Amitriptyline

Catalog No.S5947 Synonyms: MK-230, N-750, Ro41575

Amitriptyline Chemical Structure

Molecular Weight(MW): 277.40

Amitriptyline is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain.

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Biological Activity

Description Amitriptyline is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain.

Protocol

References

Solubility (25°C)

Chemical Information

Molecular Weight 277.40
Formula

C20H23N

CAS No. 50-48-6
Storage powder
in solvent
Synonyms MK-230, N-750, Ro41575

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02519400 Unknown status Drug: Amitriptyline Depression Asan Medical Center August 2015 Phase 1
NCT03587025 Completed Drug: Amitriptyline|Drug: Placebo Pain Postoperative University of Campinas Brazil June 1 2015 Phase 3
NCT02101892 Completed Drug: Amitriptyline|Drug: placebo Migraine|Preventive Treatment Rambam Health Care Campus|Migraine Research Foundation April 2014 Not Applicable
NCT00516503 Completed Drug: baclofen/amitriptyline/ketamine gel|Other: placebo Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neurotoxicity|Pain|Unspecified Adult Solid Tumor Protocol Specific Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) February 2008 Phase 3
NCT00471445 Completed Drug: ketamine/amitriptyline NP-H cream|Other: placebo Neurotoxicity|Pain|Peripheral Neuropathy|Unspecified Adult Solid Tumor Protocol Specific Gary Morrow|National Cancer Institute (NCI)|University of Rochester October 2007 Phase 3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID