Home Neuronal Signaling Serotonin Transporter inhibitor - 5-HT Receptor antagonist - Histamine Receptor inhibitor Amitriptyline For research use only.

Amitriptyline

Synonyms: MK-230, N-750, Ro41575

Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.

Amitriptyline Chemical Structure

Amitriptyline Chemical Structure

CAS: 50-48-6

Selleck's Amitriptyline has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.68%
99.68

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Biological Activity

Description Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02519400 Unknown status
Depression
Asan Medical Center
 August 2015 Phase 1
NCT03587025 Completed
Pain Postoperative
University of Campinas Brazil
 June 1 2015 Phase 3
NCT02101892 Completed
Migraine|Preventive Treatment
Rambam Health Care Campus|Migraine Research Foundation
 April 2014 Not Applicable
NCT00516503 Completed
Chronic Myeloproliferative Disorders|Leukemia|Lymphoma|Lymphoproliferative Disorder|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neurotoxicity|Pain|Unspecified Adult Solid Tumor Protocol Specific
Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI)
 February 2008 Phase 3

Chemical Information & Solubility

Molecular Weight 277.40 Formula

C20H23N
CAS No. 50-48-6 SDF --
Smiles CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
Storage (From the date of receipt) 3 years -20°C powder

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