Molecular Weight(MW): 315.24
Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.
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|Description||Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.|
|In vivo||Amprolium (APL) is administrated intravenously at dose of 13 mg/kg in healthy chickens, the half-life beta t1/2, volume of distribution (Vd) and total body clearance (Cl) after intravenous administration are 0.21 hour, 0.12 L/kg and 1.32 L/h.kg, respectively. Amprolium (APL) (13 mg/kg, orally) results in the elimination half-life (t1/2) of 0.292 hour-0.654 hour which is 1.5-3.2 times longer than after intravenous administration, suggesting the presence of a 'flip-flop' phenomenon in chickens. Amprolium (APL) (13 mg/kg, orally) results in the maximum plasma concentration (Cmax) of 13 mg/kg during fasting which is about four times higher than that during nonfasting, and bioavailability during nonfasting is from 2.3% to 2.6%, and 6.4% during fasting.  Amprolium (0.1%) feeding significantly reduces total thiamin levels in heart, liver, and muscle but not in kidney in Broodfish of Atlantic salmon Salmo salar.  Amprolium hydrochloride (30 mg/kg, i.v.) results in t1/2 alpha of 0.17 hour, t1/2 beta of 4.89 hours, the total body clearance of 0.562 mL/kg/min, volume of distribution at steady state of 0.34 L/kg in Hubbard broiler chickens. Amprolium hydrochloride (30 mg/kg, i.v.) results in the peak plasma concentrations (Cmax) of 42.9 mg/mL and occurred at 3.67 hours, and systemic bioavailability of 66% in Hubbard broiler chickens.  Amprolium (125 ppm) shows significantly lower lesion scores than infected non medicated group in broiler chickens infected Eimeria tenella. Amprolium (125 ppm) significantly reduces mortality compared with infected non medicated group in broiler chickens infected Eimeria tenella. |
|In vitro||Water||63 mg/mL (199.84 mM)|
|DMSO||2 mg/mL (6.34 mM)|
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