Amitriptyline

For research use only.

Catalog No.S5947 Synonyms: MK-230, N-750, Ro41575

1 publication

Amitriptyline Chemical Structure

CAS No. 50-48-6

Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively.

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Selleck's Amitriptyline has been cited by 1 publication

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Description Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively.

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Solubility (25°C)

Chemical Information

Molecular Weight 277.40
Formula

C20H23N

CAS No. 50-48-6
Storage powder
in solvent
Synonyms MK-230, N-750, Ro41575
Smiles CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02519400 Unknown status Drug: Amitriptyline Depression Asan Medical Center August 2015 Phase 1
NCT03587025 Completed Drug: Amitriptyline|Drug: Placebo Pain Postoperative University of Campinas Brazil June 1 2015 Phase 3
NCT02101892 Completed Drug: Amitriptyline|Drug: placebo Migraine|Preventive Treatment Rambam Health Care Campus|Migraine Research Foundation April 2014 Not Applicable
NCT00516503 Completed Drug: baclofen/amitriptyline/ketamine gel|Other: placebo Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neurotoxicity|Pain|Unspecified Adult Solid Tumor Protocol Specific Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) February 2008 Phase 3
NCT00471445 Completed Drug: ketamine/amitriptyline NP-H cream|Other: placebo Neurotoxicity|Pain|Peripheral Neuropathy|Unspecified Adult Solid Tumor Protocol Specific Gary Morrow|National Cancer Institute (NCI)|University of Rochester October 2007 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID