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Alizapride HCl Dopamine Receptor antagonist

Cat.No.S4257

Alizapride HCl(Alizapride hydrochloride) is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
Alizapride HCl Dopamine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 351.83

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Quality Control

Batch: S425701 Water]70 mg/mL]false]DMSO]42 mg/mL]false]Ethanol]Insoluble]false Purity: 99.08%
99.08

Chemical Information, Storage & Stability

Molecular Weight 351.83 Formula

C16H21N5O2.HCl

 Storage (From the date of receipt)
CAS No. 59338-87-3 Download SDF Storage of Stock Solutions

Synonyms Alizapride hydrochloride Smiles COC1=CC2=C(C=C1C(=O)NCC3CCCN3CC=C)NN=N2.Cl

Solubility

In vitro
Batch:

Water : 70 mg/mL

DMSO : 42 mg/mL (119.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
Dopamine receptor [1]
In vitro

Alizapride has a N-allyl moiety which potentially could undergo N-deallylation and/or epoxidation reactions, the formation of chemically reactive metabolites can be expected. [1]
In vivo

Alizapride demonstrates little toxicity (particularly after parenteral administration) in mice and rats. Alizapride is mainly excreted as unmodified drug after oral or parenteral administration; however, a share of about 25% undergoes metabolic transformation before deletion. [1] Alizapride (5 mg/kg, s.c.) antagonizes the decrease in gastrointestinal transit induced by the above doses of Apomorphine in the rat. [2]
References

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