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Alizapride HCl

Name: Alizapride HCl
Brand: Selleck Chemicals
SKU: S4257
Rating: 5 (1 reviews)

Synonyms: Alizapride hydrochloride

Catalog No.S4257 Purity: 99.08%

Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

Alizapride HCl Chemical Structure

CAS: 59338-87-3

Purity & Quality Control

Batch: S425701 Water] 70 mg/mL] false] DMSO] 42 mg/mL] false] Ethanol] Insoluble] false Purity: 99.08%

99.08

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Signaling Pathway

Dopamine Receptor Signaling Pathway

Choose Selective Dopamine Receptor Inhibitors

Biological Activity

Description

Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

Targets

Dopamine receptor ^[1]

In vitro
In vitro	Alizapride has a N-allyl moiety which potentially could undergo N-deallylation and/or epoxidation reactions, the formation of chemically reactive metabolites can be expected. ^[1]

In Vivo
In vivo	Alizapride demonstrates little toxicity (particularly after parenteral administration) in mice and rats. Alizapride is mainly excreted as unmodified drug after oral or parenteral administration; however, a share of about 25% undergoes metabolic transformation before deletion. ^[1] Alizapride (5 mg/kg, s.c.) antagonizes the decrease in gastrointestinal transit induced by the above doses of Apomorphine in the rat. ^[2]

References

Chemical Information & Solubility

Molecular Weight	351.83	Formula	C₁₆H₂₁N₅O₂.HCl
CAS No.	59338-87-3	SDF	Download Alizapride HCl SDF
Smiles	COC1=CC2=C(C=C1C(=O)NCC3CCCN3CC=C)NN=N2.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 70 mg/mL

DMSO : 42 mg/mL ( (119.37 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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