Amitriptyline

Catalog No.S5947 Synonyms: MK-230, N-750, Ro41575

For research use only.

Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.

Amitriptyline Chemical Structure

CAS No. 50-48-6

Selleck's Amitriptyline has been cited by 1 Publication

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Choose Selective Serotonin Transporter Inhibitors

Biological Activity

Description Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.

Protocol (from reference)

Chemical Information

Molecular Weight 277.40
Formula

C20H23N

CAS No. 50-48-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02519400 Unknown status Drug: Amitriptyline Depression Asan Medical Center August 2015 Phase 1
NCT03587025 Completed Drug: Amitriptyline|Drug: Placebo Pain Postoperative University of Campinas Brazil June 1 2015 Phase 3
NCT02101892 Completed Drug: Amitriptyline|Drug: placebo Migraine|Preventive Treatment Rambam Health Care Campus|Migraine Research Foundation April 2014 Not Applicable
NCT00516503 Completed Drug: baclofen/amitriptyline/ketamine gel|Other: placebo Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neurotoxicity|Pain|Unspecified Adult Solid Tumor Protocol Specific Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) February 2008 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

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