Alizapride HCl

Catalog No.S4257

For research use only.

Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.

Alizapride HCl Chemical Structure

CAS No. 59338-87-3

Purity & Quality Control

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Biological Activity

Description Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
Targets
Dopamine receptor [1]
In vitro

Alizapride has a N-allyl moiety which potentially could undergo N-deallylation and/or epoxidation reactions, the formation of chemically reactive metabolites can be expected. [1]

In vivo Alizapride demonstrates little toxicity (particularly after parenteral administration) in mice and rats. Alizapride is mainly excreted as unmodified drug after oral or parenteral administration; however, a share of about 25% undergoes metabolic transformation before deletion. [1] Alizapride (5 mg/kg, s.c.) antagonizes the decrease in gastrointestinal transit induced by the above doses of Apomorphine in the rat. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Water 70 mg/mL
(198.95 mM)
DMSO 42 mg/mL
(119.37 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 351.83
Formula

C16H21N5O2.HCl

CAS No. 59338-87-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC2=C(C=C1C(=O)NCC3CCCN3CC=C)NN=N2.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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