Home Neuronal Signaling Serotonin Transporter inhibitor Amitriptyline

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Amitriptyline Serotonin Transporter inhibitor

Cat.No.S5947

Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. This compound is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. It also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
Amitriptyline Serotonin Transporter inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 277.40

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Quality Control

Batch: Purity: 99.68%
99.68

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Chemical Information, Storage & Stability

Molecular Weight 277.40 Formula

C20H23N

 Storage (From the date of receipt) 2 years  -20°C  liquid
CAS No. 50-48-6 --
Synonyms MK-230, N-750, Ro41575 SMILES CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31

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Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-17)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07640061 NOT_YET_RECRUITING
Microvesicle Particles; Thermal Burn
Wright State University
 2027-06 PHASE1
NCT07640061 NOT_YET_RECRUITING
Microvesicle Particles; Thermal Burn
Wright State University
 2027-06 PHASE1
NCT07716722 NOT_YET_RECRUITING
Thermal Burn; Amitriptyline
Wright State University
 2026-07 PHASE1
NCT07716722 NOT_YET_RECRUITING
Thermal Burn; Amitriptyline
Wright State University
 2026-07 PHASE1
NCT07655440 NOT_YET_RECRUITING
Migraine Associated Vertigo; Tinnitus; Migraine; Vestibular Migraine
Stanford University
 2026-07 PHASE4
NCT07655440 NOT_YET_RECRUITING
Migraine Associated Vertigo; Tinnitus; Migraine; Vestibular Migraine
Stanford University
 2026-07 PHASE4

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