Home Peptide Products β-Amyloid (1-42), human

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β-Amyloid (1-42), human

Cat.No.P1003

β-Amyloid (1-42), human is a peptide fragment composed of 42 amino acids, derived from amyloid precursor protein (APP), and plays a crucial role in Alzheimer's disease (AD). It self-aggregates into oligomers and fibrils, with the oligomeric form being the most neurotoxic. These aggregates form amyloid plaques, a characteristic feature of AD, which interfere with cellular functions, cause mitochondrial dysfunction, and lead to neuronal cell death through oxidative stress, calcium dysregulation, and inflammation.

Amino-acid Sequence

β-Amyloid (1-42), human Amino-acid Sequence

CAS No. 107761-42-2

Quality Control

Chemical Information & Solubility

Storage (From the date of receipt) 3 years-20°C powder
1 years-80°C in solvent

In vivo
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Biological Activity

Description β-Amyloid (1-42), human is a peptide fragment composed of 42 amino acids, derived from amyloid precursor protein (APP), and plays a crucial role in Alzheimer's disease (AD). It self-aggregates into oligomers and fibrils, with the oligomeric form being the most neurotoxic. These aggregates form amyloid plaques, a characteristic feature of AD, which interfere with cellular functions, cause mitochondrial dysfunction, and lead to neuronal cell death through oxidative stress, calcium dysregulation, and inflammation.

References
  • https://pubmed.ncbi.nlm.nih.gov/23249141/

Product Information

Molecular Formula

C203H311N55O60S
Molecular Weight 4514.04
CAS No. 107761-42-2
Appearance White powder
Peptide Content (by %N) ≥80%
Purity (by HPLC) 95%min.
Assay (By Anhydrous, Acetic Acid-free) 95.0~105.0%
MS Consistent
Packing plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage
(From the date of receipt)		 3 years-20°C powder
1 years-80°C in solvent
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)