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections.

Arbidol HCl Chemical Structure

CAS No. 131707-23-8

Purity & Quality Control

Choose Selective Influenza Virus Inhibitors

Biological Activity

Description Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections.
In vitro

Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes. [1] Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5). [2] Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. [3] Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one. [4] Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 513.88
Formula

C22H25BrN2O3S.HCl

CAS No. 131707-23-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3.Cl

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01651663 Unknown status Drug: Arbidol (Umifenovir)|Other: placebo Influenza Pharmstandard September 2011 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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